• Journal of Yeungnam Medical Science
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• 제1권1호
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• pp.107-113
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• 1984

인간(人間)의 생활(生活)과 밀접(密接)한 관계(關係)가 있고 또 고혈압(高血壓)과도 불가분(不可分)의 관계(關係)가 있고 염분(鹽分)이 신동맥의 형태학적(形態學的) 변화(變化)에 미치는 영향(影響)을 연구관찰(硏究觀察)하기 위(爲)하여 백서(白鼠)를 실험동물(實驗動物)로 하여 통상(通常)의 동물사료(動物飼料)에 0.06%의 식염(食鹽)을 혼합투여(混合投與)한 대조군(對照群), 2.0%의 식염(食鹽)을 혼합(混合)한 저염분투여군(低鹽分投與群), 그리고 8.0%의 식염(食鹽)을 혼합투여(混合投與)한 고식염군(高食鹽群)으로 나누어 사육(飼育)하면서 실험시작(實驗始作) 2주후(週後)부터 2주간격(週間隔)으로 각군(各群)에서 3마리씩 도살(屠殺)하여 신동맥에 야기(惹起)된 병변(病變)을 관찰(觀察)하여 다음과 같은 결과(結果)를 얻었다. 대조군(對照群)에 있어서는 실험(實驗)16주차(週次)부터 신동맥의 내막(內膜)에 경미(輕微)한 비후성변화(肥厚性變化)를 초래(招來)하였으나 실험종료(實驗終了)인 20주(週)에도 그 정도(程度)는 경(輕)하였다. 저염분투여군(低鹽分投與群)에서는 실험(實驗)12주경(週頃)부터 경미(輕微)한 내막(內膜)의 비후성변화(肥厚性變化)를 관찰(觀察)할 수 있었으나 실험종료(實驗終了)인 20주(週)에도 그 정도(程度)는 역시 경(輕)하였다. 고염분투여군(高鹽分投與群)에서는 실험(實驗) 6주(週)부터 경미(輕微)한 내막(內膜)의 비후(肥厚)를 초래(招來)하여 그 정도(程度)가 경시적(經時的)으로 점차(漸次) 심(甚)해져서 실험종료시(實驗終了時)에는 내막비후(內膜肥厚)는 중등도(中等度) 내지(乃至) 고도(高度)로 관찰(觀察)되었으며 중막(中膜)의 비후(肥厚)나 동맥의 내막(內膜) 또는 중막(中膜)의 변성(變性)도 그 정도(程度)는 경(輕)하지만 관찰(觀察)할 수 있었다.

• Asian-Australasian Journal of Animal Sciences
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• 제6권2호
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• pp.291-300
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• 1993

The agronomic, morphologic and nutritive measurements were determined for ten varieties of the early-, medium- and late- maturing rice from five types of soil in south of China. The results are shown that (1) The higher contents of neutral detergent fibre (NDF), cellulose (CEL), hemicellulose (HC) and lignin (LIG), but lower crude protein (CP) and neutral detergent solubles (NDS) contents were noted for the whole plant of rice straw during maturation; (2) As far as the feed nutritive value, segments (S) is highest, then leaf blades (LB), leaf sheaths (LS) lowest. However, LB and LS are constituted about 75% of whole plant, the nutritive value of rice straw is depended upon the nutritive quality of LB and LS; (3) The dry matter disappearances (DMD) values of different spots of rice straw are different, the eary-maturing highest, then the medium; the late- lowest; (4) The DMD value of different fractions is different, S highest, then LB, LS lowest; (5) The different retention time in rumen, the DMD value of rice straw is different. As time following, the DMD value increased gradually, during 48-72 h, the DMD value achieves close to highest; (6) The grain yield (r = -0.91), plant height (r = -0.87) and full-filling grain percent (r = -0.75) are correlated negatively with DMD value, but the leaf/stem (r = 0.59) and the proportion of stem (r = 0.58) are correlated positively with DMD value. The relations between chemical compositions and DMD value are: Early-: DMD = 7.372 + 0.055 DM - 0.532 CP - 2.487 NDF + 1.143 ADF + 0.214 CEL + 1.456 HC + 0.718 LIG (r = 0.61). Medium-: DMD = 333.927 + 2.026 DM - 0.224 CP - 4.602 NDF + 4.524 ADF + 0.149 CEL + 2.923 HC + 0.035 LIG (r = 0.79). Late-: DMD = 133.284 + 0.282 DM - 3.455 CP - 22.185 NDF + 24.267 ADF + 0.316 CEL - 23.288 HC + 0.945 LIG (r = 0.79). Therefore, it is possible to predict the nutritive value of rice straw on the basis of the agronomic, morphologic measurements and chemical compositions and the relationship with DMD value.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1057-1060
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• 2016

Background: The tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of 53. Therefore, this study aimed to determine the role of the Mdm2 SNIP 309 polymorphism in the gastric mucosal morphological patterns in patients with Helicobacter pylori associated gastritis. Materials and Methods: A prospective cross-sectional study was carried out from November 2014 through November 2015. Biopsy specimens were obtained from patients and infection was proven by positive histology. Gastric mucosa specimens were sent to the Molecular Genetics Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 polymorphism using the real-time PCR hybridization probe method. The results were analyzed and correlated with gastric mucosal morphological patterns by using C-NBI endoscopy. Results: A total of 300 infected patients were enrolled and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygosity correlated with type 1 to type 3 gastric mucosal morphological patterns (P<0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with type 4 and type 5 (P<0.01). Conclusions: Our study finds the frequency of Mdm2 SNIP309 G/G in a Thai population is very low, and suggests that this can explain ae Thailand enigma. Types 1 to type 3 are the most common gastric mucosal morphological patterns according to the unique genetic polymorphism of MDM2 SNIP 309 in the Thai population.

• 대한관절경학회지
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• 제7권1호
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• pp.52-57
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• 2003

목적 : 정상 반월상 연골을 형태학적으로 계측하고 혈관 분포를 조사하여 연령과 해부학적 위치에 따른 차이를 비교하였다. 대상 및 방법 : 21구의 사체에서 반월상 연골을 채취하여 이를 연령별로 3군으로 나누고 각각을 10개의 절편으로 나누어 반월상 연골의 폭(width)과 혈관의 분포를 측정하였다. 결과 : 반월상 연골의 평균 폭은 내측이 $10.4{\pm}2.92mm$, 외측이 $10.55{\pm}2.05mm$로 측정 되었다. 혈관 분포 범위는 내측이 $20.29{\pm}8.44\%$, 외측이 $18.99{\pm}7.03\%$이었다. 해부학적 위치에 따른 혈관 분포는 내측의 경우 전각의 혈관 분포가 가장 풍부하였고(p<0.05), 외측의 경우 후각의 혈관 분포가 가장 풍부하였으며(p<.0.05) 슬와근부에서도 혈관 주행을 관찰할 수 있었다. 연령이 증가할수록 내측은 전각, 체부, 후각 모두 혈관 분포가 감소하며 외측은 체부와 후각에서 혈관 분포가 감소하는 것으로 나타났다(p<.0.05). 결론 : 내측 및 외측 반월상 연골의 혈관 분포는 해부학적 위치에 따라 달랐으며 연령이 증가함에 따라 내측과 외측에서 모두 전체적인 혈관 분포가 감소함을 알 수 있었다.

• 한국안광학회지
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• 제8권1호
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• pp.65-71
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• 2003

각막 상피세포는 정상적인 apoptosis과정을 거쳐 세포가 탈락하고 재생한다. 이러한 apoptosis에는 많은 요소들이 관여하여 세포가 사멸하는데 여러 가지 메커니즘이 관여한다. 본 연구에서는 세포고사 인자로 알려진 물질들을 각막 상피세포에서 apoptosis의 유도 여부를 다른 세포와 비교하여 각막 상피세포의 특성을 알아보고자 시행하였다. 본 연구에 이용된 세포고사 유도물질은 recombinant human cytokiness ($INF{\gamma}$, $TNF{\alpha}$, FASAb), actinomycin D. camptothecin, cycloheximide, dexamethasone와 etoposide이다. 이들을 세포에 48시간 처리한 후 세포독성을 MTT assay로 측정하였으며 세포고사는 Hoechst 33342 staining. Annexin V-FITC/PI staining 그리고 DePsipher assay를 이용하였다. 세포고사의 한 경로인 FAS-FAS ligand system에 대한 연구는 immunocytochemistry로 Fas protein 발현 여부를 조사하였다. 모든 유도인자는 농도의존적으로 세포고사를 유도하였는데 Actinomycin D. camptothecin와 etoposide는 제조사의 추천 농도보다 낮은 농도에서 세포고사가 유도되었고 반면에 cytokines, cycloheximide, dexamethasone은 더 높은 농도에서 세포고사를 유도하였다. FAS antigen은 대조군과 처리군 모두에서 발현되었으나 세포고사율에 비례하여 높게 발현되었다. 본 연구 결과 각막 상피세포는 RNA synthesis inhibitor와 topoisomerase inhibitors가 intracellular receptor-activators 보다 세포고사에 민감하게 나타나는 세포의 특성을 보였다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권2호
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• pp.115-131
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• 2000

In the study of craniofacial deformity, it is very important that identifying the factor which can affect the morphology and which is closely related to the morphology, because it can not only improve the comprehension of growth and developmental process but also be applied in growth prediction and treatment modality. Several investigators have already mentioned the characterstics of head posture and airway space in relations to morphologic difference. But it is very meaningful work in clarifying the correlation between morphology, head posture and airway space that observing the change of head posture after morplologic change caused by operation and the change of airway space after same procedure. To investigate above correlation, I selected normal group which is consisted of 43 adults and mandibular prognathism group which is consisted of 47 adults who had been operated by sagittal split ramus osteotomy and were followed up more than 1 year. With their lateral skull radiograghs, reference lines which can evaluate each measuring points and areas without effect of postural change were first determined. And using above reference lines, change of airway space, positional change of tongue and hyoid, change of cranial and cervical angulations were measured. The results obtained from the study were as follows 1. In the change of head posture, the position of tongue and hyoid neighboring to pharynx is more closely related to the reference line of cervical column than to reference line of cranium. 2. After mandibular setback operation, the airway dimension was decreased to 81.6% of preoperative state at 1 month postoperatively and was slightly increased to 89.7% at 1 year postoperatively. 3. Posterior movement of tongue plays important role in decrease of airway dimension and inferior movement of hyoid was closely correlated with posterior movement of tongue. 4. Postoperative anterior movement of mandible, namely, morphologic relapse had correlation with relapse phenomenon of airway dimension. 5. Craniocervical angulation increased postoperatively. Especially in the postoperative early state, there was increased foreward inclination of cervical angulation rather than increase of cranial angulation. But at postoperative 1 year it was observed that cervical inclination was returned to preoperative state and cranial angulation was increased gradually. 6. Increase rate of airway dimension was correlated with the increase of cranial angulation from postoperative 1 month to 1 year. In conclusion, relapse tendency of airway dimension following increase of cranial angulation was found after mandibular setback operation and it is considered that increase of cranial angulation is one of compensatory mechanism in airway maintenance.

• Investigative Magnetic Resonance Imaging
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• 제22권3호
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• pp.150-157
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• 2018

Purpose: To assess associations between morphological characteristics of intracranial arteries in time-of-flight MR angiography (TOF-MRA) and atherosclerotic risk factors. Materials and Methods: From January 2014 to October 2015, a total of 129 patients (65 men and 64 women) without intracranial arterial stenosis > 50% were included in this study. All MRIs were performed using a 3T machine with 3D TOF-MRA sequences. We evaluated irregularity, tortuosity, and dilatation of intracranial arteries in maximal intensity projection (MIP) of TOF-MRA. Subjects' risk factors for atherosclerosis including history of hypertension and diabetes were collected by reviewing their medical records. Associations between morphological characteristics and each known atherosclerosis risk factor were examined using univariate regression analysis. Multivariate regression models were built to determine combined association between those risk factors and morphologic changes of intracranial arteries. Results: In multivariate analysis, hypertension (coefficient [95% CI]: 0.162 [0.036, 0.289], P = 0.012) and absence of diabetes (coefficient [95% CI]: -0.159 [-0.296, -0.023], P = 0.022) were associated with large diameter of intracranial arteries. Males (coefficient [95% CI]: 0.11 [-0.006, 0.23], P = 0.062) and higher age (coefficient [95% CI]: 0.003 [-0.001, 0.008], P = 0.138) had marginal association with increased diameter. Tortuosity was associated with old age (OR: 1.04 [1.02, 1.07], P < 0.001). Irregular contour of intracranial arteries was significantly associated with old age (OR: 1.05 [1.02, 1.09], P = 0.004), presence of diabetes (OR: 2.88 [1.36, 6.15], P = 0.0058), and previous ischemic stroke (OR: 3.91 [1.41, 11.16], P = 0.0092). Conclusion: Morphological characteristics (irregularity, tortuosity, dilatation) of intracranial arteries seen in TOF-MRA might be associated with atherosclerotic risk factors in subjects with no or mild stenosis.

• Archives of Plastic Surgery
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• 제34권3호
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• pp.298-304
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• 2007

Purpose: This study was undertaken to investigate the osteogenic induction potential of PGA & FBS mixture on a calvarial defect in the rabbit. Methods: Twenty New zealand white rabbit, weighing from 3.5-4kg were allocated into each of the three groups. Four 8 mm sized bone defects were made on the parietal bone by drilling. In group I, the bony defects were implanted with $50{\mu}m$ thickness film containing mixture of PGA and FBS. In group II, with PGA only film, & in group III, the bony defects were left with no implants. Results were evaluated by using morphologic change, radiographic study, biochemical study and histologic examination at 1 week (group I n=7, group II n=7, group III n=14), 2 weeks (group I n=6, group II n=6, group III n=12) and 3 weeks (group I n=7, group II n=7, group III n=14) following implantation. Results: In the morphologic & radiographic study, the formation and corticalization of callus were observed earlier in group I than in groups II and III (p < 0.05). In histological examination, group I showed more abundant and faster new bone formation than in group II and III. In biochemical analysis, group I displayed more activity than in group II and III. Group I also showed more abundant osteopontin, osteocalcin than groups II and III. Conclusion: In conclusion, the results demonstrate that the mixture of PGA and FBS has an effect on osteoblastic formation in the rabbit model. It is considered that further evaluation of long term results on resorption, immunologic tissue reaction and response of applied mixture in the human model will be needed.

• 대한한방내과학회지
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• 제29권1호
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• pp.117-129
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• 2008

Background & Objective : Naeso-san(NSS) has been used for the treatment of functional dyspepsia, regarded as a gastric dysmotility disease. A main cause of gastric dysmotility is antral dilatation or antroduodenal uncoordination. Therefore, we investigated the effect of NSS on gastric motility and its mechanism of action, as well as the morphologic changes in antral dilatated rats. Methods : Antral dilatated rats were induced by wrapping a nonabsorbable rubber ring(D:6mm, W:4mm, T:1mm) around the 1st portion of the duodenum for 8 weeks. Then morphologic changes were investigated and compared with normal intact rats before and after 8 weeks. Gastric emptying was measured by administration of normal saline(NS) or NSS in normal intact and antral dilatated rats. In another series of experiments to evaluate the mechanism of NSS under delayed conditions, normal intact rats were treated with atropine sulfate(1mg/kg, s.c.), quinpirole HCl(0.3mg/kg, i.p.), $NAME(N^{G}-nitro-L-arginine$ methyl ester, 75mg/kg, s.c.) and cisplatin(10mg/kg, i.p.), respectively. The myoelectrical activity of the gastric smooth muscle was recorded in normal intact and antral dilatated rats. The contractile waves were measured for 30 minutes before and after administration of each solution(NS, NSS). Results : Body weight gain of antral dilatated rats was significantly lower than that of the controls. Futhermore, we found the thickness of the mucosal and muscular layers and surface area of the stomach increased significantly compared with controls. NSS 278㎎/㎏ improved gastric emptying more than normal saline or NSS 93mg/kg in normal intact(p=0.026) and antral dilatated rats(p=0.03). NSS enhanced gastric emptying significantly in the NAME treated group(p=0.002). NSS 278mg/kg increased the significant postprandial dominant power than that of NS in normal intact rats, whereas there was no statistical significance in antral dilatated rats. Conclusions : NSS stimulates gastric motility through the cholinergic pathway. We expect that pathologic model with antral dilatation can be used as an exprimental tool which is similar to dyspepsia and NSS would be effective especially in dysmotility-like functional dyspepsia with antral dilatation or impaired reservoir functions such as gastric adaptive relaxation.

• Parasites, Hosts and Diseases
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• 제53권3호
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• pp.299-305
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• 2015

Tapeworms of the genus Spirometra are pseudophyllidean cestodes endemic in Korea. At present, it is unclear which Spirometra species are responsible for causing human infections, and little information is available on the epidemiological profiles of Spirometra species infecting humans in Korea. Between 1979 and 2009, a total of 50 spargana from human patients and 2 adult specimens obtained from experimentally infected carnivorous animals were analyzed according to genetic and taxonomic criteria and classified as Spirometra erinaceieuropaei or Spirometra decipiens depending on the morphology. Morphologically, S. erinaceieuropaei and S. decipiens are different in that the spirally coiled uterus in S. erinaceieuropaei has 5-7 complete coils, while in S. decipiens it has only 4.5 coils. In addition, there is a 9.3% (146/1,566) sequence different between S. erinaceieuropaei and S. decipiens in the cox1 gene. Partial cox1 sequences (390 bp) from 35 Korean isolates showed 99.4% (388/390) similarity with the reference sequence of S. erinaceieuropaei from Korea (G1724; GenBank KJ599680) and an additional 15 Korean isolates revealed 99.2% (387/390) similarity with the reference sequences of S. decipiens from Korea (G1657; GenBank KJ599679). Based on morphologic and molecular databases, the estimated population ratio of S. erinaceieuropaei to S. decipiens was 35: 15. Our results indicate that both S. erinaceieuropaei and S. decipiens found in Korea infect humans, with S. erinaceieuropaei being 2 times more prevalent than S. decipiens. This study is the first to report human sparganosis caused by S. decipiens in humans in Korea.