• 생물정신의학
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• 제20권4호
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• pp.151-158
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• 2013

Objectives To investigate the pattern of subclinical hypothyroidism (SCH) in patients with bipolar disorders managed by lithium or valproic acid. Methods The study participants were 106 patients with DSM-IV bipolar disorders receiving planned maintenance treatment at the Mood Disorders Clinic of Seoul National University Bundang Hospital (aged between 17 and 64, mean duration of follow-up = 875.65 days). Using the bipolar disorder registry, thyroid function data were analyzed to assess the frequency of and the risk factors for SCH in patients managed by lithium (n = 64) or valproic acid (n = 42) for more than 5 months. Results Overall frequencies of SCH were 20.3% (13/64) in the lithium group, 14.3% (6/42) in the valproic acid group, and between the two groups there is no difference (p = 0.43). No differences were observed in the potential risk factors for SCH between the two groups including age, sex, subtype of bipolar disorder, baseline TSH, and concomitant antipsychotic use. In cases with SCH, thyroid-stimulating hormone (TSH) showed a tendency to increase at 3 month after the initiation of lithium or valproic acid. A gradual increase in the number of patients showing SCH was found within the first 3 years of medication. Conclusions With regular monitoring and careful assessment, there was no difference in the risk of SCH between lithium and valproic acid maintenance. The risk of mood stabilizer-associated SCH may gradually increase within 3 years following the commencement of medication, thereby mandating close monitoring for the first 3 years of treatment. Further studies with large sample size would be needed to confirm these findings.

• 정신신체의학
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• 제18권1호
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• pp.40-47
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• 2010

연구목적 : 자기신체상은 자아존중감과 체중조절행위와 밀접한 연관이 있고 특히 여자 청소년에서는 중요한 관련이 있다고 알려져있다. 이 연구는 체질량지수로 측정한 신체이미지와 식이장애와 연관된 비정상식이행동이 우울증과 자살사고에 미치는 영향을 알아보고자 한다. 방 법 : 서울 한 지역의 고등학교 여학생 239명을 대상으로 체질량지수를 측정하고, 청소년을 위한 식이태도검사(Eating Attitude Test for Korean Adolescents), 자아존중감척도, 충동성척도, 벡 우울척도, 벡 자살사고 척도를 시행하였다. 결 과 : 연구대상에서 식이장애 위험군은 총 10%(24명)이었다. 대조군에 비해 우울증상을 강하게 경험하고 있었고 현재 체질량지수와 이상적 체질량지수의 차이가 클수록 우울감, 자살사고, 비정상적 식이행동의 정도가 커지고 자아존중감은 낮아졌다. 그중에서 체질량지수의 차이가 통계적으로 가장 의미있는 예측인자였다. 결 론 : 연구대상군이 전체적으로 정상체중 범위임에도 불구하고, 현재의 체형과 이상적 체형사이의 괴리가 클수록 우울과 자살사고가 컸다. 여자 청소년의 식이장애 발생과 우울, 자살사고의 예방을 위해 체중조절, 정상식이습관에 대한 교육적 접근이 필요하다는 것을 알 수 있었다.

• 생물정신의학
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• 제28권1호
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• pp.13-22
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• 2021

Objectives Despite growing attention to anxiety in bipolar disorder (BD), little research has assessed anxiety symptoms in the course of BD. The current prospective follow-up study examines the influence of subjectively and objectively measured anxiety symptoms on the course of BD. Methods A total of 49 patients with BD were followed-up prospectively for average of one year at an average of four months interval. The Korean version of the Beck Anxiety Inventory (K-BAI), the Hamilton Anxiety Rating Scale, heart rate variability (HRV) were used to measure anxiety subjectively, objectively and physiologically. Participants were divided into high and low anxiety groups based on their K-BAI scores. Kaplan-Meier survival analysis was performed to compare the recurrence of mood episode, suicide attempt, emergency room visit, and psychiatric hospitalization between two groups. Mediators were investigated with Cox proportional hazards models. Results Compared to the low anxiety group, the high anxiety group reported significantly higher impulsiveness (p = 0.016) and lower high frequency component on HRV (p = 0.007) after controlling for severity of BD. Regarding survival analysis, the high anxiety group showed hastened depressive episode recurrence (p = 0.048) and suicidal ideation was the mediator of the hazard ratio (HR) 1.089 (p = 0.029) in the Cox model. Moreover, the high anxiety group showed a tendency of accelerated suicide attempt (p = 0.12) and impulsivity was the risk factor of suicide attempt (HR = 1.089, p = 0.036). Conclusions This interim analysis of prospective study suggests that high anxiety level in BD may anticipate unfavorable course. Further studies are needed to understand the multifactorial mechanism of anxious bipolar patients.

• 수면정신생리
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• 제11권2호
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• pp.95-99
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• 2004

목 적：계절성 정동장애에 대한 연구는 북미, 유럽과 아시아의 일본과 중국 등 여러 국가에서 시행되었지만, 한국에서는 아직 보고된 적이 없다. 이 연구는 한국의 의과대학생에서 기분과 행동의 계절적 변동의 빈도를 평가하기 위하여 시행되었다. 방 법：서울의 고려대학교 의과대학에 재학중인 학생 중 총 297명을 대상으로 하였다. 계절성을 평가하기 위하여 계절성 양상 평가 설문지(SPAQ)의 한국어 번역판을 이용하였고, 계절성 정동장애(SAD)와 아임상성 계절성 정동장애(S-SAD)를 진단하기 위하여 Kasper가 제시한 진단기준을 이용하였다. 결 과：전반적 계절성 점수(GSS)의 평균은 6.6(SD=3.9)이었다. 83.5%(N=248)가 계절성 변화가 생활에 영향을 미친다고 보고하였고, 단지 3.7%(N=11)만이 계절성 변화가 전혀 없다고 보고하였다. 전체 SAD의 유병률은 15.2%, SSAD의 유병률은 11.1%로 나타났다. 이중 여름철 SAD는 3.0%, 여름철 S-SAD는 2.7%였으며, 겨울철 SAD는 11.4%, 겨울철 S-SAD는 5.8%로 겨울철 SAD 및 S-SAD가 더 높은 유병률을 나타내었다. 결 론：이 결과를 통해 한국인에서 기분과 행동에 있어서 계절적 변동은 흔한 것임을 알 수 있다. 여름철보다 겨울철의 SAD와 S-SAD가 더 높은 유병률을 보이는 것은 미국 등에서 보고된 결과와는 일치하지만 일본, 중국과 같은 다른 아시아 국가의 보고와는 반대되는 것이다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제6권1호
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• pp.34-42
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• 1995

청소년기의 경계선 인격장애는 충동조절의 결여, 타인에 대한 평가절하와 자신보다는 대상에 대하여 만족감을 얻으려는 욕구, 분리 방어기제를 특징으로 하는 인격장애로서 성인의 경계선 인격장애와 비슷한 양상으로 나타난다. 청소년기의 경계선 인격장애의 주요한 증상은 우울, 불안, 정체성 위기와 이러한 정체성 위기로 인한 반사회적인 행동을 흔히 볼 수 있다. 따라서 이들 증상들과 정상 청소년들이 보일 수 있는 질풍노도의 양상과 구별이 힘든 경우가 있다. 경계선 인격장애에서는 대상관계의 불안정, 정동의 불안정, 분리 등 미숙한 방어기제로 인해서 심한 스트레스하에서 정신병적 삽화가 나타날 수 있으며, 이로인해 정신분열증, 정동장애, 분열형 인격장애, 편집형 인격장애등과 감별진단이 필요하다. 청소년기 경계선 인격장애의 원인으로는 정신역동적 요소, 유전적 요인을 포함한 생물학적 요소, 가족역동적인 요소등을 복합적으로 고려해야 한다. 치료는 개인정신치료, 그룹치료, 가족치료, 약물치료 등이 있다. 소아 청소년기 경계선 인격장애가 성인기 경계선 인격장애로 될 것인가에 대해서는 논란이 되고 있다.

• 대한불안의학회지
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• 제11권1호
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• pp.69-74
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• 2015

Objective : Positive psychotherapy is based on the premise that positive thoughts and satisfaction with life are determinants for improving the symptoms of depressive disorder. This article highlights the effectiveness of group positive psychotherapy on the elderly living alone with depressive disorder in Korea. Methods : A total of 25 Korean elderly living alone with depressive disorder participated in group positive psychotherapy. The participants completed the Hamilton rating scale for depression (HAMD) and the Positive Thinking Questionnaire (PTQ) before and after the group positive psychotherapy. Results : The HAMD and PTQ scores of the participants after the group positive psychotherapy were higher than before the psychotherapy. A correlation between the age of patients and improvement of symptoms after group positive psychotherapy was found : the older the patients were, the better the improvements were. Conclusion : The study shows that group positive psychotherapy in the elderly living alone is effective in improving the symptoms of depressive disorder. The participant's age was found to be a factor that affects the improvement of depressive disorder symptoms.

• 대한불안의학회지
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• 제14권2호
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• pp.120-126
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• 2018

Objective : Psychopathy has been suggested as one of the important cause of violence in patients with schizophrenia. The purpose of this study was to evaluate the personality disorder in criminal schizophrenia. Methods : A total of 187 criminal schizophrenia participated in this study. All participants filled out the Korean Inventory of Interpersonal Problem Personality Disorder Scales (K-IIP-PD), Psychopathic Personality Inventory-Revised (PPI-R), Personality Assessment Inventory (PAI). Using the correlations between the scales, we investigated whether K-IIP-PD could be used to evaluate personality disorder in criminal schizophrenia. Moreover, participants were divided into two groups of psychopathic and nonpsychopathic schizophrenics, and scores of K-IIP-PD were compared between the two subgroups. Results : The overall correlation between the scales was very high. In particular, sum of 3 item scores (interprsonal sensitivity+interpersonal ambivalence+aggression) and aggression of K-IIP-PD were highly correlated with PPI-R and PAI. Total score of personality disorder scale and subscales were higher in psychopathic schizophrenic group compared to nonpsychopathic schizophrenic group. Conclusion : The K-IIP-PD could be used to assess the antisocial and aggressive nature of criminal schizophrenia. Further studies in various clinical groups including the general population are required.

• 대한불안의학회지
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• 제14권2호
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• pp.127-134
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• 2018

Objective : The aim of this study was to examine the psychometric features of the Korean version of the Eating Disorder Diagnostic Scale-the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (K-EDDS DSM-5). Methods : A total of 72 patients diagnosed with eating disorders participated in the study. The diagnosis was based on the Korean version of the Eating Disorder Examination (KEDE) interview. All participants completed the K-EDDS and the Eating Disorder Examination Questionnaire version 6.0 (EDE-Q 6.0) for this study. The psychometric features of the K-EDDS were examined using exploratory factor analysis, convergent validity of agreement between the K-EDDS and the KEDE, and internal consistency. Results : The exploratory factor analysis initially extracted 6-factor structures which were reconstructed into 4 factors of body dissatisfaction, binge behavior, binge frequency, and compensatory behavior based on appropriateness of the items. The internal consistency of the K-EDDS was fairly acceptable (Cronbach's alpha=0.72). The diagnostic agreement between the K-EDDS and the KEDE was high (98.61%). The 4 factors of the K-EDDS showed significant correlation with the 4 subscales of the EDE-Q 6.0. Conclusion : Our data suggests that the K-EDDS is a reliable and valid tool for the diagnosis of eating disorders based on the DSM-5.

• 대한불안의학회지
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• 제2권1호
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• pp.9-16
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• 2006

As an aging population is increasing, more elderly people are exposed to traumatic stress. Although this issue has received more attention in some literature, it is clear that numerous questions exist in aftermath of trauma exposure in elderly people. In case of Korean elderly suffers, traumatic experience includes the Korean war, military dictatorship and violent demonstration. Studies regarding elderly PTSD is not active and a lot of patients are not still engaged in treatment. We suggest that concerns that are unique to this population are necessary.

• 셀메드
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• 제9권2호
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• pp.2.1-2.1
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• 2019

Depression is common psychiatric diseases characterized by diverse physical and emotional symptoms including low mood, loss of interest in pleasurable activities, and feelings of worthlessness. Depression causes of death and disability. The first antidepressant was created by the idea that central serotonin mechanism. Selective serotonin reuptake inhibitor, fluoxetine is the first-line drug in the treatment of depressive disorder and their few side effects as opposed to tricyclic antidepressants. Not all people with depression respond adequately to standard treatments. Korean music playing/listening actions appear to be a reliable approach to developing recovery from depression.