• Title/Summary/Keyword: Molecular structures

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Dual TORCs driven and B56 orchestrated signaling network guides eukaryotic cell migration

  • Kim, Lou W.
    • BMB Reports
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    • v.50 no.9
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    • pp.437-444
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    • 2017
  • Different types of eukaryotic cells may adopt seemingly distinct modes of directional cell migration. However, several core aspects are regarded common whether the movement is either ameoboidal or mesenchymal. The region of cells facing the attractive signal is often termed leading edge where lamellipodial structures dominates and the other end of the cell called rear end is often mediating cytoskeletal F-actin contraction involving Myosin-II. Dynamic remodeling of cell-to-matrix adhesion involving integrin is also evident in many types of migrating cells. All these three aspects of cell migration are significantly affected by signaling networks of TorC2, TorC1, and PP2A/B56. Here we review the current views of the mechanistic understanding of these regulatory signaling networks and how these networks affect eukaryotic cell migration.

Virus-like Particles and Cellular Changes in Plants Infected with Sweetpotato Viruses

  • Sim, Jeong-Gu;Valverde, Rodrigo;Clark, Christopher;Chun, Se-Chul
    • The Plant Pathology Journal
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    • v.24 no.1
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    • pp.36-45
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    • 2008
  • Studies with the transmission electron microscope were used to detect and attempt to identify viruses infecting sweetpotato (Ipomoea batatas) and other Ipomoea species. Flexuous-rods, short curved-rods, and spherical virus-like particles were observed in cells of symptomatic plants. Also, various cytopathic changes such as crystals, vesicles, fibril structures, and cylindrical inclusions were observed. The present study showed that some of these cytopathic changes were associated with some viral groups, which might be helpful in diagnosis.

Novel Linking Ligand Containing Sulfur-Donor Atoms and Its Compounds of Palladium and Silver

  • Lee, Hee-K.;Lee, Soon-W.
    • Bulletin of the Korean Chemical Society
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    • v.28 no.3
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    • pp.421-426
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    • 2007
  • A linking ligand containing sulfur donor atoms in the terminal thiophene rings, 1,2-bis(thiophen-2-ylmethylene) hydrazine (L), was prepared by Schiff-base condensation. Ligand L reacted with [PdCl2(NCPh)2] to produce a molecular Pd compound [PdL2Cl2] (1). On the other hand, it reacted with AgNO3 and AgClO4 to produce a 2-D network [AgL0.5(NO3)] (2) and a 1-D polymer [AgL]ClO4 (3), respectively, whose structures are based on secondary intermolecular forces such as H-bonding, van der Waals interaction, and π-π stacking. Polymer 2 exhibited photoluminescence at room temperature in the solid state.

Review on Cellulose acetate as a Packaging Materials (셀룰로오스 아세테이트 포장소재의 이용 및 고찰)

  • Lee, Ji-Yoon;Jang, Si-Hun;Park, Su-Il
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.16 no.1
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    • pp.19-25
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    • 2010
  • It is becoming increasingly important to utilize alternative raw materials for plastic industries other than petrochemical-based plastics. Cellulose derivatives were the bases of the original synthetic plastics. Cellulose and its derivatives, especially the widely used cellulose acetate (CA), constitute one of the main classes of raw materials for production on artificial fibers, films, plastics etc. CA is one of the well known polymers produced from naturally available plant substance. Many researches have focused on the isolation of cellulose from the plant cells to use them as cellulose derivatives and composite materials. Chemical and mechanical treatments provide changes on the molecular structures influencing the fundamental properties of these naturally abundant polymer. The aim of this review article is to review biodegradation, synthesis, formation, and utilization of cellulose esters, especially di-acetate, used in packaging related researches.

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First Case of Canine Infection with Hepatozoon canis (Apicomplexa: Haemogregarinidae) in the Republic of Korea

  • Kwon, Seung-Joo;Kim, Yoon-Hee;Oh, Hyun-Hee;Choi, Ul-Soo
    • Parasites, Hosts and Diseases
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    • v.55 no.5
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    • pp.561-564
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    • 2017
  • This report describes a dog infected with Hepatozoon canis, the first canine infection in the Republic of Korea. A 2-year-old intact male Maltese dog presented with anorexia and depression. Physical examinations revealed mild dehydration and hyperthermia ($39.8^{\circ}C$), and blood analysis showed pancytopenia. Diff-Quik staining of blood smear specimens showed the presence of ellipsoidal shaped structures (gamonts of H. canis) within a small number of neutrophils. Real-time PCR analysis using whole blood confirmed infection by H. canis. The clinical condition of the dog improved after symptomatic treatment and administration of doxycycline. Although a molecular epidemiologic survey in Korea showed H. canis infection of dogs, to our knowledge this is the first report of a dog infection in Korea molecularly shown to be H. canis.

Simultaneous Determination of Harman, Harmaline and Norharman by Synchronous Fluorescence

  • Karim Mohammad Mainul;Lee Sang-Hak
    • Journal of Photoscience
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    • v.12 no.3
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    • pp.143-147
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    • 2005
  • The simultaneous determination of harman, harmaline and norharman has been described using synchronous fluorescence technique. The method has been based on their natural fluorescence. It is difficult to analyze and determine their contents by conventional fluorescence method because of their similar molecular structures. The synchronous spectrum, maintaining a constant wavelength difference of ${\Delta}{\lambda}=185nm$ between the excitation and emission monochromators, was selected as optimum to perform the determination. The method was also performed in aqueous medium at pH 4.0 and in presence of sodium dodecyl sulfate (SDS), $1{\times}10^{-5}M$. Under the optimum conditions, each analyte has the linear determination range of $1{\times}10^{-7}M-\;1{\times}10^{-4}M$.

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Correlation between Magnetic-field directions and intensity gradients in Orion A region

  • Hwang, Jihye;Kim, Jongsoo
    • The Bulletin of The Korean Astronomical Society
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    • v.43 no.1
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    • pp.67.2-67.2
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    • 2018
  • Magnetic fields play an important role in star-forming processes by regulating gravitational collapse. In filamentary structures of star-forming regions, magnetic fields are likely to be aligned with minor axes of filamentary molecular clouds because matter freely moves along magnetic field lines. Orion A region, one of the well-known high-mass star forming regions, has long filament structure. In order to study magnetic field directions with respect to the filamentary structure in Orion A, we have analyzed $850{\mu}m$ dust polarization observations obtained with the James Clerk Maxwell Telescope (JCMT). We found tight correlation of dust intensity gradients and magnetic field directions. It was estimated that 81% of magnetic field segments are aligned with density gradients within 40 degree. In conclusion, we confirmed most of magnetic field segments are perpendicular to the major axis of the filament in Orion A.

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Studies on the Syntheses and Antimicrobial Activity of Substituted Benzothiazolyl Urea Derivatives (Substituted Benzothiazolyl Urea 유도체의 합성 및 항균작용에 관한 연구)

  • 강회양
    • Journal of Environmental Health Sciences
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    • v.7 no.2
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    • pp.113-117
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    • 1981
  • Twelve benzothiazolyl and 6-substituted benzothiazoly phenyl and chlorophenyl ureas have been newly synthesized by reacting 2-amino benzothiazole and 2-amino-6-substituted benzothazole with three or four phenyl and chlorophenyl isocyanate, respectively. The structures of these compounds were determined by measurement of the molecular weights and elementary analysis as well as IR spectrophotometry. The compounds generally exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli in the concentration of $50\mu g/ml$. The compounds containing chloro group exhibited stronger antibacterial activity than those containing methyl group against Eschichia coli. The difference in the antibacterial activity according to the substituted group (phenyl, o-, m-, and p-chlorophenyl) was also noted. The compounds containing o-chlorophenyl group, on the whole, exhibited more potent growth-inhibitory activity againsts staphylococcus aureus.

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Study on morphology of silsesquioxane based polymer LB films by using AFM (AFM을 이용한 Silsesquioxane based polymer의 LB막 모폴로지 관찰)

  • Lee, Ji-Yoon;Yang, Chang-Heon;Kim, Chung-Kyun;Park, Jae-Chul;Kwon, Young-Soo
    • Proceedings of the KIEE Conference
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    • 2008.07a
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    • pp.1293-1294
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    • 2008
  • The Langmuir-Blodgett (LB) method has been one of the most suitable techniques for fabricating organic thin films with well-controlled structures, compositions and thickness at the molecular level. We investigated the surface activity of dendrimer films at air-water interface by ${\pi}$-A isotherm. Also, we attempted to fabricate a 1G(4,3)-chloride dendrimer LB films. And their surface morphologies were observed by atomic force microscopy (AFM).

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Transfer RNA Acceptor Stem Determinants for Specific Aminoacylation by Class II Aminoacyl-tRNA Synthetases

  • Musier, Karin
    • BMB Reports
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    • v.31 no.6
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    • pp.525-535
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    • 1998
  • A critical step in the faithful translation of genetic information is specific tRNA recognition by aminoacyl-tRNA synthetases. These enzymes catalyze the covalent attachment of particular amino acids to the terminal adenosine of cognate tRNA substrates. In general, there is one synthetase for each of the twenty amino acids and each enzyme must discriminate against all of the cellular tRNAs that are specific for the nineteen noncognate amino acids. Primary sequence information combined with structural data have resulted in the division of the twenty synthetases into two classes. In recent years, several high-resolution co-crystal structures along with biochemical data have led to an increased understanding of tRNA recognition by synthetases of both classes. The anticodon sequence and the amino acid acceptor stem are the most common locations for critical recognition elements. This review will focus on acceptor stem discrimination by class II synthetases. In particular, the results of in vitro aminoacylation assays and site-directed and atomic group mutagenesis studies will be discussed. These studies have revealed that even subtle atomic determinants can provide signals for specific tRNA aminoacylation.

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