• Korean Membrane Journal
• /
• v.5 no.1
• /
• pp.43-53
• /
• 2003

The selectivity of a gas in the carbon molecular sieve membrane (CMSM) can be expressed as the ratio of the product of the diffusivity and the solubility of two different gases. The diffusivity is also expressed as the product of the entropy and the total energy (kinetic and potential energy) in the nano-sized pore of the membrane. The present study calculates the entropic-energy and selectivity of penetrant gases such as H$_2$, O$_2$, N$_2$, and CO$_2$ from the gas-in-a box theory to physically analyze the diffusivity of penetrant gas in slit-shaped pore of CMSM focusing on the restriction of gas motion based on the size difference between penetrant gas pairs. The contribution of each energy term is converted to entropic term separately. By the conjugated calculation for each entropic-energy, the entropic effects on diffusivity-selectivity for gas pairs such as H$_2$/N$_2$, CO$_2$/N$_2$, and O$_2$/N$_2$ were analyzed within active pore of CMSM. In the activated diffusion domain, the calculated value of entropic-selectivity lies between 9.25 and 111.6 for H$_2$/N$_2$, between 3.36 and 6.0 for CO$_2$/N$_2$, and between 1.25 and 16.94 for O$_2$/N$_2$, respectively. The size decrement of active pore in CMSM had the direct effect on the reduction of translational entropic-energy and the contribution of vibrational entropic-energy for N$_2$, O$_2$, and H$_2$ was almost negligible. However, the vibrational entropic term of CO$_2$ might extravagantly affect on the entropic-selectivity.

• Molecules and Cells
• /
• v.44 no.7
• /
• pp.517-528
• /
• 2021

A recent genetic study with Brucella abortus revealed the secretion activator gene A (SagA) as an autolysin component creating pores in the peptidoglycan (PGN) layer for the type IV secretion system (T4SS) and peptidoglycan hydrolase inhibitor A (PhiA) as an inhibitor of SagA. In this study, we determined the crystal structures of both SagA and PhiA. Notably, the SagA structure contained a PGN fragment in a space between the N- and C-terminal domains, showing the substrate-dependent hinge motion of the domains. The purified SagA fully hydrolyzed the meso-diaminopimelic acid (DAP)-type PGN, showing a higher activity than hen egg-white lysozyme. The PhiA protein exhibiting tetrameric assembly failed to inhibit SagA activity in our experiments. Our findings provide implications for the molecular basis of the SagA-PhiA system of B. abortus. The development of inhibitors of SagA would further contribute to controlling brucellosis by attenuating the function of T4SS, the major virulence factor of Brucella.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.16 no.1
• /
• pp.24-33
• /
• 2016

Mucopolysaccharidosis type VI (MPS VI) is a rare disease caused by the mutation of ARSB with prevalence range from 1/5,000 in northeast Brazil to 1/2,057,529 births in Czech Republic. In Asia, there is only one published figure in Taiwan of about 1/833,000 births. The exact prevalence in the Korean population is unknown, but we estimated the incidence of MPS VI is about 0.03/100,000 live births. Enzyme replacement therapy (ERT) with recombinant human Arylsulfatase B (rhASB) is a modality for the treatment of MPS VI that reduces the excretion of urine glycosaminoglycan (GAG) and improves joint motion, pulmonary function, and endurance. We presented the clinical features, molecular analysis and outcome of ERT in three Korean MPS VI patients. All patients had the typical characteristic clinical features of MPS IV. Short stature, dysostosis multiplex, corneal opacity and valvular heart disease were found at first presentation, while restrictive lung disease and carpal tunnel syndrome developed later in all patients. Molecular analysis demonstrated novel missense and nonsense mutation in the patients, including p.Ile 67Ser, p.Gly328Arg, $p.Arg191^*$, p.Asp352Asn, and p.Gly17Asp. After ERT, urine GAG was decreased in all patients. Skeletal involvement, corneal opacity, heart valve abnormalities and pulmonary function were not improved with ERT, but it had a better outcome on regarding joint motion and endurance. One patient underwent allogeneic bone marrow transplantation (BMT) prior to ERT, but their clinical response was not improved much after BMT. This study demonstrates clinical phenotypes and molecular analysis of the severe form of MPS VI in Korean patients.

• Advances in nano research
• /
• v.8 no.3
• /
• pp.245-254
• /
• 2020

This work examines the fundamental vibrational characteristics of a spinning CNT-based nano-rotor assuming a nonlocal elasticity Euler-Bernoulli beam theory. The rotary inertia, gyroscopic, and rotor mass unbalance effects are all taken into consideration in the beam model. Assuming a nonlocal theory, two coupled 6th-order partial differential equations governing the vibration of the rotating SWCNT are first derived. In order to acquire the natural frequencies and dynamic response of the nano-rotor system, the nonlinear equations of motion are numerically solved. The nano-rotor system frequency spectrum is shown to exhibit two distinct frequencies: one positive and one negative. The positive frequency is known as to represent the forward whirling mode, whereas the negative characterizes the backward mode. First, the results obtained within the framework of this numerical study are compared with few existing data (i.e., molecular dynamics) and showed an overall acceptable agreement. Then, a thorough and detailed parametric study is carried out to study the effect of several parameters on the nano-rotor frequencies such as: the nanotube radius, the input angular velocity and the small scale parameters. It is shown that the vibration characteristics of a spinning SWCNT are significantly influenced when these parameters are changed.

• Journal of Korea Foresty Energy
• /
• v.18 no.2
• /
• pp.55-61
• /
• 1999

This study was carried out to investigate the influence of viscoelastic properties(or chemical composition) of a series of ethylen-viny1 acetate copolymers on impact noise and vibration damping of wood/polymer/wood sandwich composites. The impact noise and vibration damping of composites were very sensitive to the state of molecular motion of polymer. The noise and vibration damping of composites were maximum when the polymer was under the glass transition(vinylacetate 55~75%) at the test-temperature, and minimum rubbery state(vinyl-acetate 47~20%) or glassy state(vinylacetate 100~87%). The polymer under glass transition reduced the impact noise by 6~12 dB.

• BMB Reports
• /
• v.40 no.2
• /
• pp.261-269
• /
• 2007

The structure and dynamics of a 37-residue antimicrobial peptide gaegurin 4 (GGN4) isolated from the skin of the native Korean frog, Rana rugosa, was determined in SDS micelles by NMR spectroscopy. The solution structure of the peptide in SDS micelles was determined from 352 NOE-derived distance constraints and 22 backbone torsion angle constraints. Dynamic properties for the amide backbone were characterized by $^1H-^{15}N $heteronuclear NOE experiments. The structural study revealed two amphipathic helices spanning residues 2-10 and 16-32 and that the helices were connected by a flexible loop. An intraresidue disulfide bridge was formed between residues Cys31 and Cys37 near the C-terminus. The loop region (11-15) connecting the two helices are were slightly more flexible than these helices themselves. From the fact that since there is no contact NOEs between two helices, it is implied that the GGN4 peptide shows an independent motion of both helices which has an angle of about $ 60^{\circ}-120^{\circ}$ from each other.

• Journal of the Korean Society of Safety
• /
• v.14 no.2
• /
• pp.83-89
• /
• 1999

The electrical properties due to mixture ratio of linear low density polyethylene(LLDPE) and ethylene vinyl acetate(EVA) films are studied. An experimental specimen is selected as LLDPE/EVA of thickness 200${\mu}{\textrm}{m}$ produced by mixture ratio of 50 : 50, 60 : 40, 70 : 30 and 80 : 2 wt%. In temperature range from $25^{\circ}C$ to 12$0^{\circ}C$, the measurement of volume resistivity using a highmegohm meter is performed within 10 minutes since each voltage of DC 100 V, 250 V, 500 V and 1000 V is applied, according to the step voltage method. From FT-IR spectrum for an analysis of physical properties, it can be confirmed that LLDPE blended with EVA shows an absence of carbonyl groups(1735 $cm^{-1}$, C=0) and ether groups(1242 $cm^{-1}$, C-O). The peak of LLDPE and EVA made of mixture ratio of 70 : 30 at 2$\theta$ =21.4$^{\circ}$ in the results of XRD is higher than the others. In the experiment for volume resistivity characteristics in order to investigate the electrical properties of specimen, it is confirmed that volume resistivity is decreased with the increase of the molecular motion and temperature.

• Proceedings of the SCSK Conference
• /
• 2003.09a
• /
• pp.1-12
• /
• 2003

Instead of sensory evaluation, we designed an evaluation method of the setting function of hairstyling products, based on an original theory focusing on changes in bending stress observed when a load with continuous bending is applied to human hair. Specifically, we developed a device to measure bending stress to quickly and objectively evaluate the condition of human hair, particularly its dynamic properties such as the setting function, following the application of hairstyling products. This device generates a load with continuous bending while applying a pendulum motion to a hair tress, one end of which is anchored. The setting function and holding power of resins of various molecular weight and ionic properties were evaluated using this device. The results demonstrated a close correlation with those obtained by experts' sensory evaluation. The evaluation results of bending stress and holding rate confirmed that the combined use of two different resins could improve the function of setting preparations. Evaluation using this device was able to substitute for sensory evaluation, and offers quick objective evaluation and detection of changes in the holding power of hairstyling products over time. We conclude that evaluation using this device is a promising new method.

• Journal of The Korean Association For Science Education
• /
• v.11 no.2
• /
• pp.49-65
• /
• 1991

There is now a large body of research which investigate the preconceptions held by the students in a variety of school levels ranging from the elementary schools to the universities. A problem exists, however, in applying the fingings of the research to the practices of science education. Meanwhile the field of science education is in urgent need of the new instructional theories. One viable means of improving such problematic situation as this is to develop the teaching/learning materials which incorporate the suggestions implied by the results of the research. A prosedure for developing an instructional material and the application of the material in the naturalistic classes are described. Also described in this article are the analyses of the effectiveness of the materials and the implications of this developmental study for the teaching strategies of science.

• Korean Journal of Materials Research
• /
• v.17 no.11
• /
• pp.569-573
• /
• 2007

The static and dynamic hydrophobicities of the water droplets placed on a hydrophobic surface coated using a fluoroalkylsilanes monolayer with different molecular chain lengths were investigated through direct observation of the actual droplet motion during the sliding process. The surface roughness of both was found to be less than 1 nm. The static contact angles of the coated FAS-3 and FAS-17 were respectively $80^{\circ}$ and $108^{\circ}$ at $150^{\circ}C$, 1 h. The slope of sliding acceleration against the water droplet mass exhibited an inflection point, thus suggesting the switching of the dominant sliding mode from slipping to rolling. While their sliding angles were similar in value, notable differences were exhibited in terms of their sliding behavior. This can be understood as being due to the contribution of the shear stress difference at the interface between the solid surface and water during the sliding process. These results show that the sliding acceleration of the water droplets depends strongly on the balance between gravitational and retentive forces on the hydrophobic surface.