• Title/Summary/Keyword: Molecular engineering

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MOLECULAR SCALE MECHANISM ON EVAPORATION AND REMOVAL PROCESS OF ADHERENT MOLECULES ON SURFACE BY BURNT GAS

  • Yang, Y.J.;Lee, C.W.;Kadosaka, O.;Shibahara, M.;Katsuki, M.;Kim, S.P.
    • International Journal of Automotive Technology
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    • v.7 no.2
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    • pp.121-128
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    • 2006
  • The interaction between adherent molecules and gas molecules was modeled in the molecular scale and simulated by the molecular dynamics method in order to understand evaporation and removal processes of adherent molecules on metallic surface using high temperature gas flow. Methanol molecules were chosen as adherent molecules to investigate effects of adhesion quantity and gas molecular collisions because the industrial oil has too complex structures of fatty acid. Effects of adherent quantity, gas temperature, surface temperature and adhesion strength for the evaporation rate of adherent molecules and the molecular removal mechanism were investigated and discussed in the present study. Evaporation and removal rates of adherent molecules from metallic surface calculated by the molecular dynamics method showed the similar dependence on the surface temperature shown in the experimental results.

Synthesis and Characterization of Degradable Polycationic Polymers as Gene Delivery Carriers

  • Kim, Hyun-Jin;Kwon, Min-Sung;Choi, Joon-Sig;Kim, Bo-Hye;Yoon, Jae-Keun;Kim, Kwan;Park, Jong-Sang
    • Bulletin of the Korean Chemical Society
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    • v.28 no.1
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    • pp.63-67
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    • 2007
  • Biodegradable cationic poly(ester-amide) polymers were synthesized by double-monomer method, that showed excellent solubility in many organic solvents and water. Different degradation patterns were obtained by the regulation of monomer ratios and overall long period of time of DNA protection up to 12 days was shown by PicoGreen reagent assay. Good transfection profiles in the presence of serum and very low toxicity on mammalian cells may allow these polymers to become suitable for long-term gene delivery systems and therapeutic applications.

Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences

  • Lee, Jung-Hoon;Lim, Yong-Beom;Choi, Joon-Sig;Choi, Myung-Un;Yang, Chul-Hak;Park, Jong-Sang
    • Bulletin of the Korean Chemical Society
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    • v.24 no.11
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    • pp.1637-1640
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    • 2003
  • Quaternary ammonium groups were introduced to Starburst polyamidoamine (PAMAM) dendrimers for a gene carrier. These quaternary dendritic carriers exhibited reduced cytotoxicity on 293T cells compared to parent dendrimers examined and their transfection efficiency were similar with parent dendrimers. Quaternization could be a promising tool to improve properties of dendrimers as a gene delivery carrier.

SYNTHESIS OF HALOGENATED 9-(DIHYDROXYCYCLOPENT -4′-ENYL) ADENINES AND THEIR INHIBITORY ACTIVITIES AGAINST S-ADENOSYLHOMOCYSTEINE HYDROLASE

  • Choi, Won-Jun;Park, Jae-Gyu;Moon, Hyung-Ryong;Gunaga Prashantha;Lee, Kang-Man;Kim, Hea-Ok;Jeong, Lak-Shin
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.365.2-365.2
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    • 2002
  • S-Adenosylhomocysteine hydrolase (SAH) catalyzes the hydrolysis of S-adenosylhomocysteine to adenosine and L -homocysteine and has been an attractive target for the development of broad spectrum antiviral agents. Neplanocin A and 9-(dihydroxycyclopent-4' -enyl)adenine (DHCeA) have been known to inhibit SAH by cofactor (NAD+) depletion mechanism and their inhibition is reversed by the addition of NAD+ or dialysis. (omitted)

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Determination of Viscosity Average Molecular Weight from Number and Weight Average Molecular Weights

  • Park, Eun-Soo;Yoon, Jin-San
    • Macromolecular Research
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    • v.8 no.5
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    • pp.243-245
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    • 2000
  • can be determined from the number and weight average molecular weight. When the value of the exponent, a, appearing in the relation between the intrinsic viscosity and the viscosity average molecular weight, is in the range from 0.6 to 0.8, as is the case for the most polymers, the viscosity average molecular weight is much more close to the weight average molecular weight than to the number average molecular weight.

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