• 한국과학교육학회지
• /
• 제14권3호
• /
• pp.293-303
• /
• 1994

The purpose of this study was to find the effect of molecular movement model based instruction on high school students' conceptions of diffusion and osmosis. The study was composed of two groups, the traditional instruction group in which the so-called traditional instruction was performed, and the other group in which interventions by researchers were made. The subjects of the traditional instruction group consisted of a total of 242 high school students from Seoul, Gwangju and Mokpo. The subjects of the model based instruction group consisted of 177 first-year high school students in Mokpo. The study was focused on the use of the term of 'molecular movement' in their explanation of diffusion and osmosis in the correct contexts. In general, students who got the molecular movement model based instruction showed more frequent use of the terms of 'molecular movement' in the correct contexts than the control group students did. It was found that misconceptions including teleological explanations changed into scientific explanations by the intervention. It seemed that the molecular movement model led students to make scientific explanations on natural phenomena. A further research is recommended to assess the improvement of teleological explanation and scientific attitude by the molecular movement model.

• 한국과학교육학회지
• /
• 제27권6호
• /
• pp.477-487
• /
• 2007

Previous studies show that students have difficulties in understanding and using molecular visualization tools. This study focuses on the ways in which first year chemistry undergraduates use ball-and-stick molecular models to explain the concept of addition reaction and the difficulties that they face using the models. Video recordings of interviews with undergraduates manipulating ball-and-stick models to solve problems related to reaction mechanisms are analysed to determine if they are able to elucidate their understanding with use of models. The results showed that students have difficulties with viewing the ball-and-stick models from the proper perspective and understanding the relationship between the various structures that they have created using the models. They also find the use of ball-and-stick models tedious and prefer drawing molecular structures on paper to explain their ideas. Implications for the teaching using ball-and-stick molecular models are discussed.

• Asian-Australasian Journal of Animal Sciences
• /
• 제32권4호
• /
• pp.494-500
• /
• 2019

Objective: Feed consumption contributes a large percentage for total production costs in the poultry industry. Detecting genes associated with feeding traits will be of benefit to improve our understanding of the molecular determinants for feed efficiency. The objective of this study was to identify candidate genes associated with feed conversion ratio (FCR) via genomewide association study (GWAS) using sequence data imputed from single nucleotide polymorphism (SNP) panel in a Chinese indigenous chicken population. Methods: A total of 435 Chinese indigenous chickens were phenotyped for FCR and were genotyped using a 600K SNP genotyping array. Twenty-four birds were selected for sequencing, and the 600K SNP panel data were imputed to whole sequence data with the 24 birds as the reference. The GWAS were performed with GEMMA software. Results: After quality control, 8,626,020 SNPs were used for sequence based GWAS, in which ten significant genomic regions were detected to be associated with FCR. Ten candidate genes, ubiquitin specific peptidase 44, leukotriene A4 hydrolase, ETS transcription factor, R-spondin 2, inhibitor of apoptosis protein 3, sosondowah ankyrin repeat domain family member D, calmodulin regulated spectrin associated protein family member 2, zinc finger and BTB domain containing 41, potassium sodium-activated channel subfamily T member 2, and member of RAS oncogene family were annotated. Several of them were within or near the reported FCR quantitative trait loci, and others were newly reported. Conclusion: Results from this study provide valuable prior information on chicken genomic breeding programs, and potentially improve our understanding of the molecular mechanism for feeding traits.

• 한국결정학회:학술대회논문집
• /
• 한국결정학회 2003년도 학술대회지
• /
• pp.10-10
• /
• 2003

• Asian-Australasian Journal of Animal Sciences
• /
• 제20권2호
• /
• pp.166-171
• /
• 2007

The objective of this study was to assess the association of polymorphisms in ${\kappa}$-cn, ${\beta}$-lg, ${\beta}$-lg 5′ flanking region, CSN1S2, and IGFBP-3 genes with milk production traits and mastitis-related traits in Chinese Holstein. Traits analyzed were 305 day standard milk yield, protein percentage, fat percentage, the ratio of fat percentage and protein percentage, pre-somatic cell count, somatic cell count, and somatic cell score, respectively. CSN1S2 locus was uninformative because only one genotype BB was found in Chinese Holstein. Allele frequencies of A and B in IGFBP-3 gene were 0.5738 and 0.4262 in Chinese Holstein population, which was different from reported Qinchuan cattle population. The genotypes of animals at IGFBP-3 locus significantly affected 305 day standard milk yield, protein percentage, and somatic cell score. The ${\beta}$-lg genotypes had a significant effect on protein percentage and the ratio of fat percentage and protein percentage. Polymorphism in ${\beta}$-lg 5′ flanking region was associated with 305 day standard milk yield, protein percentage, fat percentage, pre-somatic cell count, and somatic cell count. No significant associations of the polymorphism in ${\kappa}$-cn gene were observed for any trait.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.3223-3228
• /
• 2013

Gene expression profiling (GEP) has identified several molecular subtypes of breast cancer, with different clinico-pathologic features and exhibiting different responses to chemotherapy. However, GEP is expensive and not available in the developing countries where the majority of patients present at advanced stage. The St Gallen Consensus in 2011 proposed use of a simplified, four immunohistochemical (IHC) biomarker panel (ER, PR, HER2, Ki67/Tumor Grade) for molecular classification. The present study was conducted in 75 newly diagnosed patients of breast cancer with large (>5cm) tumors to evaluate the association of IHC surrogate molecular subtype with the clinical response to presurgical chemotherapy, evaluated by the WHO criteria, 3 weeks after the third cycle of 5 flourouracil, adriamycin, cyclophosphamide (FAC regimen). The subtypes of luminal, basal-like and HER2 enriched were found to account for 36.0 % (27/75), 34.7 % (26/75) and 29.3% (22/75) of patients respectively. Ten were luminal A and 14 luminal B (8 HER2 negative and 6HER2 positive). The triple negative breast cancer (TNBC) was most sensitive to chemotherapy with 19% achieving clinical-complete-response (cCR) followed by HER2 enriched (2/22 (9%) cCR), luminal B (1/6 (7%) cCR) and luminal A (0/10 (0%) cCR). Heterogeneity was observed within each subgroup, being most marked in the TNBC although the most responding tumors, 8% developing clinical-progressive-disease. The study supports association of molecular subtypes with response to chemotherapy in patients with advanced breast cancer and the existence of further heterogeneity within subtypes.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권12호
• /
• pp.7629-7634
• /
• 2013

Background: Cylin D1(CCDN1) is an important regulator of the cell cycle whose alterations are thought to be involved in cancer development. There have been many studies indicating CCDN1 amplification or over-expression in a variety of cancer types. In addition to gene amplification, the G870A polymorphism may be related with altered CCDN1 activity, and therefore with cancer development. This hypothesis has been tested in different cancer types but results have been contradictory. We therefore aimed to investigate any relationship between CCDN1 A870G genotypes and laryngeal squamous cell cancer development and progression. Materials and Methods: A total of 68 Turkish patients with primary laryngeal squamous cell cancer and 133 healthy controls were enrolled. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to determine the CCDN1 genotypes. Results: No significant association was detected between CCDN1 genotypes and laryngeal squamous cell cancer (LxSCCa) development. Similarly CCDN1 genotypes were not related to clinical parameters of Lx SCCa. However, there was a very significant association between CCDN1 G allele and presence of perineural invasion (p=0.003; OR: 1.464; CI% 1.073-1.999). CCDN1 G allele frequency was significantly higher in the individuals with perineural invasion (85.7%) when compared to those without (58.5%). The 2 patients who died of disease were both found to possess the GG genotype. Conclusions: These results pose a controversy in suggesting a protective role of the G allele against LxSCCa development and support the association of CCDN1 gene GG genotype with mortality in patients with LxSCCa.

• 한국콘텐츠학회논문지
• /
• 제8권12호
• /
• pp.441-448
• /
• 2008

분자 도킹 실험은 일반적으로 계산 량이 매우 많아 슈퍼 컴퓨팅 파워를 요구하는 실험이다. 따라서 시간이 많이 소요되기 때문에 일반적으로 CPU가 탑재된 컴퓨터를 여러 대 묶어서 사용하는 분산 환경 혹은 그리드 환경에서 실험을 수행하고 있다. 이와 같은 실험 환경은 시간적, 공간적 제약성이 많아 일반적으로 과학자들이 접근하기가 어렵다. 그래서 근래에는 많은 CPU를 사용하기 보다는 월등히 성능이 높은 GPU를 병렬 화하여 과학 분야에 계산하는 연구가 매우 활발히 이루어지고 있는 추세이다. CUDA는 병렬 GPU 프로그래밍을 가능하게 하는 공개 기술이다. 본 논문에서는 이러한 CUDA 기술을 사용하여 분자 도킹 실험을 할 수 있는 시스템을 제안한다. 또한, 분자 도킹 실험에 있어서 중요한 에너지 최소화 계산을 병렬 화하는 알고리즘을 제안한다. 이와 같은 실험을 검증하기 위해 본 논문에서는 일반적인 CPU에서 분자 도킹 실험 시간과 본 논문에서 제안한 병렬 CPU 기반의 분자 도킹 시간을 비교 분석 하였다.

• 한국펄프종이공학회:학술대회논문집
• /
• 한국펄프종이공학회 1999년도 Proceedings of Pre-symposium of the 10th ISWPC
• /
• pp.34-42
• /
• 1999

The present investigation has focused up on the study of the adsorption of three different molecular mass fractions of a polyDiMethylDiAllylAmmoniumChloride (DMDAAC) (8750(LM\ulcorner), 48000(MM\ulcorner) and 1200000(HM\ulcorner)) on bleached chemical fibres. Both kinetics of adsorption and equilibrium adsorption measurements have been conducted and each adsorption has been measured by polyelectrolyte titration. The results show that the LM\ulcorner polymer can reach all of the charges in the fibre wall whereas the MM\ulcorner and HM\ulcorner can only reach the external surfaces of the fibres. It is also shown that the kinetics of adsorption of the LMw polymer is not at all affected by the presence of a saturated layer of HMw polymer on the surface of the fibres. Finally, the results from the investigation show that it is possible to have full coverage of the external surface of the fibres by a high molecular mass polymer and a full coverage of the internal surface of the fibres with a low molecular mass polymer. This is true if the high molecular masspolymer is added first followed by addition of the low molecular masspolymer.

• Asian-Australasian Journal of Animal Sciences
• /
• 제14권6호
• /
• pp.894-898
• /
• 2001

Genetics has played a pivotal role in increasing the world food production through revolutions in plant and animal sciences. Though the attention on fisheries has been inadequate but the growing importance of modern genetic manipulations and biotechnological innovations to aquaculture has been realized. Recent advances in fish genetics and molecular biology have provided a suite of useful techniques, which have several applications in aquaculture. This paper reviews the advancement in the applications of selection, hybridization, chromosome engineering, sex control, gene transfer and molecular technologies for enhanced aquaculture productivity.