• The Transactions of the Korean Institute of Electrical Engineers C
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• v.48 no.6
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• pp.462-468
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• 1999

Room temperature vulcanizing (RTV) silicone rubber has been widely used to coat porcelain insulators to render water repellency to prevent formation of water film on the surface and thus to suppress the leakage current and consequently flashover. However, the electrical property and the hydrophobicity of RTV silicone rubber coating under outdoor condition may be influenced by many environmental factors. In this studyvarious treatments, such as salt-fog, salt water immerging and UV irradiation were applied to the samples to investigate the change of the electrical property and hydrophobicity. As a result the leakage current increased and contact angle decreased asthe degradation time is longer. But the degraded RTV silicone rubber has recovered its hydrophobicity during the drying time in ambient condition because LMW(Low Molecular Weight) silicone fluid diffused from the bulk to the surface.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.4
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• pp.381-385
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• 2007

Bone is a dynamic organ that bone remodeling occurs throughout life and involves the process in which the bone matrix is broken down through resorption by osteoclasts and then built back again through bone formation by osteoblasts. Usually these two processes balance each other and a stable level of bone mass is maintained. We here discuss transcription factors involved in regulating the osteoblast differentiation pathway. Runx2 is a transcription factor which is essential in skeletal development by regulating osteoblast differentiation and chondrocyte maturation. Its companion subunit, Cbf${\beta}$ is needed for an early step in osteoblast differentiation pathway. Whereas Osterix(Osx) is a new identified osteoblast-specific transcription factor which is required for the differentiation of preosteoblasts into more mature and functional osteoblasts. We also discuss other transcription factors, Msx1 and 2, Dlx5 and 6, Twist, and Sp3 that affect skeletal patterning and development. Understanding the characteristics of mice in which these transcription factors are inactivated should help define their role in bone physiology and pathology of bone defects.

• Publications of The Korean Astronomical Society
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• v.9 no.1
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• pp.111-166
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• 1994

I have developed a UV and visible spectroscopic database (UVSD) for atoms and molecules, which are found in interstellar medium, stars, galaxies, and in the atmospheres of the earth, planets, satellites, and comets. This UV and visible database, which is machine-readable, consists of three different sub-databases depending upon the characteristics of the sub-databases: (A) atomic and molecular line listings from laboratory observations or theoretical studies; (B) absorption spectra measured in laboratories; and (C) solar UV, visible, and infrared spectral atlases. The UVSD is in a very initial stage of development compared with other well organized and established infrared and microwave databases. In order to make a good quality and complete database, substantial efforts should be made for the acquisition of scattered important data from laboratories or institutions, and then the acquired heterogeneous data should be peer-reviewed and standardized.

• BMB Reports
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• v.46 no.1
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• pp.53-58
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• 2013

We constructed deletion mutants and seven point mutants by polymerase chain reaction to investigate the specificity of feline foamy virus integrase functional domains. Complementation reactions were performed for three enzymatic activities such as 3'-end processing, strand transfer, and disintegration. The complementation reactions with deletion mutants showed several activities for 3'-end processing and strand transfer. The conserved central domain and the combination of the N-terminal or C-terminal domains increased disintegration activity significantly. In the complementation reactions between deletion and point mutants, the combination between D107V and deletion mutants revealed 3'-end processing activities, but the combination with others did not have any activity, including strand transfer activities. Disintegration activity increased evenly, except the combination with glutamic acid 200. These results suggest that an intact central domain mediates enzymatic activities but fails to show these activities in the absence of the N-terminal or C-terminal domains.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2005.11a
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• pp.51-52
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• 2005

Optical characteristics of excitonic blue and green emission of Te-doped ZnSSe:Te epitaxial layers, grown by molecular beam epitaxy, were investigated by photoluminescence (PL) measurements. The Te-doped ternary specimen shows strong blue or green emission (at 300K) which is assigned to $Te_1$ or $Te_n$ $(n{\geq}2)$ cluster cluster bound exciton, respectively. Bright green and blue light emitting diodes (LEDs) have been developed using ZnSSe:Te system as an active layer. The green LEDs exhibit a fairly long device lifetime (>2000 h) when operated at 3 $A/cm^2$ under CW condition at room temperature.

• Clinical and Experimental Pediatrics
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• v.53 no.10
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• pp.909-912
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• 2010

Familial hypokalemic periodic paralysis is an autosomal-dominant channelopathy characterized by episodic muscle weakness with hypokalemia. The respiratory and cardiac muscles typically remain unaffected, but we report an atypical case of a family with hypokalemic periodic paralysis in which the affected members presented with frequent respiratory insufficiency during severe attacks. Molecular analysis revealed a heterozygous c.664 C>T transition in the sodium channel gene $SCN4A$, leading to an Arg222Trp mutation in the channel protein. The patients described here presented unusual clinical characteristics that included a severe respiratory phenotype, an incomplete penetrance in female carriers, and a different response to medications.

• BMB Reports
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• v.45 no.12
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• pp.693-699
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• 2012

Together with protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs) serve as hallmarks in cellular signal transduction by controlling the reversible phosphorylation of their substrates. The human genome is estimated to encode more than 100 PTPs, which can be divided into eleven sub-groups according to their structural and functional characteristics. All the crystal structures of catalytic domains of sub-groups have been elucidated, enabling us to understand their precise catalytic mechanism and to compare their structures across all sub-groups. In this review, I describe the structure and mechanism of catalytic domains of PTPs in the structural context.

• Molecules and Cells
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• v.24 no.1
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• pp.27-36
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• 2007

The hypothetical protein TTC0263 of Thermus thermophilus HB27 is a thermophilic tetratricopeptide repeat (TPR)-containing protein. In the present study, the TPR region (residues 26-230) was resolved at $2.5{\AA}$ with R-factors of $R/R_{free}$ = 23.6%/28.6% $R/R_{free}=23.6%/28.6%$. TTC0263 consists of 11 helices that form five TPR units. Uniquely, it contains one atypical "extended" TPR (eTPR) unit. This comprises extended helical residues near the loop region of TTC0263, such that the helical length of eTPR is longer than that of the canonical TPR sequence. In addition, the hybrid TPR domain of TTC0263 possesses oligomer-forming characteristics. TPR domains are generally involved in forming multi-subunit complexes by interacting with each other or with other subunit proteins. The dynamic structure of TTC0263 described here goes some way to explaining how TPR domains mediate the formation of multi-subunit complexes.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.577-580
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• 2002

In this paper, the pumping performance of the disk-type drag pump which works in the outlet pressure range from 4 to 0.001 Torr is studied experimentally. The pumping characteristics of various drag pumps are performed. The inlet pressures are measured for various outlet pressures of the test pump. The flow-meter method is adopted to calculate the pumping speed. Compression ratios and pumping speeds for the nitrogen gas are measured. The present experimental data show the leak-limited value of the compression ratio in the molecular transition region. The rotational speed of the pump is 24,000rpm. The inlet pressures are measured for various outlet pressures of the test pump. The ultimate Pressures for zero throughput are measured for three-stage, two-stage and single-stage disk-type, respectively.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.12 s.243
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• pp.1369-1376
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• 2005

Effective mixing gives strong advantageous impact on microfluidic applications since mixing is in general very slow process motivated by molecular diffusion transport only on the micro-scale. In this work, the mixing characteristics are analyzed in a Y-channel micromixer with obstacles. For the through analysis, our laboratory in-house unstructured grid CFD code is validated through solving a concentration transport in a uniform microchannel. The solutions well correspond to both exact solutions and those from MemCFD. Mixing in a Y-channel micromixer with obstacles is numerically investigated by the in-house code to search the optimal radius and layout of obstacles. From the simulations, the mixing efficiency appears to be proportional to the magnitude of the formation of lateral velocity component. It is also shown that the asymmetric layout and radius enlargement of obstacles greatly improves mixing efficiency.