• Title/Summary/Keyword: Molecular Analysis

Search Result 7,949, Processing Time 0.033 seconds

Molecular Application to Psychiatry (분자생물학의 정신과적 적용)

  • Lee, Min-Soo
    • Korean Journal of Biological Psychiatry
    • /
    • v.1 no.1
    • /
    • pp.60-66
    • /
    • 1994
  • Advances in molecular biology have renewed hope for the discovery of disease relevant gene. The basic strategy is gene mapping and likely to have on important role in psychiatric research and practice. Recent linkage studies of chromosomal loci to psychiatric diseases shed light on the potential for new genetics in psychiatric science. This article reviews molecular application to psychiatrymethodological issues in genetic linkage, study of gene expression by analysis of mRNA, and current linkage studies in psychiatric diseases.

  • PDF

Application of Molecular Descriptor for Prediction and Analysis of the Affinity between Alkyl Substituted Super Hydrophobic Dyes and Polypropylene Fibers (폴리프로필렌 섬유용 알킬치환 초소수성 염료의 친화력 분석과 예측을 위한 Molecular Descriptor의 활용)

  • Jang, Gyeong-Jin;Jeong, Jong-Seok;Kim, Tae-Gyeong
    • Proceedings of the Korean Society of Dyers and Finishers Conference
    • /
    • 2008.10a
    • /
    • pp.77-78
    • /
    • 2008
  • Affinity between alkyl substituted super hydrophobic dyes and polypropylene fiber has been analyzed by using the molecular descriptor as a method to predict chemical and physical characteristics of compounds. Hydrophobicity of synthesized dyes calculated by LogP which is one of molecular descriptors was increased continuously as the length of alkyl substituents increased.

  • PDF

Crystal structure and functional analysis of the surE protein identify a novel phosphatase family

  • Lee, Jae-Young;Kwak, Jae-Eun;Suh, Se-Won
    • Proceedings of the Korean Biophysical Society Conference
    • /
    • 2001.06a
    • /
    • pp.19-19
    • /
    • 2001
  • The genome sequencing has revealed a large number of proteins of unknown or little characterized functions that have been well conserved during evolution. It remains a great challenge to decipher the molecular and physiological functions of these proteins. One example of the evolutionarily conserved protein family with little understood function is the surE family.(omitted)

  • PDF

Analysis of Fatty Acyl Groups of Diacyl Galactolipid Molecular Species by HPLC/ESI-MS with In-source Fragmentation

  • Gil, Ji-Hye;Hong, Jong-Ki;Choe, Joong-Chul;Kim, Young-Hwan
    • Bulletin of the Korean Chemical Society
    • /
    • v.24 no.8
    • /
    • pp.1163-1168
    • /
    • 2003
  • The structures of molecular species of galactolipids, such as monogalactosyl diacylglycerol (MGDG) and digalactosyl diacylglycerol (DGDG), isolated from wheat flour have been investigated using negative-ion electrospray ionization (ESI) mass spectrometry interfaced with high performance liquid chromatography (HPLC). According to the result of HPLC analysis, MGDG and DGDG were found to consist of mixtures of five and four molecular species, respectively. The galactolipids have been also analyzed to determine their fatty acid compositions, using HPLC/ESI-MS combined with in-source (or cone voltage) fragmentation. HPLC/ ESI-MS is very useful for one-step analysis of mixtures of galactolipids with a small sample quantity. Especially, the carboxylate anions produced in in-source fragmentations of the negative-ion of each component separated by HPLC provide valuable information on the composition of its fatty acyl chains.

Post-translational Modifications and Their Biological Functions: Proteomic Analysis and Systematic Approaches

  • Seo, Ja-Won;Lee, Kong-Joo
    • BMB Reports
    • /
    • v.37 no.1
    • /
    • pp.35-44
    • /
    • 2004
  • Recently produced information on post-translational modifications makes it possible to interpret their biological regulation with new insights. Various protein modifications finely tune the cellular functions of each protein. Understanding the relationship between post-translational modifications and functional changes ("post-translatomics") is another enormous project, not unlike the human genome project. Proteomics, combined with separation technology and mass spectrometry, makes it possible to dissect and characterize the individual parts of post-translational modifications and provide a systemic analysis. Systemic analysis of post-translational modifications in various signaling pathways has been applied to illustrate the kinetics of modifications. Availability will advance new technologies that improve sensitivity and peptide coverage. The progress of "post-translatomics", novel analytical technologies that are rapidly emerging, offer a great potential for determining the details of the modification sites.

Calculation of Pressure Profiles in a Molecular Flow Regime using LTSpice IV

  • Choi, Won-Shik;Kang, Kun-Uk;Kim, Se-Hyun;Park, Chongdo
    • Applied Science and Convergence Technology
    • /
    • v.25 no.4
    • /
    • pp.67-72
    • /
    • 2016
  • This article describes an electrical network analysis (ENA) method to calculate the pressure distribution of a vacuum system in a molecular flow regime. The vacuum system was modeled using electrical components. For an accurate analysis, a complexly combined pipe model, excluding entrance conductance, was employed and the pressure distribution was simulated using ENA. A vacuum system comprising three vacuum pumps was used for simplicity. In addition, the ENA results were compared with results from finite element analysis (FEA) and experimental measurements. The pressure distribution profiles estimated from ENA, performed using the LTSpice IV software, were in agreement with FEA and experimental results.

Lipid analysis of streptomycetes isolated form volcanic soil

  • Kim, Seung-Bum;Kim, Min-Young;Seong, Chi-Nam;Ouk, Kang-Sa;Hah, Yung-Chil
    • Journal of Microbiology
    • /
    • v.34 no.2
    • /
    • pp.184-191
    • /
    • 1996
  • The cellular fatty acids and quinones of streptomycetes isolated from volcanic soils were analysed. The strains contained fatty acids of 14 to 17 carbon chains, and 12-methyltetradecanoic acid and 14 methylpentadecanoic acid were dominant in most strains. The total profiles consisted of 74% branched fatty acid family, 16.8% linear family and 8.2% unsaturated family. The largest cluster of grey spore meases defined by numerical classification was separated from the remainders in the principal component analysis, but the other clusters were overlapped with one another. In the analysis of respiratory quinones, all of the strains contained either the menaquinone of 9 isoprene units with 6 hydrogenations of 8 hydrogenations as the major species. The distribution of menaquinones among the clusters could provide an important key in the chemotaxonomy of streptomycetes.

  • PDF