• Genomics & Informatics
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• v.19 no.1
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• pp.6.1-6.10
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• 2021

Vascular endothelial growth factor (VEGF) is expressed at elevated levels by most cancer cells, which can stimulate vascular endothelial cell growth, survival, proliferation as well as trigger angiogenesis modulated by VEGF and VEGFR (a tyrosine kinase receptor) signaling. The angiogenic effects of the VEGF family are thought to be primarily mediated through the interaction of VEGF with VEGFR-2. Targeting this signaling molecule and its receptor is a novel approach for blocking angiogenesis. In recent years virtual high throughput screening has emerged as a widely accepted powerful technique in the identification of novel and diverse leads. The high resolution X-ray structure of VEGF has paved the way to introduce new small molecular inhibitors by structure-based virtual screening. In this study using different alkaloid molecules as potential novel inhibitors of VEGF, we proposed three alkaloid candidates for inhibiting VEGF and VEGFR mediated angiogenesis. As these three alkaloid compounds exhibited high scoring functions, which also highlights their high binding ability, it is evident that these alkaloids can be taken to further drug development pipelines for use as novel lead compounds to design new and effective drugs against cancer.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.1
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• pp.13-19
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• 2019

The accuracy of machine learning is greatly affected by amount of learning data and quality of data. Collecting existing Web-based learning data has danger that data unrelated to actual learning can be collected, and it is impossible to secure data transparency. In this paper, we propose a method for collecting data directly in parallel by blocks in a block - chain structure, and comparing the data collected by each block with data in other blocks to select only good data. In the proposed system, each block shares data with each other through a chain of blocks, utilizes the All-reduce structure of Parallel-SGD to select only good quality data through comparison with other block data to construct a learning data set. Also, in order to verify the performance of the proposed architecture, we verify that the original image is only good data among the modulated images using the existing benchmark data set.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39B no.11
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• pp.779-789
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• 2014

Cognitive radio (CR) technology based on geo-location database access approach and/or wideband spectrum sensing approach is absolutely vital in order to recognize available frequency bands in white spaces (WSs), and efficiently utilize shared spectrums. This paper presents a new structure for the TVWS database access protocol implementation based on Internet Engineering Task Force (IETF) Protocol to Access WS database (PAWS). A wideband compressive spectrum sensing (WCSS) scheme using a modulated wideband converter is also proposed for the TVWS utilization. The developed database access protocol technology which is adopted in both the TV band device (TVBD) and the TVWS database operates well in the TV frequency bands. The proposed WCSS shows a stable performance in false alarm probability irrespective of noise variance estimation error as well as provides signal detection probabilities greater than 95%. This paper also investigates Federal Communications Commision (FCC) regulatory requirements of TVWS database as well as European Telecommunications Standards Institute (ETSI) policy related to TVWS database. A standardized protocol to achieve interoperability among multiple TVBDs and TVWS databases, which is currently prepared in the IETF, is discussed.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.7
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• pp.477-483
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• 2018

A transparent antenna designed on the front glass of an automobile operating in the FM broadcast band(88~108 MHz) is proposed. A transparent antenna designed on the front glass of the automobile to avoid space limitation is typically positioned as a roof-mounted shark-fin antenna. An antenna designed on the front glass can reasonably solve the problems of low reception sensitivity and radiated interference from antennas for other service bands. The front glass has a unique closed-line structure, and this structure causes the surface current to flow to the front glass's surroundings; thus, the first resonance is caused before the broadcast band. Through the use of this closed-line structure, the surface current distribution is controlled, and an antenna for which the first resonance is operating in the frequency-modulated(FM) band can be designed. Moreover, the use of a micro-metal-mesh film that is a transparent electrode, suitable for designing a radio frequency device, enables the antenna to minimize visual perception through its transparency. The measured reflection coefficient($S_{11}$) of the antenna is less than -6 dB, and the average peak gain is -0.9 dB in the FM band. Experiments show that the transparent antenna on the front glass offers both the space and design freedom required to develop future automotive antennas.

• Polymer(Korea)
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• v.32 no.2
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• pp.143-149
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• 2008

We synthesized PEG-PLA (or PLGA) amphiphilic di-block copolymers, which consist of PEG as biocompatible and hydrophilic block and PLA (or PLGA) as biodegradable and hydrophobic block, by ring opening polymerization of LA in the presence of methoxy PEG as a macroinitiator. The compositions and the molecular weights of the copolymers were controlled by changing the feed ratio of LA (and GA) to PEG initiator. The di-block copolymers could self-assemble in aqueous media to form micellar structure. A hydrophobic model drug, pioglitazone, was loaded into the polymer micelle using solid dispersion and dialysis methods, and the drug-loaded micelles were characterized by AFM, DLS and HPLC measurements. The drug loading capacity and in vitro release studies were performed and evaluated under various conditions. These results indicated that the amphiphilic di-block copolymers of PEG-PLA (or PLGA) could solubilize pioglitazone by solid dispersion method and the drug release was modulated according to micellar chemical compositions.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.3
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• pp.331-336
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• 2013

In this paper, plasma modeling is achieved using fluid dynamics, thereby electron density is derived. The way proposes the key to overcoming the limitations of conventional researches which adopt simplified plasma model. The result is coupled with Maxwell-Boltzmann system in order to calculate scattering waves in various incident angle. The first part is dedicated to perform plasma modeling in dielectric barrier discharge(DBD) structure. Suzen-Huang model is adopted among various models due to the fact that it uses time independent variables to calculated potential and electron distribution in static system. The second part deals with finite difference time domain(FDTD) scheme which computes the scattered waves when the modulated Gaussian pulse is incident. Founded on it, radar cross section(RCS) is observed. Consequently, RCS is decreased by 1~2 dB with DBD plasma. The result is analogous to the RCS measurement in other researches.

• Journal of Korea Multimedia Society
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• v.13 no.12
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• pp.1767-1777
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• 2010

In digital TV broadcasting, such as terrestrial, cable, satellite, and IPTV, the head-end of digital TV broadcasting has a more complicated transmission structure than that of analog TV broadcasting. Furthermore, digital TV broadcasting has a feature that supports multiplex models, such as Multiple Program Transport Stream (MPTS). Therefore, the purpose of our work was to design and examine a more efficient new system of emergency alert message transmission to support the digital TV broadcasting environments. Digital TV broadcasting is the IP generation or RF transmission of 8-VSB, QAM, and QPSK modulated through a multiplexer or re-multiplexer multiplexed stream as a MPEG-2 Transport Stream after content encoding. The new system proposed in this paper transmits an emergency alert message without scrambling after replacing the PID and payload of the -packet with the message prototype in the TS stream from the multiplexer. If we need to transmit an emergency alert message under digital TV broadcasting services, then the receiver first checks the PID of each packet in the TS stream for the emergency alert message. Next, if a packet is determined to be an emergency alert message, then the set-top box displays the message on the TV screen using its function of On Screen Display, or the PC based software displays the message on the monitor screen using its function of overlay with user interface if the packet is found to be an emergency alert message. We have designed an emergency alert message protocol and a system model. By experiments and analysis of the system, we concluded that the system achieved efficiency and the ability to send and receive emergency alert messages using the system under different digital TV broadcasting service environments.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.21 no.5
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• pp.510-518
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• 2010

In this paper, the designed and implemented results of CFL linearization chip which can be used in mobile radio and TRS terminal of UHF band(380~910 MHz), using $0.6\;{\mu}m$ BiCMOS process based on Si, are shown. As gain control circuits for modifying transmit power are inserted not only in feedback path but also in forward path, the stability of CFL is maintained. And, DC-offset correction function of S/H structure, which is suitable for walkie-talkie PTT operation and is easily implemented, is realized. The performance test results of transmitter show that the regulation of FCC emission mask at PEP 3 W(34.8 dBm) is satisfied when the CQPSK modulated signal is fed and more than 30 dBc improvement of 3rd order IMD is achieved when two-tone signal is inputted.

• Natural Product Sciences
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• v.26 no.3
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• pp.191-199
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• 2020

Fucoidan, a natural component of brown seaweed, has various biological activities such as anti-cancer activity, anti-oxidant, and anti-inflammatory against various cancer cells. However, the fucoidan has been implicated in melanoma cells via apoptosis signaling pathway. Therefore, we investigated apoptosis with fucoidan in A2058 human melanoma cells with dose- and time-dependent manners. In our results, A2058 cells viability decreased at relatively short-time and low-concentration through fucoidan. This effects of fucoidan on A2058 cells appeared to be mediated by the induction of apoptosis, as manifested by morphological changes through DNA-binding dye Hoechst 33342 staining. When a dose of 80 ㎍/mL fucoidan was treated, the cells were observed: crescent or ring-like structure, chromatin condensation, and nuclear fragmentation. With the increase at 100 ㎍/mL fucoidan, the cell membrane is intact throughout the total process, including membrane blebbing and loss of membrane integrity as well as increase of sub-G1 DNA. Furthermore, to understand the exact mechanism of fucoidan-treated in A2058 cells, western blotting was performed to detect apoptosis-related protein expression. In this study, Bcl-2 family proteins can be regulated by fucoidan, suggesting that fucoidan-induced apoptosis is modulated by intrinsic pathway. Therefore, expression of Bcl-2 and Bax may result in altered permeability, activating caspase-3 and caspase-9. And the cleaved form of poly ADP-ribose polymerase was detected in fucoidan-treated A2058 cells. These results suggest that A2058 cells are highly sensitive to growth inhibition by fucoidan via apoptosis, as evidenced by activation of extracellular signal-regulated kinases/p38/Bcl-2 family signaling, as well as alteration in caspase-9 and caspase-3.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.12A
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• pp.1279-1284
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• 2004

In this paper, we propose a novel and simple optical technique for the detection of subcarrier-multiplexed(SCM) labels using optical interleavers. Optical-baseband packet signals with suppressed subcarriers appear at the through-pass port of the optical interleaver and SCM labels with suppressed optical carrier exit from the optical SCM extraction port. Since it does not require optical circulators, this structure shows less insertion loss than the previously proposed optical label detectors. The periodic nature of the interleaver transfer function makes it possible to detect multiple SCM channels simultaneously from an incoming wavelength-multiplexed signal stream. Detection of a 155-Mb/s ASK modulated 9.79-GHz subcarrier using a 10-GHz SCM optical label detector has been performed successfully and verified through optical spectra and bi t-error-rate measurements.