• 생명과학회지
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• 제22권5호
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• pp.697-701
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• 2012

본 연구에서는 항응고제로서의 역할을 가지면서 또한 혈액응고와는 관련 없는 종양세포의 전이 등을 조절하는 것으로 알려진 activated protein C (APC)가 종양세포의 사멸에는 어떠한 영향을 미치는 지에 대한 연구를 수행하였다. Tumor necrosis factor (TNF)-${\alpha}$와 cyclohexamide를 병합 처리하거나 FAS를 처리하게 되면 인간 신장암세포인 Caki에서는 유의적인 세포사멸이 일어난다. 하지만, APC는 이러한 세포사멸에 아무런 영향을 미치지 못하였다. 또한 TRAIL을 인간 뇌 암세포인 T98G와 유방암세포인 MDA231세포에 처리하여 세포사멸을 일으켰을 때에도 APC는 세포사멸을 조절하지 못하였다. 그러나, TRAIL에 대한 민감도를 증가시키기 위한 kahweol과 TRAIL의 병합처리나, kahweol과 malatonin의 병합처리에 의한 신장암세포의 사멸은 APC에 의해 유의적으로 억제되는 것을 확인하였다. 따라서, 이는 APC가 항암치료의 효율성을 조절 할 수 있는 가능성을 가짐을 의미한다.

• Journal of Ginseng Research
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• 제31권1호
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• pp.34-43
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• 2007

Background: Previous research has suggested that single doses of a standardised Panax ginseng extract can decrease fasted blood-glucose levels and modulate cognitive performance in healthy young volunteers. The latter has generally been seen in terms of improved secondary memory performance. However, both the cognitive effects of chronic administration of ginseng and the potential modulation of working memory have received comparatively little research attention. Aims: The current double-blind, placebo-controlled, balanced cross-over study investigated the effects of 8-weeks administration of Korean ginseng extract (200 mg) on cognitive performance, gluco-regulatory parameters and ratings of subjective mood and 'quality of life'. Methods: 'Eighteen healthy young participants were assessed pre-dose and 3 hours post-dose on the mornings of Day 1, Day 29 and Day 57 of 8 week treatment regimens of both placebo and ginseng. A four-week placebo wash-out separated the treatment phases. Each assessment included the Cognitive Drug Research battery, computerised working memory tasks, and Bond-Lader mood scales. The WHO Quality of Life scale (WHOQOL-BREF) was completed once per visit. Gluco-regulatory parameters were assessed with assays of blood glucose, insulin and HbA1c. Results: Data from the 16 participants that completed the study showed that there were no significant, acute treatment related differences on Day 1 of treatment, or in gluco-regulatory parameters throughout the study. However, time related performance improvements were evident following chronic administration of ginseng on the '3-Back' and 'Corsi-block' computerised working memory tasks. Ginseng was also associated with an improved score on the 'social relations' subscale of the WHOQOL-100, and a significant shift on the 'calm' factor of the Bond-Lader mood scales (from calm/relaxed towards excited/tense). Conclusion: The results of the current study suggest that Korean ginseng extract can modulate working memory performance and subjective ratings of 'quality of life' and mood. Replication with a larger sample size may further elucidate the actions of this product.

• 한국운동역학회지
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• 제27권2호
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• pp.141-147
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• 2017

Objective: We obtained force-displacement curves for countermovement jumps of multiple heights and examined the effect of an arm swing on changes in vertical jumping strategy. Countermovement jumps with hands on hips (Condition 1) and with an arm swing (Condition 2) were evaluated to investigate the mechanical effect of the arm movement on standing vertical jumps. We hypothesized that the ground reaction force (GRF) and/or center of mass (CoM) motion resulting from the countermovement action would significantly change depending on the use of an arm swing. Method: Eight healthy young subjects jumped straight up to five different levels ranging from approximately 10% (~25 cm) to 35% (~55 cm) of their body heights. Each subject performed five sets of jumps to five randomly ordered vertical elevations in each condition. For comparison of the two jumping strategies, the characteristics of the boundary point on the force-displacement curve, corresponding to the vertical GRF and the CoM displacement at the end of the countermovement action, were investigated to understand the role of arm movement. Results: Based on the comparison between the two conditions (with and without an arm swing), the subjects were grouped into type A and type B depending on the change observed in the boundary point across the five different jump heights. For both types (type A and type B) of vertical jumps, the initial vertical force at the start of push-off significantly changed when the subjects employed arm movement. Conclusion: The findings may imply that the jumping strategy does change with the inclusion of an arm swing, predominantly to modulate the vertical force advantage (i.e., the difference between the vertical force at the start of push-off and the body weight).

• 한국전자통신학회논문지
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• 제7권2호
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• pp.263-269
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• 2012

CDMA는 여러 사용자가 시간과 주파수를 공유하면서 각 사용자에게 확산코드라고 하는 서로 다른 의사잡음수열(pseudonoise sequence)을 할당한다. 각 사용자는 할당된 확산코드를 이용하여 송신할 신호를 변조한다. 신호를 변조하는데 사용하는 코드를 선택하는 것은 CDMA 시스템의 수행능력을 결정하는 데 있어 매우 중요하다. 왜냐하면 품질이 좋은 수열은 사용자들 사이의 신호들의 간섭을 줄이고 신호를 잘 복호할 수 있도록 하기 때문이다. 수신자는 데이터를 복호하기 위해 수신된 부호를 동기화한다. 서로 독립인 코드를 사용하는 것은 동시 다중접속을 가능하게 한다. 본 논문에서는 확산 스펙트럼 통신에서 다중접속 충돌을 최소화하고, 시스템의 보안을 증가시키고 사용자의 수를 늘이는데 도움을 주는 비선형 수열을 생성하고 상호상관관계를 분석한다.

• Journal of Plant Biotechnology
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• 제7권3호
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• pp.161-167
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• 2005

Brassinosteroids are steroidal plant hormones and are known to modulate physiological and cellular response in a wide range of plant species. Considerable insights has been achieved of the physiological role of brassinosteroid in Brassica species in the past few years, but their effect on direct organogenesis has not been extensively studied. In this sense, under optimal basal media and growth conditions we tested the cellular and organogenic response of 24-epibrassinolide (EBL) in a variable concentration (0.1 to $5.0\;{\mu}M$) and Zeatin (Z) (1.0 to $100\;{\mu}M$) and their synergic effect on hypocotyl explants of cauliflower and broccoli. The isolated EBL accelerated cell elongation and promotes direct organogenesis. One micromolar EBL + $10\;{\mu}M$ of Z was the most efficient combination for cell elongation, cell differentiation as well as for organogenesis. A suppressing effect on root induction was confirmed for all the tested hormone levels. The general results indicate a synergic effect of EBL-Z and EBL potentates Zeatin activity, at least in certain tissues. Besides de genetic factors, we can speculate that the natural hormone concentration in the explants might affect the responses by application of exogenous growth regulators. Experiments with new plant growth regulators, like brassinolide, are important aiming to maximize or accelerate plant regeneration for in vitro multiplication or for genetic transformation.

• Korean Journal of Acupuncture
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• 제19권2호
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• pp.13-33
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• 2002

This study was examined for effects of acupuncture of Zusanli (ST36) on the facial thermography in health subjects. The volunteers who participating in this study had taken rest for 20 - 30 mins in room temperature (23-$25^{\circ}C$) before the examination and informed them what to prohibit smoking, drinking and administration of drug for the previous day. The thermography of face was taken using Infra-Red Imaging System (IR 2000, MEDI-CORE Co., Korea) by time interval of 15 minutes at 15 min before, just before and 15 min after, 30 min after and 45 min after acupuncture stimulation. Acupuncture was applied to the left ST36 for 30 mins. The results showed that acupuncture of ST36 significantly decreased the temperature of all the areas of facial surface comparing to those of control group. Also, it was observed that the quantities of thermal changes following acupuncture of ST36 been increased significantly at the A1, A4, A6, A7 and A9 ROIs (region of interest) comparing that of control group. Observed the thermography classified by ROI, it was clear the fact that acupuncture of ST36 could modulate the specific areas concerning to the facial pathway of Stomach Meridian, because the thermal responses following acupuncture of ST36 were specific at the A1, A2, A5 and A9 ROIs, relatively. These results suggest that acupuncture of ST36 may modulate thermal distributions and changes of facial areas concerned with Stomach Meridian.

• Korean Journal of Acupuncture
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• 제20권1호
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• pp.1-20
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• 2003

This study was examined for effects of acupuncture of Zusanli (ST36) on the abdominal thermography of health subject. The volunteers who participating in this study had taken rest for 20-30 mins in room temperature (23-$25^{\circ}C$) before the examination and informed them what to prohibit smoking, drinking and administration of drug for the previous day. The thermography of abdomen including a below part of the chest was taken using Infra-Red Imaging System (IR 2000, MEDI-CORE Co, Korea) by time interval of 15 minutes at 15 min before, just before and 15 min after, 30 min after and 45 min after acupuncture stimulation. Acupuncture was applied to the left ST36 acupoint for 30 mins. The results showed that acupuncture of ST36 significantly had more potencies of changes on all the of abdominal thermography than those of control group. Also, it was observed that the quantities of thermal changes following acupuncture of ST36 been increased significantly comparing that of control group at all the ROIs (region of interest). Observed the thermography classified by ROI, however, it was failed that acupuncture of ST36 could modulate the specific areas concerning to the abdominal pathway of Stomach Meridian. These results suggest that acupuncture of ST36 may modulate thermal distributions and changes of abdominal areas including the below of chest.

• Korean Journal of Acupuncture
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• 제20권4호
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• pp.1-16
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• 2003

Objectives : This study was examined for effects of acupuncture of Hyeong points' Acupuncture of Three Foot-eum Collaterals on the abdominal thermography of health subject. Methods : The volunteers who participating in this study had taken rest for 20 - 30 minutes in room temperature $(23-25^{\circ}C)$ before the examination and informed them what to prohibit smoking, drinking and administration of drug for the previous day. The thermography of abdomen including a below part of the chest was taken using Infra-Red Imaging System (IR 2000, MEDI-CORE Co., Korea) by time interval of 15 minutes at 15 minutes before, just before and 15 minutes after, 30 minutes after and 45 minutes after acupuncture stimulation. Acupuncture was applied to the left Hyeong points' Acupuncture of Three Foot-eum Collaterals for 30 minutes. Results : The results showed that acupuncture of Hyeong points had more potencies of changes on all the ROIs of abdominal thermography than those of control group. Also, it was observed that the quantities of thermal changes following acupuncture of Hyeong points been increased comparing that of control group at all the ROIs (region of interest). Observed the thermography classified by ROI, however, it was failed that acupuncture of Hyeong points could modulate the specific areas concerning to the abdominal pathway of Three Foot-eum Collaterals. Conclusions : These results suggest that acupuncture of Hyeong points may modulate thermal distributions and changes of abdominal areas including the below of chest.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.45-45
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• 2003

We isolated a novel ankyrin-repeat containing protein, rSIAP (rSlo Interacting Ankyrin-repeat Protein), as an interacting protein to the cytosolic domain of the alpha-subunit of rat large-conductance Ca$\^$2+/-activated K$\^$+/ channel (rSlo) by yeast two-hybrid screening. Affinity pull-down assay showed the direct and specific interaction between rSIAP and rSlo domain. The channel-binding proteins can be classified into several categories according to their functional effects on the channel proteins, i.e. signaling adaptors, scaffolding net, molecular tuners, molecular chaperones, etc. To obtain initial clues on its functional roles, we investigated the cellular localization of rSIAP using immunofluorescent staining. The results showed the possible co-localization of rSlo and rSIAP protein near the plasma membrane, when co-expressed in CHO cells. We then investigated the functional effects of rSIAP on the rSlo channel using electrophysiological means. The co-expression of rSIAP accelerated the activation of rSlo channel. These effects were initiated at the micromolar [Ca$\^$2+/]$\_$i/ and gradually increased as [Ca$\^$2+/]$\_$i/ raised. Interestingly, rSIAP decreased the inactivation kinetics of rSlo channel at micromolar [Ca$\^$2+/]$\_$i/, while the rate was accelerated at sub-micromolar [Ca$\^$2+/]$\_$i/. These results suggest that rSIAP may modulate the activity of native BK$\_$Ca/ channel by altering its gating kinetics depending on [Ca$\^$2+/]$\_$i/. To localize critical regions involved in protein-protein interaction between rSlo and rSIAP, a series of sub-domain constructs were generated. We are currently investigating sub-domain interaction using both of yeast two-hybrid method and in vitro binding assay.

• 정보보호학회논문지
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• 제31권4호
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• pp.661-674
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• 2021

커널을 변조하는 루트킷과 같은 악성코드가 만약 메모리 분석을 회피하기 위한 메커니즘을 추가하게 될 경우, 분석이 어려워지거나 불가능하게 되면서 분석가의 판단에 악영향을 미칠 수 있다. 따라서 향후 고도화된 커널 변조를 통해 탐지를 우회하는 루트킷과 같은 악성코드에 선제적으로 대응하고자 한다. 이를 위해 공격자의 관점에서 윈도우 커널에서 사용되는 주요 구조체를 분석하고, 커널 객체를 변조할 수 있는 방법을 적용하여 메모리 덤프 파일에 변조를 진행하였다. 변조 결과 널리 사용되는 메모리 분석 도구에서 탐지가 되지 않는 것을 실험을 통해 확인하였다. 이후 분석가의 관점에서 변조 저항성의 개념을 사용하여 변조를 탐지할 수 있는 소프트웨어 형태로 만들어 기존 메모리 분석 도구에서 탐지되지 않는 영역에 대해 탐지 가능함을 보인다. 본 연구를 통해 선제적으로 커널 영역에 대해 변조를 시도하고 정밀 분석이 가능하도록 인사이트를 도출하였다는 데 의의가 있다 판단된다. 하지만 정밀 분석을 위한 소프트웨어 구현에 있어 필요한 탐지 규칙을 수동으로 생성해야 한다는 한계점이 존재한다.