• Clinical and Experimental Pediatrics
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• v.60 no.3
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• pp.86-93
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• 2017

Purpose: To evaluate the clinical spectrum of posttransplantation lymphoproliferative disorder (PTLD) after solid organ transplantation (SOT) in children. Methods: We retrospectively reviewed the medical records of 18 patients with PTLD who underwent liver (LT) or kidney transplantation (KT) between January 1995 and December 2014 in Seoul National University Children's Hospital. Results: Eighteen patients (3.9% of pediatric SOTs; LT:KT, 11:7; male to female, 9:9) were diagnosed as having PTLD over the last 2 decades (4.8% for LT and 2.9% for KT). PTLD usually presented with fever or gastrointestinal symptoms in a median period of 7 months after SOT. Eight cases had malignant lesions, and all the patients except one had evidence of Epstein-Barr virus (EBV) involvement, assessed by using in situ hybridization of tumor tissue or EBV viral load quantitation of blood. Remission was achieved in all patients with reduction of immunosuppression and/or rituximab therapy or chemotherapy, although 1 patient had allograft kidney loss and another died from complications of chemotherapy. The first case of PTLD was encountered after the introduction of tacrolimus for pediatric SOT in 2003. The recent increase in PTLD incidence in KT coincided with modification of clinical practice since 2012 to increase the tacrolimus trough level. Conclusion: While the outcome was favorable in that all patients achieved complete remission, some patients still had allograft loss or mortality. To prevent PTLD and improve its outcome, monitoring for EBV infection is essential, which would lead to appropriate modification of immunosuppression and enhanced surveillance for PTLD.

• Journal of the Earthquake Engineering Society of Korea
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• v.6 no.6
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• pp.33-39
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• 2002

Response Modification Factor(R-factor) approach is currently implemented to reflect inelastic ductile behavior of the structures and to reduce elastic spectral demands from earthquakes to the design level. However R factors were set empirically and simply based on the professional committee consensus on observed performance of building structures during past earthquakes. Consequently some major shortcomings linked to the current R factor approach have been pointed out. Using reinforced concrete intermediate moment-resisting frames(RC IMRFs), an analytical procedure is presented in this paper to establish R factor rationally. To this end, analytical R values were evaluated based on N2 Method and compared with the values recommended by IBC 2000. Overall, the analytical results correlated well with the code values. However the results also revealed that R factor might strongly depend on the system fundamental period. As evidenced by the interstory drift index(IDI) analysis results of this study, current R-factor based(or, Life Safety based) design tends to fail in fulfilling other implicit and hopeful performance objectives such as immediate Occupancy and Collapse Prevention. Performance based design(PBD) appears to be a promising approach to meet the multi level seismic performance objectives assigned to the building structures of nowadays.

• Journal of Korea Water Resources Association
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• v.39 no.2 s.163
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• pp.109-120
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• 2006

Permeable pavement and release of treated wastewater into streams can increase streamflow of urban streams for a dry weather period. A SWMM code was modified to have a permeable pavement option. The modified SWMM was applied to continuous simulations of urban runoff from Hakuicheon watershed and it was used to analyse the effect of a permeable pavement installation and the reuse of treated wastewater. A critical error in the pan coefficient multiplication was also corrected in the modification. The analysis results of the reuse of treated wastewater is as follows: The low flow ($Q_{275}$) increases by 1.63 times as much as the current one and the drought flow ($Q_{355}$) increases by 3.57 times as much as the current one. If the impervious area in the Hakuicheon watershed is replaced with the permeable pavement area by 10 percent, the low flow and the drought flow increases by 3 percent and 17 percent, respectively. The results shows the effectiveness of the release of treated wastewater into stream to increase urban streamflow. The permeable pavement installation also play a minor role in the drought flow increase.

• Journal of the Korean Wood Science and Technology
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• v.37 no.6
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• pp.566-577
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• 2009

The modification of wood color occurs rapidly during the service period at indoor. It is crucial to investigate the characteristics of color change, chemical and microscopical modification of wood at indoor. Wood products made of Japanese cedar at different years were used for this work. The tests were performed in order to evaluate the degree of color change of wood surface, breakpoint of brightness from surface to inside of wood, chemical analysis with FT-IR, and microscopical characteristics using the LM and TEM. Surface color of cedar wood stored indoor were rapidly changed at early stage, particularly ${\Delta}a$ (yellow), and ${\Delta}b$ (red) values were steeply decreased for one year old indoor wood, ${\Delta}L$ (white) value was dropped until 5 years old indoor wood compared with control sample. Decrease of peaks related to polysaccharide and lignin was noticed, especially, lignin was severely degraded. Although degradation of cell wall limited only to surface layers of indoor wood, degradation pattern of indoor wood showed similar degradation pattern to natural weathering of wood during outdoor weathering or wood behavior under artificial UV irradiation.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.238-238
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• 2015

There are demands for water environmental analysis of discharge processes in paddy fields, however, it is not fully understood in nutrients discharge process for watershed modeling. As hydrological processes both surface and ground water and agricultural water managements are so complex in paddy fields, the development of lowland paddy fields watershed model is more difficult than upland watershed model. In this research, the improvement of SWAT (Soil and Water Assessment Tool) model for a paddy watershed was conducted. First, modification of surface inundated process was developed in improved pot hole option. Those modification was evaluated by monitoring data. Second, the monitoring data in river and drainage channel in lowland paddy fields from 2012 to 2014 were analyzed to understand discharge characteristics. As a case study, Imbanuma basin, Japan, was chosen as typical land and water use in Asian countries. In this basin, lowland paddy fields are irrigated from river water using small pumps that were located in distribution within the watershed. Daily hydrological fluctuation was too complex to estimate. Then, to understand surface and ground water discharge characteristics in irrigation (Apr-Aug) and non-irrigation (Sep-Mar) period, the water and material balance analysis was conducted. The analysis was composed two parts, watershed and river channel blocks. As results of model simulation, output was satisfactory in NSE, but uncertainty was large. It would be coming from discharge process in return water. The river water and ground water in paddy fields were exchanged each other in 5.7% and 10.8% to river discharge in irrigation and non-irrigation periods, respectively. Through this exchange, nutrient loads were exchanged between river and paddy fields components. It suggested that discharge from paddy fields was not only responded to rainfall but dynamically related with river water table. In general, hydrological models is assumed that a discharge process is one way from watershed to river. However, in lowland paddy fields, discharge process is dynamically changed. This function of paddy fields showed that flood was mitigated and temporally held as storage in ground water. Then, it showed that water quality was changed in mitigated function in the water exchange process in lowland paddy fields. In future, it was expected that hydrological models for lowland paddy fields would be developed with this mitigation function.

• 한국체육학회지인문사회과학편
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• v.54 no.5
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• pp.867-876
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• 2015

This study was intended to closely examine an effect that the level of physically challenged person's participation in community sports had on positive psychological capital. In order to accomplish the purpose of study, data on 212 physically challenged persons who lived in B city and participated in community sports were analyzed. Korean version of positive psychological capital created by Taehong Lim (2014) through the reconstruction of scales developed by Luthans, Youssef and Avolio(2007) and Sangwan Jeon and Jonghun Yang's (2009) level of participation in community sports was reconstructed through modification·improvement as measurement instrument. An exploratory factor analysis, reliability test, paired difference test, and multiple regression analysis was carried out by using SPSS 18.0 program for data processing. First, It was shown that there was a significant difference in positive psychological capital according to gender, age, and disability grade among physically challenged persons' socio-demographic characteristics. Second, it was shown that, among sub-variables (period, frequency and intensity) of level of physically challenged persons' participation in community sports, the frequency of participation and the intensity of participation had a significant effect on self efficacy. On the other hand, it was shown that the period of participation didn't have a significant effect. Third, it was shown that the frequency of participation had a significant effect on optimism. On the other hand, it was shown that the period of participation and the intensity of participation didn't have a significant effect. Fourth, it was shown that the frequency of participation and the intensity of participation had a significant effect on hope. On the other hand, it was shown that no significant effect was produced on the period of participation. Fifth, it was shown that the frequency of participation had a significant effect on resilience. On the other hand, it was shown that no significant effect was produced on the period of participation and the intensity of participation. Sixth, it was shown that the frequency of participation and the intensity of participation had a significant effect on positive psychological capital. And it was shown that no significant effect was produced on the period of participation.

• Korean Journal of Ecology and Environment
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• v.41 no.4
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• pp.431-440
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• 2008

Turbid water or suspended sediment is associated with negative effects on aquatic organisms; fish, aquatic invertebrate, and periphyton. Effects of turbid water on fish differ depending on their developmental stage and a level of turbidity. Low turbid water may cause feeding and predation rates, reaction distance, and avoidance in fish, and it could make fish to die under high turbidity and long period. Therefore, it is very important to find out how turbid water or suspended sediment can affect fish in domestic watersheds. The objectives of this study were 1) to introduce international case studies and their standards to deal with suspended sediment, 2) to determine acute toxicity in 4 major freshwater fishes, and 3) to determine in relation to adverse effect of macroinvertebrates and fish. Impacts of turbid water on fish can be categorized into direct and indirect effects, and some factors such as duration and frequency of exposure, toxicity, temperature, life stage of fish, size of particle, time of occurrence, availability of and access to refugia, etc, play important role to decide magnitude of effect. A review of turbidity standard in USA, Canada, and Europe indicated that each standard varied with natural condition, and Alaska allowed liberal increase of turbidity over natural conditions in streams. Even though acute toxicity with four different species did not show any fatal effect, it should be considered to conduct a chronic test (long-term) for more detailed assessment. Compared to the control, dominance index of macroinvertebrates was greater in the turbid site, whereas biotic index, species diversity index, species richness index, and ecological score were smaller in the turbid site. According to histopathological analysis with gills of macroinvertebrate and fishes, morphological and physiological modification of gills due to suspended sediments can cause disturbance of respiration, excretion and secretion. In conclusion, in order to maintain good and healthy aquatic ecosystem, it is the best to minimize or prevent impact by occurrence of turbid water in stream and reservoir. We must make every effort to maintain and manage healthy aquatic ecosystem with additional investigation using various assessment tools and periodic biomonitoring of fish.

• Journal of the Korean association of regional geographers
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• v.14 no.1
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• pp.19-26
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• 2008

A validation study has been performed using the Soil and Water Assessment Tool(SWAT) model with data collected for the Neponset River watershed, which includes roughly 130 square miles of land located southwest of Boston. All of this land drains into the Neponset River, and ultimately into Boston Harbor. This paper presents the methodology of a SWAT model. The calculated contribution of the baseflow to the streamflow is far too high whereas the interflow is strongly underestimated. Alternatively, the modified and calibrated model yields far better results for the catchment. The modification allows hydrological processes to be modeled while not restraining the applicability of the model to catchments with other characteristics. For this study, the SWAT 2005 model is used with ArcGIS 9.1 as an interlace, and sensitivity analysis is performed to provide rough estimated values before adjusting sensitive input parameters during calibration period.

• Journal of Korean Dental Science
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• v.4 no.1
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• pp.26-32
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• 2011

Purpose: The quality of implant surface is one of the factors that influence wound healing of implant site and subsequently affect osseointegration. The objective of modification of the surface properties of an implant is to affect the biological consequence. The purpose of this study is to evaluate the biologic response of osseous tissue to anodized implants. Materials and Methods: Two machined titanium implants for control group were installed in a tibia of each rabbit and two anodized implants for test group were installed in the other tibia of each rabbit. At the moment the implants were installed, resonance frequency analysis (RFA) values were measured. After healing periods of 1, 2, 3, and 7 weeks, the implants were uncovered and RFA values were measured again. Removal torque was measured for one implant in the test group and one implant in the control group. Histological evaluation was executed in the other implants. Results: Both of test group and control group have the tendency of greater RFA change rate and removal torque value as healing periods became longer, but were statistically insignificant (P>0.05). However, in the case of the same healing period, the test group tended to have greater RFA change rate and removal torque than the control group (P<0.05). More active new bone formation from endosteal surface was noted on the anodized surface than machined surface in specimen after 1 week. There were no significant differences between the test group and control group in histological evaluations. Conclusion: In summary, the anodized surface showed slightly favorable results and it is postulated that it may facilitate improved stability in bone.

• Korean Journal of Agricultural Science
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• v.43 no.1
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• pp.72-79
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• 2016

It has long been known that nutritional and environmental influences during the early developmental period affect the biological mechanisms which determine animal metabolism. This phenomenon, termed 'metabolic imprinting', can cause subtle but long-lasting responses to prenatal and postnatal nutrition and even be passed onto the next generation. A large amount of research data shows that nutrient availability, in terms of quantity as well as quality, during the early developing stages can decrease the number of newborn piglets and their body weight and increase their susceptibility to death before weaning. However, investigation of potential mechanisms of 'the metabolic imprinting' effect have been scant. Therefore, it remains unknown which factors are responsible for embryonic and early postnatal nutrition and which factors are major determinants of body weight and number of new born piglets. Intrauterine undernutrition, for example, was studied using a rat model providing dams 50% restricted nutrients during pregnancy and the results showed significant decreases in birth weight of newborns. This response may be a characteristic of a subset of modulations in embryonic development which is caused by the metabolic imprinting. Underlying mechanisms of intrauterine undernutrition and growth retardation can be explained in part by epigenetics. Epigenetics modulate animal phenotypes without changes in DNA sequences. Epigenetic modifications include DNA methylation, chromatin modification and small non-coding RNA-associated gene silencing. Precise mechanisms must be identified at the morphologic, cellular, and molecular levels by using interdisciplinary nutrigenomics approaches to increase pig production. Experimental approaches for explaining these potential mechanisms will be discussed in this review.