• Coupled systems mechanics
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• 제5권4호
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• pp.285-304
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• 2016

The effects of large rotations and p-delta on the dynamic response of a structure subjected to seismic loading and local uplift of its foundation were analyzed in this work. The structure was modeled by an equivalent flexible mat mounted on a rigid foundation that is supported either by a Winkler soil type or a rigid soil. The equations of motion of the system were derived by taking into account the equilibrium of the coupled foundation-mat system where the structure was idealized as a single-degree-of-freedom. The obtained nonlinear coupled system of ordinary differential equations was integrated by using an adequate numerical scheme. A parametric study was performed then in order to evaluate the maximum response of the system as function of the intensity of the earthquake, the slenderness of the structure, the ratio of the mass of the foundation to the mass of the structure. Three cases were considered: (i) local uplift of foundation under large rotation with the p-delta effect, (ii) local uplift of foundation under large rotation without including the p-delta effect, (iii) local uplift of foundation under small rotation. It was found that, in the considered ranges of parameters and for moderate earthquakes, assuming small rotation of foundation under seismic loading can yield more adverse structural response, while the p-delta effect has almost no effect.

• Molecules and Cells
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• 제19권1호
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• pp.143-148
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• 2005

Heptaplatin, cis-malonato [(4R,5R)-4,5-bis (amino-methyl)-2-isopropyl-1,3-dioxolane] platinum(II) (SKI-2053R, Sunpla) is a new platinum derivative with antitumor activity comparable to cisplatin on various cancer cell lines. Preclinical studies suggest that it is less nephrotoxic than cisplatin. This study was undertaken to examine the combined effect of heptaplatin and ionizing radiation on two established human squamous carcinoma cell lines (NCI-H520, SQ20B). The cytotoxic activity of heptaplatin was concentration-dependent in both cell lines. When low dose heptaplatin was combined with high dose ionizing radiation, there was an additive cytotoxic effect on NCI-H520 cells (P < 0.05), while a moderate dose of heptaplatin and a low dose of ionizing radiation had an additive cytotoxic effect on the growth of SQ20B cells (P < 0.05). FACS analysis and DAPI staining showed that their additive cytotoxic effects were correlated with the induction of apoptosis. Further studies are warranted using heptaplatin and ionizing radiation in squamous cell carcinoma as a substitute for cisplatin.

• 유통과학연구
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• 제11권7호
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• pp.39-45
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• 2013

Purpose - The paper aims at testing the moderating effect of individualism dimension of culture on consumer behavioural intention about bank services in Nigeria. Research design, data, and methodology - A survey was conducted with a sample of five hundred and fifty five bank customers drawn from various retails banks. Using Statistical Package for Social Sciences and Analysis of Moment Structure, combinations of descriptive and inferential statistics were performed. Invariance test and multiple-group analysis were conducted in order to assess the moderating effect. The invariance test was necessary to confirm the equivalence of constructs so that any difference detected thereafter could be related to moderating effect. Results - The results show that individualism has a significant moderating effect on the relationship between technical quality, perceived value and corporate image on the one hand, and behavioural intention on the other. However, individualism does not moderate the association between functional quality and behavioral intention. Conclusions - It is recommended that the bank policy makers should take necessary step to enhance the customer perception of technical quality, perceived value and corporate image with respect the retail bank services.

• The Journal of Asian Finance, Economics and Business
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• 제8권1호
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• pp.169-178
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• 2021

This research aims to test, firstly, how the disclosure of corporate social responsibility (CSR) helps to moderate the effect of family ownership on investment efficiency; secondly, how CSR disclosures mediate the effect of corporate governance on investment efficiency. STATA was used to analyze archival data collected from a total sample of 210 manufacturing companies listed on the Indonesian Stock Exchange (IDX), which were in the family businesses category for the period of 2016-2018. The first finding is that CSR moderates the effect of family ownership on investment efficiency. This implies that family businesses are very careful about investing. They will avoid risky decisions that may increase the economic wealth, but reduce the socio-emotional wealth. To maintain socio-emotional wealth, they tend to choose an underinvestment strategy and are more concerned with the prestige and good reputation of their families and dynasties than with economic wealth. Thus, CSR disclosures can reduce the underinvestment strategy of family businesses listed on the IDX. The second finding is that CSR disclosures are able to mediate the effect of corporate governance on investment efficiency. CSR activities play a major role in decision-making, and through CSR disclosures, corporate governance has a greater effect on investment efficiency.

• The Journal of Asian Finance, Economics and Business
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• 제8권1호
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• pp.767-780
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• 2021

The purpose of this research is to analyze the effect of financial elements (asset growth, liability growth, equity growth, revenue growth, and profit growth) on stock price performance and to analyze the growth of Corporate Social Responsibility (CSR) costs as a moderating effect. The technique analysis used is regression analysis. Samples in this analysis are manufacturing firms listed on the Indonesian Stock Exchange (IDX) for the period 2014-2018. The use of regression models for hypothesis testing must fulfill several applicable assumptions such as Normality Test, Heteroscedasticity Test, Multicollinearity Test, Autocorrelation Test, Model Fit Test, Determination Coefficient Test, and Hypothesis Test. Data analysis used two research models, namely model 1 and model 2. Model 1 is without the moderating variable, and model 2 is with the moderating variable, that is, CSR cost growth. Based on the result of the regression analysis, it can be inferred that the asset, revenue, and profit growth have a positive impact on stock price results. Liabilities and equity growth do not affect stock price performance. Operating expense growth has a significant effect on price performance. CSR cost growth can moderate the effect of growth in financial statement elements on stock price performance but is not significant.

• 아태비즈니스연구
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• 제13권1호
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• pp.53-74
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• 2022

Purpose - This study aims to examine the relationship between flexible Human Resource Management (HRM) and individual ambidexterity and the moderating effect of trust in management. Design/methodology/approach - This study collected 971 survey data from employees in Korea. The Confimatory Factor Analysis (CFA) and the multiple regression analysis were used to analyze the data. Findings - First, the flexible human resource management have a positive effect on individual ambidexterity. Second, trust in management positively moderate the relationship between flexible human resource management and individual ambidexterity. Research implications or Originality - First, this study is critical that it examines individual ambidexterity and antecedent factor, which have not been relatively researched in Korea. This study is meaningful in that it revealed that the individual ambidexterity can be increased through flexible human resource management. Second, individual ambidexterity may vary depending on the characteristics of the human resource management system. Third, it is important to find the boundary condition of trust in management. By finding conditions that enhance the effect of flexible human resource management on individual ambidexterity, it also provides practical implications applicable to companies.

• Physical Therapy Rehabilitation Science
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• 제12권1호
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• pp.48-55
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• 2023

Objective: The purpose of this study is to compare the effects of extracorporeal shock wave therapy (ESWT) and injection therapy through qualitative and quantitative analysis by synthesizing randomized controlled trials (RCTs) conducted on patients with various shoulder diseases. Design: A systematic review and meta-analysis of randomized controlled trials Methods: This review conducted a literature search through international electronic databases in January 2023 to compare the effects of ESWT and injection therapy. Qualitative analysis was performed as a risk of bias tool, and quantitative analysis was synthesized with a random effect model to show the effect size as a standardized mean difference (SMD). Results: Five RCTs involving 298 individuals with shoulder disorders were included in this systematic review and meta-analysis. ESWT showed a moderate effect on pain (SMD=-0.44; 95% CI, -0.95 to 0.06) and a large effect on shoulder function (SMD =-0.81; 95% CI, -1.70 to 0.07) than injection therapy. A significant difference was found in the shoulder range of motion, showing a large effect size (SMD=1.50; 95% CI, 0.58 to 2.43). Conclusions: When considering treatment options for the management of patients complaining of shoulder disorders, it is appropriate to recommend ESWT first rather than injection therapy to increase the range of motion of the joint. In addition, ESWT is safe for pain control and shoulder function improvement, and a positive prognosis could be expected.

• 한국약용작물학회지
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• 제13권5호
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• pp.227-232
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• 2005

The antioxidant effect of methanol extract (ME) and water extract (WE) from Clematis trichotoma was evaluated as primary study to scavenge stable 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), inhibited iron-induce lipid peroxidation in linoleic acid emulsion, peroxidation of liposome induced by $Fe^{3+}/H_2O_2/ascorbie$ acid, and on $Fe^{2+}/H_2O_2$ induced the mitochondrial lipid peroxidation. In secondary study, five flavonoids as luteolin (1), quercetin (2), apigenin (3), hirsutrin (4), kaempferol-3-O-glucoside were isolated (5). Among them, compounds 1 and 2 showed good activities in all the model systems. Compound 3 exhibited moderate antioxidant activities in both radical scavenging and these lipid peroxidation systems tested. Compound 4 showed significant inhibitions in liposome peroxidation and compound 5 displayed weak inhibition in all four tested systems. All the results presented herein indicate that products of C. trichotoma maybe useful in inhibiting membrane lipid peroxidation and preventing free radical-linked diseases.

• 간호행정학회지
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• 제16권3호
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• pp.276-285
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• 2010

Purpose: The purpose of this study was to investigate the effects of organizational justice and dispositional affectivity on job satisfaction and intent to leave among nurses. Methods: The sample of this study consisted of 274 nurses from 2 general hospitals located in Incheon. Data were collected with self-administered questionnaires and were analyzed by hierarchical multiple regression. Results: Distributive and interactional justices had positive impacts on nurses' job satisfaction. Distributive, procedural and interactional justices had negative impacts on nurses' intent to leave. It was found out that positive affectivity significantly moderated the effect of interactional justice on job satisfaction while dispositional affectivity did not significantly moderate the effect of organizational justice on the intent to leave. Conclusion: The results imply that hospital administrators should pay attention to the dispositional affectivity of nurses to increase their job satisfaction. Further, hospital needs to maintain organizational justice to reduce nurses' turnover.

• Structural Engineering and Mechanics
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• 제21권1호
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• pp.1-18
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• 2005

Foschi's connector model is used as a basic component in the development of nonlinear analysis programs for timber structures. This paper presents the extension of the model to include the effect of shaft frictional forces. The wood medium is modeled using the Foschi embedment model, while shaft friction is modeled using an elastic Coulomb-type friction model. The initial confining pressure for the case of driven fasteners is accounted for by a lateral shift of the load-embedment curve. The model is used to compute the cyclic response of both driven and inserted fasteners. The results obtained from the cases studied indicate that initial confining pressure and friction do not have a significant effect on the computed hysteretic response, however, they significantly affect the computed amount of fastener withdrawal. This model is particularly well-suited for modeling the hysteretic response of shear walls with moderate fastener withdrawal under lateral cyclic or earthquake loading.