• Journal of Preventive Medicine and Public Health
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• v.43 no.2
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• pp.109-116
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• 2010

Objectives: The pandemic of novel influenza A (H1N1) virus has required decision-makers to act in the face of the substantial uncertainties. In this study, we evaluated the potential impact of the pandemic response strategies in the Republic of Korea using a mathematical model. Methods: We developed a deterministic model of a pandemic (H1N1) 2009 in a structured population using the demographic data from the Korean population and the epidemiological feature of the pandemic (H1N1) 2009. To estimate the parameter values for the deterministic model, we used the available data from the previous studies on pandemic influenza. The pandemic response strategies of the Republic of Korea for novel influenza A (H1N1) virus such as school closure, mass vaccination (70% of population in 30 days), and a policy for anti-viral drug (treatment or prophylaxis) were applied to the deterministic model. Results: The effect of two-week school closure on the attack rate was low regardless of the timing of the intervention. The earlier vaccination showed the effect of greater delays in reaching the peak of outbreaks. When it was no vaccination, vaccination at initiation of outbreak, vaccination 90 days after the initiation of outbreak and vaccination at the epidemic peak point, the total number of clinical cases for 400 days were 20.8 million, 4.4 million, 4.7 million and 12.6 million, respectively. The pandemic response strategies of the Republic of Korea delayed the peak of outbreaks (about 40 days) and decreased the number of cumulative clinical cases (8 million). Conclusions: Rapid vaccination was the most important factor to control the spread of pandemic influenza, and the response strategies of the Republic of Korea were shown to delay the spread of pandemic influenza in this deterministic model.

• Journal of Wetlands Research
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• v.18 no.3
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• pp.313-323
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• 2016

Water temperature affects physical and biological processes in ecologies on river system and is important conditions for growth rate and spawning of fish species. The objective of this study is to compare models for water temperature during the summer season for the Fourchue River (St-Alexandre-de-Kamouraska, Quebec, Canada). For this, three different models, which are CEQUEAU, Auto-regressive Moving Average with eXogenous input and Nonlinear Autoregressive with eXogenous input, were applied and compared. Also, future water temperature in the Fourchue river were simulated and analyzed its result based on the CMIP5 climate models, RCP 2.6, 4.5, 8.5 climate change scenarios. As the result of the study, the water temperature in the Fourchue river are actually changed and median water temperature will increase $0.2{\sim}0.7^{\circ}C$ in June and could decrease by $0.2{\sim}1.1^{\circ}C$ in September. Also, the UILT ($24.9^{\circ}C$) for brook trout are also likely to occurred for several days.

• Korean Journal of Social Welfare Studies
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• no.39
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• pp.315-342
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• 2008

The aim of this study was to examine growth trajectories of delinquent behaviors during adolescence. In addition, the effects of protective and risk factors that might account for individual difference in the level of delinquent behaviors and in the rate of change were examined. Four waves of data in the Korea Youth Panel Survey(KYPS) were used to analyze the linear growth modeling. The sample consisted of 3346 adolescents who were assessed at 4 measurement waves with approximately 1-year intervals. The results showed significant individual differences in both final level of delinquent behaviors and in the rate of change across 3 measurement occasions. Adolescent gender, family's socioeconomic background predicted the final level and the rate of change of delinquent behaviors. The protective effects of positive parenting and self-control were significantly associated with problem behaviors and the risk effects of the association with deviant peers and negative stigma were significant on the final level of delinquency. Self-control and deviant peer affiliation had differential influences over time significantly. Practice and policy implications as well as further research topic were discussed in the light of searching for important factors in preventing adolescent problem behaviors.

• Biomolecules & Therapeutics
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• v.29 no.2
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• pp.234-247
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• 2021

We used a heterozygous gene deletion library of fission yeasts comprising all essential and non-essential genes for a microarray screening of target genes of the antifungal terbinafine, which inhibits ergosterol synthesis via the Erg1 enzyme. We identified 14 heterozygous strains corresponding to 10 non-essential [7 ribosomal-protein (RP) coding genes, spt7, spt20, and elp2] and 4 essential genes (tif302, rpl2501, rpl31, and erg1). Expectedly, their erg1 mRNA and protein levels had decreased compared to the control strain SP286. When we studied the action mechanism of the non-essential target genes using cognate haploid deletion strains, knockout of SAGA-subunit genes caused a down-regulation in erg1 transcription compared to the control strain ED668. However, knockout of RP genes conferred no susceptibility to ergosterol-targeting antifungals. Surprisingly, the RP genes participated in the erg1 transcription as components of repressor complexes as observed in a comparison analysis of the experimental ratio of erg1 mRNA. To understand the action mechanism of the interaction between the drug and the novel essential target genes, we performed isobologram assays with terbinafine and econazole (or cycloheximide). Terbinafine susceptibility of the tif302 heterozygous strain was attributed to both decreased erg1 mRNA levels and inhibition of translation. Moreover, Tif302 was required for efficacy of both terbinafine and cycloheximide. Based on a molecular modeling analysis, terbinafine could directly bind to Tif302 in yeasts, suggesting Tif302 as a potential off-target of terbinafine. In conclusion, this genome-wide screening system can be harnessed for the identification and characterization of target genes under any condition of interest.

• Journal of the Korea Society for Simulation
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• v.27 no.1
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• pp.61-73
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• 2018

In the defense modeling and simulation, for the detailed analysis of the communication system, many studies have carried out the analysis under the C3 SoS(system of systems) which consists of C2(command and control) and C(communication). However, it requires time and space constraints of the C2 system. To solve this problem, this paper proposes a communication analysis method in the standalone system environment which is combined with the C system after abstracting the C2 system. In the abstraction process, we hypothesize the traffic model and mobility model for C system analysis and learn the parameters in the model based on machine learning. Through the proposed method, it is possible to construct traffic and mobility model with different output according to the battlefield. This case study shows how the process can be applied to the C3 SoS and the enhanced accuracy than the existing method. We expect that it is possible to carry out the efficient communication analysis against many experimental scenarios with various communication parameters.

• Journal of Korea Water Resources Association
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• v.55 no.5
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• pp.321-331
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• 2022

In this study, we tried to present a method for calculating the amount of regression using a watershed modeling method that can simulate the hydrological mechanism of water balance analysis and agricultural water based on watershed unit. Using the soil water assessment tool (SWAT), a watershed water balance analysis was conducted considering the simulation of paddy fields for the Manbongcheon Standard Basin (97.34 km²), which is a representative agricultural area of the Yeongsan river basin. Before evaluating return flow, the SWAT was calibrated and validated using the daily streamflow observation data at Naju streamflow gauge station (NJ). The coefficient of determination (R²), Nash-Sutcliffe Efficiency (NSE), Root-Mean-Square Error (RMSE) of NJ were 0.73, 0.70, 0.64 mm/day. Based on the calibration results for three years (2015-2017), the quick return flow and the return rate compared to the water supply amount for the irrigation period (April 1 to September 30) were calculated, and the average return flow rate was 53.4%. The proposed method of this study may be used as foundation data to optimal agricultural water supply plan for rational watershed management.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.2
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• pp.145-152
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• 2015

In the study, the effects of damping devices on damping ratio increase and wind-load reduction were investigated based on the computational platform, which is one of the parametric modeling methods. The computational platform helps the designers or engineers to evaluate the efficacy of the numerous alternative structural systems for irregular Super-Tall building, which is crucial in determining the capacity and the number of the supplemental damping devices for adding the required damping ratios to the building. The inherent damping ratio was estimated based on the related domestic and foreign researches conducted by using real wind-load records. Two types of damping devices were considered: One is inter-story installation type passive control devices and the other is mass type active control devices. The supplemental damping ratio due to the damping devices was calculated by means of equivalent static analysis using an equation suggested by FEMA. The optimal design of the damping devices was conducted by using the computational platform. The structural element quantity reduction effect resulting from the installation of the damping devices could be simply assessed by proposing a wind-load reduction factor, and the effectiveness of the proposed method was verified by a numerical example of a 455m high-rise building. The comparison between roof displacement and the story shear forces by the nonlinear time history analysis and the proposed method indicated that the proposed method could simply but approximately estimate the effects of the supplemental damping devices on the roof displacement and the member force reduction.

• Journal of the Korean Institute of Gas
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• v.23 no.6
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• pp.1-7
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• 2019

Most oil refineries and chemical plants have flare systems designed to mitigate pressure rises in process facilities in case of emergencies that require the release of large amounts of gas due to sudden process shutdowns such as power outages. However, the rise of the flame of the flare system causes civil complaints from residents around the factory due to visible pollution, and economic loss occurs in the company, which requires constant management. In this study, two items were diagnosed and analyzed in order to derive the optimal operation method of flare system. First, to detect the cause of the rise in flame height, the acoustic leak detector was used to check gas leaks in safety valves and pressure control valves. Second, to identify the cause of flame instability, the pulsation phenomenon was diagnosed through the CFD simulation and modeling experiments of the sealing drum. By confirming the leak at 4.3% of the safety valve and 10% of the pressure control valve, the cause of abnormal sparking was derived. The information presented in this study can be easily applied to any company that has a flare system, and is expected to prevent complaints and product loss.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.6073-6080
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• 2015

Background: Melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24), a unique tumor suppressor gene, has killing activity in a broad spectrum of cancer cells. Herein, plasmids producing mda-7 proteins fused to different RGD peptides (full RGD4C and shortened RGD, tRGD) were evaluated for apoptosis induction with a hepatocellular carcinoma cell line, Hep-G2. The study aim was to improve the apoptosis potency of mda-7 by tethering to RGD peptides. Materials and Methods: Three plasmids including mda-7, mda-7-RGD and mda-7-tRGD genes beside a control vector were transfected into Hep-G2 cells. After 72 hours incubation, cell viability was evaluated by MTT assay. In addition, the rate of apoptosis was analyzed by flow cytometry using PI/annexin staining. To detect early events in apoptosis, 18 hours after transfection, expression of the BAX gene was quantified by real time PCR. Modeling of proteins was also performed to extrapolate possible consequences of RGD modification on their structures and subsequent attachment to receptors. Results and Conclusions: In MTT assays, while all mda-7 forms showed measurable inhibition of proliferation, unmodified mda-7 protein exhibited most significant effect compared to control plasmid (P<0.001). Again, flow cytometry analysis showed a significant apoptosis induction by simple mda-7 gene but not for those RGD-fused mda-7 proteins. These findings were also supported by expression analysis of BAX gene (P<0.001). Protein modelling analysis revealed that tethering RGD at the end of IL-24/Mda7 disrupt attachment to cognate receptor, IL-20R1/IL-20R2. In conclusion, fusion of RGD4C and shortened RGD peptides to carboxyl terminal of mda7, not only reduce apoptosis property in vitro but also disrupt receptor attachment as demonstrated by protein modelling.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.12
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• pp.1185-1192
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• 2012

The typical operating temperature of an automotive fuel cell is lower than that of an internal combustion engine, which necessitates a refined strategy for thermal management. In particular, the performance of the cooling module has to be higher for a fuel cell system because the temperature difference between the fuel cell and the surrounding is lower than in the case of the internal combustion engine. Even though the cooling system of an automotive fuel cell determines the operating temperature and temperature distribution of the fuel cell, it has attracted little research attention. This study presents the mathematical model of a cooling system for an automotive fuel cell system using Matlab/$Simulink^{(R)}$. In particular, a radiator model is developed for design optimization from the development stage to the operating stage for an automotive fuel cell. The cooling system model comprises a fan, pump, and radiator. The pump and fan model have an empirical relation, and the dynamics of the pump and fan are only explained by motor dynamics. The basic design study was conducted, and the geometric setup of the radiator was investigated. When the control logic was applied, the pump senses the coolant inlet temperature and the fan senses the coolant out temperature. Additionally, the cooling module is integrated with the fuel cell system model so that the performance of the cooling module can be investigated under realistic operating conditions.