• Title/Summary/Keyword: Model system

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Suppression of colon cancer by administration of Canavalia gladiata D.C. and Arctium lappa L., Redix extracts in tumor-bearing mice model (종양이식 생쥐모델에서 도두(刀豆), 우방근(牛蒡根) 추출물의 대장암 억제 효과)

  • Jang, Ji-Hye;Ji, Kon-Young;Choi, Hyung-Seok;Yang, Won-Kyung;Kim, Han-Young;Kim, Kun-hoae;Kang, Hyung-Sik;Lee, Young-Cheol;Kim, Seung-Hyung
    • The Korea Journal of Herbology
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    • v.32 no.5
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    • pp.27-38
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    • 2017
  • Objective : In the present study, we examined whether Canavalia gladiata D.C. (CG) and Arctium lappa L., Redix (AL) mixture (CGAL), their components, lupeol and chicoric acid, regulate immune system and suppress the tumor in vitro and in vivo. Methods : LPS-induced reactive oxygen species (ROS) and nitric oxide (NO) were measured after treatment with CG extract (CGE), CGAL, lupeol, chicoric acid and lupeol and chicoric acid mixture (lupeol+CA) in Raw264.7 cell. To determine the effect of CGE on immune responses, immune cell population and IgG production were assessed in mice. To investigate the effect of CGAL and their component on anti-tumor activity, tumor volume and weight were measured, cell cycles and immune cell population were analyzed in MC38 injected tumor bearing mice. Also, NK cell activity was determined in splenocyte isolated from tumor bearing mice. Results : CGE, CGAL, lupeol, chicoric acid and lupeol+CA decreased the LPS-induced ROS and NO production without cell toxicity in RAW264.7 cells. CGE increased the immune cell populations of $CD4^+T$, $CD8^+T$ and macrophages in various immune organ of mice. In tumor bearing mice, CGAL, lupeol, chicoric acid and lupeol+CA suppressed tumor volume and weight. In cell cycle analysis, they decreased the percentages of S phase. In addition, CGAL, lupeol, chicoric acid and lupeol+CA immune cell populations of $CD4^+T$, $CD8^+Tcell$, NK cell and macrophage in tumor as well as NK cell activity. Conclusion : CGAL and its compounds may enhance immune responses and suppress tumor growth, and may be capable of developing health functional foods.

Numerical Simulation of Ocean - Ice Shelf Interaction: Water Mass Circulation in the Terra Nova Bay, Antarctica (해양-빙붕 상호작용을 고려한 남극 테라노바 만에서 수괴 형성과 순환의 수치 시뮬레이션)

  • Taekyun, Kim;Emilia Kyung, Jin;Ji Sung, Na;Choon Ki, Lee;Won Sang, Lee;Jae-Hong, Moon
    • Ocean and Polar Research
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    • v.44 no.4
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    • pp.269-285
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    • 2022
  • The interaction between ocean and ice shelf is a critical physical process in relation to water mass transformations and ice shelf melting/freezing at the ocean-ice interface. However, it remains challenging to thoroughly understand the process due to a lack of observational data with respect to ice shelf cavities. This is the first study to simulate the variability and circulation of water mass both overlying the continental shelf and underneath an ice shelf and an ice tongue in the Terra Nova Bay (TNB), East Antarctica. To explore the properties of water mass and circulation patterns in the TNB and the corresponding effects on sub ice shelf basal melting, we explicitly incorporate the dynamic-thermodynamic processes acting on the ice shelf in the Regional Ocean Modeling System. The simulated water mass formation and circulation in the TNB region agree well with previous studies. The model results show that the TNB circulation is dominated by the geostrophic currents driven by lateral density gradients induced by the releasing of brine or freshwater at the polynya of the TNB. Meanwhile, the circulation dynamics in the cavity under the Nansen Ice shelf (NIS) are different from those in the TNB. The gravity-driven bottom current induced by High Salinity Shelf Water (HSSW) formed at the TNB polynya flows towards the grounding line, and the buoyance-driven flow associated with glacial meltwater generated by the HSSW emerges from the cavity along the ice base. Both current systems compose the thermohaline overturning circulation in the NIS cavity. This study estimates the NIS basal melting rate to be 0.98 m/a, which is comparable to the previously observed melt rate. However, the melting rate shows a significant variation in space and time.

Is Does Failure Mindset Transmitted through Generations?: The Dual Mediating Effects of Mother's Happiness and Mother-Adolescent Open Communication (실패 마인드셋은 세대 간 전승되는가?: 어머니의 행복감과 개방적 의사소통의 이중매개효과)

  • Jung, Jiyu;Kim, Hansaem;Yang, Sujin
    • Korean Journal of Culture and Social Issue
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    • v.28 no.3
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    • pp.419-439
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    • 2022
  • The purpose of this study was to examine the relationship between failure mindset of the mother and adolescent, along with the mediating effects of mother's happiness and mother-adolescents (first and second-year middle school students in Seoul) open communication. For this study, self-reported data of 270 mother-adolescent dyads were analyzed using SPSS and Process macro Model 6. The results revealed that the mother's failure mindset directly predicted their adolescent's failure mindset. The mediating effect of the mother-adolescent open communication was significant, but the mediating effect of the mother's happiness was not significant. However, the mediation effect of the mother's failure mindset on the adolescent's failure mindset through mother's happiness and mother-adolescent open communication was significant. These results suggest that "failure-is-enhancing" mindset of mothers improve their positive affect and parenting skills, which contributes to developing adolescent's belief system about failure. Putting the results together, this study is significant in that it identified the intergenerational relationship of the failure mindset. Besides, the study results serve as a foundation for intervening on the adolescent's failure mindset by verifying the developmental mechanism of the failure mindset.

Analysis of the Optimal Window Size of Hampel Filter for Calibration of Real-time Water Level in Agricultural Reservoirs (농업용저수지의 실시간 수위 보정을 위한 Hampel Filter의 최적 Window Size 분석)

  • Joo, Dong-Hyuk;Na, Ra;Kim, Ha-Young;Choi, Gyu-Hoon;Kwon, Jae-Hwan;Yoo, Seung-Hwan
    • Journal of The Korean Society of Agricultural Engineers
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    • v.64 no.3
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    • pp.9-24
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    • 2022
  • Currently, a vast amount of hydrologic data is accumulated in real-time through automatic water level measuring instruments in agricultural reservoirs. At the same time, false and missing data points are also increasing. The applicability and reliability of quality control of hydrological data must be secured for efficient agricultural water management through calculation of water supply and disaster management. Considering the characteristics of irregularities in hydrological data caused by irrigation water usage and rainfall pattern, the Korea Rural Community Corporation is currently applying the Hampel filter as a water level data quality management method. This method uses window size as a key parameter, and if window size is large, distortion of data may occur and if window size is small, many outliers are not removed which reduces the reliability of the corrected data. Thus, selection of the optimal window size for individual reservoir is required. To ensure reliability, we compared and analyzed the RMSE (Root Mean Square Error) and NSE (Nash-Sutcliffe model efficiency coefficient) of the corrected data and the daily water level of the RIMS (Rural Infrastructure Management System) data, and the automatic outlier detection standards used by the Ministry of Environment. To select the optimal window size, we used the classification performance evaluation index of the error matrix and the rainfall data of the irrigation period, showing the optimal values at 3 h. The efficient reservoir automatic calibration technique can reduce manpower and time required for manual calibration, and is expected to improve the reliability of water level data and the value of water resources.

Efficient method for acquirement of geospatial information using drone equipment in stream (드론을 이용한 하천공간정보 획득의 효율적 방안)

  • Lee, Jong-Seok;Kim, Si-Chul
    • Journal of Korea Water Resources Association
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    • v.55 no.2
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    • pp.135-145
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    • 2022
  • This study aims to verify the Drone utilization and the accuracy of the global navigation satellite system (GNSS), Drone RGB (Photogrammetry) (D-RGB), and Drone LiDAR (D-LiDAR) surveying performance in the downstream reaches of the local stream. The results of the measurement of Ground Control Point (GCP) and Check Point (CP) coordinates confirmed the excellence. This study was carried out by comparing GNSS, D-RGB, and D-LiDAR with the values which the hydraulic characteristics calculated using HEC-RAS model. The accuracy of three survey methods was compared in the area of the study which is the ownership station, to 6 GCP and 3 CP were installed. The comparison results showed that the D-LiDAR survey was excellent. The 100-year frequency design flood discharge was applied in the channel sections of the small stream. As a result of D-RGB surveying 2.30 m and D-LiDAR 1.80 m in the average bed elevation, and D-RGB surveying 4.73 m and D-LiDAR 4.25 m in the average flood condition. It is recommended that the performance of D-LiDAR surveying is efficient method and useful as the surveying technique of the geospatial information using the drone equipment in stream channel.

Implementation of a Transition Rule Model for Automation of Tracking Exercise Progression (운동 과정 추적의 자동화를 위한 전이 규칙 모델의 구현)

  • Chung, Daniel;Ko, Ilju
    • KIPS Transactions on Computer and Communication Systems
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    • v.11 no.5
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    • pp.157-166
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    • 2022
  • Exercise is necessary for a healthy life, but it is recommended that it be conducted in a non-face-to-face environment in the context of an epidemic such as COVID-19. However, in the existing non-face-to-face exercise content, it is possible to recognize exercise movements, but the process of interpreting and providing feedback information is not automated. Therefore, in this paper, to solve this problem, we propose a method of creating a formalized rule to track the contents of exercise and the motions that constitute it. To make such a rule, first make a rule for the overall exercise content, and then create a tracking rule for the motions that make up the exercise. A motion tracking rule can be created by dividing the motion into steps and defining a key frame pose that divides the steps, and creating a transition rule between states and states represented by the key frame poses. The rules created in this way are premised on the use of posture and motion recognition technology using motion capture equipment, and are used for logical development for automation of application of these technologies. By using the rules proposed in this paper, not only recognizing the motions appearing in the exercise process, but also automating the interpretation of the entire motion process, making it possible to produce more advanced contents such as an artificial intelligence training system. Accordingly, the quality of feedback on the exercise process can be improved.

The Economic Impact of the Establishment of the China-Japan-South Korea Free Trade Area and Impact on the Communication Industry -Base on GTAP Model Analysis- (한중일 자유무역지대 설립의 경제적 영향과 통신 산업에 대한 영향 -GTAP 모형 분석을 바탕으로-)

  • Zang, Zhen
    • Journal of Digital Convergence
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    • v.20 no.5
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    • pp.85-92
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    • 2022
  • In recent years, the world's free trade system has been severely damaged by a series of protectionist measures in the United States and anti-globalization practices such as Brexit. Against this background, RCEP, the world's largest trade agreement, was officially signed on November 15, 2021. The RCEP provided a good working basis for the establishment of a Korea, China, and Japan free trade zone. First, this paper describes the current status of Korea-China-Japan trade cooperation and the current status of the trilateral telecommunication industry. Second, this paper simulates the changes in the overall economy of China, Japan, and Korea when tariffs are reduced to 0%, 5%, and 10%, respectively, after the establishment of a free trade zone using the 8th edition GTAP database. Then, using the simulated data changes and using the 2019 data as a benchmark, we calculated the changes in the RCA index for the three countries' telecommunications industries for the three tax rates. In the end, it is concluded that the economies of the three countries will grow to different levels in many ways when the Korea, China, and Japan free trade zone is established. Japan's telecommunications industry will not be significantly affected, Korea will grow significantly with higher tax rates and China will grow significantly with lower tax rates.

The Perception and Needs Analysis of Early Childhood Teachers for Development of a Play-Based Artificial Intelligence Education Program for 5-Year-Olds (만 5세 대상 놀이중심 인공지능 교육 프로그램 개발을 위한 유아교사의 인식과 요구분석)

  • Park, Jieun;Hong, Misun;Cho, Jungwon
    • Journal of Industrial Convergence
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    • v.20 no.5
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    • pp.39-59
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    • 2022
  • We analyze the perceptions and requirements of early childhood teachers for artificial intelligence(AI) education to develop an AI education program for 5-year-olds. As for the research methodology, we conducted a survey and an in-depth interview to extract the AI educational elements centering on the analysis stage, the first stage of the ADDIE model. The research result is that first, it is necessary to design a curriculum that combines the contents of early childhood education and AI education to be naturally accepted as AI education for 5-year-olds. Second, an evaluation tool for AI education that can showcase the teacher's reflection should be developed systematically. Third, it is necessary to support a play-centered AI education support and environment for early childhood teachers. Lastly, it is essential to establish a system that can be continuously operated in the field of early childhood education in consideration of AI education in the non-curricular curriculum. It is expected that in the future, a play-oriented AI education program for 5-year-olds will be developed to spread awareness of AI education for infants and present an AI education approach for each age and stage of learners.

A Study on the Optimal Location Selection for Hydrogen Refueling Stations on a Highway using Machine Learning (머신러닝 기반 고속도로 내 수소충전소 최적입지 선정 연구)

  • Jo, Jae-Hyeok;Kim, Sungsu
    • Journal of Cadastre & Land InformatiX
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    • v.51 no.2
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    • pp.83-106
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    • 2021
  • Interests in clean fuels have been soaring because of environmental problems such as air pollution and global warming. Unlike fossil fuels, hydrogen obtains public attention as a eco-friendly energy source because it releases only water when burned. Various policy efforts have been made to establish a hydrogen based transportation network. The station that supplies hydrogen to hydrogen-powered trucks is essential for building the hydrogen based logistics system. Thus, determining the optimal location of refueling stations is an important topic in the network. Although previous studies have mostly applied optimization based methodologies, this paper adopts machine learning to review spatial attributes of candidate locations in selecting the optimal position of the refueling stations. Machine learning shows outstanding performance in various fields. However, it has not yet applied to an optimal location selection problem of hydrogen refueling stations. Therefore, several machine learning models are applied and compared in performance by setting variables relevant to the location of highway rest areas and random points on a highway. The results show that Random Forest model is superior in terms of F1-score. We believe that this work can be a starting point to utilize machine learning based methods as the preliminary review for the optimal sites of the stations before the optimization applies.

Effect Analysis of Offshore Wind Farms on VHF band Communications (VHF 대역 통신에 대한 해상풍력 발전단지의 영향성 분석)

  • Oh, Seongwon;Park, Taeyong
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.28 no.2
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    • pp.307-313
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    • 2022
  • As the development of renewable energy expands internationally to cope with global warming and climate change, the share of wind power generation has been gradually increasing. Although wind farms can produce electric power for 24 h a day compared to solar power plants, Their interfere with the operation of nearby radars or communication equipment must be analyzed because large-scale wind power turbines are installed. This study analyzed whether a land radio station can receive sufficient signals when a ship sailing outside the offshore wind farm transmits distress signals on the VHF band. Based on the geographic information system digital map around the target area, wind turbine CAD model, and wind farm layout, the area of interest and wind farm were modeled to enable numerical analysis. Among the high frequency analysis techniques suitable for radio wave analysis in a wide area, a dedicated program applying physical optics (PO) and shooting and bouncing ray (SBR) techniques were used. Consequently, the land radio station could receive the electromagnetic field above the threshold of the VHF receiver when a ship outside the offshore wind farm transmitted a distress communication signal. When the line of sight between the ships and the land station are completely blocked, the strength of the received field decreases, but it is still above the threshold. Hence, although a wind farm is a huge complex, a land station can receive the electromagnetic field from the ship's VHF transmitter because the wave length of the VHF band is sufficiently long to have effects such as diffraction or reflection.