• Title/Summary/Keyword: Model reference

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Analysis on Survival and Prognostic Factors for Cancer Patients with Malignancy-associated Hypercalcemia

  • Zhang, Su-Jie;Hu, Yi;Cao, Jing;Qian, Hai-Li;Jiao, Shun-Chang;Liu, Zhe-Feng;Tao, Hai-Tao;Han, Lu
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6715-6719
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    • 2013
  • Objective: To explore the incidence, clinical characteristics, diagnosis and treatment strategies, prognosis of patients with malignancy-associated hypercalcemia (MAH). Methods: The data of 115 patients with MAH who were treated at the Medical Oncology Department of Chinese PLA General Hospital from Jan., 2001 to Dec., 2010 was retrospectively reviewed. Survival analysis was performed using the Kaplan-Meier method and the Cox proportional hazard model with statistic software SPSS 18.0. Results: The patients had blood calcium levels ranging from 2.77 to 4.87 mmol/L. Except for 9 cases who died or were discharged within 5 days after admission, all other patients recovered to normal blood calcium level after treatment with bisphosphonates or intravenous hydration and diuretics; their survival after occurrence of MAH was from 1 day to 4,051 days, and the median survival time was only 50 days. In the log-rank test, the male, renal metastasis, central nervous system symptoms and hypercalcemia occurring over 140 days after cancer diagnosis were predictors of poor survival (P=0.002, P=0.046, P=0.000, P=0.009). In the COX analysis, being male, central nervous system symptoms and hypercalcemia lasting over 140 days after cancer diagnosis were independent prognostic factors for survival time (RR=2.131, P=0.027; RR=3.054, P=0.002; RR=2.403, P=0.001). According to these factors, a score system was established to predict the patient prognosis and adjust the treatment. Conclusion: Cancer patients with MAH have an extremely poor median survival. Some independent factors indicate poor prognosis, including male gender, central nervous system symptoms and hypercalcemia lasting over 140 days after cancer diagnosis. The prognostic score can serve as a reference for MAH prognosis and treatment, worthy of further investigation.

Development of a Performance Reference Model (PRM) for Ubiquitous City Operations (U-City 전략 성과 참조모델로서의 운영성과 측정 지표체계 개발에 대한 연구)

  • Park, Dong-Wan;Lee, Jung-Hoon;Kim, Jae-Min
    • The Journal of Society for e-Business Studies
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    • v.15 no.3
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    • pp.25-44
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    • 2010
  • In recent years, Ubiquitous City (u-City), the integrated and convergence of ubiquitous services, infrastructure, technologies and city management of the new future development city, is being initiated by the Korean government and local authorities as their new national growth engine. However, a performance measurement system for evaluating and monitoring the impacts of U-City implementation is yet to be established. This paper aims to develop an integrated performance management system (PMS) and extensively used as a tool for managing performance activities to support the visions and goals of the u-City operations. Based on current reviews on the literature and interviews with experts drew Critical Success Factors (CSF) and Key Performance Indicators (KPI) by four different measurement domains including U-City services, infrastructure, technologies, management and developed into an integrated performance measurement system based on the Balanced Scored Card (BSC) perspective. The system also provides number of examples of 'u-City Strategy Map' which illustrates a causal relationship between CSFs to execute u-City visions and goals.

A Study on the Automated Compatibility Standard Test System for eBook DRM (전자책 DRM을 위한 자동화된 표준정합성 검사 시스템에 관한 연구)

  • Kim, Tae-Hyun;Kang, Ho-Gap;Ahn, Chang-Ju;Cho, Seong-Hwan
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.13 no.2
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    • pp.127-136
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    • 2013
  • The study of the compatibility of EPUB DRM, granted by the Korea Copyright Commission, as a CT R & D project (Project Title: The Development of the standard reference software technology for International Standard EPUB-based eBook DRM) developed standards such as profile standards for encryption digital signature and authentication certificates and standards for technical terms of rights information. In 2012, these four standards have been established as the Korean Industrial Standards under the names of 'Encryption specification for EPUB DRM,' 'the Digital signature specification for EPUB DRM,' 'the Certificate specification for EPUB DRM,' and 'Definitions of Right Terms for EPUB DRM' through the ODPF(Open Digital Standardization Forum) and the TTA(Telecommunications Technology Association). The research project also proposed standards of ebook DRM license protocols in order for the four standards to practically apply to ebook DRM compatibility. It is necessary for technology standards to require a compatibility standard test process for testing whether implementations which were developed on the basis of the standard specification, comply with standards. This study suggests an automated compatible standard test method and a test model under the ebook DRM standard technical specification.

Application of IHS Transform Method for Understanding of Groundwater Resources Distribution in the Haenam area (해남지역 지하수 부존 분포 파악을 위한 IHS 변환 적용)

  • 김승태;이기원;유인걸;송무영
    • Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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    • 2003.04a
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    • pp.51-55
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    • 2003
  • 본 연구는 조사대상지역인 전라남도 해남군 전역에 대해 현장조사된 지질 및 지하수 양수량 자료등과 같은 수리정보를 종합적으로 분석하고 이를 Landsat 영상자료과의 영상융합 과정을 통해 지하수 부존가능성에 대한 수리 지질 지표정보로 추출함으로서 지하수 특성정보를 위성영상정보와 연계하여 효과적으로 도시하고자 하였다. 현장조사시 획득된 자료는 해남지역을 11개 소유역으로 구분한 후 각 구역에 대한 2000여개 관점에서 측정된 양수량과 안정지하수위를 이용하여 산출한 비용출량 자료(groundwater specific capacity)와 각 소 유역 (unit watershed)에 대한 선구조 분석자료, 지질별 분포, 정밀고도자료를 추출하여 산출한 고도, 경사도 분포, 수계패턴과 수계밀도로서 이를 통합적으로 분석하여 해남지역에 대한 지하수 특성을 파악하고자 하였다. 위성영상자료의 처리과정은 Landsat 5 TM 영상자료는 '86. 12. 11 및 '98. 12. 28에 촬영된 WRS(World Reference System) Row-Path116-36로서, 1986년 영상은 12년 차이의 해남의 변화지역을 탐지하기 위한 영상자료로서 활용하였으며 98년 영상을 주요 분석 자료로 이용하였으며 지표 이용정보 추출은 크게 수역추출, 식생분포추출, 지표분류도, 변화탐지영역추출로 구분된다. 본 연구방법은 크게 위성영상분석을 통해 추출된 정보와 지표조사를 통해 획득된 선구조 및 지하수 정보를 Data fusion 방식으로 이용되고 있는 IHS 변환 기법을 통해 본 역에 대한 지하수 정보 및 간척지 등에 의한 지표 개발에 따른 지하수 부존 가능성을 탐색하기 위한 현황을 효과적인 자료로 표현하고자 하였다.및 스페클 잡영 제거 정도에 있어 다른 필터들과 큰 차이가 없지만 경계선보존지수는 다른 필터들에 비하여 가장 우수함을 확인할 수 있었다.rbon 탐식효율을 조사한 결과 B, D 및 E 분획에서 유의적인 효과를 나타내었다. 이상의 결과를 종합해볼 때, ${\beta}$-glucan은 고용량일 때 직접적으로 또는 $IFN-{\gamma}$ 존재시에는 저용량에서도 복강 큰 포식세로를 활성화시킬 뿐 아니라, 탐식효율도 높임으로써 면역기능을 증진 시키는 것으로 나타났고, 그 효과는 crude ${\beta}$-glucan의 추출조건에 따라 달라지는 것을 알 수 있었다.eveloped. Design concepts and control methods of a new crane will be introduced in this paper.and momentum balance was applied to the fluid field of bundle. while the movement of′ individual material was taken into account. The constitutive model relating the surface force and the deformation of bundle was introduced by considering a representative prodedure that stands for the bundle movement. Then a fundamental equations system could be simplified considering a steady state of the process. On th

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Perfomance Analysis for the IPC Interface Part in a Distributed ATM Switching Control System (분산 ATM 교환제어시스템에서 프로세서간 통신 정합부에 대한 성능 분석)

  • Yeo, Hwan-Geun;Song, Kwang-Suk;Ro, Soong-Hwan;Ki, Jang-Geun
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.35S no.6
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    • pp.25-35
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    • 1998
  • The control system architecture in switching systems have undergone numerous changes to provide various call processing capability needed in telecommunication services. During call processing in a distributed switching control environment, the delay effect due to communication among main processors or peripheral controllers is one of the limiting factors which affect the system performance. In this paper, we propose a performance model for an IPC(Inter Processor Communication) interface hardware block which is required on the ATM cell-based message processing in a distributed ATM exchange system, and analyze the primary causes which affect the processor performance through the simulation. Consequently, It can be shown that the local CPU of the several components(resources) related to the IPC scheme is a bottleneck factor in achieving the maximum system performance from the simulation results, such as the utilization of each processing component according to the change of the input message rate, and the queue length and processing delay according to input message rate. And we also give some useful results such as the maximum message processing capacity according to the change of the performance of local CPU, and the local CPU maximum throughput according to the change of average message length, which is applicable as a reference data for the improvement or expansion of the ATM control system.

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Long Commute Time and Sleep Problems with Gender Difference in Work-Life Balance: A Cross-sectional Study of More than 25,000 Workers

  • Kim, Soojin;Kim, Yangwook;Lim, Sung-Shil;Ryoo, Jae-Hong;Yoon, Jin-Ha
    • Safety and Health at Work
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    • v.10 no.4
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    • pp.470-475
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    • 2019
  • Background: There is a lack of statistical analysis investigating the relationship between sleep problems and commute time in Korea. We aimed to analyze the association between representative health symptoms, sleep disturbances, and commute time according to working hours in Korea. Methods: The 4th Korean Working Conditions Survey data were used for analysis, and unpaid family workers and workers who work fewer than three days in a week were excluded. Commute time, working hours, and sleep hours were assessed using self-reported questionnaires. Odds ratios (ORs) with 95% confidence intervals (CIs) for sleep problems were calculated using a multivariate logistic regression model with ≤10 min commute time as the reference group. Results: Among a total of 28,804 workers (men = 14,945, women = 13,859), 2.6% of men and 3.2% of women experienced sleep problems. In both sexes, long commute time (51-60 minutes and >60 minutes) showed an increased OR [men, 2.03 (CI = 1.32-3.13) and 2.05 (CI = 1.33-3.17); women, 1.58 (CI = 1.05-2.39) and 1.63 (CI = 1.06-2.50), respectively]. In stratification analysis of working hours, long commute time (51-60 and > 60 minutes) showed an increased OR in men working >40 hours/week [2.08 (CI = 1.16-3.71) and 1.92 (CI = 1.08-3.41), respectively]. Furthermore, long commute time (41-50, 51-60, and >60 minutes) showed an increased OR in women working >40 hours/week [2.40 (CI = 1.27-4.55), 2.28 (CI = 1.25-4.16), and 2.19 (CI = 1.17-4.16), respectively]. Moreover, commute time >60 minutes showed an increased OR in women working ≤40 hours/week [1.96 (CI = 1.06-3.62)]. Conclusion: This large cross-sectional study highlights that long commute time is related to sleep problems in both sexes. Shorter commute times and decreased working hours are needed to prevent sleep problems in workers.

Observation of the Mesoscale Phenomena by Ocean Acoustic Tomography in the East Sea (동해에서 해양음향토모그래피에 의한 중규모 현상 관측)

  • Na, Jung-Yul;Han, Sang-Kyu;Lee, Jae-Hak;Shim, Tae-Bo;Kim, Kuh
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.4 no.3
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    • pp.170-179
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    • 1999
  • The SUS (Signal, Underwater Sound)-OAT experiment was carried out in the Ulleung Basin of the East Sea on 3 June 1997. The SUS-OAT system consisted of aircraft deployed shots as sources and a vertical line array (VLA) tethered by a receiver ship was used to survey a large area where a mesoscale warm eddy appears frequently. The experiment was carried out such that explosive charges set to detonate at 800 ft depth were dropped in a rectangular ($120{\times}120$ km). Sources were a rapidly deployable SUS charge (MK 61 MOD 0), and receiver is a fixed VLA, 90 m in length (150-240 m in receiver depth), composed of 10 elements equally spaced. The reference ray paths are computed by range-dependent acoustic model in canonical ocean based on the historical data. The singular value decomposition (SVD) method is used to obtain the horizontal perturbation of the temperature fields. Horizontal distributions of temperature fields at 150 m and 200 m depth show a weak warm eddy observed by AXBT and the inversely estimated temperature shows similar patterns in terms of the location of the warm eddy. In conclusion, the SUS-OAT experiment has been successful to estimate the position of warm eddy and its temperature field in the East Sea of Korea.

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The Effects of Korean Ginseng on Memory Loss in a Rat Models (Scopolamine 유도 치매동물모델에서 고려인삼(백삼, 홍삼 및 흑삼)의 기억력 개선 효과)

  • Kang, Shin-Jyung;Woo, Jeong-Hwa;Kim, Ae-Jung
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.42 no.8
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    • pp.1190-1196
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    • 2013
  • The purpose of this study was to investigate the mechanism and effects of different types of ginseng on memory improvement in an experimental rat model. In this study, SD rats were induced for memory deficits through scopolamine treatment (1 mg/kg, i.p.) then administrated with ginseng extract for 7 weeks. The rats were divided into five groups: saline (1 mL/kg, NC: negative control), white ginseng (300 mg/kg, WG), red ginseng (300 mg/kg, RG), black ginseng (300 mg/kg, BG), and scopolamine (1 mg/kg, PC: positive control). The step through latency of the BG and RG groups was significantly longer than the PC group in the retention trial of multiple trial passive avoidance test. In the spatial reference memory triads of the Morris water maze test, the latency time of BG and RG was significantly lower than the PC group. In addition, in the prove test, the time spent in the platform quadrant of BG and RG groups were significantly longer than the PC group. Brain choline acetyltransferase (ChAT) activities BG and RG groups significantly increased compared to other groups. On the other hand, the levels of malondialdehyde (MDA) were significantly lower in the BG and RG groups compared to other groups. These result suggested that black ginseng could be useful to enhance learning memory and cognitive function by regulation of cholinergic enzymes.

Anthropometric Study of the Stomach

  • Lee, Eun-Gyeong;Kim, Tae-Han;Huh, Yeon-Ju;Suh, Yun-Suhk;Ahn, Hye-Sung;Kong, Seong-Ho;Lee, Hyuk-Joon;Kim, Woo Ho;Yang, Han-Kwang
    • Journal of Gastric Cancer
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    • v.16 no.4
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    • pp.247-253
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    • 2016
  • Purpose: The aim of this study was to establish an anthropometric reference of the stomach for gastric cancer surgery and a modeling formula to predict stomach length. Materials and Methods: Data were retrieved for 851 patients who underwent total gastrectomy at the Seoul National University Hospital between 2008 and 2013. Clinicopathological data and measurements from a formalin-fixed specimen were reviewed. The lengths (cm) of the greater curvature (GC) and lesser curvature (LC) were measured. Anthropometric data of the stomach were compared according to age, body weight, height (cm), and body mass index. To predict stomach length, two multiple regression analyses were performed. Results: The mean lengths of the GC and LC were $22.2{\pm}3.1cm$ and $16.3{\pm}2.6cm$, respectively. The men's GC length was significantly greater than the women's ($22.4{\pm}3.1cm$ vs. $21.2{\pm}2.9cm$, P=0.003). Patients aged >70 years showed significantly longer LC than those aged <50 years ($16.9{\pm}2.9cm$ vs. $15.9{\pm}2.4cm$, P=0.002). Patients with body weights >70 kg showed significantly longer GC than those with body weights <55 kg ($23.0{\pm}2.9cm$ vs. $21.4{\pm}3.2cm$, P<0.001). In the predicted models, 4.11% of the GC was accounted for by age and weight; and 4.94% of the LC, by age, sex, height, and weight. Conclusions: Sex, age, height, and body weight were associated with the length of the LC, while sex and body weight were the only factors that were associated with the length of the GC. However, the prediction model was not sufficiently strong.

Application of AutoFom III equipment for prediction of primal and commercial cut weight of Korean pig carcasses

  • Choi, Jung Seok;Kwon, Ki Mun;Lee, Young Kyu;Joeng, Jang Uk;Lee, Kyung Ok;Jin, Sang Keun;Choi, Yang Il;Lee, Jae Joon
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.10
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    • pp.1670-1676
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    • 2018
  • Objective: This study was conducted to enable on-line prediction of primal and commercial cut weights in Korean slaughter pigs by AutoFom III, which non-invasively scans pig carcasses early after slaughter using ultrasonic sensors. Methods: A total of 162 Landrace, Yorkshire, and Duroc (LYD) pigs and 154 LYD pigs representing the yearly Korean slaughter distribution were included in the calibration and validation dataset, respectively. Partial least squares (PLS) models were developed for prediction of the weight of deboned shoulder blade, shoulder picnic, belly, loin, and ham. In addition, AutoFom III's ability to predict the weight of the commercial cuts of spare rib, jowl, false lean, back rib, diaphragm, and tenderloin was investigated. Each cut was manually prepared by local butchers and then recorded. Results: The cross-validated prediction accuracy ($R^2cv$) of the calibration models for deboned shoulder blade, shoulder picnic, loin, belly, and ham ranged from 0.77 to 0.86. The $R^2cv$ for tenderloin, spare rib, diaphragm, false lean, jowl, and back rib ranged from 0.34 to 0.62. Because the $R^2cv$ of the latter commercial cuts were less than 0.65, AutoFom III was less accurate for the prediction of those cuts. The root mean squares error of cross validation calibration (RMSECV) model was comparable to the root mean squares error of prediction (RMSEP), although the RMSECV was numerically higher than RMSEP for the deboned shoulder blade and belly. Conclusion: AutoFom III predicts the weight of deboned shoulder blade, shoulder picnic, loin, belly, and ham with high accuracy, and is a suitable process analytical tool for sorting pork primals in Korea. However, AutoFom III's prediction of smaller commercial Korean cuts is less accurate, which may be attributed to the lack of anatomical reference points and the lack of a good correlation between the scanned area of the carcass and those traits.