• 아동학회지
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• 제6권1호
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• pp.17-40
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• 1985

This study investigated Korean children's early acquisition of negatives and focused on four research questions: 1) processing of negative variations; 2) the nature of negatives when negatives are completely acquired in Korean (in which meaning and form are matched in one to one mapping); 3) the validity of Bellugi's negative acquisition model in Korean; and 4) the cause of child's erroneous sentence production: limited ability or regularity in children's cognition. The language data of the five subjects (age span; 1.1 - 3.11) were collected by their parents in the natural setting of the home. The results showed that 1) the pivot form, was processed in many ways from a simple to a complicated form, such as <(X+X')+N> <(x+x')+N,Y> <(x+x') N,(y+y')>. It appeared that the children used a simple negative format to reach a one-step advanced negative format. 2) Korean negatives are divided into range of negation in the negative sentence (part or whole), strength of negation (absolute or general), functions of meaning (negation, absences, refusal, prohibition, impossibility). All five children acquired negative sentences in all functions and the complete range after 3 years of age. 3) In spite of the differences in age level, Bellugi's four stage model was in evidence; that is, Korean children's negative acquisition was almost identical with Bellugi's tour stage model in deep structure. 4) Analyses of children's error sentences showed that the sentences with errors were made not because of the children's limitation in cognitive ability but because of the strict application of regularity of rules from the original grammars. Consequently, the children produced negative sentences using two rules: the rule of additive complexity (from simple to complex) and the rule of division (from one to several).

• Journal of mucopolysaccharidosis and rare diseases
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• 제1권2호
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• pp.54-59
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• 2015

Purpose: Growth hormone (GH) therapy substantially improves several cognitive functions in PWS. However, the molecular mechanisms underlying the beneficial effects of GH on cognition remain unclear in PWS. In this study, we investigated the effects of recombinant human GH on the gene expression of GABAB receptor subunits and GH/insulin-like growth factor (IGF) axis genes in the brain regions of PWS-mimicking mice (Snord116del). Methods: Snord116del mice were injected subcutaneously with 1.0 mg/kg GH or saline, once daily for 7 days. The collected brain tissues were analyzed for mRNA content using quantitative PCR (qPCR) in the cerebellum, hippocampus, and cerebral cortex. Results: GH increased the mRNA expression level of the $GABA_{B1}$ receptor subunit ($GABA_{BR1}$) and IGF-1R in the cerebellum. Furthermore, a significant positive correlation was found between the level of $GABA_{BR1}$ mRNA and the expression of the IGF-1R transcript. GH also induced an increase in the mRNA expression of IGF-2 and IGF-2R in the cerebellum. Conclusion: These data indicate that GH may provide beneficial effects on cognitive function through its influences on the expression of $GABA_{BR1}$ and GH/IGF-1 axis genes in PWS patients.

• Journal of Preventive Medicine and Public Health
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• 제56권1호
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• pp.31-40
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• 2023

Objectives: This study investigated the effect of cognitive impairment on the association between social network properties and mortality among older Korean adults. Methods: This study used data from the Korean Social Life, Health, and Aging Project. It obtained 814 older adults' complete network maps across an entire village in 2011-2012. Participants' deaths until December 31, 2020 were confirmed by cause-of-death statistics. A Cox proportional hazards model was used to assess the risks of poor social network properties (low degree centrality, perceived loneliness, social non-participation, group-level segregation, and lack of support) on mortality according to cognitive impairment. Results: In total, 675 participants (5510.4 person-years) were analyzed, excluding those with missing data and those whose deaths could not be verified. Along with cognitive impairment, all social network properties except loneliness were independently associated with mortality. When stratified by cognitive function, some variables indicating poor social relations had higher risks among older adults with cognitive impairment, with adjusted hazard ratios (HRs) of 2.12 (95% confidence interval [CI], 1.34 to 3.35) for social nonparticipation, 1.58 (95% CI, 0.94 to 2.65) for group-level segregation, and 3.44 (95% CI, 1.55 to 7.60) for lack of support. On the contrary, these effects were not observed among those with normal cognition, with adjusted HRs of 0.73 (95% CI, 0.31 to 1.71), 0.96 (95% CI, 0.42 to 2.21), and 0.95 (95% CI, 0.23 to 3.96), respectively. Conclusions: The effect of social network properties was more critical among the elderly with cognitive impairment. Older adults with poor cognitive function are particularly encouraged to participate in social activities to reduce the risk of mortality.

• 대한치매학회지
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• 제23권1호
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• pp.1-10
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• 2024

Background and Purpose: Voice, reflecting cerebral functions, holds potential for analyzing and understanding brain function, especially in the context of cognitive impairment (CI) and Alzheimer's disease (AD). This study used voice data to distinguish between normal cognition and CI or Alzheimer's disease dementia (ADD). Methods: This study enrolled 3 groups of subjects: 1) 52 subjects with subjective cognitive decline; 2) 110 subjects with mild CI; and 3) 59 subjects with ADD. Voice features were extracted using Mel-frequency cepstral coefficients and Chroma. Results: A deep neural network (DNN) model showed promising performance, with an accuracy of roughly 81% in 10 trials in predicting ADD, which increased to an average value of about 82.0%±1.6% when evaluated against unseen test dataset. Conclusions: Although results did not demonstrate the level of accuracy necessary for a definitive clinical tool, they provided a compelling proof-of-concept for the potential use of voice data in cognitive status assessment. DNN algorithms using voice offer a promising approach to early detection of AD. They could improve the accuracy and accessibility of diagnosis, ultimately leading to better outcomes for patients.

• 한국산학기술학회논문지
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• 제16권2호
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• pp.1403-1413
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• 2015

정보시스템 감리는 정보시스템의 구축과 운영에 관한 제반 사항을 종합적으로 점검하여 문제점을 파악하고 해결방안을 제시함으로써, 정보시스템의 품질 향상과 프로젝트 성과 제고에 기여해야 한다. 그러나 현실은 감리가 지나치게 주관적인 의견에 치우치고 있다. 이 연구는 정보기술수용 모형(TAM)을 감리분야에 적용하여 감리자동화 기술에 대한 유용성과 사용 용이성에 대한 인식수준을 측정하고, 이를 토대로 감리기술(도구)에 대해 이해당사자의 인식과 활용의 관계를 분석하는 것을 주요 내용으로 한다. 가설검증 결과 감리분야에서도 정보기술에 대한 사용자의 인식수준과 활용정도에 정(+)의 상관관계가 있는 것을 확인하였다. 이 연구는 감리 분야에도 TAM을 적용하여 기술의 활용 현상을 설명하고 예측할 수 있고, 실증적 연구를 통해 감리인, 발주자 및 사업자가 인식하는 수준은 감리계획 단계와 시정조치확인 단계는 유사하게 나타난 반면, 감리수행활동 단계와 감리결과검토 단계는 서로 차이를 보이고 있으며, 유용성 및 사용의도와 활용에서 선호하는 감리기술을 확인할 수 있었다.

• 동의생리병리학회지
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• 제26권3호
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• pp.399-407
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• 2012

To evaluate age and gender differences in the relation of cardiovascular risk factors, cognitive impairment, and subclinical carotid atherosclerosis from aged people using by a cross sectional method. Sixty-nine healthy elders living in the community who had not previously undergone carotid ultrasonography were included. We conducted life style surveys, and cognitive function tests including Korean-mini-mental state examination (K-MMSE) and clinical dementia rating-Korean. Various biomarkers from blood were assessed; fasting insulin-like growth factor-1, lipid-profile, high sensitivity C-reactive protein, total homocysteine, glucose, insulin, Homeostasis model assessment (HOMA) for insulin resistance index, vitamin B12, and folate level. Carotid intima-media thickness (C-IMT), and plaques were measured using carotid ultrasonography and aortic ultrasonography, a valid index of atherosclerosis. For the elderly subjects (aged 65-82 years), cognition impairment was more prevalent in females while subclinical atherosclerosis was more prevalentin males. Increased C-IMT has been kept in males, and C-IMT shows increasing trend and the peak at about 80 year-old in females with increasing age. The significant correlations between C-IMT and many vascular risk factors including age, triglyceride, abnormal homocysteinein male, and K-MMSE, insulin, HOMA index and abnormal aortic ultrasonography in female were different in each gender, with the exception of homocysteine (p<0.05). This data suggests that there were differences of age and gender characteristics in terms of subclinical atherosclerosis, cognitive impairment and vascular risk factors in community-living elders. Further larger and longitudinal studies across entire age are required to better understand the effects of risk factors on subclinical atherosclerosis.

• 생약학회지
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• 제50권4호
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• pp.253-259
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• 2019

Chaenomeles speciose Nakai (CSP) or Chaenomeles sinensis Koehne (CSS) (Rosaceae) has been used, traditionally, to treat muscle problems and gastric dampness in eastern Asia countries. Therefore, many studies have focused on investigating its active compounds and effects on muscle pain, arthritis and gastro-intestinal diseases. Recently, several studies reported that CSS extract degrade amyloid plaques and enhance synaptic acetylcholine level in vivo and in vitro. Although these two Chaenomeles species are used without differences, CSP is reported to contains more phenolic compounds which are known to enhance memory. Therefore, in this study, we investigated the memory ameliorating effects of CSP by employing the passive avoidance test, Y-maze task and novel object recognition test. CSP (30 or 100 mg/kg) ameliorated the declined memory induced by scopolamine injection and enhanced the brain-derived neurotrophic factor (BDNF) levels along with post synaptic density protein 95 (PSD 95) levels at the hippocampus of the scopolamine-injected mouse brain. These results suggested that CSP alleviates the cognition declines caused by cholinergic blockade via enhancing BDNF levels and PSD 95, and that it would enhance memory formation and be useful for treating memory declines.

• Journal of Acupuncture Research
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• 제37권4호
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• pp.209-223
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• 2020

The purpose of this study was to evaluate the effectiveness of acupuncture treatment for the symptoms of Alzheimer's disease (AD). There were 11 databases searched for randomized controlled trials using acupuncture treatment for AD. The risk-of-bias assessment tool of the Cochrane Library was used to evaluate the quality of each study. Using the Review Manager (RevMan), a meta-analysis was performed using risk ratio, mean difference, 95% confidence interval, and random effect model. There were 32 studies selected, all of which were conducted in China. There were 16 studies where acupuncture was used as the intervention, and 23 studies used Donepezil as the control group. Acupoint GV20 was most frequently selected during the treatment. The Mini Mental State Examination (MMSE) was the most frequently used outcome variable. A period of 12 weeks was the most common treatment duration. As a result of meta-analysis (n = 25), acupuncture improved the MMSE and activities of daily living scores. Electroacupuncture improved the Alzheimer Disease Assessment Scale-Cognitive Subscale, and scalp acupuncture improved the MMSE score for AD. Acupuncture alleviates the symptoms of AD. However, further research is necessary to provide a better level of evidence.

• Molecules and Cells
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• 제39권8호
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• pp.603-610
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• 2016

Recently, an increasing number of studies have focused on the effects of CD4+ T cell on cognitive function. However, the changes of Th2 cytokines in restricted CD4+ T cell receptor (TCR) repertoire model and their effects on the adult hippocampal neurogenesis and memory are not fully understood. Here, we investigated whether and how the mice with restricted CD4+ repertoire TCR exhibit learning and memory impairment by using OT-II mice. OT-II mice showed decreased adult neurogenesis in hippocampus and short- and long- term memory impairment. Moreover, Th2 cytokines in OT-II mice are significantly increased in peripheral organs and IL-4 is significantly increased in brain. Finally, IL-4 treatment significantly inhibited the proliferation of cultured adult rat hippocampal neural stem cells. Taken together, abnormal level of Th2 cytokines can lead memory dysfunction via impaired adult neurogenesis in OT-II transgenic.

• 감성과학
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• 제6권3호
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• pp.73-87
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• 2003

이 연구는 일반적인 인지이론을 조종사 기술의 범위로 확대시켜, 조종사가 얼마나 빠르고 정확하게 상황인식을 하는지를 제시문과 비행 장면 일치성 측정을 통해 알아보았다. 이 연구의 목적은 두 가지 측면의 변인에 따라 상황인식이 전문성의 영향을 받는지를 알아보는 것이다. 비행 요소간의 관계를 나타내는 비행 상황 변인들과 비행 요소의 내용을 나타내는 비행 상황 변인들 모두 비행 상황인식에 영향을 주었다 그리고 작업기억은 다양한 정보들을 통합시키는 데 결정적인 역할을 하는 것으로 나타났다. 이러한 결과는 비행 상황인식의 바탕인 인지적 과정을 나타내는 구조화통합 모델의 이론적 틀 안에서 설명되어진다.