• Spatial Information Research
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• v.17 no.4
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• pp.469-481
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• 2009

Due to the increasing demands on the efficient use of land and the fast growth of construction technologies, human living space is expanded from on the surface to above and under the surface. By recognizing that the current cadastre system based on 2D was not appropriate to reflect the trend, the researchers are interested in a 3D cadastre. This paper proposed the 3D cadastre data model that is appropriate to protect ownership effectively in Korea. The 3D cadastre data model consists of a 3D cadastre feature model and a 3D cadastre geometry model, and the data are produced by a 3D cadastre data structure. A 3D cadastre feature model is based on 3D rights and features derived from case studies. A 3D cadastre geometry model based on ISO19107 Spatial Schema is modified to be good for 3D cadastre in Korea. A 3D cadastre data structure consists of point, line, polygon and solid primitives. This study finally purposes 1) serving and managing land information effectively, 2) creating rights and displaying ranges about infrastructures above and under surface, 3) serving ubiquitous-based geoinformation, 4) adapting ubiquitous-based GIS to urban development, and 5) regulating relationships between rights of land and registration and management systems.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.357-364
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• 2023

Sjögren syndrome (SS) is a systemic inflammatory autoimmune disease that involves exocrine glands. Shikonin is extracted from comfrey, which is conventionally used as an anti-tumor, antibacterial, and antiviral drug in China. However, the application of Shikonin in SS remains unreported. This study aimed to verify the potential functions of Shikonin in SS progression. Firstly, non-obese diabetic mice were used as the SS mouse model, with C57BL/6 mice serving as the healthy control. It was demonstrated that the salivary gland damage and inflammation were aggravated in the SS mouse model. Shikonin improved salivary gland function decline and injury in the SS mouse model. Moreover, Shikonin reduced inflammatory cytokines and immune infiltration in the SS mouse model. Further experiments discovered that Shikonin attenuated the MAPK signaling pathway in the SS mouse model. Lastly, inhibition of the MAPK signaling pathway combined with Shikonin treatment further alleviated the symptoms of SS. In conclusion, Shikonin ameliorated salivary gland damage and inflammation in a mouse model of SS by modulating the MAPK signaling pathway. Our findings indicate that Shikonin may be a useful drug for SS treatment.

• Journal of Navigation and Port Research
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• v.40 no.5
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• pp.257-263
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• 2016

Mombasa is the principle port of Kenya, serving inland countries in Eastern and central Africa. Mombasa port has undergone a massive infrastructure upgrade and dredging works with an expectation that more vessels and large post Panamax ships will be able to enter Mombasa port. Therefore, it is vital to carry out a marine traffic risk assessment in order to quantify the degree of navigation safety needed in the Mombasa approach channel and also to evaluate the navigation risk imposed on transit traffic by local ferry traffic. In this paper, a marine traffic risk assessment is carried out using the IWRAP mk2, Environmental Stress (ES) model, and the PARK model. Risk assessment results show that Likoni area has an unacceptable stress/risk ranking at 20.7% by the ES model and 38.89% by the PARK model. The IWRAP mk2 model shows that the crossing area has the highest risk of crossing collision and the area at the entrance to the inner channel has a high risk of grounding. The conclusions derived from this study will provide the basis for proposing the most effective countermeasure to improve navigation safety in the Mombasa approach channel.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2016.05a
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• pp.81-84
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• 2016

Mombasa is the principle port of Kenya, serving hinter countries in Eastern and central Africa. Mombasa port has undergone a massive infrastructure upgrade and dredging works with an expectation that more vessels and large post Panamax ships will be able to call at Mombasa port. Therefore, it is vital to carry out a marine traffic risk assessment so as to quantify the degree of navigation safety on Mombasa approach channel and also to evaluate navigation risk imposed on transit traffic by local ferry traffic. In this paper marine traffic risk assessment is carried out using IWRAP mk2, Environmental Stress model, and PARK model. Risk assessment results show that Likoni area has unacceptable stress/ risk ranking at 20.7% on ES model and 38.89% by PARK model. IWRAP mk2 model shows that crossing area has the highest risk of crossing collision and the area at the entrance to inner channel has a high risk of grounding. The conclusions derived from this study will provide the basis for proposing the most effective countermeasure so as to improve navigation safety in Mombasa approach channel.

• International Journal of Air-Conditioning and Refrigeration
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• v.11 no.2
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• pp.91-103
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• 2003

The objective of this study is to analyze and evaluate the impact of the stack effect in high-rise buildings for solving the various problems resulting from it. For the evaluation of the impacts on the stack effect, computer program simulations based on the network model were performed for a typical high-rise office building. The results of the simulations show that the impact caused by the stack effect is mainly dependent on building envelope air-tightness and internal air flow resistance. Therefore the problems due to the stack effect may be solved to some extent by installing vestibules around entrance doors and doors serving elevators, and by zoning the elevators.

• Journal of the Korean Operations Research and Management Science Society
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• v.31 no.3
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• pp.81-96
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• 2006

We consider a rental company that dynamically manages Its capacity level through capacity addition and return While serving customer with its own capacity, the company expands its capacity by renting items from an outside source so that it can avoid lost opportunities of rental which occur when stock is not sufficient. If stock becomes sufficiently large enough to cope with demands, the company returns expanded capacity to the outside source. Formulating the model into a Markov decision problem, we identify an optimal capacity management Policy which states when the company should expand its capacity and when it should return expanded capacity after capacity addition. Since it is intractable to analytically find the optimal capacity management policy and the optimal size of capacity expansion, we present a numerical procedure that finds these optimal values based on the value iteration method. Numerical analysis is implemented and we observe monotonic properties of the optimal performance measures by system parameters, which are meaningful in developing effective heuristic policies.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8307-8311
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• 2016

Lung cancer is one particular type of cancer that is deadly and relatively common than any other. Treatment is with chemotherapy, radiation therapy and surgery depending on the type and stage of the disease. Focusing on drugs used for chemotherapy and their associated side effects, there is a need to design and develop new anti-lung cancer drugs with minimal side effects and improved efficacy. The pharmacophore model appears to be a very helpful tool serving in the designing and development of new lead compounds. In this paper, pharmacophore analysis of 10 novel anti-lung cancer compounds was validated for the first time. Using LigandScout the pharmacophore features were predicted and 3D pharmacophores were extracted via VMD software. A training set data was collected from literature and the proposed model was applied to the training set whereby validating and verifying similar activity as that of the most active compounds was achieved. Therefore pharmacophore develoipment could be recommended for further studies.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.430-434
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• 2001

Virtual manufacturing system is integrated computer model that represents the precise and whole structure of manufacturing system and simulates its physical and logical behavior in operation.[1] A virtual machine is computer model that represents a CNC machine tool and one of core elements of virtual manufacturing system. In this paper, it is emphasized that a virtual machine must be web-based system for serving information to all attendants in a real machine tool without the restriction of time or location, and then in the fault diagnosis, one of important modules of a virtual machine, the methods of both using the controller signal and web-based expert system are proposed.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.14 no.6
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• pp.456-467
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• 2002

The objective of this study is to analyze and evaluate the impact of the stack effect in high-rise buildings for solving the various problems resulting from it. For the evaluation of the impact of the stack effect, computer program simulations based on the network model were performed for a typical high-rise office building. The results of the simulations show that the impact caused by the stack effect is mainly dependent on building envelope air-tightness and internal airflow resistance, so the problems due to the stack effect may be solved to some extent by installing vestibules around entrance doors and doors serving elevators, and by zoning the elevators.

• International Journal of Knowledge Content Development & Technology
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• v.12 no.2
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• pp.57-75
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• 2022

Currently, it is not easy for most domestic public libraries to collect and provide reliable health information services on their own. Health information is distributed or professional, making it inconvenient for users to use. Based on the implications derived from the case study, the Library Health Information Integration Service Model was proposed as a specialized information service. The model consists of a composition shared by librarians, health and medical experts, and users, focusing on library websites that provide integrated health information integration services, and has the following features. First, it provides health and medical information on a specialized subject. Second, it provides integrated health and medical information services provided in various ways. Third, librarians and health and medical experts work together to provide information services. Fourth, users can freely use health information integration services online and offline. The model presented in this study means that libraries can play a leading role in health information integration services to increase the utilization rate of public libraries and further contribute to librarians serving as experts in health information services.