• BMB Reports
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• v.46 no.11
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• pp.561-566
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• 2013

We examined the ways in which fenobam could promote not only the transduction of PEP-1-FK506BP into cells and tissues but also the neuroprotective effect of PEP-1-FK506BP against ischemic damage. Fenobam strongly enhanced the protective effect of PEP-1-FK506BP against $H_2O_2$-induced toxicity and DNA fragmentation in C6 cells. In addition, combinational treatment of fenobam with PEP-1-FK506BP significantly inhibited the activation of Akt and MAPK induced by $H_2O_2$, compared to treatment with PEP-1-FK506BP alone. Interestingly, our results showed that fenobam significantly increased the transduction of PEP-1-FK506BP into both C6 cells and the hippocampus of gerbil brains. Subsequently, a transient ischemic gerbil model study demonstrated that fenobam pretreatment led to the increased neuroprotection of PEP-1-FK506BP in the CA1 region of the hippocampus. Therefore, these results suggest that fenobam can be a useful agent to enhance the transduction of therapeutic PEP-1-fusion proteins into cells and tissues, thereby promoting their neuroprotective effects.

• ALGAE
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• v.30 no.2
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• pp.121-137
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• 2015

Studies on carbon flux in the oceans have been highlighted in recent years due to increasing awareness about climate change, but the coastal ecosystem remains one of the unexplored fields in this regard. In this study, the dynamics of carbon flux in a vegetative coastal ecosystem were examined by an evaluation of net and gross ecosystem production (NEP and GEP) and $CO_2$ exchange rates (net ecosystem exchange, NEE). To estimate NEP and GEP, community production and respiration were measured along different habitat types (eelgrass and macroalgal beds, shallow and deep sedimentary, and deep rocky shore) at Gwangyang Bay, Korea from 20 June to 20 July 2007. Vegetative areas showed significantly higher ecosystem production than the other habitat types. Specifically, eelgrass beds had the highest daily GEP ($6.97{\pm}0.02g\;C\;m^{-2}\;d^{-1}$), with a large amount of biomass and high productivity of eelgrass, whereas the outer macroalgal vegetation had the lowest GEP ($0.97{\pm}0.04g\;C\;m^{-2}\;d^{-1}$). In addition, macroalgal vegetation showed the highest daily NEP ($3.31{\pm}0.45g\;C\;m^{-2}\;d^{-1}$) due to its highest P : R ratio (2.33). Furthermore, the eelgrass beds acted as a $CO_2$ sink through the air-seawater interface according to NEE data, with a carbon sink rate of $0.63mg\;C\;m^{-2}\;d^{-1}$. Overall, ecosystem production was found to be extremely high in the vegetated systems (eelgrass and macroalgal beds), which occupy a relatively small area compared to the unvegetated systems according to our conceptual diagram of a carbon-flux box model. These results indicate that the vegetative ecosystems showed significantly high capturing efficiency of inorganic carbon through coastal primary production.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.2
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• pp.161-170
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• 2012

There are many factors to consider when attempting to improve the efficiency of fuel cell operation, such as the operation temperature, humidity, stoichiometry, operation pressure, geometric features, etc. In this paper, the effects of the operation pressure were investigated to find the current density and water saturation behavior on a cross section designated by the design geometry. A two-dimensional geometric model was established with a gas channel that can provide $H_2$ to the anode and $O_2$ and water vapor to the cathode gas diffusion layer (GDL). The results from this numerical modeling revealed that higher operation pressures would produce a higher current density than lower ones, and the water saturation behavior was different at operation pressures of 2 atm and 3 atm in the cathode GDL. In particular, the water saturation ratios are higher directly below the collector than in other areas. In addition, this paper presents the dependence of the velocity behavior in the cathode on pressure changes, and the velocity fluctuations through the GDL are higher in the output area than in inlet area. This conclusion will be utilized to design more efficient fuel cell modeling of real fuel cell operation.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.05a
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• pp.1851-1856
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• 2006

영화는 대표적인 경험재로 가치판단이 주관적이고 제품 수명주기가 매우 짧아 예측의 불확실성이 높기 때문에 이를 정량적인 방법으로 모형화하기는 쉽지 않다. 이러한 한계점에도 불구하고 한 영화의 상업적 성공을 예측하는 것은 영화 제작자나 배급사, 극장 등 모든 주체에게 수익과 직결되는 중요한 문제이기 때문에 지금까지 다양한 통계 모형이 제시되었다. 그러나 이들 모형의 대부분은 영화흥행에는 영향을 미치나 측정할 수 없는 효과를 반영하지 못한다거나, 추정 모수의 효과가 모든 영화에 대해서 같다는 동일성 가정으로 인해 영화간 이질성을 고려하지 못하고 있다. 따라서, 본 연구에서는 추정 모수의 사전분포를 모호사전분포로 정의함으로써 변수들의 불확실성을 반영할 수 있고, 영화간 이질성을 고려할 수 있는 베이지안 선택 모형을 제안하였다. 모수의 사후분포는 마코프체인 몬테카를로 기법인 깁스 샘플러를 이용하여 추정하였다. 또한, 감독, 배우, 장르 등의 영화 별 속성 변수뿐만 아니라, 입소문에 의한 영화관람 결정 등의 구전효과와 경쟁영화의 개봉으로 인한 효과를 반영할 수 있는 변수를 추가하여 모형의 정확성을 높였다. 2005년과 2006년 상반기에 상영된 영화를 바탕으로 모형을 구축하고 인공신경망 모형과 비교한 결과, 전체적인 예측 정확도에서는 인공신경망 모형과 비슷한 결과를 보이나 상업적으로 성공한 영화를 예측하는 데에는 베이지안 선택모형이 보다 더 우수한 것으로 나타났다. 또한, 개봉 주의 경쟁심화 정도 및 개봉 첫 주의 스크린 수 등이 영화 흥행에 가장 중요한 변수로 나타났으며, 영화 개봉 전 그 영화에 대한 기대치가 높을수록 흥행 성적 또한 좋음을 알 수 있었다. 배우의 힘 및 계절성, 영화 평점 등은 이질성을 고려하지 않은 전체수준에서는 통계적으로 유의하지 않은 것으로 나타났으나, 그룹 간 이질성을 반영한 모형에서는 어느 정도 흥행한 영화를 만들기 위해서는 고려되어야 할 요소로 나타났다.렇지 않을 경우 적절한 벤치마킹 대상을 도출할 때까지 추가적인 분석과정을 반복한다. 제안한 방법을 통하여 조직은 기술적 생산 가능성 외에도 다양한 조직 운영 관점에서 적절한 벤치마킹 대상을 선정할 수 있으며, 이에 따른 목표를 수립할 수 있을 것으로 기대한다. 또한 더 나아가 global efficiency 관점에서 효율적 조직이 되기 위하여 단계적인 벤치마킹 대상 선정과 이에 따른 목표를 수립하는데도 유용하리라 판단된다.$1.20{\pm}0.37L$, 72시간에 $1.33{\pm}0.33L$로 유의한 차이를 보였으므로(F=6.153, P=0.004), 술 후 폐환기능 회복에 효과가 있다. 4) 실험군과 대조군의 수술 후 노력성 폐활량은 수술 후 72시간에서 실험군이 $1.90{\pm}0.61L$, 대조군이 $1.51{\pm}0.38L$로 유의한 차이를 보였다(t=2.620, P=0.013). 5) 실험군과 대조군의 수술 후 일초 노력성 호기량은 수술 후 24시간에서 $1.33{\pm}0.56L,\;1.00{\ge}0.28L$로 유의한 차이를 보였고(t=2.530, P=0.017), 술 후 72시간에서 $1.72{\pm}0.65L,\;1.33{\pm}0.3L$로 유의한 차이를 보였다(t=2.540, P=0.016). 6) 대상자의 술 후 폐환기능에 영향을 미치는 요인은 성별로 나타났다. 이에 따른 폐환기능의 차이를 보면, 실험군의 술 후 노력성 폐활량이 48시간에 남자($1.78{\pm}0.61L$)가 여자($1.27{\pm}0.45L$)보다 더 높게 나타났으며 (t=2.170, P=0.042), 72시간에도 역시 남자($2.16{\pm}0.56L$)가 여자($1.50{\pm}0.47L$)보다 더

• Journal of Bio-Environment Control
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• v.24 no.4
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• pp.317-325
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• 2015

This paper attempts to present a review about simulation of different greenhouse parameters and energy supplying techniques by using building energy simulation, to find out the optimal solution for keeping greenhouse microclimate favorable for the crop production. The objectives of conducting this study were, to describe the various energy systems and techniques used for the greenhouse energy management and efficiency analysis of these technologies by using building energy simulation. We describe different models to understand the behavior of the energy saving technologies with respect to the resources available and different outside climatic conditions. We identified main features of the building energy simulation software, that enable users, to simulate hybrid agricultural building projects by using user defined parameters. At the end of the paper we draw some important concluding remarks on the basis of reviewing all the investigators contributions for the developments of simulation model of agricultural greenhouse energy management, using a building energy simulation software specifically TRNSYS. In conclusion, this paper provides information that TRNSYS have great potential for agricultural buildings energy simulation along with the renewable energy resources and energy saving techniques. This review paper provides aid to greenhouse researcher and energy planner for the future studies of greenhouses energy planning.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.9 no.2
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• pp.61-70
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• 2014

Entrepreneurship provides working opportunities to not only an entrepreneur himself but also many other people on the way its process. Boosting entrepreneurship, therefore, seems the most effective way for activating one's economy as well as creating jobs. This study examines factors that influence on entrepreneurial intention of Korean and Korean-Chinese's who will eventually be the potential entrepreneurs. This model tests various theoretical research hypotheses relating to individual psychological characteristics, and entrepreneurial motivation and entrepreneurial intention. Valid 247 questionnaires have been collected within about one month of 2013. Statistical processing of the data collected from this survey to take advantage of the statistical package SPSS 18.0 program through a process of data coding in the following ways: by frequency analysis, factor analysis, regression analysis. The result of hypothesis testing are as follows. The result of analysis shows that risk-taking propensity and desire for self-achievement is not a significant factor to entrepreneurial intention in both countries. But entrepreneurial self-efficiency and entrepreneurial motivation positively influence entrepreneurial intention both of the Korean and Korean-Chinese. At the last, the study examines moderate effect, that is, whether social support influences on entrepreneurial intention as a moderate variable. it is confirmed that the social support does play a positive role to entrepreneurial intention. Beside, discussion is made on the implications of the study for academicians and practitioners, the limitations of the study, and some directions for future studies.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.1
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• pp.39-45
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• 2016

Thermal management of a fuel cell is important to satisfy the requirements of durability and efficiency under varying load conditions. In this study, a linear state feedback controller was designed to maintain the temperature within operating conditions. Due to the nonlinearity of automotive fuel cell system, the state feedback controller results in marginal stable under load condition from $0.5A/cm^2$ to $0.7A/cm^2$. A PWM (Pulse Width Modulation) and the modified state feedback controller are applied to control the temperature under the load condition from $0.5A/cm^2$ to $0.7A/cm^2$. The cooling system model is composed of a reservoir, radiator, bypass valve, fan, and a water pump. The performance of the control algorithm was evaluated in terms of the integral time weighted absolute error (ITAE). Additionally, MATLAB/SIMULINK$^{(R)}$ was used for the development of the system models and controllers. The modified state feedback controller was found to be more effective for controlling temperature than other algorithms when tested under low load conditions.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6569-6573
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• 2015

Objective: To evaluate the application value of serum CA19-9, CEA, CA125 and CA242 in diagnosis and prognosis of pancreatic cancer cases treated with concurrent chemotherapy. Materials and Methods: 52 patients with pancreatic cancer, 40 with benign pancreatic diseases and 40 healthy people were selected. The electrochemiluminescence immunoassay method was used for detecting levels of CA19-9, CEA and CA125, and a CanAg CA242 enzyme linked immunoassay kit for assessing the level of CA242. The Kaplan-Meier method was used for analyzing the prognostic factors of patients with pancreatic cancer. The Cox proportional hazard model was applied for analyzing the hazard ratio (HR) and 95% confidential interval (CI) for survival time of patients with pancreatic cancer. Results: The levels of serum CA19-9, CEA, CA125 and CA242 in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic diseases and healthy people (P<0.001). The sensitivity of CA19-9 was the highest among these, followed by CA242, CA125 and CEA. The specificity of CA242 is the highest, followed by CA125, CEA and CA19-9. The sensitivity and specificity of joint detection of serum CA19-9, CEA, CA125and CA242 were 90.4% and 93.8%, obviously higher than single detection of those markers in diagnosis of pancreatic cancer. The median survival time of 52 patients with pancreatic cancer was 10 months (95% CI7.389~12.611).. Patients with the increasing level of serum CA19-9, CEA, CA125, CA242 had shorter survival times (P=0.047. 0.043, 0.0041, 0.029). COX regression analysis showed that CA19-9 was an independent prognostic factor for patients with pancreatic cancer (P=0.001, 95%CI 2.591~38.243). Conclusions: The detection of serum tumor markers (CA19.9, CEA, CA125 and CA242) is conducive to the early diagnosis of pancreatic cancer and joint detection of tumor markers helps improve the diagnostic efficiency. Moreover, CA19-9 is an independent prognostic factor for patients with pancreatic cancer.

• Journal of Digital Convergence
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• v.13 no.4
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• pp.227-233
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• 2015

The recent health care is growing rapidly want to receive offers users a variety of medical services, can be exploited easily exposed to a third party information on the role of the patient's hospital staff (doctors, nurses, pharmacists, etc.) depending on the patient clearly may have to be classified. In this paper, in order to ensure safe use by third parties in the health care environment, classify the attributes of patient information and patient privacy protection technique using hierarchical multi-property rights proposed to classify information according to the role of patient hospital officials The. Hospital patients and to prevent the proposed method is represented by a mathematical model, the information (the data consumer, time, sensor, an object, duty, and the delegation circumstances, and so on) the privacy attribute of a patient from being exploited illegally patient information from a third party the prevention of the leakage of the privacy information of the patient in synchronization with the attribute information between the parties.

• Economic and Environmental Geology
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• v.53 no.1
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• pp.11-21
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• 2020

One-dimensional analytical solutions were used for forward and back diffusion of trichloroethylene (TCE) and tetrachloroethylene (PCE) in a single system with high- and low-permeability layers. Concentration profiles in a low-permeability layer, diffusive fluxes at the interface between the high- and low-permeability layers, and contaminant persistence in the high-permeability layer due to back diffusion were simulated with a comparison of semi-infinite and finite analytical solutions. In order to validate the analytical solutions used in this study, the results of one-dimensional analytical solutions developed by Yang et al. (2015) were compared with Nash-Sutcliffe model efficiency coefficient (NSE). When compared with Yang et al. (2015), the analytical solutions used in this study showed good agreements (NSE = 0.99). When compared with semi-infinite analytical solutions, TCE and PCE concentration profiles in the low-permeability layer, the diffusive fluxes, and the contaminant tailings of the high-permeability layer were underestimated. In order to determine the appropriate analytical solutions based on the effective diffusion coefficient, the thickness of the low-permeability layer, and the diffusion time in the TCE and PCE contaminated site, a term of dimensionless diffusion length (Z_d) was used. If the Z_d is less than 0.7, the semi-infinite solutions can be used to simulate accurate concentration profiles in low-permeability layers. If the Z_d is greater than 0.7, the reliability of simulations may be improved by using the finite solutions.