• BMB Reports
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• 제48권2호
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• pp.121-126
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• 2015

Here we report a new chemical inhibitor against HIV-1 with a novel structure and mode of action. The inhibitor, designated as A1836, inhibited HIV-1 replication and virus production with a 50% inhibitory concentration ($IC_{50}$) of $2.0{\mu}M$ in an MT-4 cell-based and cytopathic protection antiviral assay, while its 50% cytotoxic concentration ($CC_{50}$) was much higher than $50{\mu}M$. Examination of the effect of A1836 on in vitro HIV-1 reverse transcriptase (RT) and integrase showed that neither were molecular targets of A1836. The characterization and re-infection assay of the HIV-1 virions generated in the presence of A1836 showed that the synthesis of early RT products in the cells infected with the virions was inhibited dose-dependently, due in part to abnormal protein formation within the virions, thus resulting in an impaired infectivity. These results suggest that A1836 might be a novel candidate for the development of a new type of HIV-1 inhibitor.

• Asian-Australasian Journal of Animal Sciences
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• 제14권6호
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• pp.858-861
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• 2001

Near Infrared spectroscopy was applied to the samples of processed pork to see the effect of grinding on chemical components analyses. Data from conventional chemical analyses of moisture, fat, protein, NaCl were put into calibration model by NIR of reflectance mode. The other properties observed were pH and color parameters ($L^*,\;a^*,\;b^*$). Spectral ranges of 400~2500 nm and 400~1100 nm were compared for color parameters. Spectral ranges of 400~2500 nm and 1100~2500 nm were compared for chemical components and pH. Different spectral ranges caused little changes in the coefficients of determination or standard errors. $R^{2,}s$ of calibration models for color parameters were in the range of 0.97 to 1.00. $R^{2,}s$ of calibration models of intact sausages for moisture, protein, fat, NaCl and pH were 0.98, 0.89, 0.95, 0.73 and 0.77, respectively using spectra at 1100~2500 nm. $R^{2,}s$ of calibration models of ground sausages for moisture, protein, fat, NaCl and pH were 0.97, 0.91, 0.97, 0.42 and 0.56, respectively using spectra at 1100~2500 nm.

• Asian-Australasian Journal of Animal Sciences
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• 제18권6호
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• pp.898-907
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• 2005

Chromium has emerged as an essential trace mineral in nutrition. However, it readily causes toxicity because of slightly excessive dose and/or form of chromium supplement. Therefore, developing a noble form of chromium supplement which is capable of not only an increased availability but also a reduced toxicity has been a critical issue in chromium nutrition. Chromium-methionine chelate has been, so far, one of the latest developments in its kind. Although not much information is available for the chromium-methionine chelate, especially in view of animal performances upon dietary supplementation, several studies indicated chromium methionine chelate could be effective to improve meat quality by increasing muscle mass but decreasing body fat. Highly-graded beef was produced by dietary chromium methionine supplementation during fattening stage of Korean native steers. Body muscle was increased in replace of decreasing body fat in both pig and rat that were dietary supplemented with chromium methionine chelate. However, a pig farm study did not show any significant improvement of body gain upon supplementation of chromium methionine. Immune responses of pig and rat were not always dependent upon chromium form but were varied by species. These results suggest there could be a different mode of responses due to species as well as onset time of dietary supplementation of chromium methionine. It is still early to conclude the bio-efficacy of chromium methionine chelate presumably due to its recent appearance into the field. But the chelate is certainly worth more application to animal since it certainly reduced the application level of dietary chromium.

• Journal of Microbiology and Biotechnology
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• 제32권9호
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• pp.1103-1109
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• 2022

Deoxypodophyllotoxin (DPT), a naturally occurring flavonolignan, possesses several pharmacological properties, including anticancer property. However, the mechanisms underlying DPT mode of action in oral squamous cell carcinoma (OSCC) remain unknown. This study aimed to investigate the anticancer effects of DPT on OSCC and the underlying mechanisms. Results of the MTT assay revealed that DPT significantly reduced the cell viability in a time- and dose-dependent manner. Flow cytometry analysis revealed that DPT induces apoptosis in OSCC cells in a dose-dependent manner. Moreover, DPT enhanced the production of mitochondrial reactive oxygen species (ROS) in OSCC cells. Mechanistically, DPT induced apoptosis in OSCC cells by suppressing the PI3K/AKT signaling pathway while activating the p38 MAPK signaling to regulate the expression of apoptotic proteins. Treatment with SC79, an AKT activator, reversed the effects of DPT on AKT signaling in OSCC cells. Taken together, these results provide the basis for the use of DPT in combination with conventional chemotherapy for the treatment of oral cancer.

• Asian-Australasian Journal of Animal Sciences
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• 제13권12호
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• pp.1770-1774
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• 2000

Extended use of porcine blood in food ingredients depends on the decolorization of red blood cell concentrates and the modification of its functional properties. The purpose of this study is to compare the relative effect of cation ion exchanger for decolorization of porcine red blood globin. The globin extract is freeze-dried for determination of various functional properties, such as solubility, emulsion capability and foaming ability. Since the isoelectric point of blood globin is located at pH 6.8, which is the neutral pH ranges (6-8), so its functionalities are inferior around these pHs. This weakness has been the main reason, which limit the extended use of blood globin in food industry. Acetylation and succinylation of blood globin can be an alternative way to improve its functionalities. These results may provide new information to understand the decolorization mode by cation ion exchanger for the blood globin. With chemical, the functionalities of blood globin could be obviously improved. The above findings could enable food industry to extend the use of blood globin as a food ingredient.

• Industrial Engineering and Management Systems
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• 제15권4호
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• pp.290-297
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• 2016

The successful transfer of technology, needs to recognize the industrial purposes, resources, technology, innovation and the mode of transmission, methods of transmission, influential factors, it's how to recruit and how to develop, and each of these cognitive relies on special expertise. One of the important technologies is automotive technology, and s technology is important for the transition and its development in recent years. Hence, in this paper, after studying Iran and the world's automotive and emerging technologies situation, the status of commercial vehicles and s technology model are studied based on external models, technical specifications, and cost. In this way, we examine the incidence and the applicability of the technology used in the production of heavy-duty vehicles, in recent years, with the passage of time, and we examine the technology lifecycle, from the perspective of physical characteristics and technical features. The results show that the technology of the studied heavy-duty vehicles (Titan) is close to the time of his fall, because spending puberty, so, according to the investigation of new technologies, we should strive to create changes in vehicle technology.

• 농촌계획
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• 제20권4호
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• pp.55-66
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• 2014

This study analyzed the recognition of local residents surrounding farmland conversion area. The details of the survey on the residents included recognition of farmland conversion, the usage and reason of farmland conversion in the surrounding area, impacts of farmland conversion on the local region and agricultural production, and change in farmland prices. According to the analysis, the aging of the local residents progressed, and the ratio of farming population was high in the case study area. There were many warehouse facilities and small scale factories in terms of farmland conversion in the case study area, due to the surrounding area characteristics of industrial complex and relatively cheaper land prices. The farmland conversion affected the local area and residents both positively and negatively, and the surrounding area's land prices rose. The policy implications, based on the findings in this study, indicate the following need to be carried out: the consolidation of action on farmland pollution upon farmland conversion, review of planned collective conversion mode, and return of the land price hike profits to the affected local area and residents. Actually, farmland conversion should be conducted, after a comprehensive and systematic review, because it affects the local area and residents in a complex way.

• Asian-Australasian Journal of Animal Sciences
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• 제18권10호
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• pp.1387-1402
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• 2005

Indian subcontinent is a rich source of diverse ovine germplasm, and only very few countries have such a large number of breeds with wide genetic diversity. This vast ovine biodiversity in India is being eroded rapidly and more than 50% of sheep breeds are currently under threat. It is noteworthy that the characterization of Indian sheep breeds was last done in the first half of the century since then no recent estimates are available and surveys in majority of the regions/breeds are far from complete. Starting in 1985 National Bureau of Animal Genetic Resources (NBAGR), Karnal, India, therefore, initiated activities aimed at determining the status and compiling information on indigenous farm animals including sheep. This report represents attempts made to date on the basis of field/literature surveys and additional activities on molecular characterization to ascertain their status including distribution, population changes, breed diversities and risk status. The need, mode and mechanisms of conservation are also described. Involvement of several agencies for evaluation, improvement, conservation programmes and recommendations made for effective characterization and conservation of sheep biodiversity are highlighted. This publication would promote action particularly at national level to improve the information base on domestic Indian breeds of sheep and provide input into national domestic sheep diversity conservation policy decisions.

• 정보저장시스템학회논문집
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• 제9권2호
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• pp.62-66
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• 2013

For the production method, stamp base is increasing the market share. But also, by the manufacturing method, stiffness of the stamp base is small. Many studies have been carried out in order to increase the stiffness of the stamp base. In this study, we optimally designed according to the position of bolting using a screening method in order to increase the stiffness base. After establishing a simulation model, the maximum deformation and frequency of the first mode based having relevance with stiffness of the base, were optimized. There for, it was possible to expect of increasing the stiffness of the stamp base.

• 한국해양공학회지
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• 제22권1호
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• pp.64-69
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• 2008

As it has been well appreciated from the viewpoint of efficiency, The weld-induced deformation control is one of the most important issues in marine structure production. In the case of thin plate block, weld-induced deformation is more serious than in the case of relatively thick plate block. The heat affect zone of thin plates is wider than that of thick plates with the same heat input. Among weld-induced deformations, the buckling deformation by the shrinkage and residual stress in the weld line direction is one of the most serious deformation types. This paper is concerned with controlling buckling deformations for the thin plate fillet welds, by using the tensioning method. A numerical analysis was carried out to illustrate several dominant buckling modes due to compressive residual stress in the fillet weldsof thin plates. Then, weld tests were carried out for 20 specimens with varying plate thickness, and with different magnitudes and directions for the tension load. The results graphically represented to shaw the effect of the tensioning method in reducing the weld-induced deformation. From the present findings, it was seen that the tensioning method is a useful way to control weld-induced deformations in the fillet welds of thin plates.