• CELLMED
• /
• v.5 no.3
• /
• pp.15.1-15.12
• /
• 2015

Comparative studies have established that the North-Eastern (NE) region of India which is a part of the Eastern Himalayan region is affluent in both traditional knowledge based phytomedicine and biodiversity. About 1953 ethno-medicinal plants are detailed from the NE region of India out of which 1400 species are employed both as food and ethnopharmacological resources. Nearly 70% of species diversity has been reported from the two Indian biodiversity hotspots-The Western Ghats and the Eastern Himalayas and these hotspots are protected by tribal communities and their ancient traditional knowledge system. Paris polyphylla Smith belongs to the family Melanthiaceae and is a traditional medicinal herb which is known to cure some major ailments such as different types of Cancer, Alzheimer's disease, abnormal uterine bleeding, leishmaniasis etc. The major phytoconstituents are dioscin, polyphyllin D, and balanitin 7. Phylogeny of Paris was inferred from nuclear ITS and plastid psbA-trnH and trnL-trnF DNA sequence data. Results indicated that Paris is monophyletic in all analyses. Rhizoma Paridis, which is the dried rhizome of Paris polyphylla is mainly used in Traditional Chinese Medicine and its mode of action is known for only a few cancer cell lines. The current review determines to sketch an extensive picture of the potency, diversity, distribution and efficacy of Paris polyphylla from the Eastern Himalayan region and the future validation of its phytotherapeutical and molecular attributes by recognizing the Intellectual Property Rights of the Traditional Knowledge holders.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.19 no.2
• /
• pp.114-123
• /
• 2005

A nonlinear speed control of a PMSM using a sequential parameter auto-tuning algorithm for servo equipments is presented. The nonlinear control scheme gives an undesirable output performance under the mismatch of the system parameters and load conditions. Recently, to improve the performance, an adaptive linearization scheme, a sliding mode control and an observer-based technique have been reported. Although a good performance can be obtained, the performance is not satisfactory any more under specific conditions such as a large inertia variation, a fast speed transient or an increased sampling time. The simultaneous estimation of principal parameters giving a direct influence on speed dynamics is generally not simple. To overcome this problem, a a sequential parameter auto-tuning algorithm at start-up is proposed, where dominant parameters are estimated in a prescribed regular sequence based on the method that one parameter is estimated during each interval. The proposed scheme is implemented on a PMSM using DSP TMS320C31 and the effectiveness is verified through simulations and experiments.

• Molecules and Cells
• /
• v.41 no.9
• /
• pp.842-852
• /
• 2018

Notch signaling is an evolutionarily conserved pathway and involves in the regulation of various cellular and developmental processes. Ligand binding releases the intracellular domain of Notch receptor (NICD), which interacts with DNA-bound CSL [CBF1/Su(H)/Lag-1] to activate transcription of target genes. In the absence of NICD binding, CSL down-regulates target gene expression through the recruitment of various corepressor proteins including SMRT/NCoR (silencing mediator of retinoid and thyroid receptors/nuclear receptor corepressor), SHARP (SMRT/HDAC1-associated repressor protein), and KyoT2. Structural and functional studies revealed the molecular basis of these interactions, in which NICD coactivator and corepressor proteins competitively bind to ${\beta}-trefoil$ domain (BTD) of CSL using a conserved ${\varphi}W{\varphi}P$ motif (${\varphi}$ denotes any hydrophobic residues). To date, there are conflicting ideas regarding the molecular mechanism of SMRT-mediated repression of CSL as to whether CSL-SMRT interaction is direct or indirect (via the bridge factor SHARP). To solve this issue, we mapped the CSL-binding region of SMRT and employed a 'one- plus two-hybrid system' to obtain CSL interaction-defective mutants for this region. We identified the CSL-interaction module of SMRT (CIMS; amino acid 1816-1846) as the molecular determinant of its direct interaction with CSL. Notably, CIMS contains a canonical ${\varphi}W{\varphi}P$ sequence (APIWRP, amino acids 1832-1837) and directly interacts with CSL-BTD in a mode similar to other BTD-binding corepressors. Finally, we showed that CSL-interaction motif, rather than SHARP-interaction motif, of SMRT is involved in transcriptional repression of NICD in a cell-based assay. These results strongly suggest that SMRT participates in CSL-mediated repression via direct binding to CSL.

• Composites Research
• /
• v.16 no.6
• /
• pp.23-32
• /
• 2003

Applications of advanced composite material in construction field are tending upwards and development of all composite material bridges is making progress rapidly in home and abroad due to their high strength to weight ratio. This paper formulated the dynamic responses of the laminated composite structures subjected to moving load and analyzed the various dynamic behaviors using the finite element method. The nondimensionalized natural frequencies of a simply supported square-laminated composite plate are considered for verifications. Mode superposition and Newmark direct integration method are applied for moving load analysis. For structural models, dynamic magnification factor calculated for various velocities of the moving load and displacements characteristics of laminated composite structures due to the moving load are investigated theoretically Numerical results are presented to study the effects of lamination scheme, stacking sequence, and fiber angle for laminated composite structures during moving load. The various results on moving load and lamination through numerical analysis will present an important basic data for development and grasp the behavior of all composite material bridges.

• Journal of Digital Contents Society
• /
• v.18 no.8
• /
• pp.1627-1633
• /
• 2017

Human dance is difficult to learn since there is no effective way to imitate an expert's motion, a sequence of complicated body movements, without taking an actual class. In this paper, we propose a dance learning system using human depth information. In the proposed system, a set of example motions are captured from various expert dancers through a marker-free motion capture and archived into a motion database server for online dance lessons. Given the end-user devices such as tablet and kiosk PCs, a student can learn a desired motion selected from the database and send one's own motion to an instructor for online feedback. During this learning process, our system provides a posture-based motion search and multi-mode views to support the efficient exchange of motion data between the student and instructor under a networked environment. The experimental results demonstrate that our system is capable to improve the student's dance skills over a given period of time.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2017.05a
• /
• pp.5-13
• /
• 2017

To lunch the Korea Space Launch Vehicle-II(KSLV-II), the second launch complex will be constructed on the Naro Space Center and Kerosene Filling System (KFS) will be also installed newly. KFS of KSLV-II launch complex system is being designed based on Naro Launch Complex. But this must supply fuel to fuel tanks of the vehicle with only a supply pump because KSLV-II is a 3-stage launch vehicle unlike Naro Launch Vehicle or Test Launch Vehicle (TLV). A sudden rise of pump output pressure is recognized during fuel filling scenario selection process. This occurs because return flow can not actively deal with a lot of flow change using flow control method of orifice type. To solve this problem, it is verified that fuel can be stably supplied by installation of accumulator and an appropriate adjustment of filling mode change sequence through flow analysis of various cases.

• Molecules and Cells
• /
• v.38 no.2
• /
• pp.122-129
• /
• 2015

DBM-2198, a six-membered azasugar nucleotide (6-AZN)-containing phosphorothioate (P = S) oligonucleotide (AZPSON), was described in our previous publication [Lee et al. (2005)] with regard to its antiviral activity against a broad spectrum of HIV-1 variants. This report describes the mechanisms underlying the anti-HIV-1 properties of DBM-2198. The LTR-mediated reporter assay indicated that the anti-HIV-1 activity of DBM-2198 is attributed to an extracellular mode of action rather than intracellular sequence-specific antisense activity. Nevertheless, the antiviral properties of DBM-2198 and other AZPSONs were highly restricted to HIV-1. Unlike other P = S oligonucleotides, DBM-2198 caused no host cell activation upon administration to cultures. HIV-1 that was pre-incubated with DBM-2198 did not show any infectivity towards host cells whereas host cells pre-incubated with DBM-2198 remained susceptible to HIV-1 infection, suggesting that DBM-2198 acts on the virus particle rather than cell surface molecules in the inhibition of HIV-1 infection. Competition assays for binding to HIV-1 envelope protein with anti-gp120 and anti-V3 antibodies revealed that DBM-2198 acts on the viral attachment site of HIV-1 gp120, but not on the V3 region. This report provides a better understanding of the antiviral mechanism of DBM-2198 and may contribute to the development of a potential therapeutic drug against a broad spectrum of HIV-1 variants.

• Proceedings of the Korean Institute Of Construction Engineering and Management
• /
• 2007.11a
• /
• pp.277-282
• /
• 2007

Construction process works in sequence order and there are many different software for managing project and activity. So, there are many limitations such as in the stage of activity data loss can occur, in each stage concurrent cannot operate in construction industry. In order to solve these problem, agents have to cooperate each other and they need to share of data. Therefore, the purpose of this paper is to develop a process model and the process model will be use in the future to make Construction Project Life-Cycle Management based on concept of PLM(Product Life cycle Management) in the manufacturing industry, CE(Concurrent Engineering) and BlM(Building Information Modeling)

• Journal of the Korean Society of Safety
• /
• v.29 no.4
• /
• pp.116-122
• /
• 2014

This study proposes a system reliability analysis of rack storage facilities subjected to forklift colliding events. The proposed system reliability analysis consists of two steps: the first step is to identify dominant failure modes that most contribute to the failure of the whole rack facilities, and the second step is to evaluate the system failure probability. In the first step, dominant failure modes are identified by using a simulation-based selective searching technique where the contribution of a failure mode to the system failure is roughly estimated based on the distance from the origin in the space of the random variables. In the second step, the multi-scale system reliability method is used to compute the system reliability where the first-order reliability method (FORM) is initially used to evaluate the component failure probability (failure probability of one member), and then the probabilities of the identified failure modes and their statistical dependence are evaluated, which is called as the lower-scale reliability analysis. Since the system failure probability is comprised of the probabilities of the failure modes, a higher-scale reliability analysis is performed again based on the results of the lower-scale analyses, and the system failure probability is finally evaluated. The illustrative example demonstrates the results of the system reliability analysis of the rack storage facilities subjected to forklift impact loadings. The numerical efficiency and accuracy of the approach are compared with the Monte Carlo simulations. The results show that the proposed two-step approach is able to provide accurate reliability assessment as well as significant saving of computational time. The results of the identified failure modes additionally let us know the most-critical members and their failure sequence under the complicated configuration of the member connections.

• KIPS Transactions on Computer and Communication Systems
• /
• v.2 no.2
• /
• pp.59-66
• /
• 2013

In this paper, we proposed an optimal ILP algorithm on memory address code generation for DSP in embedded system. This paper using 0-1 ILP formulations DSP address generation units should minimize the memory variable data layout. We identify the possibility of the memory assignment of variable based on the constraints condition, and register the address code which a variable instructs in the program pointer. If the process sequence of the program is declared to the program pointer, then we apply the auto-in/decrement mode about the address code of the relevant variable. And we minimize the loads on the address registers to optimize the data layout of the variable. In this paper, in order to prove the effectiveness of the proposed algorithm, FICO Xpress-MP Modeling Tools were applied to the benchmark. The result that we apply a benchmark, an optimal memory layout of the proposed algorithm then the general declarative order memory on the address/modify register to reduce the number of loads, and reduced access to the address code. Therefor, we proved to reduce the execution time of programs.