• Proceedings of the KIPE Conference
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• 2004.07a
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• pp.77-81
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• 2004

In this paper a novel line interactive UPS (Uninterruptible Power Supply) using the two 4-leg VSCs and AC line reactor is proposed. The 4-leg Voltage Source Converter(VSC) can use the DC link voltage effectively by the 3-D SVPWM method. Hence the DC battery voltage can be reduced by $15\%$ in comparison to that of the conventional line-interactive UPS system. One VSC is in parallel with the AC line reactor of the power source side, and the other is in series with the load. The parallel 4-leg voltage source inverter controls three-phase line voltage independently in order to control the line reactor current indirectly. It eliminates the neutral line current and the active ripple power of the source side using the pqr theory so that unity power factor and the sinusoidal source current can be achieved even though both the source and the load voltages have zero sequence components. The series 4-leg voltage source inverter compensates the line voltage and allows the load voltage to be balanced and harmonic-free. Both of parallel and series 4-leg voltage source inverters always act as independently controllable voltage sources, so that three-phase output voltage shows a seamless transition to the backup mode. The feasibility of the proposed UPS system has been investigated and verified through computer simulation results.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8467-8471
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• 2016

Background: One of the major mechanisms for drug resistance is associated with altered anticancer drug transport, mediated by the human-adenosine triphosphate binding cassette (ABC) transporter superfamily proteins. The overexpression of adenosine triphosphate binding cassette, sub-family B, member 1 (ABCB1) by multidrug-resistant cancer cells is a serious impediment to chemotherapy. In our study we have studied the possibility that structural single-nucleotide polymorphisms (SNP) are the mechanism of ABCB1 overexpression. Materials and Methods: A total of 101 gastric cancer multidrug resistant cases and 100 controls were genotyped with sequence-specific primed PCR (SSP-PCR). Gene expression was evaluated for 70 multidrug resistant cases and 54 controls by real time PCR. The correlation between the two groups was based on secondary structures of RNA predicted by bioinformatics tool. Results: The results of genotyping showed that among 3 studied SNPs, rs28381943 and rs2032586 had significant differences between patient and control groups but there were no differences in the two groups for C3435T. The results of real time PCR showed over-expression of ABCB1 when we compared our data with each of the genotypes in average mode. Prediction of secondary structures in the existence of 2 related SNPs (rs28381943 and rs2032586) showed that the amount of ${\Delta}G$ for original mRNA is higher than the amount of ${\Delta}G$ for the two mentioned SNPs. Conclusions: We have observed that 2 of our studied SNPs (rs283821943 and rs2032586) may elevate the expression of ABCB1 gene, through increase in mRNA stability, while this was not the case for C3435T.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.6
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• pp.111-118
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• 2008

In this paper, novel latch-up prevention method that employs power-up sequential switches has been proposed to relieve latch-up problem in liquid crystal display (LCD) driver ICs. These sequential switches are inserted in the 2'nd and 3'rd boosting stages, and are used to short the emitter-base terminals of parasitic p-n-p-n circuit before relevant boosting stages are activated during power-up sequence. To verily the performance of the proposed method, test chips were designed and fabricated in a 0.13-um CMOS process technology. The measurement results indicated that, while the conventional LCD driver If entered latch-up mode at $50^{\circ}C$ accompanying a significant amount of excess current, the driver IC adopting the proposed method showed no latch-up phenomenon up to $100^{\circ}C$ and maintained normal current level of 0.9mA.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.20 no.1
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• pp.47-52
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• 2011

It is well known that stiffness of composites depends on layup sequence of CFRP(carbon fiber reinforced plastics) laminates because the layup of composite laminates influences their properties. Ultrasonic NDE of composite laminates is often based on the backwall echoes of the sample. A pair of such transducers was mounted in a holder in a nose-to-nose fashion to be used as a scanning probe on composites. Miniature potted angle beam transducers were used (Rayleigh waves in steel) on solid laminates of composites. Experiments were performed to understand the behavior of the transducers and the nature of the waves generated in the composite (mode, wave speed, angle of refraction). C-scan images of flaws and impact damage were then produced by combining the pitch-catch probe with a portable manual scanner known as the Generic Scanner ("GenScan"). The pitch-catch signal was found to be more sensitive than normal incidence backwall echo of longitudinal wave to fiber orientation of the CFRP composites, including low level porosity, ply waviness, and cracks. Therefore, it is found that the experimentally Rayleigh wave variation of pitch-catch ultrasonic signal was consistent with numerical results and one-side ultrasonic measurement might be very useful to detect the defects.

• Bulletin of the Korean Chemical Society
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• v.26 no.2
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• pp.285-291
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• 2005

The nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is the viral RNA-dependent RNA polymerase (RdRp), which is the essential catalytic enzyme for the viral replication and is an appealing target for the development of new therapeutic agents against HCV infection. A small amount of serum from a single patient with hepatitis C was used to get the genome of a Korean HCV isolate. Sequence analysis of NS5B 1701 nucleotides showed the genotype of a Korean isolate to be subtype 1b. The soluble recombinant HCV NS5B polymerase lacking the C-terminal 24 amino acids was expressed and purified to homogeneity. With the highly purified NS5B protein, we established in vitro systems for RdRp activity to identify potential polymerase inhibitors. The rhodanine family compounds were found to be potent and specific inhibitors of NS5B from high throughput screening (HTS) assay utilizing the scintillation proximity assay (SPA) system. The binding mode of an inhibitor was analyzed by measuring various kinetic parameters. Lineweaver-Burk plots of the inhibitor suggested it binds not to the active site of NS5B polymerase, but to an allosteric site of the enzyme. The activity of NS5B in in vitro polymerase reactions with homopolymeric RNA requires interaction with multiple substrates that include a template/primer and ribonucleotide triphosphate. Steady-state kinetic parameter, such as Km, was determined for the ribonucleotide triphosphate. One of compounds found interacts directly with the viral polymerase and inhibits RNA synthesis in a manner noncompetitively with respect to UTP. Furthermore, we also investigated the ability of the compound to inhibit NS5B-directed viral RNA replication using the Huh7 cell-based HCV replicon system. The investigation is potentially very useful for the utility of such compounds as anti-hepatitic agents.

• Journal of the Korean Society of Safety
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• v.30 no.6
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• pp.1-6
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• 2015

The actual condition is that environmental pollution due to the development of various industries has recently become a serious issue. An interest in improving the gas mileage is rising due to an increase in the number of vehicles in the era of high oil price in particular. In order to solve this problem, priority should be given to light-weight design of car body, However, at present, a design method enabling the conventional steel plate to be replaced is direly needed in order to guarantee passengers' safety according to excessive light-weight design of car body. In this study, in order to apply a design method that could realize fuel savings and environmental pollution prevention through an improvement in gas mileage together with meeting the safety requirements for vehicles, it was supposed that CFRP/Al composites member would be used as primary structural member. And to this end, it was intended to obtain optimum design data by experimentally implementing external impulsive load applied to the car body. According to results of impact test of CFRP/Al composites member, a collapsed shape of folding, crack, and bending occurred. So, it was possible to find that energy was observed. And in case of specimen having an angle of $90^{\circ}$ in the outermost layer and stack sequence of $[90^{\circ}{_2}/0^{\circ}2]s$, its collapsed length was shown to be short. Therefore, it was possible to find that the absorbed energy was shown to be higher by 20% or above at the maximum.

• Journal of Korean Neurosurgical Society
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• v.37 no.2
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• pp.89-95
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• 2005

Objective: The biomechanical stabilities between the anterior plate fixation after anterior discectomy and fusion (ACDFP) and the posterior transpedicular fixation after ACDF(ACDFTP) have not been compared using human cadaver in bilateral cervical facet dislocation. The purpose of this study is to compare the stability of ACDFP, a posterior wiring procedure after ACDFP(ACDFPW), and ACDFTP for treatment of bilateral cervical facet dislocation. Methods: Ten human spines (C3-T1) were tested in the following sequence: the intact state, after ACDFP(Group 1), ACDFPW(Group 2), and ACDFTP(Group 3). Intervertebral motions were measured by a video-based motion capture system. The range of motion(ROM) and neutral zone(NZ) were compared for each loading mode to a maximum of 2.0Nm. Results: ROMs for Group 1 were below that of the intact spine in all loading modes, with statistical significance in flexion and extension, but NZs were decreased in flexion and extension and slightly increased in bending and axial rotation without significances. Group 2 produced additional stability in axial rotation of ROM and in flexion of NZ than Group 1 with significance. Group 3 provided better stability than Group 1 in bending and axial rotation, and better stability than Group 2 in bending of both ROM and NZ. There was no significant difference in extension modes for the three Groups. Conclusion: ACDFTP(Group 3) demonstrates the most effective stabilization followed by ACDFPW(Group 2), and ACDFP(Group 1). ACDFP provides sufficient strength in most loading modes, ACDFP can provide an effective stabilization for bilateral cervical facet dislocation with a brace.

• KIPS Transactions on Software and Data Engineering
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• v.6 no.3
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• pp.141-148
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• 2017

The current advancement of mobile devices enables users to collect a sequence of user positions by use of the positioning technology and thus the related research regarding positioning or location information are quite arising. An individual mobility model based on positioning data and time data are already established while group mobility model is not done yet. In this research, group mobility model, an extension of individual mobility model, and the process of establishment of group mobility model will be studied. Based on the previous research of group mobility model from two individual mobility model, a group mobility model with more than two individual model has been established and the transition pattern of the model is represented by Markov chain. In consideration of real application, the computing time to establish group mobility mode from huge positioning data has been drastically improved by use of GPGPU comparing to the use of traditional multicore systems.

• Composites Research
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• v.12 no.1
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• pp.1-10
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• 1999

In order to predict the dynamic behavior of composite laminated plate accurately, the parametric identification is performed using its mechanical properties- $E_1,\;E_2,\;V_{12},\;G_{12}$ as design parameters. After natural frequencies are measured through simple vibration test, the objective function consists of the sum of errors between experimental and numerical frequencies of a structure. As optimization algorithm, conjugate gradient method is used to minimize the objective function. Sensitivity Analysis is performed to update design parameters during this process and can explain the result of parametric identification. In order to check the propriety of result, mode shapes are compared before and after identification. The improved prediction of natural frequencies of composite laminated plate is obtained with updated properties. For the application of result, updated properties is applied to the composite laminated plate that has different stacking sequence.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.9A
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• pp.991-997
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• 2004

In this paper, we propose the architecture of modem receiver to fabricate HomePNA 2.0 chip. HomePNA suffers from inferior channel because of bridge tap, the effect of amateur HAM band and so on. To transfer data over such channel, HomePNA 2.0 uses training sequence to equalize channel and uses FD-QAM optionally as modulation method. So modem receiver demodulate QAM based signal and needs optimum architecture that fully uses these transmission feature. As a result of research, we define 2 mode function of modem receiver depending on TX/RX state. In this paper, particularly, we show the algorithm of equalizer, carrier phase recovery and frame synchromzationblock and propose architecture that improve the performance of channel equalization and is stable in operation. In the end, we estimate the performance of proposed HomePNA2.0 modem receiver over HomePNA TEST LOOP using SPW program.