• Journal of Periodontal and Implant Science
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• v.46 no.5
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• pp.337-349
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• 2016

Purpose: The aim of this study was to compare and analyze the peri-implant tissue conditions and prospective clinical outcomes associated with 2 types of hydroxyapatite (HA)-coated implants: (1) fully HA-coated implants and (2) partially HA-coated implants with resorbable blast medium on the coronal portion of the threads. Methods: Forty-four partially edentulous patients were randomly assigned to undergo the placement of 62 HA-coated implants, and were classified as the control group (partially HA-coated, n=30) and the test group (fully HA-coated, n=32). All patients had chronic periodontitis with moderate crestal bone loss around the edentulous area. The stability and clinical outcomes of the implants were evaluated using the primary and secondary implant stability quotient (ISQ), as well as radiographic, mobility, and peri-implant soft tissue assessments around the implants. The Wilcoxon signed-rank test and the Mann-Whitney test were used to evaluate differences between and within the 2 groups, with P values <0.05 considered to indicate statistical significance. Results: The fully HA-coated implants displayed good retention of crestal bone, and insignificant differences were found in annual marginal bone loss between the 2 types of HA-coated implants (P>0.05). No significant differences were found in the survival rate (group I, 100%; group II, 100%) or the success rate (group I, 93.3%; group II, 93.8%). The fully HA-coated implants also did not significantly increase the risk of peri-implantitis (P>0.05). Conclusions: The fully HA-coated implants did not lead to an increased risk of peri-implantitis and showed good retention of the crestal bone, as well as good survival and success rates. Our study suggests that fully HA-coated implants could become a reliable treatment alternative for edentulous posterior sites and are capable of providing good retention of the crestal bone.

• Natural Product Sciences
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• v.20 no.4
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• pp.227-231
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• 2014

Cimicifuga heracleifolia extract (CHE) was investigated for its effects on the release of nitric oxide (NO) and at the level of inducible nitric oxide synthase (iNOS) gene expression in mouse macrophages. We found that C. heracleifolia elicited a dose-dependent increase in NO production and the level of iNOS mRNA. Since, iNOS transcription has been shown to be under the control of the transcription factor $NF-{\kappa}B$, the effects of CHE on $NF-{\kappa}B$ activation were examined. Transient expression assays with $NF-{\kappa}B$ binding sites linked to the luciferase gene revealed that the increased level of iNOS mRNA, induced by CHE, was mediated by the $NF-{\kappa}B$ transcription factor complex. By using DNA fragments containing the $NF-{\kappa}B$ binding sequence, CHE was shown to activate the protein/DNA binding of $NF-{\kappa}B$ to its cognate site, as measured by electrophoretic mobility shift assay. These results demonstrate that C. heracleifolia stimulates NO production and is able to up-regulate iNOS expression through $NF-{\kappa}B$ transactivation.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.18 no.1
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• pp.13-23
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• 2015

This study was performed to compare the effects of different drainage layers on tree growth at the exposed sites of Saemangeum sea dike. 4 types of drainage layers including control(dredged soil), specially prepared bark, gravel, and wood chip were set in 150~165cm depth of soil. Pinus thunbergii and Celtis sinensis were planted after 9 months of soil treatment. Electrical conductivity(EC) of soil in all treated plots were decreased under $4dS{\cdot}m^{-1}$, and NaCl(%) was decreased under 0.05% after 1 year from soil treatment. Soil moisture at the 120cm depth of the bark treated plot was higher than that of the 180cm soil depth, below the drainage layer. It is considered that vertical mobility of water was inhibited. Organic matter(OM) at the 120cm soil depth increased at bark and wood chip treated plots. Survival rates after 4 years of P. thunbergii and C. sinensis were 100% in all treatments. The height of P. thunbergii was not significantly different among the treatments while the height of C. sinensis was significantly different among the treatments and it was highest at the bark treated plot.

• Convergence Security Journal
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• v.13 no.3
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• pp.25-31
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• 2013

Looking at the recent value change of users and the usage pattern of network users, it is changing from simple web information, one-way information acquisition and data transmission to increase of usage of multimedia, increasing demand for security and customization, and increasing demands for free mobility. Due to this change of demand, the services which were provided individually, developed into a form which is merged, the network also seems to develop into the combined network from the individual network for individual service, and the communication network control technology which is the core technology is also rapidly developing. To reflect the users' demands, the next generation network created the multi-layer network which is based on the WDM/IP transmission system and added the to make it easy to restructure. P-OTS (Packet-Optical Transport System) can be defined as a platform that combines SONET/SDH, Ethernet, DWDM, optical transport network (OTN) switching and reconfigurable optical add-drop multiplexers (ROADMs). In this paper, we suggested that the optimum path choice be performed through diversification of the PCE-based path selection using the information of various layers altogether in the multi-layer environment, compared with the established path selection method when the path was selected using the information of each layers.

• BMB Reports
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• v.38 no.4
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• pp.474-480
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• 2005

Curcumin, a major active component of turmeric, has been identified as an inhibitor of the transcriptional activity of activator protein-1 (AP-1). Recently, it was also found that curcumin and synthetic curcumin derivatives can inhibit the binding of Jun-Fos, which are the members of the AP-1 family, to DNA. However, the mechanism of this inhibition by curcumin and its derivatives was not disclosed. Since the binding of Jun-Fos dimer to DNA can be modulated by redox control involving conserved cysteine residues, we studied whether curcumin and its derivatives inhibit Jun-Fos DNA binding activity via these residues. However, the inhibitory mechanism of curcumin and its derivatives, unlike that of other Jun-Fos inhibitors, was found to be independent of these conserved cysteine residues. In addition, we investigated whether curcumin derivatives can inhibit AP-1 transcriptional activity in vivo using a luciferase assay. We found that, among the curcumin derivatives examined, only inhibitors shown to inhibit the binding of Jun-Fos to DNA by Electrophoretic Mobility Shift Assay (EMSA) inhibited AP-1 transcriptional activity in vivo. Moreover, RT-PCR revealed that curcumin derivatives, like curcumin, downregulated c-jun mRNA in JB6 cells. These results suggest that the suppression of the formation of DNA-Jun-Fos complex is the main cause of reduced AP-1 transcriptional activity by curcuminoids, and that EMSA is a suitable tool for identifying inhibitors of transcriptional activation.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.8
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• pp.837-848
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• 2014

This paper describes the development of a walking assistive robot for effective self-rehabilitation for elderly people facing an inconvenience in walking. The main features of the developed robot are enhanced safety and mobility using the baby walker and electric wheelchair mechanisms and an accurate walking tracking control algorithm using potentiometers and stereo cameras. Specifically, a pelvis supporter is designed to prevent the user from falling down and reduce the burden on their legs, and electric motors are used for easy locomotion with low effort. Next, the walking intention and direction of the user are automatically recognized by using potentiometers attached at the pelvis supporter so that the robot can track the user, and the rapidity and accuracy of the tracking were increased by applying a lower-body motion analysis algorithm with stereo cameras. Finally, the user-tracking performance of the developed robot was experimentally verified through stepwise walking assistance experiments.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3309-3314
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• 2013

Spleen tyrosine kinase (SYK) is a non-receptor type cytoplasmic protein and a known tumor suppressor gene in breast cancer. Polymorphisms in SYK have been reported to be associated with cell invasion/cell morality and an increased risk of cancer development. In this case control study, all exons of the SYK gene and its exon/ intron boundaries were amplified in 200 breast cancer cases and 100 matched controls and then analyzed by single stranded conformational polymorphism. Amplified products showing altered mobility patterns were sequenced and analyzed. Twelve variations were identified in exonic and intronic regions of DNA encoding SH2 domain and kinase domain of the SYK gene. All of these mutations are novel. Among them, 5 missense mutations were observed in exon 15 while one missense mutation was found in exon 8. In addition to these mutations, six mutations were also identified in intronic regions. We found a significant association between SYK mutations and breast cancer and observed that Glu241Arg, a missense mutation is associated with an increase risk of ~7 fold (OR=6.7, 95% CI=1.54-28.8), Thr581Pro (missense mutation) is associated with increased risk of ~16 fold (OR=15.5, 95%CI=2.07-115.45) and 63367 T>G (missense mutation) is associated with increased risk of ~13 fold (OR=12.8, 95%CI=1.71-96.71) for breast cancer. Significant associations were observed for each of these variations with both late menopause (p<0.01) and early menarche (p<0.005) cases when compared to controls. Our findings suggest that the polymorphic gene SYK may contribute to the development of breast cancer in at least the Pakistani population. This study provides an insight view of SYK which may provide a significant finding for the pharmaceutical and biotechnology industry.

• Journal of Korean Academy of Nursing
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• v.17 no.2
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• pp.137-144
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• 1987

The main purpose of this study was to examine the validity of the vital sign as an instrument of stress reaction measurement. From July to August 1986, stress reaction was evaluated by the difference of endoscopic vital sign on 93 G-I troubled out-patients who underwent endoscopy for the first time and did not have any evidence of cardiovascular disease. The data were analysed by x$^2$-test, Paired . t-test, ANCOVA and Multiple Comparison Test. The result of study were as follows: 1. The frequency of gastric disease was differed by the family type, and the mobility of gastritis and gastric cancer were more increased in nuclear family than in large family (p=0.019). 2. In a comparison of before with after 5 minutes endoscopic vital sign, and a Pulse rate (P=0.0001), respiration rate (p=0.0001), systolic blood pressure (p=0.0002) and diastolic blood Pressure (P=0.006) were significantly increased after 5minutes by endoscopy in contrast with before 5minutes. 3. The control of before 5 minutes of endoscopic vital sign, after 5 minutes of endoscopic systolic (p=0.024) and diastolic blood pressure (p=0.0146) were more elevated in biopsyed group than in non-biopsyed, group. And after 5minutes of endoscopic respiration rate was more increased in gastric cancer than in gastritis (p=0.0406) or gastric ulcer (p=0.0073). And after 5 minutes of endoscopic systolic blood pressure was elevated over 50years old men (P=0.0238). In short, the increase of a pulse rate af ter 5 minutes of endoscopy was not influenced by general characteristics of samples in this experiment. And systolic blood pressure over 50years old men must be considered of physiological hypertension.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.207.1-207.1
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• 2014

High-mobility and two dimensional conduction at the interface between two band insulators, LaAlO3 (LAO) and SrTiO3 (STO), have attracted considerable research interest for both applications and fundamental understanding. Several groups have reported the photoconductivity of LAO/STO, which give us lots of potential development of optoelectronic applications using the oxide interface. Recently, a giant photo response of Pd nano particles/LAO/STO is observed in UV illumination compared with LAO/STO sample. These phenomena have been suggested that the correlation between the interface and the surface states significantly affect local charge modification and resulting electrical transport. Water and gas adsorption/desorption can alter the band alignment and surface workfunction. Therefore, characterizing and manipulating the electric charges in these materials (electrons and ions) are crucial for investigating the physics of metal oxide. Proposed mechanism do not well explain the experimental data in various ambient and there has been no quantitative work to confirm these mechanism. Here, we have investigated UV photo response in various ambient by performing transport and Kelvin probe force microscopy measurements simultaneously. We found that Pd nano particles on LAO can form Schottky contact, it cause interface carrier density and characteristics of persistence photo conductance depending on gas environment. Our studies will help to improve our understanding on the intriguing physical properties providing an important role in many enhanced light sensing and gas sensing applications as a catalytic material in different kinds of metal oxide systems.

• Journal of KIISE:Information Networking
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• v.31 no.3
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• pp.289-297
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• 2004

State-of-the-art wireless communication networks allow dynamic relocation of mobile terminals. A location management mechanism is required to keep track of a mobile terminal for delivering incoming calls. In this paper, we propose a fuzzy logic-based selective paging method to reduce paging cost. In the proposed fuzzy logic-based location management method, the location update uses the area-based method that uses direction-based together with movement-based methods, and the location search uses the fuzzy logic-based selective paging method based on the mobility information of mobile terminals. A partial candidate paging area is selected by fuzzy control rules, then the fuzzy logic-based selective paging method pages only the cells within the partial candidate paging area. The performance of proposed fuzzy logic-based location management method is to be evaluated by both an analytical model and a simulation, and is compared with those of LA and BVP methods. From these evaluation results, we know that the proposed fuzzy logic-based location management method provide better performance than other location management methods.