• Title/Summary/Keyword: MoCA

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Cognitive Functions, Instrumental Activities of Daily Living, Depression and Quality of Life in the Elderly with Mild Cognitive Impairment (경도인지장애 노인의 인지기능, 도구적 일상생활수행능력, 우울 및 삶의 질 관계)

  • Kim, Yeon Ok;Shim, Moon Sook
    • Journal of Korean Public Health Nursing
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    • v.29 no.2
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    • pp.219-230
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    • 2015
  • Purpose: This research study not only examine the relationship between cognitive function, IADL, depression and quality of life, but also clarifies factors impacting quality of life for the elderly. The purpose of this study is to administer health promotion programs and to improve quality of life for the elderly. Methods: Data were collected from May 20, to June 10, 2014. The participants were 157 elderly persons with mild cognitive injury (MCI), who had under 23 points on MoCa-K from three different senior welfare centers in Daejeon. The questionnaires were conducted by four university students after receiving instruction from the researcher and consisted of general characteristics, cognitive function, depression and quality of life. SPSS WIN 19.0 program was used for data analysis. Results: Cognitive function showed positive correlation with quality of life (r=175, p=.028). IADL did not show correlation with quality of life (r=-.005, p=.947). However cognitive function(r=-.344, p<.001) and depression (r=-.623, p<.001) showed negative correlation with quality of life. In addition, the factors impacting quality of life were cognitive function (${\beta}=.14$, p=.29) and depression (${\beta}=-.61$, p<.001) which accounted for 39% of quality of life. Conclusion: These findings showed that the participants had depression and their cognitive function was low. As a result, the more participants' cognitive function decreased, the more their quality of life decreased. In addition, the more their depression decreased, the more their quality of life improved.

Gap comparison between single crown and three-unit bridge zirconia substructures

  • Anunmana, Chuchai;Charoenchitt, Masnisa;Asvanund, Chanavut
    • The Journal of Advanced Prosthodontics
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    • v.6 no.4
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    • pp.253-258
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    • 2014
  • PURPOSE. To compare marginal and internal gaps of zirconia substructure of single crowns with those of three-unit fixed dental prostheses. MATERIALS AND METHODS. Standardized Co-Cr alloy simulated second premolar and second molar abutments were fabricated and subsequently duplicated into type-III dental stone for working casts. After that, all zirconia substructures were made using $Lava^{TM}$ system. Marginal and internal gaps were measured in 2 planes (mesial-distal plane and buccal-palatal plane) at 5 locations: marginal opening (MO), chamfer area (CA), axial wall (AW), cusp tip (CT) and mid-occlusal (OA) using Replica technique. RESULTS. There were significant differences between gaps at all locations. The $mean{\pm}SD$ of marginal gap in premolar was $43.6{\pm}0.4{\mu}m$ and $46.5{\pm}0.5{\mu}m$ for single crown and 3-unit bridge substructure respectively. For molar substructure the $mean{\pm}SD$ of marginal gap was $48.5{\pm}0.4{\mu}m$ and $52.6{\pm}0.4{\mu}m$ for single crown and 3-unit bridge respectively. The largest gaps were found at the occlusal area, which was $150.5{\pm}0.5{\mu}m$ and $154.5{\pm}0.4{\mu}m$ for single and 3-unit bridge premolar substructures respectively and $146.5{\pm}0.4{\mu}m$ and $211.5{\pm}0.4{\mu}m$ for single and 3-unit bridge molar substructure respectively. CONCLUSION. Independent-samples t-test showed significant differences of gap in zirconia substructure between single crowns and three-unit bridge (P<.001). Therefore, the span length has the effect on the fit of zirconia substructure that is fabricated using CAD/CAM technique especially at the occlusal area.

Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors

  • Park, Joonhong;Yoo, Han Mo;Sul, Hae Jung;Shin, Soyoung;Lee, Seung Woo;Kim, Jeong Goo
    • Journal of Gastric Cancer
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    • v.20 no.1
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    • pp.29-40
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    • 2020
  • Purpose: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors. In this study, a targeted next-generation sequencing (NGS) assay with an Oncomine Focus Assay (OFA) panel was used for the genetic characterization of molecular targets in 30 Korean patients with GIST. Materials and Methods: Using the OFA that enables rapid and simultaneous detection of hotspots, single nucleotide variants (SNVs), insertion and deletions (Indels), copy number variants (CNVs), and gene fusions across 52 genes relevant to solid tumors, targeted NGS was performed using genomic DNA extracted from formalin-fixed and paraffin-embedded samples of 30 GISTs. Results: Forty-three hotspot/other likely pathogenic variants (33 SNVs, 8 Indels, and 2 amplifications) in 16 genes were identified in 26 of the 30 GISTs. KIT variants were most frequent (44%, 19/43), followed by 6 variants in PIK3CA, 3 in PDGFRA, 2 each in JAK1 and EGFR, and 1 each in AKT1, ALK, CCND1, CTNNB1, FGFR3, FGFR4, GNA11, GNAQ, JAK3, MET, and SMO. Based on the mutation types, majority of the variants carried missense mutations (60%, 26/43), followed by 8 frameshifts, 6 nonsense, 1 stop-loss, and 2 amplifications. Conclusions: Our study confirmed the advantage of using targeted NGS with a cancer gene panel to efficiently identify mutations associated with GISTs. These findings may provide a molecular genetic basis for developing new drugs targeting these gene mutations for GIST therapy.

Environmental Feature Causing a Bloom of the Novel Dinoflagellate Heterocapsa circularisquama (Dinophyceae) in Uranouchi Bay, Kochi Prefecture, Japan (일본 Kochi현 Uranouchi만의 와편모조류, Heterocapsa circularisquama (Dinophyceae) 적조발생에 대한 환경 고찰)

  • O, Seok-Jin;Ma,;O,;Mo,;U,
    • ALGAE
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    • v.18 no.4
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    • pp.281-288
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    • 2003
  • To study the environmental features causing a bloom of the novel dinoflagellate Heterocapsa circularisquama (Dinophyceae), hydrographic and chemical aspects were measured in the Uranouchi Bay, Kochi Prefecture, Japan, from January to December, 1997. The cell density of H. circularisquama increased rapidly in early October, and dropped sharply in mid-October. Growth rate of H, circularisquama during bloom period appeared 1.50 division day$^{-1}$ under high water temperature (25$^{\circ}C$) and salinity (32 psu) conditions. Althought the result from hydrographic aspect indicated good condition for their growth, dissolved inorganic phosphorus (DIP) concentration in surface layer before bloom formation was less than 0.70uM, which is lower than their half saturation constant(Ks). Dissolved inorganic nitrogen(DIN): DIP ratio was > 30, indicating potential P-limitation. However, before bloom formation period of H. circularisquama, DIP concentrations were high in bottom layer (> 4.0 uM). Some studies reported that H. circularisquama had the ability to migrate vertically and to utilize dissolved organic phosphorus (DOP). Thus, DIP in bottom layer might have been utilized by H. circularisquama for their growth.DOP might have weakly affected their growth because of low reactive DOP concentrations owing to low DOP concentration (ca. 0.39 uM). Thus, if nutrient condition of bottom layer in Uranuchi Bay is not improved, the outbreaks of H. circularisquama red tides may became an annual feature.

Reversion to Normal Cognition and Its Correlates among the Community-dwelling Elderly with Mild Cognitive Impairment: the Longitudinal Cohort Study (경도인지장애 노인의 인지기능 회귀와 관련요인: 종단적 코호트 연구)

  • Kang, Younhee;Whang, Sun A;Park, Kuemju
    • Korean Journal of Adult Nursing
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    • v.27 no.6
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    • pp.656-664
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    • 2015
  • Purpose: The purposes of this study were to identify the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) among the community-dwelling elderly and to determine if there were differences in cognitive function, leisure activities, and exercises between the group with MCI-maintained and the group with reversion to NC. Methods: This study utilized a longitudinal descriptive comparative design. A total of 346 subjects over age 65 was recruited from public health center at baseline. Finally 152 elderly were enrolled at 1 year follow-up. Data were collected through MoCA-K, K-MMSE, KDSQ-C5 and questionnaires on leisure activities and exercises. Data were analyzed by IBM SPSS Statistics 21.0 using descriptive statistics, $x^2$ test, and t-test. Results: The rate of reversion from MCI to NC among the subjects was 44.1%. At baseline, the group with MCI-maintained had lower cognitive function than the group with reversion to NC. At 1 year follow-up, the group with reversion to NC had higher subjective cognitive function than the group with MCI-maintained. Regarding leisure activities, there were differences between the groups at baseline and 1 year follow-up. Conclusion: It is suggested that age, education year, subjective cognitive function, and leisure activities should be considered at planning a nursing intervention for MCI.

An Analysis of Saengmaegsan's Ingredients and a Comparison Study on Anti-Oxidation Effects According to Kinds of Extract (생맥산(生脈散)과 구성 약물의 성분 분석 및 항산화(抗酸化) 효능 비교)

  • Lee, Sang-Heon;Park, Chi-Sang;Kim, Dae-Jun;Kim, Seung-Mo
    • The Journal of Korean Medicine
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    • v.30 no.5
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    • pp.26-41
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    • 2009
  • Objectives: The experiment was to estimate the value of Saengmaegsan as a therapeutic anti-aging agent with an analysis of ingredients and their bio-activating effects by enzymologic methods. Methods: We analyzed anti-aging effects of the ingredients of Saengmaegsan being Liriope Platyphylla, Schizandrae Chinensis, and Schizandrae Chinensis. Results: In Liriope Platyphylla and Schizandrae Chinensis, reducing sugar concentration was shown at the highest level. Of mineral contents, K+ and Na+ were the highest in Saengmaegsan and each ingredient also, and then Ca++ and Al. The amount of polyphenol showed was in order Schizandrae Chinensis > Saengmaegsan > Panax Ginseng > Liriope Platyphylla. The electron donating ability of Schizandrae Chinensis doubled that of Saengmaegsan and Panax Ginseng, at the same time that one per 1 ml in Saengmaegsan was significantly found the greatest level as compared to each single ingredient. SOD-like activity was high in Saengmaegsan and Schizandrae Chinensis. SOD-like activity of Saengmaegsan was higher than in single components. Nitric oxide inhibition in pH 1.2 was high in Saengmaegsan and Schizandrae Chinensis, and for per 1 ml it showed the same pattern as above. In pH 3.0 the result was not different from in pH 1.2. Xanthine oxidase inhibition was high in Schizandrae Chinensis and for per 1 ml showed the greatest activity in Liriope Platyphylla. Tyrosinase inhibition in Omija was the most noticeable, and for per 1 ml was Liriope Platyphylla more than any others. Conclusions: With this analysis of ingredients, it is proven that Saengmaegsan and each component fosters antioxidation. On the whole, the composite prescription Saengmaegsan was superior to each individual component.

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Estimation of Carrying Capacity in Kamak Bay ( II ) - Estimation of carrying capacity of oyster culture ground - (가막만의 환경용량 산정 ( II ) -굴양식장 환경용량 산정-)

  • CHO Eun-Il;PARK Chung-Kil;LEE Suk-Mo
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.29 no.5
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    • pp.709-715
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    • 1996
  • In order to estimate the carrying capacity of oyster culture ground in Kamak Bay, primary productivity was calculated using the ecosystem model. The allowable maximum oyster production, namely, the carrying capacity of Kamak Bay was estimated by using the annual phytoplankton production and conversion coefficient to oyster meat. On the environmental conditions of oyster culture period from lune, 1994 to March, 1995, phytoplankton production, the allowable maximum oyster production were estimated to be 181,594 tons of carbon and 287,033 tons of oyster meat, respectively. The allowable maximum oyster production was estimated to be 15,443 tons in the actual culture ground where oyster culture facilities are installed in Kamak Bay. In 1994 4,532 tons of actual oyster meat production was equivalent to ra. $29\%$ of carrying capacity, and in 1987 it was 14,592 tons equivalent to ca. $95\%$.

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Evaluation of the health status of preschool children stratified based on the weight-length index (WLI)

  • Shin, Kyung-Ok;Chung, Keun-Hee;Park, Hyun-Suh
    • Nutrition Research and Practice
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    • v.4 no.5
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    • pp.383-392
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    • 2010
  • This study was conducted to prepare basic materials and offer advice regarding dietary habits to prevent and cure childhood obesity by comparing and analyzing dietary habit, nutritional status, blood factors, and mineral contents of hair. All subjects were stratified by their weight-length index (WLI). According to the standard WLI values, 64.9% of children were within the normal value, 13.5% of children were underweight, and 21.6% of children were overweight and obese (WLI ${\geq}$ 110%). Overall, the score assessed dietary habit for all children was $21.32{\pm}2.55$ point (921 subjects), with 5.1% of children having excellent dietary habits and 3.1% having poor dietary habits. Additionally, 37.9% of underweight children, 37.6% of normal weight children, and 43.2% of overweight and obese children consumed higher amounts of protein than underweight children did (meat, fish, eggs, and soy products) (P < 0.05). Overweight and obese children consumed more fried foods than underweight or normal weight children (P < 0.05). Moreover, 38.0% of the children had hemoglobin levels of 12 g/dl, while 7.6% were anemic (11.1 g/dl). When a hematocrit level of 33% was taken as the standard, 11.0% of children were anemic. The plasma transferrin content was $263.76{\pm}54.52$ mg/dl in overweight and obese children. The mean values of Fe, Cu, Ca, Cr, Mn, Se, Na, K, Li, V, Co, and Mo were within the reference values, but the Zn concentrations of underweight, normal weight, and overweight and obese children were $67.97{\pm}28.51$ ppm, $70.09{\pm}30.81$ ppm, and $73.99{\pm}30.36$ ppm, respectively. The Zn concentration of overweight and obese children ($73.99{\pm}30.36$ ppm) was lower than that of the standard value (180~220 ppm). Therefore, a nutritional education program and new guidance for dietary pattern should be developed to reduce the number of underweight and overweight and obese children.

Electromagnetic Properties of Magnetic Core Materials and Attenuation of Blocking Filter (Blocking filter용 자심 재료의 전자기 특성 및 신호 감쇄율)

  • 오영우;이해연;김현식
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.16 no.6
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    • pp.490-495
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    • 2003
  • The electromagnetic properties and thermal behavior of Mn-Zn ferrite cores for the blocking filter of Power Line Communication(PLC) application were investigated as a function of additives. The highest density and permeability were 4.98 g/$\textrm{cm}^2$ and 8,221, respectively and were obtained to the specimen with composition of MnO 24 mol%, ZnO 25 mol% and Fe$_2$O$_3$ mol%, added MoO$_3$ of 400 ppm, SiO$_2$ of 100 ppm, and CaO of 200 ppm. The uniform grains were organized, and the microstructures were densified due to reduction of pores in the specimen. The permeability was increased up to 13,904 as the temperature of specimen increased to 110$^{\circ}C$. However, it was decreased precipitously under 100 over 110$^{\circ}C$. The exothermic behavior was observed in the frequency range from 1 kHz to 1 MHz, and the maximum temperature of specimen was 102$^{\circ}C$ at 1 MHz. In the consequence, the Mn-Zn ferrite core developed in this research will maintain the stable electromagnetic properties since the temperature of ferrite core rose to 93$^{\circ}C$ in the range of 100 kHz to 450 kHz bandwidth qualified for PLC. The blocking filters were designed for single phase and three phases using the in-line and non-contact core. The best attenuation ratios of -46.46 dB and -73.9 dB were measured in the range of 100 kHz to 450 kHz bandwidth, respectively.

Inoculation with Indole-3-Acetic Acid-Producing Rhizospheric Rhodobacter sphaeroides KE149 Augments Growth of Adzuki Bean Plants Under Water Stress

  • Kang, Sang-Mo;Adhikari, Arjun;Lee, Ko-Eun;Khan, Muhammad Aaqil;Khan, Abdul Latif;Shahzad, Raheem;Dhungana, Sanjeev Kumar;Lee, In-Jung
    • Journal of Microbiology and Biotechnology
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    • v.30 no.5
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    • pp.717-725
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    • 2020
  • The use of plant growth-promoting rhizobacteria is economically viable and environmentally safe for mitigating various plant stresses. Abiotic stresses such as flood and drought are a serious threat to modern agriculture. In the present study, the indole-3-acetic acid-producing rhizobacterium R. sphaeroides KE149 was selected, and its effects on the growth of adzuki bean plants under flood stress (FS) and drought stress (DS) were investigated. IAA quantification of bacterial pure culture revealed that KE149 produced a significant amount of IAA. Moreover, KE149 inoculation notably decreased stress-responsive endogenous abscisic acid and jasmonic acid and increased salicylic acid in plants under DS and FS. KE149 inoculation also increased proline under DS and methionine under FS. In addition, KE149 inoculation significantly increased the levels of calcium (Ca), magnesium (Mg), and potassium (K) while lowering the sodium (Na) content in the plant shoot under stress. KE149-treated plants had markedly greater root length, shoot length, stem diameter, biomass, and higher chlorophyll content under both normal and stressed conditions. These results suggest that KE149 could be an efficient biofertilizer for mitigating water stress.