• 한국지구과학회지
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• 제43권4호
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• pp.498-510
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• 2022

Cloud-aerosol interactions are one of the paramount but least understood forcing factors in climate systems. Generally, an increase in the concentration of aerosols increases the concentration of cloud droplet numbers, implying that clouds tend to persist for longer than usual, suppressing precipitation in the warm boundary layer. The cloud lifetime effect has been the center of discussion in the scientific community, partly because of the lack of cloud life cycle observations and partly because of cloud problems. In this study, the precipitation susceptibility (S_o) matrix was employed to estimate the aerosols' effect on precipitation, while the non-aerosol effect is minimized. The S_o was calculated for the typical coupled, well-mixed maritime stratocumulus decks and giant cloud condensation nucleus (GCCN) seeded clouds. The GCCN-artificially introduced to the marine stratocumulus cloud decks-is shown to initiate precipitation and reduces S_o to approximately zero, demonstrating the cloud lifetime hypothesis. The results suggest that the response of precipitation to changes in GCCN must be considered for accurate prediction of aerosol-cloud-precipitation interaction by model studies

• 한국미생물·생명공학회지
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• 제50권4호
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• pp.512-521
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• 2022

Since the main symptoms of COVID-19 involve the respiratory system, the infection rate of this disease is predicted to be higher in patients with other respiratory conditions such as allergic rhinitis. In such a situation, it will be meaningful to conduct research on an allergy treatment that has fewer side effects and can effectively reduce allergy symptoms. Here, we prepared experimental samples under various fermentation conditions with mixed extracts of six medicinal plants. To examine the anti-allergic efficacy of these samples, an egg albumin-induced allergic rhinitis animal model experiment, a serum histamine and IgE experiment, and a COX and LO inhibitory activity experiment were conducted. As a result of animal experiments, OVA+SP-4 showed superior efficacy compared to OVA+SP-1 in nasal rubbing and sneezing experiments and had anti-allergic efficacy similar to that of OVA-cetirizine. The serum histamine concentration of OVA+SP-4 was also 1.3 times higher than that of the OVA+cetirizine group, showing a high histamine reduction ability, and IgE showed the same trend. An analysis of COX inhibitory efficacy also confirmed that COX-1 and COX-2 inhibitory efficacy is high, and the longer the fermentation time, the higher the antiallergic efficacy. The composition proposed by this study is expected to have a significant effect on sustainable allergy prevention and treatment in the future by applying it to human patients.

• Radiation Oncology Journal
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• 제30권4호
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• pp.189-196
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• 2012

Purpose: To investigate the safety of high dose hypofractionated radiotherapy (RT) in patients with small hepatocellular carcinoma (HCC) in terms of liver volumetric changes and clinical liver function. Materials and Methods: We retrospectively reviewed 16 patients with small HCC who were treated with high dose hypofractionated RT between 2006 and 2009. The serial changes of the liver volumetric parameter were analyzed from pre-RT and follow-up (FU) computed tomography (CT) scans. We estimated linear time trends of whole liver volume using a linear mixed model. The serial changes of the Child-Pugh (CP) scores were also analyzed in relation to the volumetric changes. Results: Mean pre-RT volume of entire liver was 1,192.2 mL (range, 502.6 to 1,310.2 mL) and mean clinical target volume was 14.7 mL (range, 1.56 to 70.07 mL). Fourteen (87.5%) patients had 4 FU CT sets and 2 (12.5%) patients had 3 FU CT sets. Mean interval between FU CT acquisition was 2.5 months. After considering age, gender and the irradiated liver volume as a fixed effects, the mixed model analysis confirmed that the change in liver volume is not significant throughout the time course of FU periods. Majority of patients had a CP score change less than 2 except in 1 patient who had CP score change more than 3. Conclusion: The high dose hypofractionated RT for small HCC is relatively safe and feasible in terms of liver volumetric changes and clinical liver function.

• 한국콘텐츠학회논문지
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• 제15권3호
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• pp.206-218
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• 2015

본 연구는 간호대학생에게 적용한 시뮬레이션기반 임상추론 교육의 임상판단 수행능력, 협력 및 의사소통기술에 대한 효과와 교육 후 교육상황과 설계특성 인식의 변화를 확인하기 위한 비동등성 대조군 전후 유사실험 연구설계이다. 연구대상은 A시 소재 4년제 2개 대학 간호학과의 3학년 학생을 각각 편의표집한 실험군 19명, 대조군 28명으로 실험군에게는 시뮬레이션 기반 임상추론 교육 프로그램을 매주 1회 120분씩 총 7회 제공하였고 대조군에게는 일상적 간호교육을 제공 후 두군 모두 사전조사와 중재 7주후에 임상판단 수행능력, 협력 및 의사소통기술을 측정하되, 협력은 중재 4주후에도 측정하였다. 교육상황과 설계 특성 인식은 시뮬레이션 교육 경험 후에 응답할 수 있어 실험군에서만 중재 1주, 4주, 7주후에 측정하였다. 자료는 SAS 9.2 프로그램의 반복측정 분산분석 및 Linear mixed model으로 분석하였다. 분석결과 실험군에서 임상판단 수행능력, 의사소통기술과 협력이 유의하게 증가하였으며, 중재 1회와 7회 간의 시뮬레이션 교육상황과 설계특성의 인식이 증가하였고, 이러한 변화가 임상수행능력, 협력, 의사소통기술 효과에 긍정적 영향을 미쳤다. 연구결과에 근거할 때 시뮬레이션 기반 임상추론 교육은 임상판단 수행능력, 협력, 의사소통기술을 행동수준까지 향상시킬 수 있는 교수학습 전략으로 적극적 활용되어야 하며 추후 표본 수를 확대하여 교육효과를 검증하고, 교육상황과 설계특성 인식 정도를 시뮬레이션 교육 프로그램 평가 지표로 고려하여야 하겠다.

• 공업화학
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• 제30권5호
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• pp.606-614
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• 2019

본 연구에서는 palm oil과 서로 다른 HLB (hydrophile-lipophilie balance) value를 갖는 Tween-Span계 비이온성 계면활성제를 혼합하여 O/W (oil in water) 유화액을 제조하고, 유화액의 유화안정성을 향상시키기 위한 최적 유화조건을 결정하였다. 이를 위해 CCD-RSM (central composite design model-response surface methodology)을 이용하여 각 계량인자의 주효과 및 교호효과를 해석하였으며, 두 가지 반응치를 동시에 만족하는 최적조건을 결정하였다. CCD-RSM의 계량인자로는 유화시간, 유화속도, HLB value, 계면활성제의 첨가량 등을 설정하고, 반응치로는 O/W 유화액의 점도와 평균액적크기를 설정하였다. CCD-RSM 최적화 분석결과 반응치인 O/W 유화액이 점도와 평균액적크기의 목표치를 동시에 부합하는 최적조건은 유화시간(12.7 min), 유화속도(5,551 rpm), HLB value (8.0), 계면활성제의 첨가량(5.7 wt.%)으로 산출되었으며, 이 조건에서의 CCD-RSM 예측결과는 점도(1,551 cP)와 평균액적크기(432 nm)이었다. 이 조건의 실제 실험 결과 오차율은 2.5% 이하로 나타나 O/W 유화액 제조과정에 CCD-RSM 최적화 분석을 적용할 경우 비교적 높은 유의수준의 만족하는 결과를 얻을 수 있었다.

• 대한교통학회지
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• 제17권1호
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• pp.131-139
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• 1999

신호 교차로의 지체도에 미치는 가장 큰 영향요소중의 하나는 신호연동인데 신호연동지체도 예측모형으로서 T7RANSTY-7F모형과 NETSIM모형이 가장 널리 사용되고 있다. 이는 컴퓨터 프로그래밍기법을 이용해야 하는 복잡함과 실행과정이 쉽지않다. 본 연구는 연동지체의 산정을 도로용량편람의 사용예처럼 간편하면서 시뮬레이션모형과 유사한 결과를 갖는 모형을 연구하기 위하여 이루어졌다. 연구의 범위는 차량군을 대상으로한 거시적모형이며 신호교차로 연동지체를 평가하는 해석적 모형이다. 그리고 정상류상태(v/c<1)를 대상으로 하면서 차량군지체만을 산정하는 모형이다. 본 연구방법은 차량군도착으로 형성되는 누적교통량·시간함수에 의한 지체도산정을 적분법으로서 두 개의 도착유형으로 구분하여 산출하였으며 본 연구결과로는 제안모형내에 차량군 연속진행의 도착패턴을 직접적으로 반영하였고 현실 특성에 부합된 차량군형태를 구성하였다. TRANSTY-7F모형과 유사한 결과를 도출하였으며 수계산으로도 적용할 수 있고 기존의 해석적 모형이 결여된 경우에 대한 지체도예측도 가능하였다.

• 한국유기농업학회지
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• 제24권4호
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• pp.957-967
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• 2016

The present study was conducted to investigate effect of dietary protected amino acid on milk yield and composition in dairy cow using meta-analysis. Total 21 research papers were employed in analysis, and mixed model was used for the analysis of effects. Effect of protected methionine (PM) and combination of protected methionine and lysine (PML) were investigated under two different levels of dietary crude protein (CP, <18% and >18%). For performance of dairy cow, milk yield, milk composition including milk fat and protein content and yield and 4% FCM (fat corrected milk) production were used for analysis. In case of milk yield, a trend of increment was found at PM supplementation at low CP (P=0.055). However, the effect of PM at high CP was detected as not significant (P>0.05). In case of milk protein, inclusion of PM at low CP showed significant decrement (P<0.05). However, there was no significant effect of MP on milk protein at high CP (P>0.05). Supplementation of MP at high CP level showed significant increment of milk fat (P<0.05). MP supplementation represented significant increment of 4% FCM production (P<0.05) regardless of dietary CP levels. Effects of PML on milk yield and composition at both of low and high dietary CP were not significant in this study. However, it seem to be that there was a possible positive effect of MPL application at high dietary CP on performance of dairy cow.

• 대한치과교정학회지
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• 제16권1호
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• pp.51-70
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• 1986

Parathyroid hormone (PTH) is known to exert its effects on bone cells through the mediation of adenosine 3', 5'-monophosphate (cAMP). Orthodontic forces have also been shown to alter the cAMP content of paradental cells, particularly the alveolar bone osteoblasts. The objective of this experiment was to determine whether a combined orthodontic treatment-PTH administration regimen would have an additive effect on cAMP content in paradental cells in sites of periodontal ligament (PDL) tension. Seven groups of 4 one year old female cats each were treated for 1,3,6,12,24 h, 7 and 14 d by tipping one maxillary canine. PTH was administered twice daily, 30u/kg. Maxillary horizontal sections were stained immunohistochemically for cAMP and the degree of cellular staining intensity was determined microphotometrically as per cent light transmittance at 600nm. Alveolar bone osteoblasts, progenitor cells, PDL fibroblasts and cementoblasts in tenion sites were measured and the data were analyzed statistically by a mixed model analysis of variance. PTH administration increased the cAMP staining of nonorthodontically treated paradental cells in comparison to cells untreated by force or hormone. Cells in PDL tension sites of PTH-treated cats demonstrated significantly darker cAMP staining than cells in non-orthodontically-treated sites. Osteoblasts demonstrated the greatest response in terms of cAMP elevation, while in PDL fibroblasts orthodontic force did not increase cAMP levels above those measured in non-stretched hormonally-treated cells. These results demonstrate that PTH increases cAMP levels in paradental cells, particullarly in osteoblasts, and that the effects of PTH and orthodontic forces on paradental target cells may approach additivity.

• Nutritional Sciences
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• 제7권4호
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• pp.189-195
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• 2004

1bis study investigated the antioxidative effect in kidney of senescence-accelerated prone SAMP8 mice with calorie restriction. 4-weeks-old SAMP8 female mice were divided into 4 groups according to the experimental feeding period: for 4, 8, 12 month, and at natural death. Each group was subdivided into 2 groups, with thirteen mice each one, as ad libitum group and as dietary restriction group (60% of ad libitum feeding amount). After feeding for a given period, the mice were sacrificed to get the following results: among the experimental groups, there wereno significant differences in xanthine oxidase (XOD) activity in their kidney tissues. The contents of cytochrome $P_{450}$ decreased in ad libitum group and dietary restriction group by age. The activity of NADPH-cytochrome $P_{450}$ reductase showed a trend similar to cytochrome $P_{450}$. Superoxide radical content increased with age. At the 4th, 8th and 12 months of the experimental period, the activity in the dietary restriction group was less than that of ad libitum group by as much as 17% 14% and 14% respectively. For hydrogen peroxide, the contents were increased in the ad libitum group with age, while no correlation between content and age was observed in the dietary restriction group. In the 8th and 12th months of the experimental period, the were in the dietary restriction group less than that of ad libitum group counterpart as much as 17% and 20o/c, respectively. For the cellular membrane stability of the kidney, no significant correlation with age was observed in either the dietary restriction group or the ad libitum group. However at the 12th month of the experiment, however, the stability in the dietary restriction group was 11 % higher than that in the ad libitum group. In conclusion, with these results obtained from the SAMP8 mouse model, we demonstrate that dietary restriction has the effects of anti-oxidation and anti-senescence in the kidney.

• 한국정보시스템학회지:정보시스템연구
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• 제26권3호
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• pp.119-147
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• 2017

Purpose In an online e-commerce environment without face-to-face contact between the seller and the buyer, the attitudes of consumers differ greatly depending on which framing strategy is applied, even in cases when the benefits of the deals represent the same value. The purpose of this study is to explore the effects of price-framing and message-framing strategies on consumer attitudes through an experimental analysis in the context of online travel product purchasing. This study suggests a research model based on prospect theory and prior literature on price-framing and message-framing strategies. Design/methodology/approach The experiment was structured as a 2 (discount price presentation: 'Won' vs. '%') ${\times}$ 2 (discount level: low vs. high) ${\times}$ 2 (time-limit message: none vs. one) mixed design. The research hypotheses were tested in a study of 200 undergraduate and graduate students assigned randomly and distributed evenly to each of the eight cells. Findings The findings indicate that consumer attitudes become more favorable when the '%' discount, higher discount rate, and time-limit message are presented. However, no significant interaction effect is found between the discount price presentation and the discount level/time-limit message. This study has a theoretical implication in that it extends the scope of research by examining the influence of framing strategies on experience goods such as online travel products. Moreover, this study can provide managers with more specific guidelines when establishing framing strategies in the context of purchasing online travel products.