• Title/Summary/Keyword: Mixed Methods Research

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Animal Model for Sequential Bilateral Reimplantation of the Lung in Dog (순차적 자가 양측 폐재식을 위한 황견에서의 실험 model -2례 보고)

  • 이두연;김해균
    • Journal of Chest Surgery
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    • v.30 no.7
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    • pp.733-738
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    • 1997
  • Sequential bilateral lung transplantation may result in a variety of perioperative and postoperative complications, showing high perioperative morbidity and mortality rates. This research was performed to investigate the hemodynamic changes in adult mongrel dogs after bilateral reimplantation, two methods preferred for avoiding or minimizing graft rejection. The anterior portion of the pulmonary artery and the left atrium proximal to the superior and the inferior pulmonary veins were resected out and then re-anastomosed one hour later to prevent torsion or stenosis of the anastomotic site and the formation of a thrombosis in the left atrium. An everted suture technique was employed for the left atrium; An hour after the division, however, the main bronchus was tightly anastomose by interrupted sutures of No. 4-0 prolene in a telescope method. A modified I-C solution mixed with PGEI was infused into the cut portion of the pulmonary artery at the rate of 15 mllkglmin and at a pressure of 40 cmH20 for a total dosage of 70 mlfkg in order to preserve the transected lung. Topical cooling using wet gauzes soaked with cold I-C solution was performed for one hour to prevent ischemic lung injury. The above procedures are considered to be beneficial for achieving a satisfactory outcome for bilateral lung reimplantation.

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Effect of Suppressing the Activation of Macrophage Migration Inhibitory Factor by $Sambucus$ $williamsii$ $H_{ANCE}$ Extract & Pharmacopuncture Solution on Type II Collagen-induced Arthritis (접골목(接骨木)추출물 및 약침액에 의한 MIF 활성 조절능이 생쥐의 제2형 Collagen 유발 관절염에 미치는 영향)

  • Lee, Dong-Gun;Kim, Eun-Jung;Lee, Eun-Sol;Wang, Kai-Hsia;Cho, Hyun-Seok;Lee, Seung-Deok;Kim, Kap-Sung;Kim, Kyung-Ho
    • Journal of Acupuncture Research
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    • v.29 no.1
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    • pp.103-113
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    • 2012
  • Objectives : The purpose of this study is to evaluate effect of suppressing the expression of cyclo-oxygenase-type-2 (COX-2) as a consequence of inhibition macrophage migration inhibitory factor (MIF) activation by $Sambucus$ $williamsii$ $Hance$ (SWH) pharmacopunctureon rheumatoid arthritis (RA). Methods : In vitro test, synoviocytes extracted from type II collagen-induced arthritis (CIA) mouse's knee joint were cultivated After that, each well of synoviocytes was mixed with the extract of SWH at the dosage of $0.4mg/m{\ell}$, $0.6mg/m{\ell}$, $0.8mg/m{\ell}$, and $1.0mg/m{\ell}$ respectively, and cultivated for 24 hours after the addition. Reverse transcriptase - polymerase chain reaction (RT-PCR) is used to investigate the expression of MIF, Tumor necrosis factor (TNF)-${\alpha}$, COX-2 mRNA. $In$ $vivo$ test, thirty DBA female mice were used, and each ten mice were allocated into three group; normal group, CIA-elicitated group, and group treated with SWH pharmacopuncture on it's the point of $ST_{35}$ after CIA elicitation. It is investigated that change of mice foot thickness, histologic change of sliced synovial joint of mouse, and extent change of MIF, TNF-${\alpha}$, COX-2 in synovial membrane. Results : $In$ $vitro$ test, the expressions of cytokine(MIF, TNF-${\alpha}$, COX-2) mRNAs related to RA were dose-dependent decreased. In the SWH pharmacopuncture group, foot thickness and histologic change of sliced synovial joint were decreased comparing with CIA-elicitated group's change. In the SWH pharmacopuncture group, the suppression of MIF, TNF-${\alpha}$, COX-2 in synovial membrane was clearly shown comparing with CIA-elicitated group's change. Conclusions : It might be suggested that SWH pharmacopuncture mitigate tissue damage originated from rheumatoid arthritis by suppressing the expression of COX-2 as a consequence of inhibition MIF activation.

The Effects of Acupuncture on the Electroencephalogram of Patients with Stroke (자침이 중풍환자의 뇌파 변화에 미치는 영향)

  • Yoon, Ga-Young;Park, Ji-Min;Kim, Dong-Hyuk;Seon, Jong-In;Kang, Jung-Won;Nam, Dong-Woo;Lee, Seung-Deok;Choi, Do-Young;Lee, Jae-Dong
    • Journal of Acupuncture Research
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    • v.29 no.5
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    • pp.1-16
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    • 2012
  • Objectives : The purpose of this study was to examine the effects of manual acupuncture at the $LI_4$, $ST_{36}$ and $LR_3$ on Electroencephalogram(EEG) of patients with stroke. Methods : 32 channel EEG measurement was carried out in 35 Stroke patients(23 males and 12 females). EEG was measured for 21 minutes(made up of 7 sessions, 1 session means 3 minutes time interval) including 15 minutes(5 sessions) of acupuncture time. Power spectrum analysis was used as a measure of complexity. Statistical analysis was performed using Linear mixed model and DUNNETT's multiple comparison. Results : The results were as follows; 1. EEG amplitude was reduced during acupuncture except electrodes PG1 and PG2. 2. There was a notable change during 6~9 minutes after needling in ${\delta}{\cdot}{\beta}{\cdot}{\gamma}$ wave, and during 6~9 minutes after needling in ${\Theta}{\cdot}{\alpha}$ wave. Overall, during 6~9 minutes after needling. 3. TP8 is a common significant electrode among five wave forms. Conclusions : These results suggest that TP8 could be typical electrodes and change of EEG compared to baseline happens most often during 6~9 minutes after manipulated acupuncture at the $LI_4$, $ST_{36}$ and $LR_3$ of patients with stroke.

Application of Poultry Industry Using Methods of Environmental Management - A Study on Decreasing Soluble Metals from Poultry Litter with Chemical Additives - (환경경영 기법을 이용한 가금산업에 적용(I) - 화학제재를 첨가한 깔짚으로부터 수용성 중금속 저감에 관한 연구를 중심으로 -)

  • Choi, In-Hag;Choi, Sun;Choi, Jung-Hoon
    • Journal of Environmental Science International
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    • v.18 no.12
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    • pp.1437-1442
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    • 2009
  • Recent studies have shown that alum addition to litter results in many environmental and economic advantages, such as reductions in metal runoff, lower ammonia emission and improved poultry performance. However, no research has been conducted to evaluate the effects of different types of alum on soluble metals in poultry litter. The objective of this study was conducted to investigate changes in soluble metal from poultry litter with different types of aluminum sulfate (alum) under laboratory condition. The treatments used in this study, which were mixed in the upper 1 cm of litter or sprayed onto the litter surface, were 4 g alum, 8 g alum, 8.66 g liquid alum, 17.3 g liquid alum, 11.2 g A7 (high acid alum), and 22.4 g A7 (high acid alum)/100 g litter. Applying different types of alum to poultry litter reduced (P<0.05) concentrations of soluble Fe (9 to 54%), Cu (9 to 49%) and Zn (11 to 40%), relative to untreated litter, whereas it increased Ca and Mg (P<0.05). Mean soluble Fe and Cu levels in poultry litter from different types of alum decreased in the order: 22.4 g A7 (54% and 49%) > 17.3 g liquid alum (48% and 42%) > 8 g alum (48% and 31%) > 4 g alum (28% and 10%) > 8.6 g liquid alum (10% and 9%) > 11.2 g A7 (8.6% and 9%). Additionally, the high reduction in soluble Zn concentration was 4 g alum (40%), followed by 8 g alum (26%), 22.4 g A7 (25%), 17.3 g liquid alum (23%), 8.66 g liquid alum (18%), and 11.2 g A7 (11%), respectively. In conclusion, the current studies suggest that treating poultry litter with different types of alum can be applied to reduce soluble metal (Fe, Cu, and Zn) and to develop a production to merchandise for poultry litter that would result in reduction in pollutants from these materials. Furthermore, in order to improve environmental management in the poultry industry, the use of alum, liquid alum and high acid alum all should be provided a valid means of reducing negative environmental impact.

Investigation into Tenth Graders' Understanding of the "Nature of Scientific Inquiry" (일반 고등학교 1학년 학생들의 과학적 탐구의 본성에 관한 이해)

  • Cho, Eunjin
    • Journal of the Korean earth science society
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    • v.41 no.3
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    • pp.273-290
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    • 2020
  • This study aims to investigate tenth graders' understanding of the nature of scientific inquiry (NOSI). A total of 100 public school students participated. A questionnaire of Views about Scientific Inquiry was used to assess their understanding of the NOSI, and data were collected using qualitative research methods such as open-ended questionnaires and, when necessary, semi-structured interviews. By employing a constant comparison method to analyze their responses, five students were consistently categorized as the group with informed views regarding all the eight aspects of the NOSI. The rest of the students showed different levels of understanding regarding each aspect. A large portion of the students represented a group with mixed views about four aspects and informed views about three aspects, whereas naive views about one aspect prevailed among them. The results showed that many students comparatively lacked understanding of the aspect related to the scientists' process of constructing explanations and formulating theories. This study discusses the relationship between its results and the current science curriculum and presents implications for the overall enhancement of students' understanding of the NOSI. Finally, it encourages the acquisition of scientific inquiry ability and makes suggestions to promote further studies.

A Convergence Study on Nursing Needs of Hospitalized Children's Mothers and Quality of Care in Pediatric Unit (입원 아동 어머니의 간호요구와 소아병동 간호의 질에 관한 융합 연구)

  • Kim, Yae Young;Cho, Haeryun
    • Journal of the Korea Convergence Society
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    • v.8 no.10
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    • pp.155-166
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    • 2017
  • This study aimed to investigate the nursing needs of hospitalized children's mothers and the quality of care in a pediatric unit. A secondary data analysis was conducted using mixed methods design. The qualitative data from 8 mothers of hospitalized children gathered through an in-depth interview were analyzed to investigate nursing needs. The quantitative data from 194 hospitalized children's mothers were analyzed to examine the quality of care in the pediatric unit using IBM SPSS 24.0. The results of qualitative research were categorized into 4 themes: dignity and respect, explanation, participation and collaboration, and nursing practice. The importance of quality of care, performance, and quality index were $8.76{\pm}1.19$ (0~10), $.30{\pm}.19$ (0~1), and $7.52{\pm}1.62$ (0~10), respectively. The quality of care scores differed according to the stage of development of the children (F=2.75, p=.044), and the score of the quality index of nursing skill varied according to the age of the mother (t=-2.08, p=.039). The results of this study are expected to contribute to the development of strategies to improve the quality of nursing care for children.

A Study on Organic-Inorganic Hybrid Sound Absorbing Materials Using by Recycling Gypsum (재활용 석고 부산물을 이용한 유무기 하이브리드 흡음재 개발 연구)

  • Shin, Hyun-Gyoo;Jeon, Bo-Ram;Ha, Joo-Yeon;Jeon, Chan-Soo
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.5 no.4
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    • pp.481-487
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    • 2017
  • The purpose of this study is to develop the hybrid sound-absorbing materials that is made from organic polyurethane sponge impregnated with inorganic binder solutions. The inorganic slurry which is made from ${\alpha}$-hemihydrate gypsum mixed with 60% water, and various additives including plasticizer are used as binder. The test specimens are prepared and tested for sound absorption performance by the impedance tube methods. From the test results, noise reduction coefficient(NRC) of development materials specimen bound by the inorganic binder slurry is 0.41. They are 2 times or more higher than commercial products specimens bound by organic materials only which have NRC values in the range of 0.14 to 0.28. The polyurethane sponge specimens impregnated with inorganic gypsum slurry binder have a good balance between performance and cost, and have proper properties in density, thermal conductivity, non-combustible, and absence of harmful substances as sound-absorbing internal boards for noise barrier wall. It is apparent that the good sound absorption materials can be produced according to the optimum mix design that is recommended from this study.

Global Trends of Sciences Information on the Sour Gas (사워가스 학술정보 동향)

  • Cho, Jin Dong
    • Economic and Environmental Geology
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    • v.48 no.1
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    • pp.89-101
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    • 2015
  • The sour gas is natural gas containing components such as hydrogen sulphide and carbon dioxide that form acids when mixed with water. Element sulfur precipitates from sour gas when reservoir pressure and temperature decrease. According to the International Energy Agency, about 43% of the world's natural gas reserves(2,580 tcf or 73.057 tcm), excluding North America, are sour. The sour gas is often derived from the Germanic word 'sauer or acidic' and the etymology referred to as 'sour'. Sour gas requires special handling and infrastructure because it contains significant amounts of hydrogen sulphide, making it highly corrosive, flammable and explosive, and there fore more costly and dangerous to process. So the business of sour gas is affected by two important factors: the economic value of the gas, and the methods used in its production. According to be analyzed in the academic literature to sour gas(2000~2014) by the program of 'web of science', the research activities 145 papers in sour gas.

Effects of Induced Microcurrent Shoes on Fatigue and Pain in Painful Foot to Patients with Plantar Fascitis (족저근막염 환자의 미세전류발생 신발 착용이 족부 근피로 및 통증 완화에 미치는 영향)

  • Park, Rae-Joon;Choi, Sang-Joon;Cheng, Goh Ah;Cho, Jeong-Sun;Lee, Yoon-Mi;Cho, Yong-Ho;Park, So-Hyun;Cho, Mi-Suk
    • The Journal of Korean Physical Therapy
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    • v.18 no.1
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    • pp.1-10
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    • 2006
  • Purpose: This study was to investigate how induced microcurrent shoes affect relief of feet pain, which often occurs to persons who are more than fifty years old and how they prevent fatigue of feet generated during everyday life. The subjects of this study were comprised af five males and five females, who agreed with this research and ate more than fifty years old. And they all have plantar faciitis and pain in their feet. Methods: Subjects ware the induced microcurrent shoes far more than 4 hours everyday during the test. When they wore those shoes, they also wore the specially produced shacks made of silver-mixed thread and they were asked to avoid serious exercise. Prior to starting test and after the test, assessments were carried out two times. In the examination before the test, general shoes were used and in examination after the test, induced microcurrent shoes used. Muscle fatigue was measured by electromyography(MP150, Biopac, USA). When the walking rate of subjects on a treadmill was increased from 2.Km/h to 3Km/h for 10 minutes, muscle activities of a lower leg were measured during the whale walking process by MP150 remote monitoring system(TEL 100C). And pain was measured by VAS. Results: The results are as follows. 1. Comparisons of VAS before and after experimentation showed that degree of pain was significantly decreased(p < .05). 2. Degree of fatigue of Tibialis anterior was significantly decreased after 6 weeks of treatment(p < .05). 3. Degree of fatigue of Soleus was slightly decreased after 6 weeks of treatment, but did not show significant difference (p > .05). Conclusion: The above results suggest that induced microcurrent shoes is helpful decreasing fatigue of feet and relief of feet pain.

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Clinical analysis and review of literature on pilomatrixoma in pediatric patients

  • Hu, Ju Long;Yoo, Hyokyung;Kwon, Sung Tack;Kim, Sukwha;Chung, Jee Hyeok;Kim, Hyeonwoo;Kim, Jinhyun;Yu, Na Hee;Kim, Byung Jun
    • Archives of Craniofacial Surgery
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    • v.21 no.5
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    • pp.288-293
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    • 2020
  • Background: Pilomatrixoma is a benign tumor that originates from the hair follicle matrix. It usually presents as a hard, slow growing, solitary mass that can be easily misdiagnosed as other skin masses. The aim of this study was to clinically analyze a case series of pilomatrixoma in pediatric patients from Korea. Methods: A total of 165 pediatric patients from 2011 to 2018 with a histological diagnosis of pilomatrixoma were included. A retrospective review was performed using the electronic medical records, including patient demographics, number and location of the mass, clinical and imaging presentation, and postoperative outcomes. Results: There were 61 male and 104 female patients with 152 solitary and 13 multiple pilomatrixomas. Among solitary pilomatrixomas, the lesion commonly occurred in the head and neck (84.2%), followed by upper limbs (11.2%), lower limbs (3.3%), and trunk (1.3%). The pilomatrixoma lesion presented as the following types based on our clinical classification: mass (56.02%), pigmentation (25.31%), mixed (12.65%), ulceration (4.82%), and keloid-like (1.2%). Ultrasonography showed a high positive predictive value (95.56%). There were no specific complications observed except for two cases of recurrence. Conclusion: Pilomatrixoma has various clinical feature presentations and commonly occurs in the head and neck. Ultrasonography is a helpful diagnostic tool. Surgical removal of the lesion is the main treatment method with a low recurrence rate.