• 제목/요약/키워드: Mixed Loading

검색결과 407건 처리시간 0.021초

PLGA 미립구가 함유된 젤란검 스폰지를 이용한 추간판 조직 재생 (Regeneration of Intervertebral Disc Using Gellan Sponge Loading PLGA Microspheres)

  • 박현우;김혜윤;권순용;강길선;김용식
    • 폴리머
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    • 제39권1호
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    • pp.144-150
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    • 2015
  • 젤란검은 천연재료로써 내열성, 내산성, 내효소성 등이 우수하여 용도가 광범위하나 기계적 강도가 약하다는 단점이 있다. 따라서 본 연구에서는 기계적 성질을 개선하고자 젤란검 스폰지에 PLGA 미립구를 혼합하였다. PLGA 미립구의 다양한 함량의 젤란검 스폰지는 기계적 강도를 알아보고자 압축강도를 측정하였고, MTT 분석, SEM, 생체활성조직학적 평가 및 RT-PCR을 통해 세포의 증식 및 ECM 분비 효과를 확인하였다. 그 결과, PLGA 미립구가 50% 함유된 젤란검 지지체에서 섬유륜세포의 꾸준한 증식과 세포외기질 분비가 우수한 것을 확인할 수 있었다. 이 연구를 통하여 PLGA 미립구가 함유된 젤란검이 디스크조직 재건을 위한 지지체로서 적합함을 알 수 있었으며, 젤란검의 다양한 응용가능성을 제시하였다.

고농도 휴믹성분이 포함된 강 원수에서 응집-침전 및 오존 공정을 전처리로 적용한 오존 내성막 pilot plant에서의 운전성 및 투과수 수질변화에 관한 연구 (Pre-Coagulation and Pre-Ozonation for Ozone Resisting Microfiltration Membrane Filtration System of a High Humic Contained Surface Water)

  • 이상협;와타나베 요시마사;이석헌;안규홍
    • 상하수도학회지
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    • 제18권5호
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    • pp.598-607
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    • 2004
  • In this study, the effects of two pre-treatment processes were observed prior to membrane filtration: pre-coagulation and pre-ozonation. To compare the effect of two above-mentioned pre-treatments, we adopted the four schemes: first one is direct membrane filtration of river surface water, second one is membrane filtration after pre-coagulation, third one is membrane filtration after pre-ozonation and fourth one is membrane filtration after pre-coagulation and pre-ozonation. There are two exceptional characteristics in applied processes. One is the usage of the MF membrane which has high ozone resisting characteristic. Therefore, ozone resides in membrane module during filtration. The other is adoption of Jet Mixed Separator (JMS) as coagulation-sedimentation process. The change in transmembrane pressure and permeate water quality were also examined. As a result, considering the filtration performance efficiency and permeate water quality, the process composed of filtration with combination of both pre-coagulation and pre-ozonation was proved most effective. The improved efficiency was due to the reduction of loading rate of fouling inducing materials to membrane module by coagulation process as well as variable reactions, such as degradation, particle destabilization and coagulation, occurred by residual ozone in membrane module. The additional effect of pre-coagulation before pre-ozonation is suppression of AOC, one of the by-products induced by ozonation. Therefore, combination of pre-coagulation and pre-ozonation is the effective process to overcome the major de-merit of ozonation i.e. by-products formation.

베릴륨이 포함되지 않은 도재용착주조관용 비 귀금속 합금의 재사용에 따른 금속과 도재간의 전단결합강도에 관한 연구 (The study of Shear Bond Strength on recasting of non-beryllium non-precious alloy for Porcelain between Metal)

  • 김소리;김웅철;김혜영;김지환
    • 대한치과기공학회지
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    • 제35권1호
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    • pp.43-48
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    • 2013
  • Purpose: This study aimed to investigate the shear bond strength for non-precious alloy castings without beryllium, which has been used repeatedly for economical reason. Methods: The Schmitz-Schulmeyer test method was used to evaluate the shear bond strength between the non-beryllium Ni-Cr alloy Vera Bond 2V(AlbaDent, Inc. USA) and the Ceramco 3(Dentstply, York, PA, USA) porcelain powder. The maximum loading and shear bond strength were measured. The average shear strength(MPa) was analyzed with the one-way ANOVA and the Tukey's test( =.05). The fracture specimens were examined using Microscope to determine the failure pattern. Results: The mean shear bond strengths(SD) in MPa were group A(100% new metal) control 28.72(3.31); group B(50% new + 50% reused) 27.28(1.13); group C(all reused) 26.61(5.47). Microscope examination showed that group A and B specimens presented mixed failure, and group C specimens showed adhesive failure. Conclusion: In conclusion, forward this non-precious alloy dose not contain beryllium for how should use a more systematic study and for future advanced research is performed giving effect to be considered desirable.

수용성 규산나트륨의 물리 · 화학적 특성 (Physical and Chemical Properties of Soluble Sodium Silicate)

  • 하윤식;박경일;서무룡
    • 대한화학회지
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    • 제43권2호
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    • pp.172-181
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    • 1999
  • 수용성 규산나트륨 빌더를 개발하기 위하여 물유리와 수산화나륨을 적정비율로 혼합한 후 메탄올에 분산시켜 $SiO_2/Na_2O$의 몰 비율이 2.4∼2.8인 무정형 규산나트륨 고체분말을 제조하였다. 이때 규산나트륨의 $SiO_2/Na_2O$의 몰비, 용해도, thermogram, SEM, BET 등을 통하여 그 물리적 특성을 조사하였으며 빌더로서의 기본적인 특성을 규명하기 위해 $SiO_2/Na_2O$의 몰비가 1.0, 2.4, 2.8인 규산나트륨 빌더와 제올라이트를 사용하여 pH 유지능력, 온도에 따른 칼슘이온 결합능, 계면활성제 흡착능 등을 조사하였다. 그 결과 수용성 규산나트륨 화합물이 세제용빌더로서 가져야할 특성인 pH 유지능력 및 용해도에 있어서 제올라이트 보다 우수한 성능을 나타냈으나 칼슘이온 결합능 및 계면활성제 흡착능은 낮게 나타났으며, 규산나트륨의 $SiO_2/Na_2O$의 비율이 증가할수록 pH 유지능력과 이온교환능력은 감소하지만 계면활성제 흡착능력은 다소 증가함을 알 수 있었다.

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FTA가 유가공업에 미치는 영향과 원유 수급 전망 (The Effect on Dairy Industry of FTA and the Raw Milk Demand and Supply Outlook)

  • 신승열;김현중;최세균
    • Journal of Dairy Science and Biotechnology
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    • 제22권2호
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    • pp.131-141
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    • 2004
  • The FTA(Free Trade Agreements) are loading the world trade liberalization. Entering into FTA with Chile on 1 Apr 2004, Korea is trying to tie with Singapore and Japan in FTA. It also has a long-term plan for free-trading with China, USA, ASEAN, Canada and India. The portion of the dairy products imported from Chile, Japan and Singapore is under 1% of total dairy product imports. However, in the long run the conclusion of FTA with dairy product exporting countries such as USA, Australia, New Zealand and Netherlands will give a big impact on the dairy industry with abrupt increment in dairy product imports. Especially, whole and skim milk powder imports which are imported on the high tariff rate expect to increase. Furthermore mixed milk powder(Food preparations of goods and other whey powders) imports which domestic price is higher than world market also will dramatically increase. The milk powder stocks have increased since 2002. That made the government carry out some policies. Those include slaughtering milking cow(2002) and terminating the dairy farm enterprise and decreasing in milk production(2003). Also the case of artificial insemination by a Hanwoo fertilized egg has increased with the rise of Hanwoo farm price in 2003. By those reason, it is forecasted that the downward trend in the number of cow will be continued in 2004. It is also forecasted that the raw milk production in 2004 will decrease 4.4% compared to last year due to decreasing in the number of milking cow and raw milk collecting quota.

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In-Vitro, In-Vivo 동물모델에서 귀리 유래 수용성 베타-글루칸의 칼로리 제한 효과 작용기전 규명 (Mode of Action of Water Soluble β-Glucan from Oat (Avena sativa) on Calorie Restriction Effect In-Vitro and In-Vivo Animal Models)

  • 강한나;김세찬;강용수;권영인
    • 한국식품영양학회지
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    • 제30권6호
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    • pp.1222-1228
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    • 2017
  • In the current study, we investigated the inhibitory activity of water soluble ${\beta}-glucan$ from oat (Avena sativa) against various digestive enzymes such as ${\alpha}-glucosidase$, sucrase, maltase and glucoamylase. Inhibition of these enzymes involved in the absorption of disaccharide can significantly decrease the post-prandial increase of blood glucose level after a mixed carbohydrate diet. The ${\beta}-glucan$ had the highest documented rate of small intestinal sucrase inhibitory activity (2.83 mg/mL, $IC_{50}$) relevant for potentially managing post-prandial hyperglycemia. Furthermore, we evaluated the effects of ${\beta}-glucan$ on the level of post-prandial blood glucose in animal model. The post-prandial blood glucose levels were tested two hours after sucrose/starch administration, with and without ${\beta}-glucan$ (100, and 500 mg/kg-body weight). The maximum blood glucose levels (Cmax) of ${\beta}-glucan$ administration group were decreased by about 23% (from $219.06{\pm}27.82$ to $190.44{\pm}13.18$, p<0.05) and 10% (from $182.44{\pm}13.77$ to $165.64{\pm}10.59$, p<0.01) in starch and sucrose loading test, respectively, when compared to control in pharmacodynamics study. The ${\beta}-Glucan$ administration significantly lowered the mean, maximum, and minimum level of post-prandial blood glucose at 30 min after meal. In view of the foregoing, it is felt that our findings suggest that ${\beta}-glucan$ from oat serves to reduce post-prandial blood glucose rise secondary to slower absorption of glucose in the small intestine, via carbohydrate hydrolyzing enzymes inhibition.

Anaerobic Biotreatment of Animal Manure - A review of current knowledge and direction for future research -

  • Hong, Jihyung
    • 한국축산시설환경학회지
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    • 제11권2호
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    • pp.97-102
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    • 2005
  • Anaerobic decomposition is one of the most common processes in nature and has been extensively used in waste and wastewater treatment for several centuries. New applications and system modifications continue to be adapted making the process either more effective, less expensive, or suited to the particular waste in question and the operation to which it is to be applied. Animal manure is a highly biodegradable organic material and will naturally undergo anaerobic fermentation, resulting in release of noxious odors, such as in manure storage pits. Depending on the presence or absence of oxygen in the manure, biological treatment process may be either aerobic or anaerobic. Under anaerobic conditions, bacteria carry on fermentative metabolisms to break down the complex organic substances into simpler organic acids and then convert them to ultimately formed methane and carbon dioxide. Anaerobic biological systems for animal manure treatment include anaerobic lagoons and anaerobic digesters. Methane and carbon dioxide are the principal end products of controlled anaerobic digestion. These two gases are collectively called biogas. The biogas contains $60\~70\%$ methane and can be used directly as a fuel for heating or electrical power generation. Trace amounts of ammonia and hydrogen sulfide ($100\~300\;ppm$) are always present in the biogas stream. Anaerobic lagoons have found widespread application in the treatment of animal manure because of their low initial costs, ease of operation and convenience of loading by gravity flow from the animal buildings. The main disadvantage is the release of odors from the open surfaces of the lagoons, especially during the spring warm-up or if the lagoons are overloaded. However, if the lagoons are covered and gases are collected, the odor problems can be solved and the methane collected can be used as a fuel. Anaerobic digesters are air-tight, enclosed vessels and are used to digest manure in a well-controlled environment, thus resulting in higher digestion rates and smaller space requirements than anaerobic lagoons. Anaerobic digesters are usually heated and mixed to maximize treatment efficiency and biogas production. The objective of this work was to review a current anaerobic biological treatment of animal manure for effective new technologies in the future.

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하수슬러지 Biogas의 신재생에너지화 타당성 연구 (A Feasibility Study for Renewable Energy from Sewage Sludge Biogas)

  • 강호;이혜미;조상선;박선욱;정지현
    • 한국물환경학회지
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    • 제26권5호
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    • pp.754-760
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    • 2010
  • This study was carried out not only to evaluate optimal operating condition to increase biogas production, but also to estimate feasibility of renewable energy from anaerobic digester of sewage sludge. Semi- continuous Fed and Mixed Reactors (SCFMRs) were operated in various condition to quantify the reactor variables. The result of SCFMR operation showed that the biogas productivity and total volatile solids (TVS) removal of total solids (TS) 4% reactor at hydraulic retention time (HRT) 20 days with Organic Loading Rate (OLR) of $1.45kg/m^3-d$ were $0.39m^3/m^3-d$ and 26.7%, respectively which was two times higher than that of TS 2.5% reactor. Consequently the daily biogas production of $20,000m^3$ would be possible from the total volume of $52,000m^3$ of anaerobic digesters of the municipal wastewater treatment plant in D city. In feasibility study for the Biogas utilization, combined heat and power system (CHP) and CNG gasification were examined. In case of CHP, the withdrawal period of capital cost for gas-engine (GE) and micro gas-turbine (MGT) were 7.7 years and 9.1 years respectively. biogas utilization as Clean Natural Gas (CNG) shows lower capital cost and higher profit than that of CHP system. CNG gasificaion after biogas purification is likely the best alternative for Biogas utilization which have more economic potential than CHP system. The withdrawal period of capital cost appeared to be 2.3 years.

양이온성 전분과 MFC 투입이 GCC의 응집거동에 미치는 영향 (Effect of Cationic Starch and MFC Addition on the Flocculation Behaviour of GCC)

  • 용성문;이용규;원종명
    • 펄프종이기술
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    • 제48권1호
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    • pp.82-92
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    • 2016
  • The reduction of carbon dioxide emission is hot issue in the world because we are confronted with serious global warming and climate change. As a part of carbon dioxide reduction efforts, various approaches for increasing filler loading have been carried out in order to decrease the energy consumption in papermaking processes. Effects of the pretreatment of GCC with cationic starch and MFC on the flocculation behaviour of GCC were investigated in this study. Pretreatment of GCC with cationic starch caused the change of electric charge of suspension and flocculation behaviour of GCC. Largest flocculation size was obtained near the isoelectric point in the case of cationic starch treatment. When MFC (30 times grinded) was added after preflocculation of GCC with cationic starch, the flocculation size was increased, but largest flocculation size was obtained at -150 mV of electric charge of suspension in this study. However the addition of highly grinded MFC (60 times grinded) caused smaller flocculation size of GCC than those of MFC (30 times grinded). When GCC and MFC were mixed first, and then cationic starch was added, the characteristics of MFC and the change of electric charge which could be brought by cationic starch did not affect the flocculation size of GCC at all. The flocculation size obtained by the combination of cationic starch and MFC was smaller than those of cationic starch. These results show that flocculation behaviour could be controlled by the change of electric charge of suspension and the combination methods of cationic starch and MFC.

경막외 Morphine 부작용 치료를 위한 Nalbuphine의 적정 정주 용량 (Optimal Dose of Intravenous Nalbuphine for Treatment of Side Effects of Epidural Morphine)

  • 한찬수;최일석;김일호
    • The Korean Journal of Pain
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    • 제10권1호
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    • pp.48-53
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    • 1997
  • Background : Epidural morphine provides excellent postoperative analgesia but is often associated with side effects such as nausea, vomiting and pruritus. It has been reported that mixed agonist-antagonist, nalbuphine can reverse side effects of epidural morphine without compromising analgesia. This study was designed to compare the efficacy of each intravenous dose of nalbuphine for treatment of side effects following epidural morphine. Methods : All patients received continuous infusion(2 ml/hr) of epidural morphine-local anesthetics mixture(morphine 4 mg, 1% mepivacaine 50 ml and 0.25% bupivacaine 50 ml) following a loading dose (morphine 2 mg with 1% mepivacaine 7 ml). Patients requesting treatment for nausea, vomiting and pruritus randomly received intravenous nalbuphine 0.05 mg/kg(Group 1; n=20), 0.1 mg/kg(Group 2; n=20) or 0.15 mg/kg(Group 3; n=20). The severity of nausea, vomiting, pruritus, degree of pain, sedation and vital sign were assessed prior to and 30 min after each dose. Results : The severity of nausea, vomiting and pruritus decreased significantly in all groups(p<0.01). Pain and sedation scores were unchanged in all groups. One patient received nalbuphine 0.15 mg/kg, complained of dizziness, agitation and palpitation. His blood pressure who had increased to 170/100 after first dose. Conclusions : This study suggests that intravenous nalbuphine is good for treatment of side effects following epidural morphine, and the dose of Group 1, 0.05 mg/kg, may be recommended as an optimal dose.

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