• 환경정책연구
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• 제12권2호
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• pp.3-16
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• 2013

보편 일률적으로 적용가능한 생태계서비스 정의 및 분류체계는 이상적이기는 하나 현실, 특히 의사결정지원에는 한계가 있다. 본 소고는 생태계서비스 개념과 분류체계의 발전과정 검토를 통하여 문헌상의 용어를 비교 분석하고 최근 연구동향을 반영하여 생태계서비스와 편익의 개념을 재정립하였다. 또한 '정책목표에 기반을 둔 복수의 생태계서비스 정의와 분류체계가 필요하다'는 전제하에 환경계정, 환경가치추정, 자연자원관리와 같은 특정 정책목표에 따라 생태계서비스의 정의와 범위를 차별화하여 제시하였다. 특히 의사결정지원을 위해서는 정책목표 달성을 위한 최종생산물의 확인, 목록화, 역방향 경로분석(편익-서비스-기능-구조/과정)의 필요성을 제시하고 그 유용성을 예시하였다.

• Molecules and Cells
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• 제37권7호
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• pp.503-510
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• 2014

Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical importance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endothelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lymphedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in vertebrates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.

• 대한기계학회논문집A
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• 제23권7호
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• pp.1205-1214
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• 1999

A new quadrilateral plane stress element is developed for efficient and accurate analysis of thermal stress problems. It is convenient to use the same mesh and the same shape functions for thermal analysis and stress analysis. But, because of the inconsistency between deformation related strain field and thermal strain field, oscillatory responses and considerable errors in stresses are resulted in. To avoid undesired oscillations, strain approximation is enhanced by supplementing several assumed strain terms based on the variational principle. Thermal deformation is incorporated into the generalized mixed variational principle for displacement, strain and stress fields, and basic equations for the modified enhanced assumed strain method are derived. For the stress approximation of bilinear elements, the $5{\beta}$ version of Pian and Sumihara is adopted. The numerical results for several problems show that the present element behaves well and reduces oscillatory responses. it also results in almost the same magnitude of error as compared with the quadratic element.

• Journal of Microbiology and Biotechnology
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• 제7권1호
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• pp.56-61
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• 1997

A strain producing immunosuppressive substances was isolated from a soil in Cheju island. By morphological, cultural, and physiological studies, the strain was identified as Streptomyces lydicus MCY-524. Cultured broth was purified by silica gel, sephadex LH-20 and preparative HPLC and gave two immunosuppressive compounds, MCH-22 and MCH-32. They dramatically suppressed the B cell activation with lipopolysaccharide, T cell activation by mixed lymphocyte response, and primary T-dependent antibody response at a final concentration of 1 ${\mu}g$/ml. They also markedly suppressed the proliferation of lymphocytes induced by lipopolysaccharide, pokeweed mitogen, and concanavaline A at the same concentration. Their suppressive activities, which were comparable to those of cyclosporin A, suggested that they were potent and broad immunotoxic agents on the immune functions of murine lymphocytes.

• Advances in Traditional Medicine
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• 제7권5호
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• pp.459-465
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• 2008

The present study was undertaken to investigate the effect of in vivo administration of neem oil intra-peritoneally (i.p.) to mice bearing a progressively growing transplantable T cell lymphoma of spontaneous origin, designated as Daltons lymphoma (DL), on the tumor growth. Mice were administered various doses of neem oil mixed in groundnut oil, which was used as a diluting vehicle or for administration to control DL-bearing mice. Administration of neem oil resulted in an acceleration of tumor growth along with a reduction in the survival time of the tumor-bearing host. Neem oil administered DL-bearing mice showed an augmented apoptosis in splenocytes, bone marrow cells and thymocytes along with an inhibition in the anti-tumor functions of tumor-associated macrophages. Thus this study gives an altogether a novel information that neem oil instead of the popular belief of being anti-tumor and immunoaugmentary may in some tumor-bearing conditions, behave in an opposite way leading to an accelarated tumor progression along with a collapse of the host's anti-tumor machinery. These observations will thus have long lasting clinical significance, suggesting caution in use of neem oil for treatment of cancer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권7호
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• pp.3076-3092
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• 2020

An IKPCA-ELM-based intrusion detection method is developed to address the problem of the low accuracy and slow speed of intrusion detection caused by redundancies and high dimensions of data in the network. First, in order to reduce the effects of uneven sample distribution and sample attribute differences on the extraction of KPCA features, the sample attribute mean and mean square error are introduced into the Gaussian radial basis function and polynomial kernel function respectively, and the two improved kernel functions are combined to construct a hybrid kernel function. Second, an improved particle swarm optimization (IPSO) algorithm is proposed to determine the optimal hybrid kernel function for improved kernel principal component analysis (IKPCA). Finally, IKPCA is conducted to complete feature extraction, and an extreme learning machine (ELM) is applied to classify common attack type detection. The experimental results demonstrate the effectiveness of the constructed hybrid kernel function. Compared with other intrusion detection methods, IKPCA-ELM not only ensures high accuracy rates, but also reduces the detection time and false alarm rate, especially reducing the false alarm rate of small sample attacks.

• Journal of the Korean Data and Information Science Society
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• 제26권2호
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• pp.347-354
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• 2015

본 논문은 균형불완비블럭설계 (balanced incomplete block design)의 자료분석에 사영을 이용한 블럭내 분석 (intrablock analysis)방법을 다루고 있다. 블럭내 분석을 위해 단계별 방법 (stepwise procedure)에서 유도되는 분석모형을 이용하고 있다. 단계별 방법의 적용으로 인해 모형행렬로 주어지는 사영공간이 변동요인에 따른 부분공간들로 직교분할됨을 보여주고 있다. 단계별 과정에서 변동요인에 따른 변동량을 구하기 위해 해당하는 효과벡터의 계수행렬에 근거한 사영의 구조적 형태를 기술하고 있으며 상호직교하는 부분공간으로의 사영을 이용하여 블럭효과에 적합된 처리효과의 변동량를 구하는 과정을 구체적으로 다루고 있다. 또한, 사영에 의해 처리효과를 구하는 과정을 제시하고 있으며 단계별로 잔차벡터를 이용하여 모형설정하는 방법과 고유벡터에 의한 추정가능함수의 구성과 추정가능성을 논의하고 있다.

• Environmental Analysis Health and Toxicology
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• 제13권1_2호
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• pp.33-41
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• 1998

Chlorpyrifos, o,o diethyl-o-(3,5,6-trichloro-2-pyridyl) phosphorothioate, is a broad spectrum organophosphate insecticide. The use of chlorpyrifos has been increased more and more as pesticide. But the effects of chlorpyrifos on the immune alterations has not been yet observed. Therefore, we investigated the effects of chlorpyrifos on the immune alterations in CICA male mice. Chlorpyrifos was administered to mice by a single intraperitoneal injection for the purpose of observing acute effects. On the one hand to get the information on immunopathologic alterations we observed hematological values, counted total circulating leukocytes and assessed the ratio of lymphocytes and neutrophils from the peripheral blood, measured the ratio of organ/body weight and counted splenic cellularity in CBA male mice which treated chlorpyrifos intraperitoneally. But we could not find any significant immunopathologic alterations statistically by a single intraperitoneal injection. Also, the exposure of chlorpyrifos caused no significant change in the number of PFC/10$^6$ spleen cells at any three given doses. On the other hand a singte intraperitoneal injection of chlorpyrifos decreased the lymphocyte proliferation response slightly to ConA or LPS stimulation at a dose of 6 mg/kg b.w. Administrations of chlorpyrifos reduced mixed leukocyte response(MLR). MLR was decreased moderately at doses of 3mg/kg b.w. and 6mg/kg b.w. Therefore, all these findings suggest that chlorpyrifos may alter the immune functions acutely. especially by the changes of T lymphocyte activity.

• 설비공학논문집
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• 제10권5호
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• pp.619-629
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• 1998

An experimental work was conducted to investigate a feasibility of simultaneous measurement of gas-liquid two-phase flowrates with double orifice plates using air and water. The tests were carried out under the atmospheric pressure and at the ambient temperature using two different tube sizes. Qualities of an air-water flow in the present study have values less than 0.1 and thus the mixed flow showed bubbly, plug, slug flow regimes. The probability density function (PDF) and the power spectral density function (PSDF) of the instantaneous pressure drop traces for the flow regimes were obtained. It is found that some distinctive features exist in the distribution of these functions, depending upon the two-phase flow pattern. The time-averaged value of the instantaneous pressure drop increases with increasing gas and liquid flowrates, showing a single-valued function for the total mass flowrate and the quality. It is also found that the two-phase discharge coefficient exhibits a consistent trend for variation of dimensionless parameters such as the superficial velocity ratio and the gas Reynolds number. The results indicate that simultaneous measurement of two-phase flowrate may be possible based upon a statistical analysis of the instantaneous pressure drop curves monitored using double orifice plates.

• 한국실내디자인학회논문집
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• 제15권6호
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• pp.188-195
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• 2006

The development of a general hospital has a close connection with the trend of the society in general and it flows to the ways that satisfies the demanded value of the time. Therefore, various internal changes have occurred since a hospital has built. The changes is appearing through the time not only in the quantitative changes, but also in functional changes and correlations between each department. This study focused on these changes, and observed the St. Mary's Hospital - one of the major hospitals - which is constructed in 1980's. And then, it was divided into the D/T, O.P.D and ward as function that focused on the time of hospital's establishment (1980), the present (2006), and new hospital (2009) to observe the changing aspect of the function and department. As a result, according as age passes, this study shows function of each department is mixed. Among the D/T, O.P.D and ward, mixing functions of O.P.D is most notable. The mixing function brings changes in hospital's arrangement type. In the past, verticality style hospital was evaded, but recently verticality style hospital is appearing. Through this study, it is expected to forecast the new aspects of hospital and apply it to the new project.