• 한방안이비인후피부과학회지
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• 제33권4호
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• pp.1-15
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• 2020

Objectives : To investigate aggravating and mitigating factors of atopic dermatitis and to utilize the outcome in treatment planning. Methods : The research has a cross-sectional study design. Patients' SCORing Atopic Dermatitis (SCORAD) Index, demographic, physical characteristics, social history, serologic index and skin related instrumental measurements were analyzed with correlation and regression analysis method. Results : 48 patients in total were enrolled in the study. Skin Surface Hydration (SSH) and sex were found to be statistically significant aggravating and mitigating factors. As SSH increased, Total SCORAD (tSCORAD) and Objective SCORAD (oSCORAD) increased as well. As SSH decreased, tSCORAD and oSCORAD decreased as well. Female patient had a higher probability of suffering from severer subjective symptoms than that of male. Age, body mass index (BMI), alcohol consumption and smoking, transepidermal water loss (TEWL), IgE, IL-4, IL-5, IL-6, IFN-γ were found not to be statistically significant. There was no correlation between Subjective SCORAD (sSCORAD) and oSCORAD neither with Eczema Area and Severity Index (EASI). Conclusions : Increasing cutaneous moisture should be included in the treatment plan of atopic dermatitis. More emphasis should be put on alleviating subjective discomforts of female patients than that of male. Establishing separate strategies of managing objective eczema status and subjective discomforts respectively should be considered.

• 대한토목학회논문집
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• 제37권2호
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• pp.379-387
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• 2017

최근 고속철도 평균 좌석이용률이 98% 수준에 이르면서 고속철도 차량 내 혼잡이 발생하는 문제가 나타났고, 이러한 배경에서 본 연구는 고속철도 차량 내 혼잡도 완화에 따른 고속철도 이용자들의 편익을 추정하기 위하여 이용자들의 지불 용의액을 산정하였다. 진술선호자료에 근간한 조건부 가치측정법과 토빗(Tobit) 모형을 통해 지불 용의액을 추정한 결과, 지불 용의액은 소득 수준 및 혼잡도 수준과 비례하는 것으로 나타났으며, 남성, 특실이용자, 자유석 및 정기권 이용자의 지불 용의액이 높고, 주말 이용자, 주부, 통근목적이나 여가목적 이용자들은 지불 용의액이 낮은 것으로 나타났다. 본 연구에서 산정된 지불 용의액은 철도운영자들의 좌석공급 확대를 위한 노력에 대하여 정부의 지원근거나 사회적 편익을 계량화할 수 있는 근거를 제공하였다는 점에서 의의가 있다고 하겠다.

• 보건교육건강증진학회지
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• 제30권1호
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• pp.1-11
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• 2013

Objectives: This study aimed to investigate life stressors and mitigating factors affecting suicide ideation amongst university students in Korea. Methods: Study participants were recruited online from one of the universities in Seoul. The total of 794 samples were included in the final dataset. First, correlation analyses were performed among life stressors, depression and mitigating factors. Second, factorial analysis was conducted to explore different dimensions of he life stressors experienced by the university students. Finally, we used logistic regression to find out the relationship between university students' sub-stressors or mitigating factors, and suicide ideation. Results: Three sub-stressors were identified - interpersonal relationship stress, academic stress and economic stress. All of these stressors were significantly associated with suicide ideation. However, none of them significantly predicted suicide ideation controlling for depression. All mitigating factors - health related behaviors, social support and leisure activities - were statistically significant and negatively related to depression, yet only social support had a significantly negative association with suicide ideation. Conclusions: In conclusion, Social support is the most important factor which may affect suicide ideation among university students in Korea.

• Food Science and Biotechnology
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• 제17권6호
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• pp.1272-1278
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• 2008

The purpose of this study was to investigate the effects of Kyung Hee Allergic Disease Herbal Formula (KAHF) on atopic dermatitis (AD) and its mode of action. Our clinical study showed KAHF reduced Severity Scoring of Atopic Dermatitis (SCORAD) indexes and subjective symptom scores. In parallel, the decreased levels of interferon (IFN)-$\gamma$ and interleukin (IL)-5 in serum, which contributed to its AD-mitigating effect was observed. To reveal the underlying mechanisms of KAHF in AD, its anti-inflammatory effect on lipopolysaccharide (LPS)-induced responses in RAW 264.7 cells was examined. KAHF was found to significantly inhibit the productions of nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and IL-$1{\beta}$ in LPS-stimulated RAW 264.7 macrophages. Consistently, KAHF potently inhibited protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, KAHF inhibited LPS-induced activation of nuclear factor (NF)-$\kappa}B$. Taken together, our data suggest that KAHF has a beneficial effect on several eicosanoid-related skin inflammations, such as atopic dermatitis.

• 소음진동
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• 제8권4호
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• pp.700-705
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• 1998

Recent past work has demonstrated that hydraulic semiactive vibration absorbers hold the promise of providing an ideal means of mitigating structural vibration. This paper examines a factor that must be treated when designing a hydraulic semiactive vibration absorber for application to a full scale structure; fluid compressibility. An expanded and consistent dynamic model of the flow process is first established. A simple feedback control is then tested on a single degree of freedom laboratory structure to verify the findings.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• 제5B권4호
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• pp.374-381
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• 2005

The ability to provide quality power has become a significant issue in power systems. The main causes of poor power quality are harmonic currents, poor power factor, supply-voltage variations, etc. A technique of achieving both active current distortion compensation, power factor correction and also mitigating the supply-voltage variation (sag or swell) at the load side is presented in this paper. The operation and rating issues of the proposed Single-phase Unified Power Quality Conditioner are also highlighted. To reduce the total cost while simultaneously increasing the performance, the system is fully digitally controlled using the fixed-point TMS320F240 digital signal processor. The performances of the UPQC, which is composed by shunt and series PWM controlled-converters, have been verified on a laboratory prototype.

• East Asian Economic Review
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• 제23권3호
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• pp.261-284
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• 2019

This paper explores the ramifications of international outsourcing on unemployment, income distribution and welfare, which is an important but yet unresolved issue. Using the well-known Harris-Todaro (1970) model of sector-specific unemployment, it shows that the effects of outsourcing on employment, income-distribution and welfare depend on the sector in which the outsourcing occurs, whereby sectoral factor intensities, unemployment-outsourcing response and the dynamic stability condition play crucial roles. In particular, outsourcing in the manufacturing (primary) sector widens (narrows) income inequality by increasing (decreasing) the sectoral wage gap and raising (not affecting) the rental income of the capital owners in the economy. Moreover, outsourcing in the manufacturing (primary) sector can be welfare-decreasing (is always welfare-increasing) due to its negative (positive) employment effect mitigating (reinforcing) the primary gains from the outsourcing.

• 환경영향평가
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• 제23권6호
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• pp.477-491
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• 2014

본 연구는 창원시 도시지역을 대상으로 다양한 물리적 환경요인과 복사에너지 간의 관계성을 분석함으로서 열쾌적성을 개선하기 위한 계획 방안을 마련하는데 목적이 있다. 물리적 환경요인은 건물의 배치형태를 고려한 Sky view factor(SVF)와 토지피복 및 토지이용유형을 고려하였고, 복사에너지는 여름철에 주간 및 야간으로 3일 동안 이동식으로 태양 및 지구복사에너지의 유입과 유출량을 측정하였다. SVF를 분석한 결과 주변에 건물이 거의 존재하지 않는 도시공원에서 높았고, 반면에 고층의 건물이 밀집된 고층아파트와 상업지역은 매우 낮은 수치를 보였다. 복사에너지는 주간시간은 지표면으로 유입되는 태양복사에너지가 약 $700W/m^2$로 가장 높았고, 야간시간에는 지구복사에너지의 유입과 유출만 있고, 그 양은 약 $450W/m^2$이였다. 지표면으로 유입되는 태양복사에너지는 건물이 밀집된 공간형태일수록 감소하는 경향을 보였고, 대기중으로 향하는 태양 및 지구복사에너지는 반사율과 방사율, 그리고 열용량과 같은 열적특성에 따른 영향이 큰 것으로 나타났다. 그러므로 도시지역의 열쾌적성을 개선하기 위해서는 건물이 밀집된 지역에 대해 배치형태를 조정하거나 벽면녹화를 조성하고, 지표면에 자연적 피복재질로 교체하는 계획방안이 필요할 것으로 판단된다.

• Journal of Yeungnam Medical Science
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• 제34권2호
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• pp.149-160
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• 2017

Streptococcus pneumoniae, pneumococcus, is the most common cause of community-acquired pneumonia (CAP). CAP is an important infectious disease with high morbidity and mortality, and it is still one of the leading causes of death worldwide. Many genetic factors of the host and various environmental factors surrounding it have been studied as important determinants of the pathophysiology and outcomes of pneumococcal infections. Various cytokines, including transforming growth factor $(TGF)-{\beta}1$, are involved in different stages of the progression of pneumococcal infection. $TGF-{\beta}1$ is a cytokine that regulates a wide range of cellular and physiological functions, including immune and inflammatory responses. This cytokine has long been known as an anti-inflammatory cytokine that is critical to preventing the progression of an acute infection to a chronic condition. On the other hand, recent studies have unveiled the diverse roles of $TGF-{\beta}1$ on different stages of pneumococcal infections other than mitigating inflammation. This review summarizes the recent findings of the role of $TGF-{\beta}1$ on the pathophysiology of pneumococcal infections, which is fundamental to developing novel therapeutic strategies for such infections in immune-compromised patients.

• Structural Engineering and Mechanics
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• 제29권6호
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• pp.603-622
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• 2008

This work deals with the design optimization of tuned mass damper (TMD) devices used for mitigating vibrations in high-rise towers subjected to seismic accelerations. A stochastic approach is developed and the excitation is represented by a stationary filtered stochastic process. The effectiveness of the vibration control strategy is evaluated by expressing the objective function as the reduction factor of the structural response in terms of displacement and absolute acceleration. The mechanical characteristics of the tuned mass damper represent the design variables. Analyses of sensitivities are carried out by varying the input and structural parameters in order to assess the efficiency of the TMD strategy. Variations between two different criteria are also evaluated.