• Title/Summary/Keyword: Minimum Dose

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Clinical Applications of Microwave and Ultrasound in Hyperthermia: Preliminary Results (극초단파와 초음파온열치료에 의한 각종암의 임상치료)

  • Koh Kyoung Hwan;Park Young Hwan;Cho Chul Koo;Yoo Seong Yul
    • Radiation Oncology Journal
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    • v.6 no.1
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    • pp.75-80
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    • 1988
  • Twenty seven lesions of 25 patients with locally advanced malignant tumors were treated with combined hyperthermia introduced by microwave and ultrasound and radiotherapy. Most of all patients were failed with previous conventional therapeutic trial. Hyperthermia had been done immediately after radiotherapy, twice a week, $43^{\circ}C$ for one hour and radiotherapy had been done 5 fractions per week with fraction size of 2Gy upto 30 to 60Gy. Conclusions are as follows. 1. Total response rate (PR+PR) to thermoradiotherapy with microwave and ultrasound was $81\%$. 2. Tumor depth, minimum temperature of tumor center, number of heat fraction and radiation dose were statistically significant factors affecting response. 3. Hyperthermia with microwave and ultrasound can be used efficiently to control locally advanced malignant disease whether previously received near tolerance dose of radiotherapy or not.

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Investigation into the mechanism of action of Moringa oleifera for its anti-asthmatic activity

  • Mehta, Anita;Agrawal, Babita
    • Advances in Traditional Medicine
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    • v.8 no.1
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    • pp.24-31
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    • 2008
  • In the present investigation, we studied the effect of alcoholic extract of Moringa oleifera (M. oleifera) seed kernels on various experimental models of bronchial asthma. Significant (P < 0. 05) increase in preconvulsion time was observed due to pretreatment with M. oleifera when the guinea pigs were exposed to either acetylcholine (Ach) or histamine aerosol. This bronchodilating effect of M. oleifera was comparable to ketotifen fumarate. Spasmolytic effect of M. oleifera was also observed by dose dependent inhibition of ideal contractions induced by Ach, 5HT, histamine and $BaCl_2$. Alcoholic extract of M. oleifera produced significant dose dependent protection by egg albumin and compound 48/80 induced mast cell degranulation. Pretreatment with alcoholic extract of M. oleifera also decreased carrageenan induced rat paw edema, which was comparable to that of standard diclofenac sodium. Minimum inhibitory concentration for alcoholic extract of M. oleifera was low as compared to cold-water extract and hot water extract when antimicrobial activity was tested against various respiratory pathogens like Escherichia coli (E. coli), Staphylococus aureus (S. aureus) and pseudomonas aeruginosa (P. aeruginosa). Our data suggest that antiasthmatic activity of M. oleifera seed kernels may be due to its bronchodilator, anti-inflammatory, mast cell stabilization and antimicrobial activity.

Feasibility Study of UV-Disinfection for Water Reuse of Effluent from Wastewater Treatment Plant (용수재이용을 위한 하수처리 유출수의 UV 소독 효율 연구)

  • 윤춘경;정광욱;함종화;전지홍
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.45 no.2
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    • pp.126-137
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    • 2003
  • The feasibility study of UV-disinfection system was performed for disinfection of effluent from wastewater treatment plant. Three low-pressure UV lamps of 17, 25, and 41 W were examined with various flow rates. Low-pressure UV lamps of 17W were examined with various turbidity, DOM (dissolved organic matter), and SS (suspended solid). The pilot plant was a flow-through type UV-disinfection system, and the range of exposure time varied from 5 to 40 seconds, turbidity from 0 to 40 NTU, DOM from 0 to 30 mg/L, and SS from 10 to 40 mg/L. The 41W lamp demonstrated complete disinfection showing no survival ratio in all the experimental conditions, and generally 17W and 25W lamps also showed high removal ratio over 97%. For the same UV dose (UV intensity times exposure time), high intensity-short exposure conditions showed better disinfection efficiency than low intensity-long exposure conditions. While the effects of turbidity and DOM were not apparent, the effects of SS was significant on the disinfection efficiency which indicates that SS control before UV-disinfection appears to be necessary to increase removal efficiency. Considering characteristics of effluent from existing wastewater treatment plants, cost-effectiveness, stable performance, and minimum maintenance, the flow-through type UV-disinfection system with high intensity and low-pressure lamps was thought to be a competitive disinfection system for wastewater reclamation.

Thermoluminescent Characteristics of Newly Developed LiF:Mg,Cu,Na,Si TL Detectors

  • Lee J. I.;Kim J. L.;Chang S. Y.
    • Nuclear Engineering and Technology
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    • v.36 no.1
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    • pp.47-52
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    • 2004
  • Recently, a new sintered pellet-type LiF:Mg,Cu,Na,Si TL detector which has a high sensitivity and good reusability, named KLT-300(KAERI LiF:Mg,Cu,Na,Si TL detector), was developed by the variation of the dopants concentrations and the parameters of the preparation procedure at KAERI (Korea Atomic Energy Research Institute). In this study, the thermoluminescent characteristics of the newly developed TL detectors were investigated. The sensitivity of the TL detector was compared with that of the TLD-100 by light integration. The dose linearity of the detector was tested from $10^{-6}$ Gy up to 30 Gy. The dose response was very linear up to 10 Gy and a sublinear response was observed at higher doses. The energy response of the detector was studied for photon energies from 20 keV to 662 keV. The result shows that a maximum response of 1.004 at 53 keV and a minimum response of 0.825 at 20 keV were observed. The reproducibility study for the TL detector was also carried out. The coefficients of variation for each detector separately did not exceed 0.016, and for all the 10 detectors collectively was 0.0054. Lower limit of detection for the detector was investigated at 70 nGy by the Harshaw 4500 TLD Reader and the residual signal of the TL detector was found to be $0.57\%$.

Women's Calcium Intake during Late Pregnancy and Breastfeeding (일 지역 여성의 임신기와 수유기 칼슘섭취 양상)

  • Ahn, Suk-Hee;Kim, Jin-Hee
    • Journal of muscle and joint health
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    • v.18 no.1
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    • pp.63-72
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    • 2011
  • Purpose: The purpose of the study was to identify the amount of calcium intake during late pregnancy and breastfeeding and compare the differences in the amount of calcium by subjects' characteristics. Methods: With a descriptive survey design, 121 Korean breastfeeding women were recruited in a community setting. The list of foods and drinks with calcium extracted from the study of Song and So (2007) was used to measure the amount of calcium intake during pregnancy and lactation. The subjects' characteristics were collected to identify differences in the amount of calcium intake. Results: Mean age of the women was 31 years old. Amount of calcium intake was 568mg per day during late pregnancy and 431mg per day during breastfeeding. These amounts were quite lower than a recommended dose that adult women should consume a daily minimum of 1,000mg of calcium. Women who had higher household income and attending experience for nutritional education took more calcium during breastfeeding and late pregnancy, respectively. Conclusion: More than a half of the breast-feeding women do not consume the recommended dose of calcium. Education for proper calcium consumption during pregnancy and lactation should be an additional subject in the prenatal and breastfeeding education program for women's bone health.

Do neonicotinoid insecticides impaired olfactory learning behavior in Apis mellifera?

  • Imran, Muhammad;Sheikh, Umer Ayyaz Aslam;Nasir, Muhammad;Ghaffar, Muhammad Abdul;Tamkeen, Ansa;Iqbal, Muhammad Aamir
    • International Journal of Industrial Entomology and Biomaterials
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    • v.38 no.1
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    • pp.1-5
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    • 2019
  • Bee's population is declining and disappearing at alarming rate. There are many factors responsible for declining the population of bees including diseases, natural enemies, environmental conditions and pesticides. Insecticides play its role dramatically for their population decline and neonicotinoid insecticides are critically important due to their wide application for pest control. Keeping in view of above problem, effect of neonicotinoid insecticides on olfactory learning behavior in Apis mellifera was observed using Proboscis Extension Reflex (PER) method. In this method, bees were harnessed in centrifuges tubes and feed on insecticides mixed sugar solution after three hours hunger. Bees were checked by feeding on non-treated sugar solution to observe PER response. Minimum proboscis extension was observed for acetamiprid and imidacloprid with 26% and 20% respectively at their recommend field doses while it was maximum for dinotefuran and thiamethoxam with 73% and 60% respectively. Only 40% bees showed response when exposed at 1/10 concentration of field dose for imidacloprid and the least at 1/100 of field dose. At control (Sugar solution) about 90% bees showed PER response. Among these neonicotinoid insecticides tested, imidacloprid and acetamiprid were the most damaging which impaired the olfactory learning performance in Apis mellifera.

Evaluation of dose received by workers while repairing a failed spent resin mixture treatment device

  • Choi, Woo Nyun;Byun, Jaehoon;Kim, Hee Reyoung
    • Nuclear Engineering and Technology
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    • v.54 no.2
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    • pp.442-448
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    • 2022
  • Intermediate-level radioactive waste (ILW) is not subject to legal approval for cave disposal in Korea. To solve this problem, a spent resin treatment device that separates 14C-containing resin from zeolite/activated carbon and desorbs 14C through a microwave device has been developed. In this study, we evaluated the radiological safety of the operators performing repair work in the event of a failure in such a device treating 1 ton of spent resin mixture per day. Based on the safety evaluation results, it is possible to formulate a design plan that can ensure the safety of workers while developing a commercialized device. When each component of the resin treatment device can be repaired from the outside, the maximum and minimum allowable repair times are calculated as 263.2 h and 27.7 h for the 14C-detached resin storage tank and zeolite/activated carbon storage tank, respectively. For at least 6 h per quarter, the worker's annual dose limit remains within 50 mSv/year; further, over 5 years, it remained within 100 mSv. At least 6 h of repair time per quarter is considered, under conservative conditions, to verify the radiological safety of the worker during repair work within that time.

Extraction and Characterization of Aloe Glucomannan: Assessing Its Flocculation Capability

  • Hye Mi Kwon;Shin Young Lee;Won Hur
    • Applied Chemistry for Engineering
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    • v.34 no.6
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    • pp.626-632
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    • 2023
  • Acemannan, a highly acetylated glucomannan, was extracted from fresh Aloe vera leaves by ethanol fractionation, resulting in a concentration increase of more than threefold. The presence of acemannan was confirmed using FTIR and 1H NMR analysis, revealing an average molecular weight of 780 kDa. The flocculating activity of the fractionated aloe gel polysaccharide was assessed through settling tests in a 1% (w/v) bentonite suspension. The results demonstrated that the aloe polysaccharide exhibited remarkable stability within a temperature range of 20~70 ℃. The maximal flocculation rate at different pH levels ranged from 93% to 97%, with an optimal dose for maximum flocculation rate between 0.25 mg/mL. Notably, the minimum dose required for flocculation was achieved at a pH of 3, attributed to the compression of electrostatic repulsion on the surface of bentonite particles. However, the flocs obtained under acidic conditions were less dense and compact, exhibiting lower sedimentation velocity compared to those formed under neutral and alkaline pH conditions. Additionally, the addition of salt showed a slight synergistic effect on flocculation, significantly enhancing the sedimentation velocity. This investigation highlights the potential of Aloe vera polysaccharide as a natural and edible flocculant, offering promising applications in various industries.

Radiation-hardened-by-design preamplifier with binary weighted current source for radiation detector

  • Minuk Seung;Jong-Gyun Choi ;Woo-young Choi;Inyong Kwon
    • Nuclear Engineering and Technology
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    • v.56 no.1
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    • pp.189-194
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    • 2024
  • This paper presents a radiation-hardened-by-design preamplifier that utilizes a self-compensation technique with a charge-sensitive amplifier (CSA) and replica for total ionizing dose (TID) effects. The CSA consists of an operational amplifier (OPAMP) with a 6-bit binary weighted current source (BWCS) and feedback network. The replica circuit is utilized to compensate for the TID effects of the CSA. Two comparators can detect the operating point of the replica OPAMP and generate appropriate signals to control the switches of the BWCS. The proposed preamplifier was fabricated using a general-purpose complementary metal-oxide-silicon field effect transistor 0.18 ㎛ process and verified through a test up to 230 kGy (SiO2) at a rate of 10.46 kGy (SiO2)/h. The code of the BWCS control circuit varied with the total radiation dose. During the verification test, the initial value of the digital code was 39, and a final value of 30 was observed. Furthermore, the preamplifier output exhibited a maximum variation error of 2.39%, while the maximum rise-time error was 1.96%. A minimum signal-to-noise ratio of 49.64 dB was measured.

Assessment of soil density and distribution coefficient of Cs-137 for deriving DCGLs in korea research reactor unit 1 and 2

  • Geun-Ho Kim;Ilgook Kim;Kwang Pyo Kim
    • Nuclear Engineering and Technology
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    • v.56 no.7
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    • pp.2452-2457
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    • 2024
  • To obtain site-specific values of the Derived Concentration Guideline Levels (DCGLs) for decommissioning of KRR-1&2, the soil density and distribution coefficient values for Cs-137, a major contaminant radionuclide, were determined. The soil density was evaluated according to the test method established by the Korean Agency for Technology and Standards of the Ministry of Trade, Industry, and Energy (KATS). The distribution coefficient was evaluated using a batch test. The validity of using the evaluated soil density and distribution coefficient as site-specific values was assessed through radiation dose assessment reflecting these values. Average soil density value obtained was 1.738 g/cm3, which was within the typical range of normal soil density, 1.0-1.8 g/cm3. The average distribution coefficient value was 7,754 mL/g. Applying the maximum, average, and minimum values of the evaluated soil density and distribution coefficient showed similar radiation dose results, thus suggesting that it is reasonable to use the average values of each parameter as site-specific values. Findings of this study can help determine DCGLs that reflect the characteristics of the research reactor site.