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Optimization of PET Scan Time Using Phantom Studies (팬텀 영상을 이용한 PET 스캔시간의 최적화 연구)

  • 정하규;김동현;정해조;손혜경;홍순일;윤미진;이종두;김희중
    • Progress in Medical Physics
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    • v.13 no.3
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    • pp.139-148
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    • 2002
  • The measured attenuation correction with transmission (Tx) scans produced quantitatively accurate images. However, it was not clear for optimal emission (Ex) and Tx scan time in PET imaging. This study was to evaluate acceptable Ex and Tx scan time by simulating clinical situations using various phantoms. Cylindrical and NEMA phantom were used for $^{18}$ F-PET scan using 2D protocol in GE Advance PETTM scanner. Cylindrical phantom was filled with 136 MBq 18F, and five regions of interests (ROI) were drawn on 23 slices. NEMA phantom had three inserts containing water, air and polytetrafluoro-ethylene (PTFE). Outside of these inserts were filled with 309 MBq of $^{18}$ F, and total 12 ROIs were drawn on 23 slices. Scans were carried out according to five Ex scan times: 2, 5, 10, 15, and 30 min, and nine Tx scan times: 2, 3, 4, 5, 7, 10, 15, 20, and 30 min. Images were reconstructed using measured attenuation correction, and ROI analyses were performed for all images, and mean, standard deviation (SD), coefficient of variation and percent errors were calculated. For cylindrical phantom study, ROI mean and SD were decreased as Ex and Tx time increased. Coefficients of variation were kept constant, when Tx was greater than 10 min. The amount of error decreased for the increment of Ex time from 10 min to 15 min was almost the same to that from 15 min to 30 min. In NEMA phantom Tx 15 min showed the lowest er개r level when the percent errors for three inserts were summed for all of the Ex times. This study suggested that Ex 15 min and Tx 15 min were acceptable as optimal scan time for the scanning protocol and the dose of radiopharmaceuticals used in these phantom study.

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Maximal Oxygen Uptake in middle-aged Men and Women (중년 남녀의 최대 산소 섭취량)

  • Kwon, Seung-Rak;Nam, Kee-Yong
    • The Korean Journal of Physiology
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    • v.2 no.2
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    • pp.45-52
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    • 1968
  • Maximal oxygen uptake was measured in twenty-eight middle-aged men aged 45.0 (range: 40.3-50.7) years and fourteen middle-aged women aged 40.5 (range: 34.3-47.5) years by means of a treadmill test. The physique of subjects were:mean skinfold thickness at 4 sites, namely, back, arm, waist and abdomen was 7.59 mm in men and 14.5 mm in women; total body fat estimated from the mean skinfold thickness, 11.9% fat in men and 25.5% fat in women. The detailed observations are as follows: 1. Maximal oxygen uptake expressed on any reference unit in men was greater than that of women. The values of men to women were: 2.61 to 1.92l/min., 45.1 to 37.0 ml/min./kg, 51.8 to 46.5 ml/min./kg lean body mass (LBM), 15.7 to 12.6 ml/min./cm body height. 2. Maximal pulmonary ventilation in men was 80.2 l/min. and 63.5 l/min. in women. 3. There was a correlation of fairly high degree between maximal oxygen uptake and body weight, namely, r=0.56 in men and r=0.79 in women. The correlation between maximal oxygen uptake and lean body mass also was fairly high, namely, r=0.58 in men and r=0.69 in women. 4. The correlation between maximal pulmonary ventilation and body weight or lean body mass was r=0.51 and r=0.25 in middle-aged men and r=0.41 and r=0.19 in middle-aged women, respectively. 5. Maximal heart rate in men was 176.4 beat/min. and it was 183.9 beat/min. in women. 6. Maximal oxygen pulse in men was 14.6 ml/beat and 9.5 ml/beat in women. 7. Aerobic work capacity of korean middle-aged men and women maintained the same level as that of young men and women, respectively, as shown by maximal oxygen uptake expressed ml/min./kg or ml/min./kg lean body mass.

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COB, COH Package LED Module Thermal Analysis Simulation (COB, COH Package LED Module 열 해석 시뮬레이션)

  • Choi, Keum-Yeon;Eo, Ik-Soo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.11
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    • pp.5117-5122
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    • 2011
  • In this paper, thermal analysis simulation program by taking advantage of COMSOL Multiphysics, LED Module for the production of the most preferred package type, omitting the COH Type COB Type and board simulation of the thermal analysis is in progress. LED Module that passes through the Heat-sink of the simulation results, depending on the location of the COB Type Max. Approximately $78^{\circ}C$ ~ Min. Approximately $62^{\circ}C$, COH Type the Max. Approximately $88^{\circ}C$ ~ Min. Approximately $67^{\circ}C$ has been confirmed that the temperature stability. Compared with COB Type Max. AIthough temperature difference is about $10^{\circ}C$, Min. At a temperature of about $5^{\circ}C$ confirmed to be enough to reduce the gap, LED Point confirming the results of the temperature curves for COB Type Max. Approximately $100^{\circ}C$ ~ Min. Approximately $77^{\circ}C$, COH Type the Max. Approximately $100^{\circ}C$ ~ Min. Approximately $86^{\circ}C$ temperature stability was confirmed that, COB Type COH Type, compared to approximately $10^{\circ}C$ temperature was higher.

Monitoring on Heating Condition and Enzyme Treatment Condition for Manufacture of Oriental Melon Concentrate (참외 농축액 제조를 위한 가열 및 효소 처리조건 모니터링)

  • 이기동;권승혁;이명희;김숙경;주길재;권중호
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.5
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    • pp.905-910
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    • 2004
  • This study was carried out to observe the change of oriental melon juice quality during manufacture by heating condition and enzyme treatment. To use over-production oriental melon effectively, oriental melon juice was prepared with change of heating temperature and heating time. The heating conditions for minimum filtration time were 98.57$^{\circ}C$ and 11.29 min. The optimum conditions Predicted for separation ratio of clear solution, filtration time and browning color intensity of oriental melon juice were 98$^{\circ}C$, 13 min. In the pectin-degrading enzyme treatment test, turbidity showed minimum value in 4.40 mg%(pectin-degrading enzyme content), 39.72 mg% (gelatin content) and 24.09 min (treatment time).Browning color intensity showed minimum value in 9.33 mg% (pectin-degrading enzyme content),44.70 mg% (gelatin content) and 115.56 min (treatment time). The optimum conditions predicted for turbidity and browning color intensity of oriental melon concentration Juice were 6.6 mg% (pectin-degrading enzyme content), 33.6 mg% (gelatin content) and 70 min (treatment time).

Evaluation of Two Kinetic Models on the Inactivation of Major Foodborne Pathogens by Aqueous Chlorine Dioxide Treatment (이산화염소수 처리에 의한 주요 식중독균의 불활성화에 관한 두 kinetic models의 비교)

  • Lee, Ji-Hye;Song, Hyeon-Jeong;Song, Kyung-Bin
    • Food Science and Preservation
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    • v.18 no.3
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    • pp.423-428
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    • 2011
  • Inactivation kinetic data of Escherichia coli O157:H7, Listeria monocytogenes, Staphylococcus aureus, Salmonella Typhimurium, and Salmonella Enteritidis via treatment with aqueous chlorine dioxide treatment at a specific concentration were evaluated using the first-order kinetic and Weibull models. The Weibull model showed a better fit with the kinetic data than the first-order kinetic model. The survival curves after the aqueous chlorine dioxide treatment showed $t_R$ values(time required to reduce microbial populations by 90%) of 2.49 min for E. coli O157:H7 at 5 ppm, 1.47 min for L. monocytogenes at 5 ppm, 0.94 min for S. aureus at 5 ppm, 0.87 min for S. Typhimurium at 1 ppm, and 0.08 min for S. Enteritidis at 1 ppm, according to the Weibull model.

Heavy Metals Extraction from Contaminated Soils using Aqua Regia Extraction (왕수를 이용한 중금속 오염토양에서의 추출방안 연구)

  • Lee, Dukyoung;Jung, Sunkook;Son, Younggyu
    • Journal of Soil and Groundwater Environment
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    • v.23 no.2
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    • pp.15-22
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    • 2018
  • Aqua regia extraction for the quantification of heavy metals and As in contaminated soils was investigated as one of preliminary steps for on-site monitoring using sensor technology. Soil samples were taken from closed railway depot, closed mines, and closed refinery and various extraction conditions including $30^{\circ}C/15min$, $30^{\circ}C/30min$, $30^{\circ}C/60min$, $30^{\circ}C/120min$, $80^{\circ}C/15min$, $80^{\circ}C/30min$, $80^{\circ}C/60min$, $80^{\circ}C/120min$ were tested. The optimal extraction condition was determined as $80^{\circ}C/60min$ because the extraction efficiencies of Zn were relatively low and did not reach the targeted level (80-100% of original concentrations) for $30^{\circ}C$ conditions. It was found that the fractionation of heavy metals and As using the sequential extraction method was useful to understand the degree of metal extraction. In order to enhance the extraction efficiency within short extraction time, ultrasound technology using a 20 kHz horn-type sonicator was additionally used for $30^{\circ}C/15min$. It was revealed that ultrasound could significantly enhance the extraction efficiency and pulsed irradiation showed higher efficiency than continuous irradiation due to the less formation of bubble clouds. However high temperature condition ($80^{\circ}C$) was required to achieve high extraction efficiency for Zn in spite of the use of ultrasound.

Effect of the supplementation of fructose and taurine on energy metabolism during exercise

  • Kim, Young Min;Chang, Myoung Jei;Choi, Sung Keun
    • Korean Journal of Exercise Nutrition
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    • v.16 no.2
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    • pp.101-111
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    • 2012
  • The purpose of this thesis is to investigate whether taurine supplementation in combination with fructose improves both energy metabolism and exercise capacity. Eight collegiate female subjects were recruited for the study. Each subject went through threecross-over designs: control(fluid), fructose, and taurine plus fructose supplementation trials. Subjects received taurine supplementation 100 mg/kg a day for two weeks. After the supplementation, all subjects take 10% fructose at 15 min prior to exercise, immediately before exercise, and every 15 min during exercise. Subjects received 150 ml fluid as placebo during the same procedure. The subjects performed submaximal exercise at the exercise intensity of 60% for 45 min and then 80% of maximal oxygen uptake (VO2max) until exhaustion time. A 10ml blood sample was taken for measuring the level of glucose, ammonia, lactate, free fatty acids, and insulin every 15 min during exercise at 60% of VO2max. The blood glucose levels was significantly higher at 45 min and 50 min exercise after supplementation of fructose, and immediately before exercise and 50 min exercise after taurine plus fructose compared to the placebo trial. However, the values tended to be lower in taurine plus fructose supplementation compared to the fructose trial. The levels of both lactate and ammonia were significantly lower compared to the placebo, while the exhaustion time was significantly increased. The level of free-fatty acids was significantly lower at 30, 45, and 50 min after fructoseand fructose plus taurine supplementation compared to the placebo trial. The level of glucagon was significantly lower at 15, 30, 45, and 50 min after fructose and fructose plus taurine supplementation compared to the placebo trial. There was no differences in insulin concentration among three treatments. This thesis concludes that combined taurine and fructose supplementation prior to exercise may improve exercise tolerance time and energy metabolism, lowering the muscle fatigue factors such as lactate and ammonia.

Fumigant Toxicity of Essential Oils against Adults of Culex pipiens pallens (빨간집모기 성충(Culex pipiens pallens)에 대한 식물오일의 훈증효과)

  • Kang, Shin-Ho;Kim, Min-Ki;Seo, Dong-Kyu;Kim, Gil-Hah
    • The Korean Journal of Pesticide Science
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    • v.10 no.2
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    • pp.117-123
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    • 2006
  • Fumigant toxicity of 34 plant essential oils were tested against female adults of Culex pipiens pallens. Seven oils (basil, coriander, fennel, pennyroyal, peppermint, thyme red, thyme white) showed more than 60% mortality at 1 ${\mu}L\;L^{-1}$ air concentration and pennyroyal oil appeared to have the highest adulticidal activity. GC and GC-MS analysis of the seven essential oils and bioassay of their components revealed that pulegone (a major component of pennyroyal oil) and anethole (a major component of fennel and basil oil, $LD_{50}$, ${\mu}L\;L^{-1}$ air =0.49) showed higher adulticidal activities than others. In addition to the above two components, linalool ($LT_{50}$, min=0.91), camphor ($LT_{50}$, min=1.06), fenchone ($LT_{50}$, min=1.16), 1,8-cineole ($LT_{50}$, min=2.93), and geranyl acetate ($LT_{50}$, min=1.60) also showed higher adulticidal activity than empenthrin ($LT_{50}$, min=3.45).

The Study of HR and Energy Expenditure Change according to Walking Types (걷기유형에 따른 심박수 및 에너지소비량 변화에 관한 연구)

  • Lee, hyung-kook
    • Proceedings of the Korea Contents Association Conference
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    • 2009.05a
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    • pp.405-409
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    • 2009
  • There are many types of walking exercise. We have choice the way according to the walking exercise purpose. Nordic walking(NW) is one of walking types with nordic poles. Also, power walking(PW) has motion of large swing the arm in walking, and dumbbell walking(DW) way is walking with 3-pound dumbbell. This study compared the physiological response(heart rate, energy expenditure) of general walking(GW) to another types(nordic, power, and 3-pound hand weights walking way). Seven apparently male health volunteers between the ages 19 and 24 years participated. Each complete a treadmill test. The tests were assigned randomly, as submaximal walking trials on separate days. Each walking trial was conducted on a level treadmill, for 40 minutes(3-5mile/hour 5min warm-up, 6mile/hour speed for 15min walking and 7mile/hour speed for 15min Jogging exercise, and 5-3mile/hour cool down 5min), at an same pace. Heart rate in beats per minute(bpm), and energy expenditure in kcal per minute(kcal/min) were recorded each minute. Results between trials were compared using repeated measures analysis of variance and Tukey's post hoc tests. In slow walking, it was found that walking with 3-pound hand weight way resulted in and average of ($127.8{\pm}8.27bpm$) the highest score HR, Caloric expenditure($85.4{\pm}14.51kcal/min$), responses compared to regular walking way($117.4{\pm}7.27bpm$ and $70.4{\pm}10.99kcal/min$). Nordic walking way($121.4{\pm}11.74bpm$, and $77.0{\pm}16.83kcal/min$) is second, power walking way($118.5{\pm}9.98bpm$, and $68.7{\pm}20.62kcal/min$) is next. In fast walking, it was found that walking way with 3-pound hand weight resulted in and average of ($160.1{\pm}8.72bpm$) the highest score HR, caloric expenditure($126.1{\pm}13.86kcal/min$), responses compared to regular walking way($148.4{\pm}11.94bpm$, and $109.0{\pm}4.70kcal/min$). Nordic walking way($156.7{\pm}10.82bpm$, and $113.5{\pm}14.51kcal/min$) is second, power walking way($149.7{\pm}12.56bpm$, and $109.2{\pm}17.64kcal/min$) is next. Thus, it is the unavoidable conclusion that, comparing with general walking, 3-pound hand weight walking, nordic walking, and power walking methods have the advantage of high exercise intensity and energy expenditure to meet the purpose of performers without the problem. Furthermore, 3-pound hand weight walking ways were proved to be a useful aerobic exercise method as whole body that achieves high-energy efficiency. To this extent, 3-pound hand weight walking ways can be recommended as a continuous and regulative aerobic exercise for some people.

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The Effects of Alcohol-Steamed Rhei Rhizoma and Row Rhei Rhizoma on varied Extraction Time in Blood Stasis Model (전탕시간(煎湯時間)에 따른 생대황(生大黃) 및 주대황(酒大黃)이 어혈병태모형(瘀血病態模型)에 미치는 영향(影響))

  • Kim, Do-Wan;Park, Chang-Gook
    • The Journal of Internal Korean Medicine
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    • v.19 no.1
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    • pp.114-133
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    • 1998
  • In order to investigate the effects of Alcohol-Steamed Rhei Rhizoma and Row Rhei Rhizoma on varied extract time in both endotoxin-induced blood stasis model(hereafter Endotoxin Model) and hydrocortisone acetate-induced blood stasis model (hereafter HA Model), Half of rats were treated with endotoxin(0.4mg/kg, single Ⅳ, into caudal vein) for Endotoxin Model. Thereafter, they were orally administrated water extract of Alcohol-Steamed Rhei Rhizoma or Row Rhei Rhizoma, which were boiled during 30, 60, 120 minute, respectively. Finally, the number of platelet, fibrinogen, prothrombin time, hematocrit, the number of RBC and WBC were measured after sacrifice. The remainder rats were treated with hydrocortisone acetate(10mg/kg, daily IM for 7 days into the muscular rump) for HA significantly decreased. Together, they were orally administrated for 7 days water extract of Alcohol-Steamed Rhei Rhizoma or Row Rhei Rhizoma that were boiled above methods Finally, the number of platelet, fibrinogen, prothrombin time, hematocrit, the number of RBC and WBC were measured after sacrifice. The results were summarized as follows : 1. The number of platelet was significantly increased in boiled water extract for 30 min of Row Rhei Rhizoma group as compared with that of control group in Endotoxin Model. 2. Fibrinogen level was significantly increased in all administration groups as compared with that of control group in Endotoxin Model. It was significantly increased in all administration groups except boiled water extract for 30 min of Alcohol-Steamed Rhei Rhizoma group as compared with that of control group in HA Model. 3. Prothrombin time was significantly shortened in boiled water extract for 60 min of Alcohol-Steamed Rhei Rhizoma group and boiled water extract for 120 min of Alcohol-Steamed Rhei Rhizoma group as compared with that of control group in Endotoxin Model It was significantly shortened all administration groups as compared with that of control group in HA Model. 4 Hematocrit was significantly increased in all administered groups except boiled water extract for 60 min of Alcohol-Steamed Rhei Rhizoma group and boiled water extract for 30 min of Row Rhei Rhizoma group as compared with that of control group in Endotoxin Model. It was significantly increased in all administration groups as compared with that of control group in HA Model. 5. The number of RBC was significantly decreased in boiled water extract for 60 min of Alcohol-Steamed Rhei Rhizoma group, boiled water extract for 120 min of Alcohol -Steamed Rhei Rhizoma group and boiled water extract for 30 min of Row Rhei Rhizoma administered group in Endotoxin Model. It was significantly increased boiled water extract for 30 min of Row Rhei Rhizoma group and boiled water extract for 60 min of Row Rhei Rhizoma group in HA Model as compared with data of control group. 6 The number of WBC was significantly decreased in all administered groups except boiled water extract for 30 min of Alcohol-Steamed Rhei Rhizoma group and boiled water extract for 60 min of Alcohol-Steamed Rhei Rhizoma group as compared with that of control group in HA Model.

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