• Title/Summary/Keyword: Mimetic

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A Study on the Relationship between Assault and Victim in the Film Act of Killing (영화 "액트 오브 킬링"에 나타난 가해자와 피해자의 관계 연구)

  • Kim, Seok-Weon;Kim, Seong-Ho
    • Journal of Digital Convergence
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    • v.17 no.7
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    • pp.299-309
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    • 2019
  • The purpose of this study was to look at the relationship between perpetrators and victims in Joshua Oppenheimer's Act of Killing. The theoretical tools used for this purpose were to study $Ren{\acute{e}}$ Girard's "Mimetic desire" and Hannah Arrent's "banality of evil" and to look at $Ren{\acute{e}}$ Girard's theory of "Le Bouc emissaire". The meaning of the study used the reproducible narrative of the film to challenge the reproducibility of past genocide and seek the combination of documentary and fiction as a way to show the truth. Also, the reconciliation between the assailant and the victim is meaningful in securing 'neutrality of fairness'.but they are still lacking, and more in-depth studies will need to be conducted in future further studies.

IMMUNOSTIMULATION BY THE EXTRACTS OF SALICORNIA HERVACEA

  • Jeon, Young-Jin
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.99-99
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    • 2002
  • In the present study, the potent lipopolysaccharide (LPS)-mimetic stimulation of B cells and macrophages by hot water extract from Salicornia herbacea (S. europeae L.) is described. The extract activated spleen cells to proliferate in a dose-related manner as measured by [$^3$ H)-thymidine incorporation response.(omitted)

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Induction of insulin receptor substrate-2 expression by Fc fusion to exendin-4 overexpressed in E. coli: a potential long-acting glucagon-like peptide-1 mimetic

  • Kim, Jae-Woo;Kim, Kyu-Tae;Ahn, You-Jin;Jeong, Hee-Jeong;Jeong, Hyeong-Yong;Ryu, Seung-Hyup;Lee, Seung-Yeon;Lee, Chang-Woo;Chung, Hye-Shin;Jang, Sei-Heon
    • BMB Reports
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    • v.43 no.2
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    • pp.146-149
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    • 2010
  • Exendin-4 (Ex-4), a peptide secreted from the salivary glands of the Gila monster lizard, can increase pancreatic $\beta$-cell growth and insulin secretion by activating glucagon-like peptide-1 receptor. In this study, we expressed a fusion protein consisting of exendin-4 and the human immunoglobulin heavy chain (Ex-4/IgG-Fc) in E. coli and explored its potential therapeutic use for the treatment of insulin-resistant type 2 diabetes. Here, we show that the Ex-4/IgG-Fc fusion protein induces expression of insulin receptor substrate-2 in rat insulinoma INS-1 cells. Our findings therefore suggest that Ex-4/IgG-Fc overexpressed in E. coli could be used as a potential, long-acting glucagon-like peptide-1 mimetic.

Vasorelaxing Effect of Hypoxia via Rho-kinase Inhibition on the Agonist-specific Vasoconstriction

  • Je, Hyun-Dong;Shin, Chang-Yell
    • Biomolecules & Therapeutics
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    • v.16 no.3
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    • pp.249-254
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    • 2008
  • The present study was undertaken to determine whether hypoxia influences on the agonist-induced vascular smooth muscle contraction and, if so, to investigate the related mechanism. The measurement of isometric contractions using a computerized data acquisition system was combined with molecular experiments. Hypoxia significantly inhibited fluoride-induced contraction regardless of endothelial function, but there was no relaxation on thromboxane $A_2$ mimetic U-46619-induced contraction suggesting that other pathway such as $Ca^{2+}$ entry or thin filament regulation was not affected. In addition, hypoxia significantly decreased fluoride-induced increase of phospho-myosin-targeting subunit of myosin light chain phosphatase (pMYPT1). Interestingly, hypoxia didn't inhibit significantly phenylephrine-induced contraction suggesting that myosin light chain kinase (MLCK) activity or thin filament regulation is less important on the hypoxia-induced vasorelaxation in the denuded muscle than Rho-kinase activity. In conclusion, this study provides the evidence and possible related mechanism concerning the vasodilation effect of hypoxia on the agonist-specific contraction in rat aortic rings regardless of endothelial function.

Control of IPMC-based Artificial Muscle for Myoelectric Hand Prosthesis

  • Lee Myoung-Joon;Jung Sung-Hee;Moon Inhyuk;Lee Sukmin;Mun Mu-Seong
    • Journal of Biomedical Engineering Research
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    • v.26 no.5
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    • pp.257-264
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    • 2005
  • This paper proposes an ionic polymer metal composite (IPMC) based artificial muscle to be applicable to the Myoelectric hand prosthesis. The IPMC consists of a thin polymer membrane with metal electrodes plated chemically on both faces, and it is widely applying to the artificial muscle because it is driven by relatively low input voltage. The control commands for the IPMC-based artificial muscle is given by electromyographic (EMG) signals obtained from human forearm. By an intended contraction of the human flexor carpi ulnaris and extensor carpi ulnaris muscles, we investigated the actuation behavior of the IPMC-based artificial muscle. To obtain higher actuation force of the IPMC, the single layered as thick as $800[{\mu}m]$ or multi-layered IPMC of which each layer can be as thick as $178[{\mu}m]$ are prepared. As a result, the bending force was up to the maximum 12[gf] from 1[gf] by actuating the single layered IPMC with $178[{\mu}m]$, but the bending displacement was reduced to 6[mm] from 30[mm]. The experimental results using an implemented IPMC control system show a possibility and a usability of the bio-mimetic artificial muscle.

Biphasic Effects of Rosiglitazone on Agonist-induced Regulation of Vascular Contractility (항당뇨약 Rosiglitazone의 혈관 수축성에 대한 이중성 조절)

  • Park, Jin-Gun;Je, Hyun-Dong
    • YAKHAK HOEJI
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    • v.51 no.5
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    • pp.301-306
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    • 2007
  • Rosiglitazone ($Avandia^{(R)}$) represents a new class of antidiabetic drugs which are $PPAR{\gamma}$ agonists. The present study was undertaken to determine whether the new antidiabetic rosiglitazone influences on the agonist-induced regulation of vascular smooth muscle contraction as an antihypertensive and, if so, to investigate the related mechanism. Endothelium-denuded arterial rings from male Sprague-Dawley rats were used and isometric contractions were recorded using a computerized data acquisition system. Rosiglitazone decreased Rho-kinase activating agonist (NaF or thromboxane $A_2$ mimetic)-induced contraction but not depolarization- or phorbol ester-induced contraction. Surprisingly, it slightly potentiated the latter contraction possibly opening a voltage-dependent calcium channel by its chemical structure on 50 mM KCI- or $1{\mu}M$ phorbol 12,13-dibutyrate-induced vasoconstriction. In conclusion, this study provides the evidence and possible related mechanism concerning the biphasic effect of an antidiabetic rosiglitazone as a possible antihypertensive on the agonistinduced contraction in rat aortic rings regardless of endothelial function.

Neural Learning-Based Inverse Kinematics of a Robotic Finger (뉴럴 러닝 기반 로봇 손가락의 역기구학)

  • Kim, Byoung-Ho
    • Journal of the Korean Institute of Intelligent Systems
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    • v.17 no.7
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    • pp.862-868
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    • 2007
  • The planar motion of the index finger in general human hands is usually implemented by the actuation of three joints. This task requires a technique to determine the joint combination for each fingertip position which is well-known as the inverse kinematics problem in robotics. Especially, it is an essential work for grasping and manipulation tasks by robotic and humanoid fingers. In this paper, an intelligent neural learning scheme for solving such inverse kinematics is presented. Specifically, a multi-layered neural network is utilized for effective inverse kinematics, where a dynamic neural learning algorithm is employed for fast learning. Also, a bio-mimetic feature of general human fingers is incorporated to the learning scheme. The usefulness of the proposed approach is verified by simulations.

An Analysis of the Differences between English and Translated Picture Books in Korean in Predictable Pattern Books (예측 가능한 패턴의 영어그림책과 한국어 번역그림책 간의 차이 분석)

  • Lee, Myoung Shin;Kim, Ji Yeon
    • Korean Journal of Child Studies
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    • v.35 no.2
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    • pp.157-169
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    • 2014
  • This study sought to explore the types of predictable pattern books are suitable for reading aloud, the differences between English and translated Korean picture books in terms of their characteristics of speakability and the meaning of sentences. This study investigated a total of 112 picture books. The predictable pattern types were analyzed specifically, compared with onomatopoeia, mimetic words, repetition, rhyme, the shift of sentence and style types. The results indicated that predictable pattern books could be classified into eight types and the number of sentences in translated books increased owing to the difference of sentence structure. In terms of speakability, words in repetition, onomatopoeia and mimetic words represented higher frequency except rhyme because of the difference of characteristics of the two languages. Furthermore, translations used strategies of the shift in sentence and style types for speakability. These findings demonstrate that predictable pattern books can serve as good materials to read aloud for young children not only in terms of English picture books but also translated books regardless of concerns regarding their speakability.