• 한국식품영양과학회지
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• 제27권3호
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• pp.553-562
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• 1998

Food allergy is defined as an immunologically-mediated adverse reaction to food.The food allergy as a clinical entity has been recognized for many years, although there is yet no general consensus as to the incidence of this syndrome. One difficulty in studying food allergies has been the lock of a reasonable animal model in which reactions could be induced by orally administrating foods. It has been generally accepted that the initial target for an immediate reaction to food is the mast cells, within the gastronitestinal mucosa, and such cells are sensitize in vivo by food-specific immunoglobulin(Ig) E. Degranulation of these cells facilitates the entry of an antigenic epitope into the lymphatic system and blood stream, thereby causing further degranulation of the mast cells and basophils throughout the boy. Accordingly, the author attempted to develop an animal model that is indicative of evaluating IgE-mediated immediate hypersensitivity. It is also necessary to evaluate the effects of nutritional envioronments on dietary protein-dependent allergy and the regulatory mechanisms of dietary fats on IgE-mediated immune response. In this review, animal models to evaluate a food ingredient, effects of dietary fats and curcuminoids, milk whey protein hydrolysates on allergic reaction, and effect of dietary fat in splenic immune cells are presented.

• Journal of Nutrition and Health
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• 제32권4호
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• pp.419-429
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• 1999

This study was conducted to investigate the dietary habits and assess the dietary intake of preschool children. Food habit, preference and nutritional supplement status were investigated using a questionnaire answered by the mothers of 453 subjects aged 3 to 6 years old. Also, a dietary intake survey using a 24-hour recall method was performed by mothers of the children. It was found that 81.2% of subjects had milk, dairy products, cookies, fruit and bread between meals once or twice per day. As well, 60.3% of subjects had an unbalanced diet and 20.7% had an overeating habit. Thus, unbalanced diet was a serious problem for many of the subjects. Due to weight controls, digestion problems and allergies, 11.7% of subjects had special dietary consideration. And 26.4% of subjects were using nutritional supplements. From the 24-recall survey, it was found that all nutrient intakes were higher than the Korean RDA except calcium and vitamin A. Nutrient intakes for protein, calcium, phosphorus and vitamin B2 were significantly different by sex, and also increased with age but not significantly. Children received 35% of daily energy, 44% of daily fat and 52% of daily calcium from snacks, so snacks clearly play an important role in dietary intake. The average number of foods consumed per day by subjects was 17.6 and that dishes was 11.0. Most children consumed 4 or 5 food groups per day. In conclusion, the dietary intake of children aged 3 to 6 were deemed adequate judging from nutrient intake and dietary diversity. More attention should be paid to the nutritional value of snacks in this age group.

• Clinical and Experimental Pediatrics
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• 제60권4호
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• pp.99-105
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• 2017

Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending on the countries: peanuts in the United States and Switzerland, wheat in Germany and Japan, tree nuts in Spain, sesame in Israel, and walnuts in Korea. These common food allergens are different and difficult to identify because of differing study methodologies, population, geography, age, and dietary exposure patterns. The current management of FA relies on the strict avoidance of culprit allergens, the prompt treatment of allergic reactions, including epinephrine use for food-induced anaphylaxis, monitoring, and education to prevent further reactions. Newer approaches for tolerance induction to FA and FA immunotherapy have been under investigation but are not yet ready for real-world application. Thus, consistent and systematic education of patients, caregivers, and food-handling people is of primary importance for the management and prevention of FA reactions. This review assesses and compares IgE-mediated FA in children in Korea and other countries, with a focus on summarizing the prevalence, common triggers, and management of FA.

• Child Health Nursing Research
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• 제21권3호
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• pp.227-235
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• 2015

Purpose: The purpose of this study was to investigate disease prevalence, parent's educational needs, and disease management according to severity of respiratory infections in early childhood. Methods: Participants for this study were 173 mothers whose child was admitted to I university hospital in Seoul and whose child was an infant or toddler. Data were collected from December, 17, 2014 to February, 15, 2015 using self-report structured questionnaires. Data were analyzed using IBM/SPSS 21.0 program. Results: There were significant differences in the severity of respiratory infection according to neonatal admission due to dyspnea, feeding type, atopic dermatitis in the infant or allergic disease in father and siblings. Parent's educational needs for the severe respiratory infection group were higher than for the non-severe group. Parent's disease management for the severe respiratory infection group was lower than the non-severe group. Conclusion: As important care factors in neonatal admissions include dyspnea, cow milk feeding, eczema, family history of allergies, parent's educational needs and disease management, they should be considered when caring for young children with respiratory infections and their parents.

• 한국식생활문화학회지
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• 제35권1호
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• pp.97-106
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• 2020

This study aimed to evaluate dietary behaviors and food allergy status of preschool children in Gwangsan-gu, Gwangju Metropolitan city. The survey included 592 preschool children aged 1-5 years old in 31 childcare facilities. General characteristics, feeding type, complementary feeding, food allergy, dietary behaviors based on the NQ-P questionnaire, and dietary habits of their family were considered. Exclusively breast-fed children was 32.2% of the subjects and the breast feeding duration was 6.5 months. Subjects who had complementary feeding within 6 months was 77.2% and starting time of complementary feeding was 6.1 months. Fifteen percent of the subjects had food allergies and foods that induced allergy were instant foods, eggs, milk and dairy products, nuts, seafood. Food allergy was not related to breast feeding nor complementary feeding. The NQ-P score and its 3 factors including 'balance', 'moderation', and 'environment' were 59.9, 61.1, 56.0, 62.6, respectively. There were positive relations between children's dietary behaviors and family dietary habits such as breakfast eating frequency and meal regularity. As age of children increased, instant food intake increased and breakfast eating frequency decreased. Proper nutrition education is needed to children, their parents, and their care givers at childcare facilities to improve children's dietary behavior and health.

• Journal of Nutrition and Health
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• 제48권6호
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• pp.530-541
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• 2015

본 연구에서는 제주지역 6개 초등학교를 임의 선정하여 초등학교 4, 5, 6학년 학생 1,500명을 대상으로 2014년 7월 설문조사를 실시, 최종 1,000부를 분석하여 식품알레르기 유병률을 알아보고 식품알레르기에 대한 지식정도, 학교급식 서비스를 이용하는 학생들의 식품알레르기 유발표시제에 대한 인식도와 그에 따른 학교급식의 대체식 운영현황 및 영양교육의 관리 실태를 조사하였다. 연구결과는 다음과 같다. 1) 조사대상자는 남학생 49.6%, 여학생 44.2%이었고, 4학년 28.4%, 5학년 27.5%, 6학년 44.1% 이었다. 식품알레르기를 경험한 적이 있는 학생이 16.7%이며, 여학생이 19.2%, 남학생이 14.1%로 여학생이 남학생보다 식품알레르기를 경험한 학생이 유의적으로 많은 것으로 나타났다. 이들 중 의사진단을 받은 학생은 26.4%로 나타났다. 2) 식품알레르기의 증상으로는 두드러기, 가려움, 구토, 설사, 호흡곤란 순으로 나타났으며, 알레르기 유발 식품으로는 우유, 게, 새우, 땅콩, 밀과 계란, 대두, 메밀과 돼지고기, 복숭아, 토마토, 아황산염 등의 순으로 조사되었다. 3) 식품알레르기 지식 점수는 여학생이 남학생보다 높은 점수를 기록하였고, 학년별로는 학년이 올라갈수록 지식점수 또한 유의적으로 높아짐을 관찰하였다. 식품알레르기와 관련 있는 영양소에 대한 지식 정답률만이 식품알레르기 경험 여부에 따라 차이를 보였고, 전체적인 식품알레르기 지식점수는 식품알레르기 경험 유무에 따라 차이를 보이지 않았다. 4) 학교급식 식품알레르기 유발표시제 인식도의 평균점수는 5점 만점에 2.25점으로 비교적 낮게 나타났으며, 성별과 학년 그리고 식품알레르기 경험유무에 따른 식품알레르기 유발표시제에 대한 인식도의 차이는 관찰되지 않았다. 5) 성별과 학년에 따른 식습관 평균점수의 유의적인 차이는 없었으나, 식품알레르기 경험 유무에 따라서는 식품알레르기를 경험한 학생의 식습관 점수가 그렇지 않은 학생보다 유의적으로 낮게 나타났다. 6) 식품알레르기 유발 학생들에 대한 학교급식의 관리실태 결과, 20.4%의 학생이 대체식을 제공받고 있었으며, 대체식으로 제공받은 음식으로는 김, 계란후라이, 멸치볶음, 두부 등 조사되었다. 7) 조사대상자 중 30.8%만이 식품알레르기 관련 영양교육을 받은 경험이 있으며, 교육방법으로는 가정통신문과 학교홈페이지 등과 같은 간접적인 방법을 통한 교육으로 나타났다. 이상의 연구결과를 토대로 살펴볼 때, 초등학교 고학년 학생과 학부모 및 담임교사 등으로 대상을 확대하여 학교차원에서의 보다 체계적이고 세심한 식품알레르기 교육이 실시되어야 할 것이며, 학교급식의 식품알레르기 유병학생을 대상으로 성장기에 필요한 영양소들을 충분히 공급할 수 있도록 다양한 대체식의 개발 방안이 모색되어야 할 것으로 사료된다.

• 한국생활과학회지
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• 제22권5호
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• pp.491-506
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• 2013

The allergenic food labeling system for 12 foods has been operated in Korean school food service since 2012. This study was conducted to evaluate the food allergy status of Korean elementary school children's and their parents' perceptions of allergenic food labeling system. The parents of school aged(6-9yr olds) children in Gyeongbuk area were recruited to assist in this survey. Surveys were conducted by 404 parents. The prevalence of food allergy was 18.1%(73 students) and about one-half of the food allergic children had a family history of allergies, in particular, maternal family history. The major symptoms were related to skin and the major allergenic foods were mackerel, eggs, milk, wheat, crab and tomatoes. The parents eliminated the allergenic food from diet of 43.8% of the children with food allergy. Participants had an average knowledge score of 68% correct. The average knowledge score was higher for parents with food allergic children than for parents with intact children(p<.05). Over 61% of the respondents were not satisfied with allergenic food labeling system operated in school food service. The requirements for the allergenic food labeling system were the front-of-package labeling, conspicuous description and insert of warning sign. The parents estimated that the most important effect of the allergenic food labeling system was the improvement of psychological and physical health in children with food allergy. Because the only prevention method for food allergy is the restriction of allergenic food, the institutional device to expand the food labeling to unpackaged food as well as packaged food and to make people trust the food labeling should be prepared.

• 동아시아식생활학회지
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• 제13권3호
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• pp.167-175
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• 2003

This study was conducted to investigate the actual state of the food allergy and food behavior in adults by using a questionnaire. The subjects of this study were consisted of 207 males and 355 females in Gyeongbuk area. The results are as follows: Among the respondents, 54.9% kept up with proper eating habits, 41.2% knew how much they would have to eat appropriately in a day, and women ate more milk and snacks than men in a day and men ate more meat than women. 58.3% of men and 46% of women were eating 3 meals a day. This finding indicated that women skipped the meal more than men. 77.2％ of the respondents skipped their breakfast, 13.5％ the lunch, and 9.3% the dinner. 48.5％ of men and 28.8% of women evacuated over 8 times a week(p<0.001). Eczema was the allergy symptom which broke out the most highly in both male and female; 25% of men and 29.9% of women. Atopic dermatitis and pollen allergy broke out similarly in both male and female. Allergic rhinitis occurred twice more in men than in women. Asthma broke out in men about three times more than in women. 36.3% of men and 46.5% of women visited a doctor when they had an allergic reaction. 40.9% of men and 40.7% of women believed that the allergy was caused mainly by the dust in the house and mites. The other factors, which caused the allergic reaction, were thought to be the specific food and the pollution from cars and factories by men and the specific food and others by women. 35.4% of men and 44.2% of women ate homemade food to prevent allergies.

• Clinical and Experimental Pediatrics
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• 제61권11호
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• pp.348-354
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• 2018

Purpose: The purpose of this study was to identify the causes, symptoms, and complications of hypoproteinemia to prevent hypoproteinemia and provide appropriate treatment to children with atopic dermatitis. Methods: Children diagnosed with atopic dermatitis with hypoproteinemia and/or hypoalbuminemia were retrospectively reviewed. The patients' medical records, including family history, weight, symptoms, treatment, complications, and laboratory test results for allergies and skin cultures, were examined. Results: Twenty-six patients (24 boys) were enrolled. Seven cases had growth retardation; 7, keratoconjunctivitis; 6, aural discharges; 5, eczema herpeticum; 4, gastrointestinal tract symptoms; and 2, developmental delays. In 21 cases, topical steroids were not used. According to the blood test results, the median values of each parameter were elevated: total IgE, 1,864 U/mL; egg white-specific IgE, $76.5kU_A/L$; milk IgE, $20.5kU_A/L$; peanut IgE, $30kU_A/L$; eosinophil count, $5,810/{\mu}L$; eosinophil cationic protein, $93.45{\mu}g/L$; and platelet count, $666.5{\times}10^3/{\mu}L$. Serum albumin and total protein levels decreased to 2.7 g/dL and 4.25 g/dL, respectively. Regarding electrolyte abnormality, 10 patients had hyponatremia, and 12, hyperkalemia. Systemic antibiotics were used to treat all cases, and an antiviral agent was used in 12 patients. Electrolyte correction was performed in 8 patients. Conclusion: Hypoproteinemia accompanying atopic dermatitis is common in infants younger than 1 year and may occur because of topical steroid treatment continuously being declined or because of eczema herpeticum. It may be accompanied by growth retardation, keratoconjunctivitis, aural discharge, and eczema herpeticum and can be managed through skin care and topical steroid application without intravenous albumin infusion.

• Journal of Microbiology and Biotechnology
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• 제25권10호
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• pp.1687-1696
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• 2015

Supplementation with probiotics can protect against the development of food allergies by modulating the host immune response; however, the mechanisms are not fully understood. The objective of this study was to investigate the allergy-reducing effects of regulatory dendritic cells (regDCs) induced by Lactobacillus paracasei L9 (L9) in β-lactoglobulin (BLG)-sensitized mice. The L9 supplement suppressed the aberrant balance of Th1/Th2 responses to BLG in mice, via upregulation of the CD4+CD25+Foxp3+Treg cell responses. The amount of CD4+CD25+Foxp3+Treg cells in mesenteric lymph nodes increased by 51.85%. Furthermore, administration of L9 significantly induced the expression of CD103 and reduced the maturation status of DCs in mesenteric lymph nodes, Peyer's patches, and spleen. Bone marrow-derived dendritic cells (BM-DCs) were activated by L9 in vitro, with an approximate 1.31-fold and 19.57-fold increase in expression of CD103 in CD11c+DCs and the level of IL-10 production, respectively, while the expression of CD86 did not change significantly. These data demonstrate that L9 reduced the BLG allergic sensitization, likely through regDCs mediated active suppression.