• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1051-1056
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• 2015

Aberrant expression of genes in de novo lipogenesis (DNL) pathway were associated with various cancers, including hepatocellular carcinoma (HCC). Single nucleotide polymorphisms (SNPs) of DNL genes have been reported to be associated with prognosis of some malignancies. However, the effects of SNPs in DNL genes on overall survival of HCC patients receiving transarterial chemoembolization (TACE) treatment are still unknown. In present study, nine SNPs in three genes (ACLY, ACACA and FASN) in DNL pathway were genotyped using the Sequenom iPLEX genotyping system in a hospital-based cohort with 419 HCC patients treated with TACE, and their associations with HCC overall survival were evaluated by Cox proportional hazard regression analysis under three genetic models (additive, dominant and recessive). Although we did not find any significant results in total analysis (all p>0.05), our stratified data showed that SNP rs9912300 in ACLY gene was significantly associated with overall survival of HCC patients with lower AFP level and SNP rs11871275 in ACACA gene was significantly associated with overall survival of HCC patients with higher AFP level. We further identified the significant interactions between AFP level and SNP rs9912300 or rs11871275 in the joint analysis. Conclusively, our data suggest that genetic variations in genes of DNL pathway may be a potential biomarker for predicting clinical outcome of HCC patients treated with TACE.

• Journal of Preventive Medicine and Public Health
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• 제30권2호
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• pp.267-278
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• 1997

The purpose of this study was to investigate the incidence rate of hepatitis B in the military service and to examine the effect of the asymptomatic hepatitis B surface antigen(HBsAG) carries on the incidence of hepatitis B. The subject were 223,270 men who were conscripted to the Korean Army from 1991 to 1994. According to the conscripted year, four conscription cohort were constructed. At the screening examination for military service no test for hepatitis B were performed in 1991 and 1992. In 1993, a screening test for hepatitis B were performed and those who were confirmed as HBsAg positive o. showed high titers $(\geqq100IU)$ of nm glutamic-pyruvic transaminase(SGPT) were excluded from conscription. In 1994, the criteria for conscription was changed and those who were HBsAg positive were not excluded from conscription. Only those who showed $\geq$ SGPT 100IU were excluded. The main results were as follows ; 1. The positive rate of HBsAg is 5.5% in the conscripted men. 2. The incidence rates of the hepatitis B in 1991 and 1992 conscription cohort were 9.96 and 8.10 per ten thousand person-year, respectively. The incidence rate of the hepatitis B was 1.34 per ten thousand person-year in 1993 conscription cohort which was confirmed as HBsAg negative at the screning test, and 7.41 per ten thousand person-year in 1994 conscription cohort which included the HBsAg positive. 3. The incidence rate of hepatitis B was 99.98 per ten thousand person-year in HBsAg positive group and 2.25 per ten thousand person-year in HBsAg negative group. The incidence rate of the group with high SGPT and HBsAg positive was 255 times higher than that of normal population. 4. The incidence of hepatitis B in HBsAg negative group did not increase even though the probability of personal contact with HBsAg positive had been increased. from the above results, the men who have high SGPT with HBsAg positive should be excluded from military service, and it can not be said that asymptomatic HBsAg carriers influence on the hepatitis B incidence among the HBsAg negative through personal contact.

• Parasites, Hosts and Diseases
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• 제61권2호
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• pp.198-201
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• 2023

In the past decade, experts have conducted parasitological research on archaeological specimens in Korea to collect historical parasite infection data. In these studies, parasitologists successfully described the infection pattern of each parasite species in history. However, in the first half of the 20th century, archaeoparasitological reports have been scant. In 2021, we conducted a parasitological examination of a toilet-like structure that emerged in the early 20th century. This structure was built by stacking 2 wooden barrels; and in the study samples, we found ancient Trichuris trichiura, Ascaris lumbricoides (unfertilized), and Taenia spp. eggs and therefore proposed a higher possibility that the barrels could have been used as a toilet at the time. To understand how the antihelminthic campaign since the 1960s helped reduce parasite infection rates in Korea, more research should focus on early-20th-century toilet ruins.

• 치위생과학회지
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• 제10권3호
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• pp.131-139
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• 2010

이 연구는 우리나라 군 장병이 복무를 하는 과정에서 병영 안의 내무반생활과 병영 밖의 군사훈련생활에서 흡연 양상의 차이와 이와 관련한 구강보건행태와 인식의 변화를 알아보고자 하였다. 이를 위해 2009년 3월 16일부터 6월 16일까지 육군 ${\bigcirc}{\bigcirc}$부대에 복무하고 있는 장병 367명의 설문 응답을 분석하여 다음의 연구결과를 얻었다. 1. 군인의 복무 상황에 따른 구강보건행태를 비교한 결과, 군사훈련생활에서는 내무반생활에 비하여 구강 건강을 적절히 관리하지 못하고 있었다. 칫솔 사용률은 내무반생활에서는 96.2%이었지만 군사훈련생활에서는 72.0%로 감소하였다. 내무반생활을 할 때에는 하루 3회 이상 칫솔질을 한다는 군인이 55.3%이었으나, 군사훈련생활을 할 때에는 29.3%로 크게 감소하였다. 2. 군에 입대한 후 구강예방진료, 구강보건교육, 금연교육을 받은 경험이 없는 군인이 각각 84.1%, 90.7%, 87.9%이었다. 3. 군인의 52.8%가 흡연자이고, 47.2%는 비흡연자이었다. 흡연자의 31.1%는 흡연 후에 아무런 구강건강관리행위를 하지 않았다. 흡연하는 담배 개비의 수는 내무반생활에서는 평균 13.97개비(표준편차 7.51), 군사훈련생활에서는 평균 13.02개비(표준편차 8.36)로서 통계적으로 유의한 차이는 없었다(p=0.109). 4. 흡연자는 칫솔질 횟수와 칫솔질 시간이 적을수록 Pack years가 높은 경향을 보이지만, 통계적으로 유의한 차이는 없었다(각각 p=0.063, p=0.184). 5. 흡연에 대한 구강보건인식을 조사한 결과, 흡연자의 77.9%와 비흡연자의 88.8%가 흡연이 구강건강에 영향을 미친다고 생각하였고(p=0.0095), 흡연자의 52.4%와 비흡연자의 72.5%가 구강건강이 전신건강에 영향을 미친다고 생각하였으며(p=0.0007), 또한 흡연자의 35.8%와 비흡연자의 59.1%가 군대 내에서 금연교육이 필요하다고 생각하였다(p<0.0001). 아울러 전체 대상자의 77.8%와 64.5%가 각각 군대 내에서 구강검진이 필요하고, 구강보건교육이 필요하다고 생각하였으나 이 두 가지의 인식에서는 흡연자와 비흡연자 사이에 통계적으로 유의한 차이는 없었다. 6. 군사훈련생활과 흡연 여부에 따른 칫솔질의 횟수 및 시간을 조사한 결과, 내무반생활에 비하여 군사훈련 생활에서 1회만 칫솔질을 할 확률은 2회 이상 칫솔질을 할 확률보다 9.29배 높았으며(p<0.01), 내무반 생활에 비하여 군사훈련생활에서 1분 이내로 칫솔질을 할 확률은 1분 이상 칫솔질을 할 확률보다 2.19배 높아 통계적으로 유의한 차이가 있었다(p<0.01). 하지만 칫솔질의 횟수와 시간 전체에 대해서는 군사훈련생활 여부와 계급을 보정한 결과, 비흡연자와 흡연자 사이에 통계적으로 유의한 차이가 없었다. 이번 연구를 통하여 우리나라의 군 병사는 내무반에서 생활할 때에 비하여 군사훈련의 생활을 할 때에 자가구강 관리에 어려움을 겪고 있으며, 흡연율이 높지만 군대 내의 금연교육과 구강보건교육은 부족하다는 사실을 확인할 수 있었다. 따라서 군에서는 군 장병이 군 복무를 하는 동안 구강건강이 증진될 수 있도록 의무 환경을 적극적으로 개선해야 할 것이다.

• 한국환경보건학회지
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• 제39권3호
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• pp.197-210
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• 2013

Several US veterans stationed in Korea have told the press that around 250 fifty-five gallon drums of herbicides, including Agent Orange, were buried at Camp Carroll in 1978. Joint Korean-US Agent Orange investigation and environmental and health studies were started in July 2011. Korean soldiers and military personnel who served in Vietnam during 1964-1973 or near the demilitarized zone in Korea during 1967-1970 were exposed to dioxincontaminated Agent Orange. The joint Korean-US Agent Orange investigation team found that herbicides, pesticides, solvents and other chemicals -not Agent Orange- were buried at Camp Carroll. However, there remains the possibility that Agent Orange was stored and buried at Camp Carroll or other military camps in Korea. Adverse health effects have not been clearly explained despite a number of health studies among veterans in Korea with potential Agent Orange exposure. Although the Korean government has been compensating veterans and military personnel with 18 presumptive-service-connected-diseases and their offspring with three diseases, there are many veterans, military personnel and civilians who require the government°Øs support. The environmental study on contaminated sites and health studies among veterans and civilians were initiated three or four decades after possible Agent Orange contamination and exposure. Several toxic chemicals, including dioxin-contaminated Agent Orange, could remain in the environment and could have hazardous effects on the health of exposed people for more than several decades. Further environmental investigations and health studies are needed to ensure public safety and health, and government support should be guaranteed for people potentially exposed to these toxic chemicals.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3253-3258
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• 2012

Objective: To evaluate the efficacy and safety of whole brain radiotherapy (WBRT) plus chemotherapy versus WBRT alone for treating brain metastases (BM) from lung cancer by performing a meta-analysis based on randomized controlled trials (RCTs). Methods: The PubMed, Embase, CENTRAL, ASCO, ESMO, CBM, CNKI, and VIP databases were searched for relevant RCTs performed between January 2000 and March 2012. After quality assessment and data extraction, the meta-analysis was performed using the RevMan 5.1 software, with funnel plot evaluation of publication bias. Results: 19 RCTs involving 1,343 patients were included. The meta-analyses demonstrated that compared to WBRT alone, WBRT plus chemotherapy was more effective with regard to the objective response rate (OR = 2.30, 95% CI = 1.79 - 2.98; P < 0.001); however, the incidences of gastrointestinal reactions (RR = 3.82, 95% CI = 2.33 - 6.28, P <0.001), bone marrow suppression (RR = 5.49, 95% CI = 3.65 - 8.25, P < 0.001), thrombocytopenia (RR = 5.83, 95% CI = 0.39 - 86.59; P = 0.20), leukopenia (RR = 3.13, 95% CI = 1.77 - 5.51; P < 0.001), and neutropenia (RR = 2.75, 95% CI = 1.61 - 4.68; P < 0.001) in patients treated with WBRT plus chemotherapy were higher than with WBRT alone. There was no obvious publication bias detected. Conclusion: WBRT plus chemotherapy can obviously improve total efficacy rate, butalso increases the incidence of adverse reactions compared to WBRT alone. From the limitations of this study, more large-scale, high-quality RCTs are suggested for further verification.

• Journal of Yeungnam Medical Science
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• 제14권2호
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• pp.467-473
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• 1997

저자들은 1994년에서 1995년 사이에 경기도 북부 휴전선 부근에서 말라리아가 유행할 때 그 지역에서 근무하고 제대한 후에 외국 여행이나 수혈의 경력이 없는 젊은 남자에서 오한과 동반된 발작적 발열 등의 임상 증상과 말초 혈액 도말 검사에 의해 삼일열 말라리아로 확진되어 치료한 8예를 경험하였다. 삼일열 말라리아의 재정착이 확인되었으므로 오한을 동반한 발열 환자의 원인으로서 말라리아가 반드시 고려 대상이 되어야 하며 말라리아 재유행에 대한 조사와 함께 감시 대책이 필요하리라 생각된다.

• 디지털융복합연구
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• 제11권11호
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• pp.471-478
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• 2013

이 연구는 군인의 여가활동 유형에 따른 군대생활만족도를 경로분석 모형을 통하여 분석하였다. 조사대상은 경기도 북부, 남부지역의 두 부대에서 군 생활을 하고 있는 장병들을 대상으로 2011년 9월부터 8주 동안 해당부대를 직접 방문하여 설문 실시하였으며, 856부의 설문지를 회수하여 분석에 사용하였다. 연구 결과 군인들의 생활만족도에는 신체증상, 우울, 사회적 지지가 유의하게 영향을 미치는 관련요인으로 밝혀졌으며, 본 연구를 토대로 군은 군인의 신체증상과 우울을 완화시키고 사회적 지지 체계의 구축에 효과적인 여가활동을 통해 군인들의 생활만족도를 향상시킬 수 있도록 제도적인 뒷받침이 있어야 할 것이다.

• 기본간호학회지
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• 제15권3호
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• pp.387-394
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• 2008

Purpose: This study was done to identify whether the program, improving adjustment to military life would have an effect on stress, depression, idea of suicide, adjustment to military living, and self-esteem in auxiliary police. Method: This quazi experimental study using a non-equivalent control group pretest and posttest design was conducted from February 1 to May 30, 2007. Using convenience sampling, the researcher recruited 120 auxiliary police and randomly assigned each to either the experimental and the control group. The experimental group received an 8-week program to improve adjustment to military life. Results: Anxiety, stress, depression, idea of suicide, self-esteem, and adjustment to military living were significantly different between the experimental and control groups. Conclusion: These results suggest that programs to improve adjustment to military life would improve psychological health and adaptation of military living in auxiliary police. Replication studies are needed to confirm the effects of this program and to identify the long-term maintenance effects of the program.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.691-694
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• 2013

Purpose: By carrying out a meta-analysis of randomized controlled trials that compared sorafenib or combined chemotherapy with placebo or combined chemotherapy, the effectiveness of sorafenib in hepatocellular carcinoma was evaluated in the present study, which also provided clinical practice guidelines of evidence-based-medicine. Methods: We reviewed PubMed citations concerning sorafenib treating hepatocellular carcinoma in randomized controlled trials from Jan 2000 to July 2012. All the literature was extracted by Cochrane systematic reviews and underwent meta-analysis with RewMan 5.0 software. Results: Finally, four papers documenting randomized controlled studies were included. Compared with controls, sorafenib was shown to significantly increase overall survival (OS), time to progression (TTP), and disease control rates (DCR), but not the time to symptom progression (TTSP) in hepatocellular carcinoma patients. The incidence of grade-III/IV adverse reactions, including hand-foot-skin reactions, diarrhea, hypertension and skin rash or desquamation, in sorafenib treatment group was higher than that in controls. However, there was no significant difference in the incidence of hypodynamia between the two groups. Conclusions: Sorafenib exerts significant curative effects in hepatocellular carcinoma.