• Biomolecules & Therapeutics
• /
• 제25권5호
• /
• pp.471-481
• /
• 2017

The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of $Ca^{2+}$ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions such as contraction, relaxation, proliferation, and dysfunction. This review, organized into seven main sections, will provide an overview of current knowledge about the underlying pathogenesis of TRPCs in cardio/cerebro-vascular diseases, including hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury. Collectively, TRPCs could become a group of drug targets with important physiological functions for the therapy of human cardio/cerebro-vascular diseases.

• KSBB Journal
• /
• 제24권2호
• /
• pp.177-181
• /
• 2009

This study was initiated to investigate the impacts of media types and other components on the callogenensis and cell mass production of Panax vietnamensis in the first step of the cell biomass procedure. Four media were checked: Murashige-Skoog (MS), White, Gamborg and Nitch-AII. All the four media were shown potential media for Panax vietnamensis callogenensis and cell mass production, in which the MS medium showed the best results: the successful callogenensis ratio and cell mass formation were 30% and 62,93 ${\pm}$ 3,63 mg (DW) respectively, the Nitch medium showed the lowest results: the successful callogenensis ratio and cell mass formation were 15% and 27,10 ${\pm}$ 2,24 mg (DW) respectively. The results showed that the MS medium is the most suitable medium for Panax vietnamensis callogenensis and cell mass production.

• 한국군사과학기술학회지
• /
• 제18권1호
• /
• pp.66-83
• /
• 2015

Global Positioning System(hereafter; GPS) is recently an essential element in the various navigation and weapon delivery systems of military aircraft. However, GPS is vulnerable to the jamming threats since its signal power is very weak. Therefore, ROK defense has been concerning how to resolve this issue and how to integrate these systems needed, and is trying to acquire the proper anti-jamming GPS system. This study is to provide several schemes against the jamming threats effectively. We propose the several processes to analyze the required capability and demonstrate the result's of modeling and simulations(hereafter; M&S) for this integration of military aircraft, and the mathematical programming model for system optimization of military aircraft anti-jamming GPS system on the basis analysis of M&S results which could be considered available budget and the project characteristic. These schemes will be helpful on proper acquisition of these systems and. We are looking forward to contributing to the integration of anti-jamming GPS system of ROK military aircraft.

• 항공우주시스템공학회지
• /
• 제15권4호
• /
• pp.64-74
• /
• 2021

Unmanned Aircraft Systems (UAS) are rapidly emerging not only as a key military power, such as surveillance and reconnaissance for military purposes but also as a new air transportation means in the form of Urban Air Mobility (UAM). Currently, airworthiness certification is carried out focused on the verification of technical standards for flight safety suitability of aircraft design in accordance with the Military Aircraft Flight Safety Certification Act and does not employ the model for operational risk assessment for mission areas and airspace. In this study, in order to evaluate the risk of the mission area from the perspective of the UAS operator, a risk assessment simulation has been conducted by applying the Specific Operations Risk Assessment (SORA) model to the operating environment of the Korean military UAS. Also, the validity of the SORA model has been verified through the analysis of simulation results, and a new application plan for airworthiness certification of the military unmanned aerial system has been presented.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권10호
• /
• pp.4265-4269
• /
• 2015

Introduction: The aim of the study was to explore the distribution of eyelid tumors in Ankara, the capital city of Turkey, from a histopathological point of view. Materials and Methods: Medical records of 1,502 patients who had eyelid surgery because of tumoral lesions were retrospectively reviewed after obtaining institutional review board approval. A total of 1,541 lesions with histopathologic diagnosis were included. Inflammatory tumoral lesions were excluded. The lesions were categorized into three groups according to the origin: epidermal, adnexal tumors and 'others', including melanocytic, neural and vascular lesions. Results: Of the total of 1,541, 908 lesions were epidermal in origin. Only 22 (1.5%) were malignant, and 6.0% was premalignant lesions such as actinic keratosis and Bowen's disease. Twenty-one of 22 malignant lesions were basal cell carcinoma. There was only one patient with squamous cell carcinoma and no sebaceous cell carcinoma. Among the benign tumors (92.5%), squamous papilloma was the most frequent (21.8% of all lesions). The other frequent lesions were nevus (17.6%), seborrheic keratosis (17.3%), hydrocystomas (10.6%), xanthelasma (7.6%) and epidermal cysts (7.2%). Conclusions: The results of this study are in accordance with published literature. The absence of sebaceous cell carcinomas needs to be stressed.

• 농촌계획
• /
• 제28권4호
• /
• pp.31-39
• /
• 2022

This study empirically analyzed the welfare effect of the military purveyance program, which plays an important role in maintaining the sales channel and demand base in Korea's agricultural and livestock industry, as well as the stable supply of safe ingredients for military meals essential for the morale and combat power of soldiers. The military purveyance program causes additional demand for domestic livestock products, affecting the trading volumes and price levels in the market. This will change the welfare of producers and consumers, and affect the welfare of soldiers who are subject to military meals. The analysis results obtained through a simulation method based on the equilibrium displacement model are as follows. In the case of pork delivered for military service, producer surplus increased by KRW 55.3-62.2 billion and consumer surplus decreased by KRW 55.1~62.0 billion based on pork production in 2021. It wad analyzed that the consumer surplus in the military supply market, rather than the conventional market, increased by KRW 96.9 billion won, resulting in a total welfare gain of KRW 97.1 billion.

• 한국군사과학기술학회지
• /
• 제22권3호
• /
• pp.425-432
• /
• 2019

Modeling and Simulation(M&S) has widely been used in various areas such as industry, academy and military. Especially, military have used the technology for acquisition, training, and combat assessment. In this paper, we introduce our experience using M&S technique to analyze the network traffic amount and packet delay time between two military bases. For this, we modeled the current network configuration of the military bases and simulated the model with NS-3 tool. The result provided us for an insight regarding the required network performance between two bases.

• 한국군사과학기술학회지
• /
• 제17권6호
• /
• pp.836-843
• /
• 2014

The infrastructure of North Korea has serious problems such as stability, usability, and durability because the facilities were built a long time ago. In recent years, the infrastructure improvement of North Korea has emerged as the important issue to preparing for reunification. However, there are no research institutions about the infrastructure in South Korea as well as the experts for operating or constructing the infrastructure. Therefore, the objective of this study is to propose the military use of infrastructure in North Korea by analyzing various data. The facilities such as road, railroad and electricity has been focused in this study. In the future, if the more specific data regarding condition and problems in each facility are collected, the more detailed military use of the infrastructure of North Korea can be suggested.

• Journal of Ginseng Research
• /
• 제40권2호
• /
• pp.196-202
• /
• 2016

Background: Ginsenoside Rd (GSRd), a main component of the root of Panax ginseng, exhibits anti-inflammation functions and decreases infarct size in many injuries and ischemia diseases such as focal cerebral ischemia. M1 Macrophages are regarded as one of the key inflammatory cells having functions for disease progression. Methods: To investigate the effect of GSRd on renal ischemia/reperfusion injury (IRI) and macrophage functional status, and their regulatory role on mouse polarized macrophages in vitro, GSRd (10-100 mg/kg) and vehicle were applied to mice 30 min before renal IRI modeling. Renal functions were reflected by blood serum creatinine and blood urea nitrogen level and histopathological examination. M1 polarized macrophages infiltration was identified by flow cytometry analysis and immunofluorescence staining with $CD11b^+$, $iNOS^+$/interleukin-12/tumor necrosis factor-${\alpha}$ labeling. For the in vitro study, GSRd ($10-100{\mu}g/mL$) and vehicle were added in the culture medium of M1 macrophages to assess their regulatory function on polarization phenotype. Results: In vivo data showed a protective role of GSRd at 50 mg/kg on Day 3. Serum level of serum creatinine and blood urea nitrogen significantly dropped compared with other groups. Reduced renal tissue damage and M1 macrophage infiltration showed on hematoxylin-eosin staining and flow cytometry and immunofluorescence staining confirmed this improvement. With GSRd administration, in vitro cultured M1 macrophages secreted less inflammatory cytokines such as interleukin-12 and tumor necrosis factor-${\alpha}$. Furthermore, macrophage polarization-related pancake-like morphology gradually changed along with increasing concentration of GSRd in the medium. Conclusion: These findings demonstrate that GSRd possess a protective function against renal ischemia/reperfusion injury via downregulating M1 macrophage polarization.

• Yonsei Medical Journal
• /
• 제59권9호
• /
• pp.1131-1137
• /
• 2018

Purpose: Previous reports have shown that hyperglycemia-induced inhibition of transient receptor potential vanilloid sub type 4 (TRPV4), a transient receptor potential ion channel, affects the severity of hearing impairment (HI). In this study, we explored the role of TRPV4 in HI using HEI-OC1 cells exposed to high glucose (HG). Materials and Methods: HEI-OC1 cells were cultured in a HG environment (25 mM D-glucose) for 48 hours, and qRT-PCR and Western blotting were used to analyze the expression of TRPV4 at the mRNA and protein level. TRPV4 agonist (GSK1016790A) or antagonist (HC-067047) in cultured HEI-OC1 cells was used to obtain abnormal TRPV4 expression. Functional TRPV4 activity was assessed in cultured HEI-OC1 cells using the MTT assay and a cell death detection ELISA. Results: TRPV4 agonists exerted protective effects against HG-induced HI, as evidenced by increased MTT levels and inhibition of apoptosis in HEI-OC1 cells. TRPV4 overexpression significantly increased protein levels of phosphorylated p38 mitogen-activated protein kinase (p-p38 MAPK), while TRPV4 antagonists had the opposite effect. Our results indicated that TRPV4 is a hyperglycemia-related factor that can inhibit cell proliferation and promote cell apoptosis by activating the MAPK signaling pathway in HEI-OC1 cells. Conclusion: Our results show that the overexpression of TRPV4 can attenuate cell death in HEI-OC1 cells exposed to HG.