• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.9
• /
• pp.4103-4107
• /
• 2015

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Transarterial chemoembolisation (TACE) is the standardized therapy for intermediate stage HCC. However, the prognosis for HCC patients treated by TACE greatly varies. Thus, there is a critical need for finding biomarkers to predict the prognosis of HCC patients. The amino acid transporter-2 (ASCT2) is involved in tumorigenesis and progression of many malignancies. This study aimed to evaluate the predictive role of two single nuclear polymorphisms (SNPs, rs3826793 and rs2070246) in the ASCT2 gene in HCC patients treated by TACE. Materials and Methods: Two functional SNPs (rs3826793 and rs2070246) in the ASCT2 gene were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 448 unresectable Chinese HCC patients treated by TACE. Univariate and multivariate Cox proportional hazards models and Kaplan-Meier curves were used for the prognosis analyses. Results: There was no significant association between two SNPs (rs3826793 and rs2070246) in the ASCT2 gene and overall survival of TACE treated HCC patients. However, we demonstrated that patients with early stage HCC carrying T genotype in rs2070246 showed better OS than those carrying CC genotype (P=0.023). Conclusions: We demonstrated that patients with early stage HCC carrying T genotype in rs2070246 showed better OS than those carrying CC genotype.

• Journal of the Optical Society of Korea
• /
• v.13 no.4
• /
• pp.468-471
• /
• 2009

We propose a simple nondestructive method to obtain refractive-index profiles of a graded-index (GRIN) light-focusing rod by means of a diffraction grating. In our proposed method, a laser beam is illuminated through a diffraction grating perpendicular to the axis of the GRIN lens and the separation between the zeroth and first-order diffraction peaks is measured and analyzed. The results demonstrate that the refractive-index profiles of commercially available GRIN lenses can be successfully reconstructed.

• BMB Reports
• /
• v.43 no.12
• /
• pp.789-794
• /
• 2010

A novel gene, designated mgt-6, containing four splicing variants, was isolated from a gene trap clone library of C3H/10T1/2 cells transfected with retroviral promoterless gene-trap vector, ROSAFARY. The transcript variants were differentially expressed in murine tissues and cell lines and differentially responded to diverse stimuli including TGF-${\beta}1$ and mitogen-activated protein kinase (MAPK) inhibitors. The mgt-6 gene encoded a protein of 37 or 11 amino acid residuals with cytoplasmic distribution. However, when C3H/10T1/2 cells were treated with 5-azacytidine, the protein translocated into cell nucleus as indicated by fused LacZ or C-terminally tagged EGFP. Our preliminary results suggest that further study on the role of mgt-6 gene in cell transformation and differentiation may be of significance.

• BMB Reports
• /
• v.44 no.1
• /
• pp.28-33
• /
• 2011

MicroRNAs are potential key regulators in mesenchymal stem cells chondrogenic differentiation. However, there were few reports about the accurate effects of miRNAs on chondrogenic differentiation. To investigate the mechanisms of miRNAs-mediated regulation during the process, we performed miRNAs microarray in MSCs at four different stages of TGF-${\beta}3$-induced chondrogenic differentiation. We observed that eight miRNAs were significantly up-regulated and five miRNAs were downregulated. Interestingly, we found two miRNAs clusters, miR-143/145 and miR-132/212, kept on down-regulation in the process. Using bioinformatics approaches, we analyzed the target genes of these differentially expressed miRNAs and found a series of them correlated with the process of chondrogenesis. Furthermore, the qPCR results showed that the up-regulated (or down-regulated) expression of miRNAs were inversely associated with the expression of predicted target genes. Our results first revealed the expression profiles of miRNAs in chondrogenic differentiation of MSCs and provided a new insight on complicated regulation mechanisms of chondrogenesis.

• Convergence Security Journal
• /
• v.23 no.2
• /
• pp.95-102
• /
• 2023

The purpose of this paper was to confirm the operational level of the military department of universities, which plays a key role in the officer training process, through empirical research and confirm meaningful results for improvement. There are 11 university military departments operated through the Army, agreements, and semi-agreement, and the Data Envelopment Analysis (DEA) was applied from the perspective of resource input and performance for each university's military department operation to analyze relative efficiency and confirm specific directions for improvement. As a result of operational efficiency analysis, 6 DMUs (Decsision Making Unit) were found to be efficient in the BCC model out of 11 DMUs, and the evaluation results could be confirmed through classification of efficient and inefficient groups through data capture analysis. This paper may be of practical value in that it checks the efficiency of the comparative university military departments and confirms specific information for development through the DEA-Additive model that reflects several evaluation factors at once. Through this, the operators of each university's military department are admitted.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.25 no.2
• /
• pp.125-134
• /
• 2022

Recently, there are an increased the number of reports on the misuse or malicious use of an UAS. Thus, many researchers are studying on defense schemes for UAS by developing or improving C-UAS sensor technology. However, the wrong placement of sensors may lead to a defense failure since the proper placement of sensors is critical for UAS defense. In this study, a multi-object optimization model for C-UAS sensor placement in an air base is proposed. To address the issue, we define two objective functions: the intersection ratio of interested area and the minimum detection range and try to find the optimized placement of sensors that maximizes the two functions. C-UAS placement model is designed using a NSGA-II algorithm, and through experiments and analyses the possibility of its optimization is verified.

• Asian-Australasian Journal of Animal Sciences
• /
• v.20 no.4
• /
• pp.471-476
• /
• 2007

Little is known about the origin and genetic diversity of swamp buffaloes in China. To obtain more knowledge on genetics of the water buffalo in China, the complete mitochondrial D-loop sequences of 30 samples from 6 native types were investigated. The results revealed 12 mitochondrial haplotypes with 50 polymorphic sites. Among these polymorphic sites, there were 49 transitions and 1 transversion. The average nucleotide diversity and haplotype diversity estimated from mtDNA D-loop region in 6 Chinese water buffalo types were 0.00684 and 0.798, respectively, showing rather abundant mitochondrial genetic diversity. The Neighbor-Joining (NJ) tree of mtDNA of Chinese water buffaloes was constructed according to the 12 haplotypes. The NJ tree indicated two lineages being designated lineage A and lineage B, in which lineage A was predominant, and lineage B was at low frequency. The new lineage B was first discovered and defined in 6 Chinese water buffalo types. These results showed that two different maternal lineages were involved in the origin of domestic swamp buffaloes in China and the lineage B was probably an introgression from Southeast Asian buffaloes.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.25 no.6
• /
• pp.757-765
• /
• 2021

To carry out multi-domain operations included in the U.S. Department of Defense's national security strategy in 2018, timely data sharing between C4I systems is critical. Several studies of the Korean military have also raised the problems of interface and standardization between C4I systems, and it is necessary to establish a new plan to solve this problem. In this study, a solution to the problem was derived through case analysis that the U.S. Department of Defense has been pursuing for about 20 years to implement the data strategy after establishing the data strategy in 2003. and by establishing a data strategy suitable for the ROK military C4I system operating environment, developing a data model, selecting a standard for data sharing, and proposing a shared data development procedure, we intend to improve the data sharing capability between ROK military C4I systems.

• The Korean Journal of Physiology and Pharmacology
• /
• v.21 no.3
• /
• pp.279-286
• /
• 2017

The root bark extract of Aralia taibaiensis is used traditionally for the treatment of diabetes mellitus in China. The total saponin extracted from Aralia Taibaiensis (sAT) has effective combined antihyperglycemic and hypolipidemic activities in experimental type 2 diabetic rats. However, the active compounds have not yet been fully investigated. In the present study, we examined effects of twelve triterpenoid saponins on AMP-activated protein kinase (AMPK) activation, and found that compound 28-O-${\beta}$-D-glucopyranosyl ester (AT12) significantly increased phosphorylation of AMPK and Acetyl-CoA carboxylase (ACC). AT12 effectively decreased blood glucose, triglyceride (TG), free fatty acid (FFA) and low density lipoprotein-cholesterol (LDL-C) levels in the rat model of type 2 diabetes mellitus (T2DM). The mechanism by which AT12 activated AMPK was subsequently investigated. Intracellular ATP level and oxygen consumption were significantly reduced by AT12 treatment. The findings suggested AT12 was a novel AMPK activator, and could be useful for the treatment of metabolic diseases.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.1
• /
• pp.407-411
• /
• 2014

Objective: To observe local and systemic toxicity after sustained-release 5-fluorouracil (5-Fu) implantation in canine peritoneum and para-aortic abdominalis and the changes of drug concentration in the local implanted tissue with time. Methods: 300 mg sustained-release 5-Fu was implanted into canine peritoneum and para-aorta abdominalis. Samples were taken 3, 5, 7 and 10 days after implantation for assessment of changes and systemic reactions. High performance liquid chromatography was applied to detect the drug concentrations of peritoneal tissue at different distances from the implanted site, lymphatic tissue of para-aortic abdominalis, peripheral blood and portal venous blood. Results: 10 days after implantation, the drug concentrations in the peritoneum, lymphatic tissue and portal vein remained relatively high within 5 cm of the implanted site. There appeared inflammatory reaction in the local implanted tissue, but no visible pathological changes such as cell degeneration and necrosis, and systemic reaction like anorexia, nausea, vomiting and fever. Conclusions: Sustained-release 5-Fu implantation in canine peritoneum and para-aortic abdominalis can maintain a relatively high tumour-inhibiting concentration for a longer time in the local implanted area and portal vein, and has mild local and systemic reactions. Besides, it is safe and effective to prevent or treat recurrence of gastrointestinal tumours and liver metastasis.