• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.767-773
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• 2012

The esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with a poor prognosis. Understanding molecular changes in ESCC should improve identification of risk factors with different molecular subtypes and provide potential targets for early detection and therapy. Our study aimed to obtain a molecular signature of ESCC through the regulation network based on differentially expressed genes (DEGs). We used the GSE23400 series to identify potential genes related to ESCC. Based on bioinformatics we constructed a regulation network. From the results, we could establish that many transcription factors and pathways closely related with ESCC were linked by our method. STAT1 also arose as a hub node in our transcriptome network, along with some transcription factors like CCNB1, TAP1, RARG and IFITM1 proven to be related with ESCC by previous studies. In conclusion, our regulation network provided information on important genes which might be useful in investigating the complex interacting mechanisms underlying the disease.

• Journal of National Security and Military Science
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• s.15
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• pp.31-55
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• 2018

It has been fifteen years since military science was introduced into private and public universities since 2004. The department focuses on the improvements of the South Korean Army quality based on the Korean Army's traits including: an increase of power in the armed force and operations through research, development, and the expansion of a cooperation between the public (civilians) and military. Approximately, four hundred students from various universities in the military science department graduate in order to become an officer. The fourth industrial revolution causes structural transformation to our lives. Through the use of Artificial Intelligence (AI,) war and the military as a whole will be altered significantly particularly with regard to efficiency. Nevertheless, it is important for us to train officers in creative ways so that they can deal with situations where machines will be unable to handle situations. Considering this change in our lives, it is necessary for the military science departments to change the way to teach and train their students. In order to accomplish this goal, we need to introduce a method called "Flipped Learning" and during the process all the members need to participate and communicate in an interactive way. By doing this, the military science departments will play an important role by improving human resource in terms of military and national security.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6681-6686
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• 2013

Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.

• Journal of National Security and Military Science
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• s.13
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• pp.83-108
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• 2016

• Journal of National Security and Military Science
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• s.15
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• pp.1-30
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• 2018

This study focused on how to supplement and develop military spiritual education in response to promotion of peace and prosperity and Change of Security Environment on the Korean Peninsula. In order to succeed in the peace and prosperity on the Korean Peninsula policy, Strengthening the military spiritual education is necessary. This study was analyzed through the survey and the results are as follows: First, the awareness level of military spiritual education is more than 68%. Second, the satisfaction level of education has been quit motivated, but, the respondents demands various methods of eduction. Third, the current mental power scores showed no significant difference for environmental change. In addition, based on the results of the research, the problem of military spiritual education is as follows. It is not enough to secure the identity that can firmly support the era of peace and prosperity on the Korean peninsula. Poor budget support might hinder improving poor education facilities and outdated equipment. Furthermore, there is a lack of research on future-oriented educational system in support of traditional education methods of repetition-type repeated education and unification. Therefore, we deducted the following development strategies for the military spiritual education in this paper. First, it is necessary to strengthen the military spiritual education to support the era of peace and prosperity on the Korean Peninsula. Second, for enhancing educational environments, the educational facilities and equipments should be improved by understanding the characteristics of the education target. Third, the integrated management of military research institutes specialized in military spiritual education should be pursued as a system development for ensuring the continuous effect of education. In conclusion, continuous attention and research are needed to establish national perspective and national security perspective, raise the military spirit and utilize various education development programs in order to develop efficient military spiritual education in the future.

• Agribusiness and Information Management
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• v.10 no.2
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• pp.18-27
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• 2018

This study aims to confirm the appropriateness of fruit and vegetable sales at military commissaries, with the purpose of enhancing the physical health and morale of military personnel. In order to achieve this objective, we examined the actual conditions of fruit and vegetable sales at military commissaries and analyzed the soldiers' awareness of fruit and vegetable sales through questionnaire surveys. The conclusions of this study are as follows: Firstly, fresh fruits and vegetables were not sold at military commissaries. Secondly, soldiers acknowledged the need for the consumption of fruits and vegetables and strongly expressed the desire for these fresh food products to be sold at military commissaries. Although the ROK Navy privatized military commissaries for the purposes of increasing management efficiency of national defense and strengthening combat power by transferring PX salesclerk soldiers to join combat personnel, this effort produced a negative effect of price increase. The following are proposals for improving this condition: fruit and vegetable products should be introduced to military commissaries through military welfare funds; fresh food markets should be established by closely cooperating with the local community's agricultural producers; processed fruit and vegetable product (dry, frozen, airtight packaged, etc.) sales should be increased; and the privatization of the navy commissaries should be abolished.

• Journal of the Korea Institute of Military Science and Technology
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• v.18 no.4
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• pp.402-408
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• 2015

Protection against direct projectiles has been adapted just to the main command posts in the existing protective facility standards. However, protective capacity for the shelters against direct projectiles is also required because the initial survivability as well as the operation sustainment of the shelters is critical during a couple of days from outbreak of war. In this study, the Russian artillery is used to determine the existing and future threat of the North Korean Armed Forces indirectly. And then, required protective capacity of military shelters in the contact areas is calculated along with UFC 3-340-02 and it is verified using modeling and simulation. Based on the assessed capacity, actual inspect of military facilities with contact areas on spot is performed whether military shelters have enough protection capacity against determined threats. According to the field study, it is verified that proper earth bermed shelter has enough protection capacity. The results in this study could be used how to retrofit the current shelters in the contact areas.

• Journal of Korean society of Dental Hygiene
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• v.13 no.1
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• pp.122-128
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• 2013

Objectives : The purpose of this study was to investigate the traumatic injuries by first aid education and mouth protector in some military men. Methods : Among 195 military men, a total of 164 military men filled out the self-administered questionnaire and the return rate was 84.1%. The data were evaluated statistically using chi-square analysis. Results : 81.5% of respondents agreed that first aid education is necessary and 48.2% of respondents agreed that mouth protector of is necessary. In managing tooth fracture, subluxation, and avulsion, the military men answered the necessity of the first aid education revealed 87.2%, 86.8%, and 91.5%, respectively. The questions in managing tooth fracture, subluxation showed that mouth protector is necessary 56.3%, 49.0% respectively. In managing tooth fracture with reattachment, the necessity of the first aid education showed 88.9%. Conclusions : In order to get the knowledge about emergency treatment of traumatic injuries in military men, it is necessary to develop the professional education program for the dental hygiene personnel.

• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.1
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• pp.82-95
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• 2022

Since military weapon accidents or breakdowns are directly linked to enormous damage, it is important to analyze the causes of weapons system accidents. Recently, in the defense sector, there have been cases in which budget has been saved through analysis of the causes of frequent breakdowns and improvement activities that have occurred in the process of operating weapon systems since 2015. But due to the nature of the defense sector, it is not easy to collect data and studies on weapons system accidents have been insufficient so far. Therefore, this study aims to investigate the causes and types of military weapon accidents by collecting military weapon accident data for military weapon systems and analyzing trends by weapon system classification through the analysis process. It analyzes statistically and visually through social network analysis, NodeXL. It is expected that this study will help improve the stability of the weapon system by reducing the number of military weapon accidents and failures.

• Biomolecules & Therapeutics
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• v.25 no.3
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• pp.279-287
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• 2017

The chemical property of cinnamaldehyde is unstable in vivo, although early experiments have shown its obvious therapeutic effects on viral myocarditis (VMC). To overcome this problem, we used cinnamaldehyde as a leading compound to synthesize derivatives. Five derivatives of cinnamaldehyde were synthesized: 4-methylcinnamaldehyde (1), 4-chlorocinnamaldehyde (2), 4-methoxycinnamaldehyde (3), ${\alpha}$-bromo-4-methylcinnamaldehyde (4), and ${\alpha}$-bromo-4-chlorocinnamaldehyde (5). Neonatal rat cardiomyocytes and HeLa cells infected by coxsackievirus B3 (CVB3) were used to evaluate their antiviral and cytotoxic effects. In vivo BALB/c mice were infected with CVB3 for establishing VMC models. Among the derivatives, compound 4 and 5 inhibited the CVB3 in HeLa cells with the half-maximal inhibitory concentrations values of $11.38{\pm}2.22{\mu}M$ and $2.12{\pm}0.37{\mu}M$, respectively. The 50% toxic concentrations of compound 4 and 5-treated cells were 39-fold and 87-fold higher than in the cinnamaldehyde group. Compound 4 and 5 effectively reduced the viral titers and cardiac pathological changes in a dose-dependent manner. In addition, compound 4 and 5 significantly inhibited the secretion, mRNA and protein expressions of inflammatory cytokines TNF-${\alpha}$, IL-$1{\beta}$ and IL-6 in CVB3-infected cardiomyocytes, indicating that brominated cinnamaldehyde not only improved the anti-vital activities for VMC, but also had potent anti-inflammatory effects in cardiomyocytes induced by CVB3.