• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4421-4426
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• 2013

Objective: The present study employed 5-aza-2'-deoxycytidine (5-Aza-CdR) to treat non-small cell lung cancer (NSCLC) cell line A549 to investigate the effects on proliferation and expression of the TFPI-2 gene. Methods: Proliferation was assessed by MTT assay after A549 cells were treated with 0, 1, 5, 10 ${\mu}mol/L$ 5-Aza-CdR, a specific demethylating agent, for 24, 48 and 72h. At the last time point cells were also analyzed by flow cytometry (FCM) to identify any change in their cell cycle profiles. Methylation-specific polymerase chain reaction (MSPCR), real time polymerase chain reaction(real-time PCR) and western blotting were carried out to determine TFPI-2 gene methylation status, mRNA expression and protein expression. Results: MTT assay showed that the growth of A549 cells which were treated with 5-Aza-CdR was significantly suppressed as compared with the control group (0 ${\mu}mol/L$ 5-Aza-CdR). After treatment with 0, 1, 5, 10 ${\mu}mol/L$ 5-Aza-CdR for 72h, FCM showed their proportion in G0/G1 was $69.7{\pm}0.99%$, $76.1{\pm}0.83%$, $83.8{\pm}0.35%$, $95.5{\pm}0.55%$ respectively (P<0.05), and the proportion in S was $29.8{\pm}0.43%$, $23.7{\pm}0.96%$, $15.7{\pm}0.75%$, $1.73{\pm}0.45%$, respectively (P<0.05), suggesting 5-Aza-CdR treatment induced G0/G1 phase arrest. MSPCR showed that hypermethylation in the promoter region of TFPI-2 gene was detected in control group (0 ${\mu}mol/L$ 5-Aza-CdR), and demethylation appeared after treatment with 1, 5, 10 ${\mu}mol/L$ 5-Aza-CdR for 72h. Real-time PCR showed that the expression levels of TFPI-2 gene mRNA were $1{\pm}0$, $1.49{\pm}0.14$, $1.86{\pm}0.09$ and $5.80{\pm}0.15$ (P<0.05) respectively. Western blotting analysis showed the relative expression levels of TFPI-2 protein were $0.12{\pm}0.01$, $0.23{\pm}0.02$, $0.31{\pm}0.02$, $0.62{\pm}0.03$ (P<0.05). TFPI-2 protein expression in A549 cells was gradually increased significantly with increase in the 5-Aza-CdR concentration. Conclusions: TFPI-2 gene promoter methylation results in the loss of TFPI-2 mRNA and protein expression in the non-small cell lung cancer cell line A549, and 5-Aza-CdR treatment could induce the demethylation of TFPI-2 gene promoter and restore TFPI-2 gene expression. These findings provide theoretic evidence for clinical treatment of advanced non-small cell lung cancer with the demethylation agent 5-Aza-CdR. TFPI-2 may be one molecular marker for effective treatment of advanced non-small cell lung cancer with 5-Aza-CdR.

• 벤처창업연구
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• 제17권2호
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• pp.115-128
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• 2022

본 연구는 전역(예정)장병을 대상으로 하는 육군 창업지원 프로그램이 군 복무만족도에 미치는 영향 분석에 관하여 연구하고자 한다. 또한 육군이 지원하고 추진하는 프로그램인 창업경진대회, 창업동아리 멘토링, 찾아가는 창업캠프, 창업사관학교 등 장병들이 프로그램 참여로 기대되는 군 복무만족도 대해 연구하고자 하였다. 본 프로그램의 취지는 전역(예정)장병들이 육군 창업지원 프로그램 참여를 통해 개인의 군 복무기간을 경력단절이 아닌 '꿈과 희망을 열어주는 기회의 시간'으로 활용 할 수 있도록 하였으며, 군 복무만족도 향상이 될 수 있도록 추진되었다. 이를 통해 전역(예정)장병 대상 정부기관 및 지자체의 창업지원 프로그램 확산과 청년들의 개인역량 강화를 확대하기 위한 방안을 제시하고자 한다. 연구를 위해 독립변수로는 육군 창업지원 프로그램인 창업경진대회, 창업동아리 멘토링(찾아가는 창업캠프), 창업사관학교로 하였고, 통제변수로는 참여자의 신분, 전역 후 진로 등 인구통계학적 요소를 설정하였다. 실증분석 결과 창업지원 프로그램이 군 복무만족도에 직접적인 영향을 미치는 것으로 위계적 회귀분석의 통계적 결과가 유의미하게 나타났다. 하지만 통제변수인 참여자의 신분, 전역 후 진로에 따라 창업지원 프로그램의 군 복무만족은 차이가 발생하는 것으로 나타났다. 본 연구의 시사점은 육군이 국가·사회와의 인재육성 연결자로서 장병들에게 군 복무기간 동안 개인역량을 강화할 수 있는 기회로 실질적으로 도움이 되는 프로그램임을 입증한다고 볼 수 있다. 또한 정부 및 지자체의 전역(예정)장병 대상 창업지원 사업의 확대 필요성에 대해 실증적 결과를 제시함으로써 청년 고용률 및 지원사업 개선에 도움을 주고자 한다.

• 디지털융복합연구
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• 제14권10호
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• pp.173-181
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• 2016

본 논문의 목적은 델파이 (Delphi) 기법과 분석적계층과정 (AHP; Analytic Hierarchy Process)를 통해서 전술적 고려요소인 METT+TC (임무, 적, 지형 및 기상, 가용부대, 가용시간, 민간요소)를 세분화하고 우선순위를 정하는 것이다. 군의 작적수행과정상의 의사결정과정에서 전술적 고려요소는 매우 중요한 요소로 작용하지만, 6개 요소의 세분화 및 우선순위 결정에 관한 연구는 그동안 충분히 수행되지 않았다. 델파이와 분석적계층과정은 군사 전문가들의 인터뷰와 설문지 작성을 통해 이루어졌으며, 최초 6개의 전술적 고려요소는 델파이 분석을 통해 34개의 하위요소로 세분화되었고, 분석적계층과정을 통해 6개의 고려요소와 34개의 하위요소는 우선순위가 정량적으로 공격과 방어 국면을 구분하여 제시되었다. 본 연구결과는 군의 ATCIS와 같은 의사결정지원시스템상의 DB로 활용되고, 이를 활용할 수 있는 의사결정 애플리케이션이 도입된다면, 효과적이고 빠른 의사결정에 도움이 될 것으로 기대된다.

• 한국군사과학기술학회지
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• 제13권2호
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• pp.243-251
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• 2010

The military has been putting great efforts into applying data communication on existing voice communication systems being used in NCW(Network Centric Warfare). Data communication will be an effective choice in one of many effort to yield a minimum kill chain, comparing to legacy voice communications, when tactical units conduct their missions. However, the required budget will be enormous, in case of the replacement of a lot of legacy communication systems with new one. As a cost-effective alternative, the tactical data communication systems using the conventional radio systems instead of the development of new radio systems has been proposed. It is mandatory, though, to ensure QoS while maintaining data communication by making use of legacy radio systems already in use. This paper focuses on the performance issues experimented and analyzed for tactical data communication through the legacy radio systems as the first step towards guaranteed QoS. We have conducted various experiments such as the transmission error rate on certain tactical messages, performance evaluation of redundant transfers, the relationship between the transmission frame size and rate of error, the identification of error points in the transmission frame, and techniques to reduce the errors in both hopping and non-hopping modes. As a result of the performance experiments, The adaptive communication module which decides the redundant transmission or the Forward Error Correction(FEC) technique by analyzing channel status and current transmission status(hopping/non-hopping) of the legacy radio should be designed. the FEC technique in non-hopping, and the redundant transmission technique in hopping mode was recommended from the result of experiment with the frame size is 20bytes in non-hopping and 10Bytes frame size in hopping mode.

• Tuberculosis and Respiratory Diseases
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• 제82권4호
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• pp.298-305
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• 2019

Background: Tuberculosis (TB) causes substantial health burden to the Korean military. This study aims to assess the impact of infectious TB cases on close and casual contacts in the Korean Army settings based on contact investigation data. Methods: Six Army units with infectious TB cases from September 2012 to May 2013 were enrolled in the study. We analyzed the clinical data from close and casual contacts screened using the tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube to identify latent tuberculosis infection (LTBI) cases. For the control group, 286 military conscripts with no reported TB exposure were tested by TST only. Results: Of the 667 contacts of index cases, LTBI cases identified were as follows: 21.8% of close contacts of smearpositive cases (71/326), 8.5% of casual contacts of smear-positive cases (26/305), and 2.8% of close contacts of smearnegative cases (1/36). In the control group, 16.8% showed positivity in TST. In a multivariate analysis, having stayed in the same room or next room with TB patients was identified as a risk factor of LTBI. Conclusion: Using the data from TB contact investigations in the Korean Army units, we found an overall LTBI rate of 14.7% among the contacts screened. This study demonstrates that contacts living in the same building, especially the same room or next room, with TB patients are at a high risk of acquiring LTBI, serving as additional evidence for defining close and casual contacts of a TB patient with regard to Army barrack settings.

• 한국정보통신학회논문지
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• 제26권9호
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• pp.1412-1422
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• 2022

무기체계 간 상호운용성의 중요성이 점점 커지고 있다. 체계 간 상호운용성은 주로 자료 연동을 통해 구현된다. 그런데 체계 간 정보 이질성 해소 비용으로 인해 전군 차원의 자료 연동 효율과 품질이 저하되고 있다. 다른 선진국들은 정보교환모델을 공통 적용함으로써 자료 연동 구현의 효율과 품질을 높이고 있지만 한국군은 아직 그에 대한 중요성과 필요성을 충분히 인식하지 못하고 있다. 이 연구는 한국 지휘통제 정보교환모델(KC2IEM)의 개발과 적용의 필요성을 설명하고, 그에 필요한 개발 방법론을 제시하고 프로토타입 모델 개발을 통해 검증하고 개선한다. 정보교환모델의 완성은 학술연구 수준에서는 제한되며, 이 연구는 후속 연구 및 개발을 위한 계기와 발판으로서 기여한다.

• 한국군사과학기술학회지
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• 제12권3호
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• pp.333-343
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• 2009

Tactical Information Communication Network(TICN) is a concept-type integrated Military Communication system that enables precise command control and decision making by unifying the diversified military communication network and conveying diverse range of battle field information on real-time, at right place at right time. TICN is designed to advance into high speed, large capacity, long distance wireless relay transmission. To support mobility in battlefield environments, the application of Ad-hoc networking technology to its wireless communication has been examined. Ad-hoc network is consist of mobile nodes and nodes in the network depends on the cooperation of other nodes for forwarding of packets. In this context, some non-cooperating nodes may delay forwarding of packets or drop the packets. This may hamper the network as a whole and disrupt communication between the cooperating nodes. To solve this problem, we present a solution with a Node Weight Management Server(NWMS), which manages each node's weight according to its behavior in local area. When the NWMS detects misbehaving node, it increases the node's weight. If the node's weight exceeds a predefined threshold then the NWMS broadcasts the node's information into network to isolate the misbehaving node from the network. These mechanisms show that they are highly effective and can reliably detect a multitude of misbehaving node.

• 한국군사과학기술학회지
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• 제17권3호
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• pp.358-363
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• 2014

In this paper, we present two constructions of the attribute-based broadcast encryption(ABBE) algorithm. Attribute-based encryption(ABE) algorithm enables an access control mechanism over encrypted data by specifying access policies among private keys and ciphertexts. ABBE algorithm can be used to construct ABE algorithm with revocation mechanism. Revocation has a useful property that revocation can be done without affecting any non-revoked uers. The main difference between our algorithm and the classical ones derived from the complete subtree paradigm which is apt for military hierarchy. Our algorithm improve the efficiency from the previously best ABBE algorithm, in particular, our algorithm allows one to select or revoke users by sending ciphertext of constant size with respect to the number of attributes and by storing logarithm secret key size of the number of users. Therefore, our algorithm can be an option to applications where computation cost is a top priority and can be applied to military technologies in the near future.

• 한국군사과학기술학회지
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• 제18권4호
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• pp.441-450
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• 2015

The tactical communications network has to be deployed rapidly at military operation area and support the communications between the military command systems and the weapon systems. For that, the frequency assignment is required for backbone wireless links of tactical communications network without frequency interferences. In this paper, we propose a frequency assignment method using net filter discrimination (NFD) and graph coloring to avoid frequency interferences. The proposed method presents frequency assignment problem of tactical communications network as vertex graph coloring problem of a weighted graph. And it makes frequency assignment sequences and assigns center frequencies to communication links according to the priority of communication links and graph coloring. The evaluation shows that this method can assign center frequencies to backbone communication links without frequency interferences. It also shows that the method can improve the frequency utilization in comparison with HTZ-warfare that is currently used by Korean Army.

• 한국정밀공학회지
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• 제25권3호
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• pp.141-146
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• 2008

The purpose of this study is to develop the algorithm which can control muscle power assist robot especially for elderly. Recently, wearable robots for power assistance are developed by many researchers, and its application fields are also variable such as for medical or military equipment. However, there are many technical barriers to develop the wearable robot. This study suggest a control method improving performance of a wearable robot system by using a EMG signal of major muscles and a force sensor signal as command signal of system. The result of the robot Prototype efficiency experiment, the case of Maximum Isometric motion it suggest 100% power of muscle, the man need only 66% of MVIC(Maximum Voluntary Isometric Contraction) to lift 5kg dumbbell without robot assist. However the man needs only 52% of MVIC to lift 5kg dumbbell with robot assist. Therefore 20% muscle power increased with robot assist. Also, we designed light weight robot mechanism that extract the command signal verified and drive the wanted motions.