• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4807-4814
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• 2012

Purpose: The chemoresistance of human hepatocellular carcinoma (HCC) to cytotoxic drugs, especially intrinsic or acquired multidrug resistance (MDR), still remains a major challenge in the management of HCC. In the present study, possible mechanisms involved in MDR of HCC were identified using a 5-fluorouracil (5-FU)-resistant human HCC cell line. Methods: BEL-7402/5-FU cells were established through continuous culturing parental BEL-7402 cells, imitating the pattern of chemotherapy clinically. Growth curves and chemosensitivity to cytotoxic drugs were determined by MTT assay. Doubling times, colony formation and adherence rates were calculated after cell counting. Morphological alteration, karyotype morphology, and untrastructure were assessed under optical and electron microscopes. The distribution in the cell cycle and drug efflux pump activity were measured by flow cytometry. Furthermore, expression of potential genes involved in MDR of BEL-7402/5-FU cells were detected by immunocytochemistry. Results: Compared to its parental cells, BEL-7402/5-FU cells had a prolonged doubling time, a lower mitotic index, colony efficiency and adhesive ability, and a decreased drug efflux pump activity. The resistant cells tended to grow in clusters and apparent changes of ultrastructures occurred. BEL-7402/5-FU cells presented with an increased proportion in S and G2/M phases with a concomitant decrease in G0/G1 phase. The MDR phenotype of BEL-7402/5-FU might be partly attributed to increased drug efflux pump activity via multidrug resistance protein 1 (MRP1), overexpression of thymidylate synthase (TS), resistance to apoptosis by augmentation of the Bcl-xl/Bax ratio, and intracellular adhesion medicated by E-cadherin (E-cad). P-glycoprotein (P-gp) might play a limited role in the MDR of BEL-7402/5-FU. Conclusion: Increased activity or expression of MRP1, Bcl-xl, TS, and E-cad appear to be involved in the MDR mechanism of BEL-7402/5-FU.

• Journal of Internet Computing and Services
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• v.22 no.6
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• pp.129-140
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• 2021

The next generation mBcN should be built to cooperate with the wireless network to support hyper-speed and hyper-connectivity. In this paper, we propose a network architecture for the cooperation mBcN and 5G commercial network and architecture of the cooperative security gateway required for the cooperation. The proposed cooperative security gateway is between gNB and UPF to support LBO, SFC, and security. Our analysis shows that the proposed architecture has several advantages. First of all, user equipment connected with the mBcN can be easily connected through the 5G commercial radio network to the mBcN. Second, the military application traffic can be transmitted to mBcN without going through the 5G core network, reducing the end-to-end transmission delay without causing the traffic load on the 5G core network. In addition, the security level of the military application can effectively be maintained because the user equipment can be connected to the cooperative security gateway, and the traffic generated by the user equipment is transmitted to the mBcN without going through the 5G core network. Finally, we demonstrate that LBO, SFC, and security modules are essential functions of the proposed gateway in the 5G test-bed environment.

• Journal of the Korean Society of Food Culture
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• v.18 no.3
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• pp.261-269
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• 2003

This was preliminary study that was to find out the developing point in military meal service to focus on seafood dishes that recently increased plate waste. This study was conducted to analyze menu patterns in military meal service. The result of this study was using to develop new seafood dishes in military meal service. On the basis of some findings, several developing points how to plan meals include many kinds of seafood dishes and to modify taste and cooking method that was more highly prefered by young military persons were suggested. This preliminary study findings were as follows: 1. Each meal was served cooked rice and 4 kinds of dishes(soup or stew, main dish, side dish and kimchi) 2. The seafood dishes was served as 28.6% in soup or stew, 35.0% in main dish and 36.4% in side dish of total serving of seafood dishes. 3. All of raw materials of seafood were supplied by frozen, several items were supplied dried material. Supplying seafood items were limited. Numbers of using seafood items were using 2.7 times per day. Laver and squid was most frequently used. 4. Seafood dishes were frequently serving in breakfast, especially seasoned & toasted laver was served 28.8% of seafood menu in breakfast because of convenience. 5. The nutrients contents of each dishes were as follows, the soup was $86.5{\pm}3.2kcal$ and $10.9{\pm}8.9g$ of animal protein, stew was $165.3{\pm}70.2kcal$ and $13.3{\pm}7.9g$ of animal protein. Nutrients content of other main dish and side dishes was different from 108.1kcal (in steaming dish) to 412.4kcal (in deep-fat frying dish) according to different cooking method. The highest animal protein dish that contented $18.9{\pm}5.1g$ of protein was pan-frying dish or grilling dish. Lowest one was $8.4{\pm}4.9g$ in braising dish. 6. Major cooking method of seafood was stew and the next was deep fat frying, stirfrying and braising. Pan-frying or grilling was seldomly used in military menu because of limitation of kitchen facilities and cooking utensils. On the basis of these findings, newely developing military seafood menus were focused on combination dish(such as seafood cooked rice or seafood fried rice) and many kinds of sauce that was applied to deep-fat frying dishes.

• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.1
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• pp.1-8
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• 2022

Electronic equipment mounted on military vehicles is exposed to external shocks and vibrations. This causes problems in tactical operation and also causes cost loss in equipment maintenance. Therefore, to optimize the test standards for military vehicles with vibration, dynamic characteristics should be analyzed and standardized through actual driving tests. In this paper, the internal structure of 2.5tons military vehicle is designed in the form of a drawer and lathe, and the dynamic characteristics are identified by experiment, and the design is proposed.

• Journal of Food Hygiene and Safety
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• v.10 no.2
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• pp.103-109
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• 1995

Microbiological and organoleptic qualities of boiled anchovies were evaluated during storage for 8 months at different temperatures and packaging methods. Microbial populations of marketing samples were 106~107 CFU/g in aerobic bacteria, 103~106 CFU/g in yeasts/molds and 103~105 CFU/g in coliforms, respectively, which were the highest in retail sample, followed by in military goods and wholesale sample. Moreover, anchovies supplied for retail sale and military goods were contaminated with sanitary indicative microbes. The samples stored at ambient condition(15~33$^{\circ}C$, RH 5$0^{\circ}C$95%) lost their marketable quaity mainly due to microbial propagation prior to 6 months, irrespective of packaging methods, corrugated-cardboard box and laminated-film(nylon 15${\mu}{\textrm}{m}$/PE 100${\mu}{\textrm}{m}$). However, cooling(5~1$0^{\circ}C$) as well as well as freezing temperatures($\leq$-18$^{\circ}C$) following laminated-film packaging were effective for keeping the organoleptic qualities of stored anchovies up to 8 months. The population of yeasts and molds was shown the quality-indicative criteria for stored anchovies and their critical levels were 5.00 log counts/g, showing a higher negative-correlationship(r=-0.901) with changes in organoleptic quality.

• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.5
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• pp.687-696
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• 2019

To identify the driving dynamic characteristics of the Tractor-Trailer Type Transporter for mounting a large scale precision equipment, real vehicle driving tests on the 3 inch-bump-space-road were performed. And using general Dynamics Analysis Program - RecurDyn(V8R5), Dynamics M&S were carried out assuming the similar condition with real tests. Then the acceleration data obtained from real tests and M&S were analyzed and compared with each other in the part of root-mean-square-acceleration($g_{rms}$), peak-acceleration($g_{peak}$) and frequencies. In simple view of the $g_{rms}$ & $g_{peak}$, although the results of MRBD are more similar to ones of the real vehicle driving tests, but the results of RFlex have more information to get various useful dynamic characteristics.

• Journal of the Korea Society for Simulation
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• v.27 no.2
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• pp.25-33
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• 2018

When developing military equipment, it should be designed considering the temperature condition so that the operator can operate in a stable environment. The shelter for storing various military equipments is operated in various environments. The storage temperature and operating requirements of the test equipment and repair accessories shall be $-32^{\circ}C$ to $50^{\circ}C$ and the inside of the shelter shall be designed to meet the storage temperature and operating requirements. In this study, thermal analysis of a 2.5 ton military shelter operating under high temperature and solar heat conditions is performed considering MIL-STD-810G. The thermal analysis was applied by using the concept of heat resistance and heat circuit, and the solar thermal test was performed on the actually manufactured military shelter in order to verify the analysis results.

• Journal of the Korea Institute of Military Science and Technology
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• v.6 no.4
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• pp.132-144
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• 2003

Numerical analysis of the spray angles of Dual swirl injector were investigated to obtain basic design data and to predict the combustion performance. Using the commercial thermal hydraulic program, discharge coefficients and spray angles were numerically analyzed with recess length, pressure drop, velocity ratio, mixture ratio and back hole length. Water was used as simulants for oxidizer and fuel, respectively to compare the experimental results. Swirl injectors were designed to inject oxidizer of 70.5g/s and fuel of 29.5g/s at the pressure drop of 1MPa and two recess lengths were considered. In addition, the effect of injector geometry coefficient and velocity ratio on the discharge coefficient was studied.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.10a
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• pp.597-599
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• 2021

5G technology will be applied to various technologies related to game changers in the defense field. In addition, the establishment of a mobile work environment will be utilized. 5G has emerged as a new threat due to major technologies different from previous technologies. And due to 5G technology, there is an increasing demand to apply mobile technology to the defense sector. In this paper, we look at the security policy for defense 5G operation and the step-by-step construction plan consisting of three.

• Journal of National Security and Military Science
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• s.7
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• pp.1-24
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• 2009

This article deals with military thought in general. First I tried to distinguish 'thought' from 'theory', 'philosophy', and 'principle'. Thought means the act of thinking about or considering something, an idea or opinion, or a set of ideas about a particular subject, e.g. military affairs in the present discussion. Theory means a formal statement of the rules on which a subject of study is based or of ideas which are suggested to explain a fact or event or, more generally, an opinion or explanation. Philosophy means the use of reason in understanding such things as the nature of reality and existence, the use and limits of knowledge. Principle means a basic idea or rule that explains or controls how something happens or works. Chapter 3 summarized the characteristics of military thoughts into five points', (i) it is closely related with concrete experiences of a nation; (ii) it includes philosophical and logical arguments; (iii) it relies heavily on the political thought of a nation; (iv) it includes necessarily value-judgments; (v) it contains visions of a nation which are not only descriptions or explanations of military affairs, but also evaluations and advocacies. Chapter 4 considers the relation of international political thoughts to military thought. Throughout the history of the modem states system there have been three competing traditions of thought: the Hobbesian or realist tradition, which views international politics as a state of war; the Kantian or universalist tradition, which sees at work in international politics a potential community of mankind; and the Grotian or internationalist tradition, which views international politics as taking place within an international society. Chapter 5 considers the law of war, which is a body of law concerning acceptable justifications to engage in war (jus ad bellum) and the limits to acceptable wartime conduct (jus in bello). Among other issues, modem laws of war address declarations of war, acceptance of surrender and the treatment of prisoners of war, military necessity along with distinction and proportionality, and the prohibition of certain weapons that may cause unnecessary suffering.