• Title, Summary, Keyword: Microencapsulation

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Encapsulation of Bromelain in Liposome

  • Lee, Dong-Hoon;Jin, Bong-Hwa;Hwang, Yong-Il;Lee, Seung-Cheol
    • Preventive Nutrition and Food Science
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    • v.5 no.2
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    • pp.81-85
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    • 2000
  • Bromelain has been used as a meat-tenderizing agent in food processing. To increase the availability of bromelain, microencapsulation into liposome was carried out by the dehydration and rehydration method. Small unilamellar vesicles prepared by sonication treatment showed higher encapsulation efficiency (EE) than by the French press method. In the preparation of liposome, the effect of pH and centrifugal force on EE was also investigated and it showed a higher EE at acidic pH than at alkaline pH with centrifugation at 80, 000$\times$g. The actual EEs except unencapsulated bromelain which bound on the outside surface of liposome by electrostatic interaction also were investigated, and the optimal EE was at pH 4.6, at 0.6 of a ratio of bromelain to phosholipid(18.2%, w/w). Release of bromelain from liposomes was stimulated as the temperature increased at neutral pH.

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Preparation of Silica Microcapsules containing Water-Soluble UV Absorbers by a W/O Microemulsion Sol-Gel Process (W/O 마이크로에멀젼 졸-겔 법을 이용한 수용성 UV 흡수제를 함유한 실리카 마이크로캡슐의 제조)

  • 함경국;안복엽;석상일
    • Proceedings of the Materials Research Society of Korea Conference
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    • pp.220-220
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    • 2003
  • The microencapsulation of droplets or particles within a solid shell leads to the formation of core-shell particles. Microencapsulation provides protection and controlled release of core materials such as drugs, vitamins, enzymes, perfumes, and the like. Such particles have, therefore, found a diverse range of applications in the pharmaceutical, agricultural, cosmetic, and food industries. UV absorbers are widely used for cosmetics to screen out ultra violet (UV) rays which have side effects on human skin. The absorbers are made generally from synthetic organic compounds, which can stimulate the human skins to develop allergic phenomena.

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Effects of Aluminum Tristearate in the Preparation of Sustained Release Ethambutol Hydrochloride Microcapsules (지속 방출형 염산에탐부톨 마이크로캅셀의 제조에 있어서 스테아린산알루미늄의 효과)

  • Yoo, Bong-Shin
    • Journal of Pharmaceutical Investigation
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    • v.18 no.4
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    • pp.175-180
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    • 1988
  • The role and effect of aluminum tristearate in microencapsulation were investigated based on the dispersion system of ethambutol hydrochloride in acetone-liquid paraffin. Eudragit RS was used as a wall-forming material. Eudragit RS microcapsules prepared using aluminum tristearate were uniform, free-flowing particles. The phase diagram of ethambutol hydrochloride-Eudragit RS-aluminum tristearate indicated that spherical microcapsules ranging from 250 to 1400 ${\mu}m$ in diameter could be prepared only in a very limited region. Instrumental analysis using an energy dispersive-type X-ray microanalyser and a scanning electron microscope showed that aluminum tristearate was localized near the surface of microcapsules. From these results, it was presumed that aluminum tristearate reduced the phase tension between Eudragit microcapsules and liquid paraffin. The dissolution rates of ethambutol hydrochloride from Eudragit RS microcapsules were consideraly lower than those from ethambutol hydrochloride powders and decreased as the amount of aluminum tristearate decreased.

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A Study of Antibacterial and Aromatic Fibers Vsing Microencapsulation of Antibiotics and Perfume (1) -Microencapsulation of Antibiotics/Perfume- (항균제 및 향료의 마이크로캡슐을 이용한 항균 . 방향섬유에 관한 연구(1) -항균제/향료의 마이크로캡슐화 -)

  • Kim, Ho-Jung;Park, Cha-Cheol;Kim, Han-Do
    • Journal of the Korean Society of Clothing and Textiles
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    • v.20 no.3
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    • pp.512-518
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    • 1996
  • Microcapsules containing 2, 4, 4'-trichloro-2-hydroxydiphenyl ether and perfumes were prepared by the coacervation using poly (vinyl alcohol) and crosslinking agents. Effects of dispersing agents, core materials, agitating speed and crosslinking agents on microcapsule size were investigated. The mean and deviation of microcapsule diameters decreased with increasing agitation speed. The diameters of m;crocapsules decreased with increasing dispering agent concentration at 6, 000 rpm of agitation speed, but it was not changed at 10, 000 rpm. The dispering effect of PVA is better than that of gum arabic. The slight increase in the diameter of microcapsule was observed when the amount of core material was increased. As the amount of crosslinking agent was increased, the diameter of microcapsule was decreased.

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Microencapsulation of Isoprinosine with Ethylcellulose

  • Kim, Chong-Kook;Hwang, Sung-Joo
    • Archives of Pharmacal Research
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    • v.14 no.4
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    • pp.298-304
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    • 1991
  • Isoprinosine, an antiviral agent with a bitter taste, has been clinically used up to a maximum of 4 g daily in 4-8 doses. In this investigation, isoprinosine was microencapsulated with ethylcellulose 22 cps, 50 cps and 100 cps by means of polymer deposition from cyclohexane through temperature change. Complete removal of cyclohexane from the microcapsules was necessary, since ethylcellulose-coated microcapsules obtained from cyclohexane medium were heavily solvated with cyclohexane and formed lumps even after drying. The displacement of cyclohexane by n-hexane during isolation of microcapsules (Method III) or the freezing of the anal-washed microcapsules before drying (Mothod II) provided the dried products which were more discrete microcapsules than those which were simply dried in the air overnight (Method I). Method III was especially the most effective procedure in preparing finer and more discrete microcapsules. The drug-release from microcapsules was influenced by the ratio of core to wall, the viscosity grade of ethylcellulose and the overall microcapsule size. The release rate was adequately fitted to both the first-order and the diffusion-controlled processes. It is therefore possible to design the release-controlled microcapsules with ethylcellulose of different viscosity along with various core to wall ratio.

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Improvement of the Stability of Lactobacillus casei YIT 9018 by Microencapsulation Using Alginate and Chitosan

  • Koo, Sun-Mo;Cho, Young-Hee;Huh, Chul-Sung;Baek, Young-Jin;Park, Ji-Yong
    • Journal of Microbiology and Biotechnology
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    • v.11 no.3
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    • pp.376-383
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    • 2001
  • Lactobacillus casei YIT 9018 was microencapsulated within alginate or alginate/chitosan double membrane using an air atomizer. Microbiological analysis revealed that the viability of encapsulated L. casei in gastric juice, hydrogen peroxide, and pepsin was 2-3 log cycle higher than that of the nonencapsulated cell. However, the encapsulated cells did not show a signifciant increase in survival when subjected to in virto high acid and 0.6% bile salt condition. Alginate-encapsulated, alginate/chitosan-encapsulated, and nonencapsulated cells were stored at different temperatures eencapsulated cells showed similar stability at $4^{\circ}C$. However, at $22^{\circ}C$, the alginate/chitosan-encapsulted cell was the most stable.

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Microencapsulated Ascorbic Acid for Milk Fortification

  • Lee, J.B.;Ahn, J.;Kwak, H.S.
    • Archives of Pharmacal Research
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    • v.26 no.7
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    • pp.575-580
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    • 2003
  • The present study was designed to develop a microencapsulated L-ascorbic acid and iron that could be used to fortify milk and to determine the sensory properties of milk fortified with microencapuslation. Coating material was medium-chain triacylglycerol (MCT), and selected core material was ferric ammonium sulfate and L-ascorbic acid. The highest efficiency of microencapsulation was 95.0% in the ratio of 15:1 as coating to core material. Ascorbic acid release was increased sharply up to 5 d storage as 6.5%. TBA value was the lowest when both capsulated iron and ascorbic acid were added during 12 d storage, compared with other treatments. In sensory analysis, most aspects were not significantly different between control and capsulated ascorbic acid fortified milk at 5 d storage. The present study indicated that the use of microencapsulated ascorbic acid with MCT is effective for fortifying milk. In addition, these results suggest that acceptable milk products can be prepared with microencapsulated ascorbic acid and iron.

Encapsulation of Flavors by Molecular Inclusion Using $\beta$-Cyclodextrin: Comparison with Spray-drying Process Using Carbohydrate-based Wall Materials

  • Cho, Young-Hee;Park, Ji-Yong
    • Food Science and Biotechnology
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    • v.18 no.1
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    • pp.185-189
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    • 2009
  • Microencapsulation of flavor was carried out by molecular inclusion process using $\beta$-cyclodextrin (${\beta}CD$). ${\beta}CD$-flavor complex was prepared at various flavor-to-${\beta}CD$ ratios (1:6-1:12) to determine the effect of ${\beta}CD$ concentration on the inclusion efficiency. Maximum total oil retention and minimal surface oil content were obtained at flavors to ${\beta}CD$ ratio of 1:10. The physical properties and controlled release pattern of flavors from ${\beta}CD$-flavor complex were measured and compared with spray-dried microcapsules prepared using carbohydrate wall system. ${\beta}CD$-flavor complex showed higher total oil retention and surface oil contents, smaller mean particle size, lower moisture uptake, and higher oxidation stability than spray-dried microcapsule. Oxidative stability of flavor was correlated with hygroscopicity of wall materials. The controlled release mechanism was highly affected by temperature and characteristics of wall materials.

Microencapsulation of Lactobacillus plantarum DKL 109 using External Ionic Gelation Method

  • Chun, Honam;Kim, Cheol-Hyun;Cho, Young-Hee
    • Food Science of Animal Resources
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    • v.34 no.5
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    • pp.692-699
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    • 2014
  • The aim of this study was to apply the external ionic gelation using an atomizing spray device comprised of a spray gun to improve the viability of Lactobacillus plantarum DKL 109 and for its commercial use. Three coating material formulas were used to microencapsulate L. plantarum DKL 109: 2% alginate (Al), 1% alginate/1% gellan gum (Al-GG), and 1.5% alginate/3% gum arabic (Al-GA). Particle size of microcapsules was ranged from 18.2 to $23.01{\mu}m$ depending on the coating materials. Al-GA microcapsules showed the highest microencapsulation yield (98.11%) and resulted in a significant increase in survivability of probiotic in a high acid and bile environment. Encapsulation also improved the storage stability of cells. The viability of encapsulated cells remained constant after 1-mon storage at ambient temperature. The external ionic gelation method using an atomizing spray device and the Al-GA seems to be an efficient encapsulation technology for protecting probiotics in terms of scale-up potential and small microcapsule size.