• Title, Summary, Keyword: Microencapsulation

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Optimization of Onion Oil Microencapsulation by Response Surface Methodology (반응표면분석법에 의한 양파유 미세캡슐화 공정의 최적화)

  • Hong, Eun-Mi;Yu, Mun-Gun;Noh, Bong-Soo;Chang, Pahn-Shick
    • Korean Journal of Food Science and Technology
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    • v.34 no.3
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    • pp.437-443
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    • 2002
  • Using agar and gelatin as wall materials, onion oil was microencapsulated using the extrusion spraying technology. A sensitive methodology was developed for quantitative determination of the microencapsulation yield through ethyl acetate extraction and gas chromatographic analyses. Optimal conditions for the microencapsulation process consisting of the ratio of [core material, Cm] to [wall material, Wm] ($X_1$), temperature of dispersion fluid ($X_2$), detergent concentration in dispersion fluid ($X_3$), and concentration of emulsifier $(X_4)$ were determined using response surface methodology. The regression model equation for the yield of microencapsulation (Y, %) of onion oil could be predicted as $Y\;=\;97.028571-0.775000\;(X_1)-0.746726\;(X_1){\cdot}(X_1)\;-\;1.100000\;(X_3){\cdot}(X_2)$. The optimal conditions for the microencapsulation of the onion oil were determined as the ratio of [core material] to [wall material] of 4.5 : 5.5 (w/w), the temperature of dispersion fluid of $17.1^{\circ}C$ detergent concentration in dispersion fluid of 0.03%, and the concentration of emulsifier of 0.42%. Results revealed the most stable microcapsule of onion oil could be formed with the highest yield of microencapsulation (more than 95%) under optimal conditions.

The Study of Encapsulation Technique for Microcapsule Using Core Materials with Low Melting Point (저융점을 가진 Core 물질을 이용한 내구성 Microcapsule 제조 기술)

  • Noh, Kun-Ae;Gang, Eu-Gene;Kim, Sang-Hern
    • Journal of the Korean Applied Science and Technology
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    • v.18 no.4
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    • pp.273-284
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    • 2001
  • A series of microcapsule were synthesized by using several PCM(Phase Change Material) as a core material and gelatin/arabic gum, melamine/formaldehyde as a shell material. Coacervation technique and in situ polymerization were adopted in synthesizing microcapsules. In the microencapsulation by coacervation, tetradecane and octadecane were used as core materials. In the microencapsulation by situ polymerization tetradecane, pentadecane, hexadecane, heptadecane, octadecane, and nonadecane were used as core material. The synthesized microcapsule was examined to observe the shape of the microcapsule. The particle size analysis was performed by particle size analyzer. The thermal properties(e.g. melting point, heat of melting, crystallization temperature, heat of crystallization, differences between melting point and crystallization temperature) were obtained by DSC(Differential Scanning Calorimeter). The stirring rate effect was investigated during the microencapsulation. It was found that with increasing the stirring rate much smaller microcapule was produced. However, this did not necessarily lead to formation of spherical microcapsule.

Microencapsulation of Propranolol.HCl with Cellulose Acetate Phthalate (Propranolol.HCl의 Cellulose Acetate Phthalate Microencapsulation에 관한 연구)

  • Ku, Young-Soon;Kim, Jae-Youn
    • YAKHAK HOEJI
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    • v.33 no.5
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    • pp.312-318
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    • 1989
  • Microcapsule of Propranolol HCl with Cellulose Acetate Phthalate (CAP) by coacervation-phase separation method was studied. Encapsulation was carried out in the CAP-liquid paraffin-acetone ethanol solvent system. The optimum weight ratio for microencapsulation in the CAP-liquid paraffin-solvent system was 1.32:89.18:9.50 or 1.65:89.42:8.93. The wall thickness of microcapsules increased according to increasing of CAP concentration, but dissolution rate decreased. The dissolution of propranolol-HCl in simulated gastric and intestinal fluid test solution was completed within 3 min., but T50% of propranolol HCl from 10.0% CAP-microcapsules were 390 min. and 210 min. respectively. The released amount from 12.5% CAP-microcapsules was 41.8% within 720 min. in simulatd gastric fluid test solution and T50% of those in simulated intestinal fluid test solution was 250 min.

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Effect of Polyisobutylene and Sealant Treatments on Ethylcellulose-Walled Methyldopa Microcapsules (폴리이소부틸렌 및 밀폐제 처리가 메칠도파의 마이크로캅셀화에 미치는 영향)

  • Shin, Sang-Chul;Koh, Ik-Bae
    • Journal of Pharmaceutical Investigation
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    • v.19 no.1
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    • pp.29-37
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    • 1989
  • For the prevention of the aggregation during microencapsulation, the effects and role of polyisobutylene(PIB), as a protective colloid, were studied. The effects of sealant treatment on the microencapsulation were studied. Methyldopa was microencapsulated with ethylcellulose (EC) by polymer deposition from cyclohexane by temperature change using PIB. The EC-microencapsulated methyldopa was sealed with spermaceti. The dissolution of methyldopa was influenced by the drug to wall ratio. When PIB was used, low aggregation of microcapsules occurred and the surface was smooth with a few pores. Treatment of microcapsules with spermaceti retarded the release of methyldopa, the release being affected by the percentage of sealant used and the particle size of the product.

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Studies on the Development for Sustained Release Preparation (II):Preparation and Evaluation of Eudragit Microcapsules of Sodium Naproxen

  • Shin, Sang-Chul;Lee, Keong-Ran
    • Archives of Pharmacal Research
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    • v.16 no.1
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    • pp.50-56
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    • 1993
  • The microencapsulation of sodium naproxen with Eudragit. RS was studied by coacrtvation/phase separation process using Span 80 in mineral oil/acetone system. Various factors which affect the mciroencapsulation, e.g., stirring speed, and surfactant concentraction, Eudagit RS concentration and loading drug amounts were examined. For the evaluation of the prepared microcapsules, release rate, particle size distribution and surface appearance as well as in vivo test were carried out. The addition of n-hexane and freezing of microcapsules accelerated the hardening of microcapsules. The optimum concentration of Span 80 ti prepare the smallest microcapsules was the same value with the CMC of Span 80 in solvent system. When 1.5% (w/w) Span 80 was used, the smallest microcapsules were formed $(30.02\pm5.05\mu$ in diameter) belonging to the powder category showing smooth, round and uniform surface. The release of sodium naproxen was retarded by microencapsulation with Eudragit RS. The Eudragit RS microcapsules showed significantly increased AUC and MRT and deceased Cl/F in rabbits.

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Microencapsulation Technology for Enhancement of Bifidobacterium spp. Viability: A Review (비피도박테리아의 생존성 증진을 위한 캡슐화 기술)

  • Song, Minyu;Park, Won Seo;Yoo, Jayeon;Ham, Jun-Sang
    • Journal of Dairy Science and Biotechnology
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    • v.35 no.3
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    • pp.143-151
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    • 2017
  • The intestinal microbiota has been shown to have a vital role in various aspects of human health, and accumulating evidence has shown the beneficial effects of supplementation with bifidobacteria for the improvement of human health, ranging from protection against infection to various positive effects. However, maintaining bacterial cell viability during storage and gastrointestinal transit remains a challenge. Microencapsulation of probiotic bacterial cells provides protection against adverse conditions during processing, storage, and gastrointestinal passage. In this paper, we review the current knowledge, future prospects, and challenges of microencapsulation of probiotic Bifidobacterium spp.

Optimization of Fish Oil Microencapsulation by Response Surface Methodology and Its Storage Stability (반응표면분석법에 의한 정제어유 미세캡슐화 공정의 최적화 및 미세캡슐 저장안정성 분석)

  • Chang, Pahn-Shick;Ha, Jae-Seok
    • Korean Journal of Food Science and Technology
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    • v.32 no.3
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    • pp.646-653
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    • 2000
  • Using agar and waxy com starch as the wall material, we could encapsulate the purified fish oil. Firstly, we have developed a simple and sensitive method for the quantitative analysis of the microencapsulation yield using 5% cupric acetate pyridine solution. Then, the optimum conditions such as the ratio of [core material] to [wall material]$(X_1)$, the temperature of dispersion fluid$(X_2)$, and the emulsifier concentration$(X_3)$ for the microencapsulation process were determined by using response surface methodology(RSM). The regression model equation for the yield of microencapsulation(Y, %) of purified fish oil upon three kinds of independent variables could be predicted as follows; Y = 100.138621-0.735000$(X_1)$+0.840000$(X_1)(X_2)$+0.817500$(X_1)(X_3)$-0.852500$(X_2)(X_3)$. And the optimum conditions for the microencapsulation of the purified fish oil were the ratio of [core material] to [wall material] of 4.9 : 5.1(w/w), the emulsifier concentration of 0.48%, and dispersion fluid temperature of $19.4^{\circ}C$. The microcapsules containing the purified fish oil showed the highest storage stability at pH 7.0 and $20{\sim}25^{\circ}C$.

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Optimization of Emulsification and Spray Drying Process for the Microencapsulation of Flavor Compounds (향기성분 미세캡슐화를 위한 유화 및 분무건조 공정 최적화)

  • Cho, Young-Hee;Shin, Dong-Suck;Park, Ji-Yong
    • Korean Journal of Food Science and Technology
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    • v.32 no.1
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    • pp.132-139
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    • 2000
  • This study was conducted to optimize the emulsion process and the spray drying process for the microencapsulation of flavor compounds. Using the wall system selected, emulsion process for microencapsulation was optimized on the change of the pressure of piston-type homogenizer. Emulsification pressure of 34.5 MPa was found to be the most suitable for preparing flavor emulsion. Effects of drying temperature and atomizer speed of the spray drier on total oil, surface oil, and flavor release of the flavor powder were investigated using response surface methodology. The optimum spray drying conditions for minimal surface oil and flavor release and maximum total oil were $170{\circ}C$ inlet temperature and 15,000 rpm atomizer speed. The spray-dried powder processed with the highest drying temperature showed spherically-shaped particles with smooth surface.

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Slow release of microencapsulated model compounds of insect pheromone using low molecular weight polyethylene and urea-formaldehyde resin (저분자량 polyethylene과 urea-formaldehyde 수지를 이용한 microencapsulation에 의한 곤충 페로몬의 model 화합물들의 slow release)

  • Kim, Jung-Han;Oh, Won-Taek;Kim, Yong-Jin
    • Applied Biological Chemistry
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    • v.34 no.2
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    • pp.110-116
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    • 1991
  • As the model compounds, citral and n-octanol which possess similar characteristics and structures of low molecular weight insect pheromones and $({\pm})-5-hydroxy-4-methyl-heptan-3-one$ which shows the aggregation pheromones activity of the rice weevil and the maize weevil were microencapsulated with low molecular weight polyethylene(LMPE) and urea-formaldehyde resin as wall materials. The core materials were microencapsulated as small particles in LMPE and urea-formaldehyde resin polymers and the microencapsulated polymers were white powders. And the polymer made from urea-formaldehyde resin was better than that from LMPE as wall material. The slow releasing effect and the releasing patten of the microencapsulated core materials were examined by solvent extraction method and headspace sampling method. Citral and n-octanol and $({\pm})-5-hydroxy-4-methyl-heptan-3-one$ were release more than 40 days and 15 days, respectively. The releasing pattern of urea-formaldehyde resin microcapsules showed rather smooth decrease than that of LMPE and was maintained at steady level longer.

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