• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.927-930
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• 2006

While Intel has been increasing its exclusive possession in the system IC semiconductor market, IBM, Sony, and Toshiba founded an alliance to develop the next entertainment multi-core processor, which is named CELL. Cell is designed upon the Power architecture and includes 8 SPE (Synergistic processor Element) cores for data handling, and supports SIMD architecture for optimal execution of multimedia, or game applications. Also, it includes expanded Power microarchitecture. In this paper, we analyzed and researched the Cell microprocessor, which is evaluated as the most powerful processor in this era.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.11
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• pp.56-62
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• 2008

Modern microprocessors must deliver high application performance, while the design process should not subordinate power. In terms of performance and power tradeoff, the instructions window is particularly important. This is because a large instruction window leads to achieve high performance. However, naive scaling conventional instruction window can severely affect the complexity and power consumption. This paper explores an architecture level approach to reduce power dissipation. We propose a low power issue logic with an efficient tag translation. The direct lookup table (DTL) issue logic eliminates the associative wake-up of conventional instruction window. The tag translation scheme deals with data dependencies and resource conflicts by using bit-vector based structure. Experimental results show that, for SPEC2000 benchmarks, the proposed design reduces power consumption by 24.45% on average over conventional approach.

• Journal of KIISE:Computer Systems and Theory
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• v.34 no.10
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• pp.467-473
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• 2007

Power-aware design is one of the most important areas to be emphasized in multimedia mobile systems, in which data transfers dominate the power consumption. In this paper, we propose a new architecture for motion compensation (MC) of H.264/AVC with power reduction by decreasing the data transfers. For this purpose, a reconfigurable microarchitecture based on data type is proposed for interpolation and it is mapped onto the dedicated motion compensation IP (intellectual property) effectively without sacrificing the performance or the system latency. The original quarter-pel interpolation equation that consists of one or two half-pel interpolations and one averaging operation is designed to have different execution control modes, which result in decreasing memory accesses greatly and maintaining the system efficiency. The simulation result shows that the proposed method could reduce up to 87% of power consumption caused by data transfers over the conventional method in MC module.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.4
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• pp.95-101
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• 2010

The aim of this study was to detect longitudinal alterations on lumbar vertebral trabecular bone quality (microarchitecture and degree of mineralization) and bone mineral density (BMD) during pregnancy Virginal eighteen mice were used. Then, twelve mice were mated. Mice lumbar vertebrae were scanned before mate, at 7 days of pregnancy (early pregnancy, 6 mice) and immediately after delivery (late pregnancy, 6 mice) by using in-vivo micro-computed tomography Structural parameters, degree of mineralization and BMD were measured. During early pregnancy, there were no significant alterations on structural parameters, degree of mineralization and BMD. At late pregnancy, Tb.Th (11.8%) and BMD (12.7%) were significantly decreased and Tb.N (6.3%), Tb.Pf (43.0%) and BS/BV (15.1%) were significantly increased (p<0.05). Additionally, the lower degree of mineralization was increased, although, the higher degree of mineralization was decreased. These results indicated that the quality and BMD might be not affected during early pregnancy. At late pregnancy, however the bone quality and BMD were likely to be negatively affected.

• Nutrition Research and Practice
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• v.7 no.3
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• pp.185-191
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• 2013

In previous studies, we found that the consumption of legumes decreased bone turnover in ovariectomized rats. The purpose of the present study is to determine whether the protective effects on bone mineral density (BMD) and the microarchitecture of a diet containing legumes are comparable. In addition, we aim to determine their protective actions in bones by studying bone specific gene expression. Forty-two Sprague-Dawley rats are being divided into six groups during the 12 week study: 1) rats that underwent sham operations (Sham), 2) ovariectomized rats fed an AIN-93M diet (OVX), 3) ovariectomized rats fed an AIN-93M diet with soybeans (OVX-S), 4) ovariectomized rats fed an AIN-93M diet with mung beans (OVX-M), 5) ovariectomized rats fed an AIN-93M diet with cowpeas (OVX-C), and 6) ovariectomized rats fed an AIN-93M diet with azuki beans (OVX-A). Consumption of legumes significantly increased BMD of the spine and femur and bone volume of the femur compared to the OVX. Serum calcium and phosphate ratio, osteocalcin, expression of osteoprotegerin (OPG), and the receptor activator of nuclear factor ${\kappa}B$ ligand (RANKL) ratio increased significantly, while urinary excretion of calcium and deoxypyridinoline and expression of TNF-${\alpha}$ and IL-6 were significantly reduced in OVX rats fed legumes, compared to OVX rats that were not fed legumes. This study demonstrates that consumption of legumes has a beneficial effect on bone through modulation of OPG and RANKL expression in ovariectomized rats and that legume consumption can help compensate for an estrogen-deficiency by preventing bone loss induced by ovarian hormone deficiency.

• BMB Reports
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• v.53 no.3
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• pp.154-159
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• 2020

We investigated the effects of physalin A, B, D, and F on osteoclastogenesis induced by receptor activator of nuclear factor κB ligand (RANKL). The biological functions of different physalins were first predicted using an in silico bioinformatic tool (BATMAN-TCM). Afterwards, we tested cell viability and cell apoptosis rate to analyze the cytotoxicity of different physalins. We analyzed the inhibitory effects of physalins on RANKL-induced osteoclastogenesis from mouse bone-marrow macrophages (BMMs) using a tartrate-resistant acid phosphatase (TRAP) stain. We found that physalin D has the best selectivity index (SI) among all analyzed physalins. We then confirmed the inhibitory effects of physalin D on osteoclast maturation and function by immunostaining of F-actin and a pit-formation assay. On the molecular level, physalin D attenuated RANKL-evoked intracellular calcium ([Ca(2+)](i)) oscillation by inhibiting phosphorylation of phospholipase Cγ2 (PLCγ2) and thus blocked the downstream activation of Ca2+/calmodulin-dependent protein kinases (CaMK)IV and cAMP-responsive element-binding protein (CREB). An animal study showed that physalin D treatment rescues bone microarchitecture, prevents bone loss, and restores bone strength in a model of rapid bone loss induced by soluble RANKL. Taken together, these results suggest that physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via suppressing the PLCγ2-CaMK-CREB pathway.

• Biomedical Science Letters
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• v.20 no.3
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• pp.156-161
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• 2014

It has been reported that safflower seeds have preventive effects against osteoporosis. Recently, safflower buds (SB) were found to have more useful functional ingredients than safflower seeds. In the current study, we evaluated the anti-osteoporosis effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus $17{\beta}$-estradiol ($E^2$ $10{\mu}g/kg$, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 1%) to OVX rats markedly increased bone mineral density (BMD) of femurs, compared to the OVX group. The OVX rats exhibited a marked increase in trabecular separation (Tb.Sp) and this change was inhibited by the feeding of SB diet, similar to that seen with OVX+E2 group. Moreover, feeding of SB diet to OVX rats decreased the markers of bone turnover, including osteocalcin and alkaline phosphatase (ALP). These results suggest that SB extract has a bone sparing effect in OVX-induced trabecular bone loss and prevents deterioration of bone microarchitecture by suppressing the rate of bone turnover. Therefore, SB may be useful for preserving bone mass and structure in estrogen deficient women with a potential role in reducing postmenopausal osteoporosis.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.5
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• pp.137-147
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• 2008

Recently, Power and thermal management are becoming major concerns in computer system design. The energy efficiency is an important attribute of the mobile and embedded systems. Today's powerful mobile processors needs more energy and longer battery life. Many research has been focused to reduce energy consumption for the mobile processors.In this paper, performance monitoring system for the Power-management techniques is implemented for Intel's XScale microarchitecture-based Marvell PXA320 processor on Windows CE platform. It also provides software interface for changing DVFS configuration. Performance and power consumption are measured for benchmark programs through performance counter value and voltage/current measurements on LabVIEW platform. By using the developed monitoring system, it is possible for dynamic power management to track processor's workload and to determine the actual power consumption.

• The Journal of Korean Association of Computer Education
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• v.18 no.2
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• pp.71-81
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• 2015

In the EISC processor, the Instruction Queue (IQ) supporting LERI folding and loop buffering occupies roughly 20% of real estate, and its efficient utilization is a key for performance. This paper presents an architectural enhancement for the IQ utilization with return address stack (RAS) in the EISC processor. The proposed architecture eliminates the RAS corruption from the wrong-path, taking advantage of shallow pipeline. In experiments, a 4-entry RAS reduces the number of IQ flushes by up to 58.90% over baseline, and an 8-entry RAS by up to 61.28%. The experiments show up to 3.47% performance improvement with 8-entry RAS and up to 3.15% performance improvement with 4-entry RAS.

• Molecules and Cells
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• v.41 no.6
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• pp.575-581
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• 2018

Postmenopausal osteoporosis (PMOP) is a common systemic skeletal disease characterized by reduced bone mass and microarchitecture deterioration. Although differentially expressed SOX5 has been found in bone marrow from ovariectomized mice, its role in osteogenic differentiation in human mesenchymal stem cells (hMSCs) from bone marrow in PMOP remains unknown. In this study, we investigated the biological function of SOX5 and explore its molecular mechanism in hMSCs from patients with PMOP. Our findings showed that the mRNA and protein expression levels of SOX5 were upregulated in hMSCs isolated from bone marrow samples of PMOP patients. We also found that SOX5 overexpression decreased the alkaline phosphatase (ALP) activity and the gene expression of osteoblast markers including Collagen I, Runx2 and Osterix, which were increased by SOX5 knockdown using RNA interference. Furthermore, $TNF-{\alpha}$ notably upregulated the SOX5 mRNA expression level, and SOX5 knockdown reversed the effect of $TNF-{\alpha}$ on osteogenic differentiation of hMSCs. In addition, SOX5 overexpression increased Kruppel-like factor 4 (KLF4) gene expression, which was decreased by SOX5 silencing. KLF4 knockdown abrogated the suppressive effect of SOX5 overexpression on osteogenic differentiation of hMSCs. Taken together, our results indicated that $TNF-{\alpha}$-induced SOX5 upregulation inhibited osteogenic differentiation of hMSCs through KLF4 signal pathway, suggesting that SOX5 might be a novel therapeutic target for PMOP treatment.