• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제50권3호
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• pp.136-143
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• 2001

A micro particle manipulator, which is devised for trapping particles at fixed positions by negative dielectrophoretic force (DEP force), has been fabricated and experimented. It is composed of square type electrode arrays fabricated by nickel electroplating with the height of 28 ${\mu}m$. To improve the quality of electroplated nickel electrodes, plating conditions have been optimized. Micro particles used in this study are polystyrene spheres and their to the specific position and trapped. The DEP force along the moving path of the particles has been estimated by the motion equation of a single particle. The displacement of a particle with an elapsed time was measured using a high-speed camera (1000 frames/sec). The velocity and acceleration of the particle were calculated from the measured data. The DEP force acting on the particle was estimated.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.566-569
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• 2008

Recently, the biolistic process is emerging as an effective needle-free drug delivery technique to transfer adequate concentrations of pharmacologic agents to soft living tissues with minimum side effects. We have started developing an effective method for delivering drug coated particles using laser ablation. A thin metal foil with deposited micro-particles on one side is irradiated with laser beam on the opposite side so that a shock wave is generated. This shock wave travels through the foil and is reflected, which causes and instantaneous deformation of the foil. Due to such a sudden deformation, the micro-particles are ejected at a very high speed. Here we present the experimental results of direct and confined laser ablation, which correspond to the initial stage of the whole experiment.

• 한국항공우주학회지
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• 제36권6호
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• pp.587-593
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• 2008

본 연구의 목적은 신체 조직의 손상을 최소화할 수 있는 경피(transdermal) 및 국부적인(topical) 약물전달을 가능하게 하는 마이크로 입자가속시스템 개발에 있다. Ballistic 역학을 기반으로 하는 본 방법을 통하여 체순환을 위한 경피 및 국부적 약물 전달이 가능하다. 얇은 금속 포일의 한 쪽 면에 마이크로 입자들을 얹어놓고 뒷면에 레이저를 조사하면 충격파가 발생하고, 이 충격파는 포일을 통과하며 포일의 끝에서 금속-공기간의 acoustic impedance 차이로 expansion wave로 반사되어 포일이 반대 방향으로 변형을 일으키게 한다. 이 순간적인 변형으로 인해 포일에 붙어있던 마이크로 입자들이 가속되어 튕겨 나가게 된다. 입자들이 가속되는 속도가 굉장히 크기 때문에 이들은 신체 조직을 침투할 만한 충분한 운동량을 갖고 있다. 입자들의 침투 여부를 확인하기 위해 우리는 5${\mu}m$ 크기의 코발트 입자들을 연조직을 묘사하는 젤라틴에 가속시켰으며, 주목할 만한 침투 깊이를 얻으며 실험에 성공하였다.

• Journal of the Optical Society of Korea
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• 제13권1호
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• pp.48-52
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• 2009

Micro-hole targets are studied to generate energetic protons from laser-thin foil targets by using 2-dimensional particle-in-cell simulations. By using a small hole, the maximum energy of the accelerated proton is increased to 4 times higher than that from a simple planar target. The main proton acceleration mechanism of the hole-targets is the electrostatic field created between the fast electrons accelerated by the laser pulse ponderomotive force combined with the vacuum heating and the target rear surface. But in this case, the proton angular distribution shows double-peak shape, which means poor collimation and low current density. By using a small cone-shaped hole, the maximum proton energy is increased 3 times higher than that from a simple planar target. Furthermore, the angular distribution of the accelerated protons shows good collimation.

• International Journal of Precision Engineering and Manufacturing
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• 제9권3호
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• pp.68-71
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• 2008

Transdermal and topical drug delivery with minimal tissue damage has been an area of vigorous research for a number of years. Our research team has initiated the development of an effective method for delivering drug particles across the skin (transdermal) for systemic circulation, and to localized (topical) areas. The device consists of a micro particle acceleration system based on laser ablation that can be integrated with endoscopic surgical techniques. A layer of micro particles is deposited on the surface of a thin metal foil. The rear side of the foil is irradiated with a laser beam, which generates a shockwave that travels through the foil. When the shockwave reaches the end of the foil, it is reflected as an expansion wave and causes instantaneous deformation of the foil in the opposite direction. Due to this sudden deformation, the microparticles are ejected from the foil at very high speeds, and therefore have sufficient momentum to penetrate soft body tissues. We have demonstrated this by successfully delivering cobalt particles $3\;{\mu}m$ in diameter into gelatin models that represent soft tissue with remarkable penetration depth.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.837-841
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• 2008

Propulsion of gene coated micro-particles is desired for non-intrusive drug delivery inside biological tissue. This has been achieved by the development of a device that uses high power laser pulses. The present paper looks at the mechanisms of micro-particle acceleration. Initially, a high power laser pulse is focused onto the front side of a thin aluminium foil leading to its ablation. The ablation front drives a compression wave inside the foil, thus leading to the formation of a shock wave, which will later reflect from the rear side of the foil, due to acoustic impedance mismatch. The reflected wave will induce an opposite motion of the foil, characterized by a very high speed, of the order of several millimeters per microsecond. Micro-particles, which are deposited on the rear side of the foil, thus get accelerated and ejected as micro-projectiles and are able to penetrate several hundreds of micrometers inside tissue-like material. These processes have been observed experimentally by using high-speed shadowgraphy and considered analytically.

• 한국군사과학기술학회지
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• 제23권1호
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• pp.37-42
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• 2020

This study is for a bulletproof experiment through speed acceleration of steel ball(2.385 mm) at the laboratory level. The secondary propulsion method is used for speed acceleration, which uses a sabot assembly consisting of a sabot body, a plunger, water, and a sabot cap. At the core of the secondary drive, it is important that the energy in the water of the private particle is transferred well to the steel ball. The experiment was conducted by selecting a plunger that pushes water and water charged with variables. judging that the longer the contact time, the greater the energy transferred to the steel ball. As a result of experiments with each variable, the amount of water does not affect the speed acceleration efficiency of the steel ball and, when the length of the plunger is increased by 200 %, the speed of the steel ball can be accelerated up to 130 m/s.

• Journal of the Optical Society of Korea
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• 제13권1호
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• pp.22-27
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• 2009

Target design study to improve the quality of an accelerated proton beam from the interaction of a high-intensity short pulse laser with an overdense plasma slab has been accomplished by using a two-dimensional, fully electromagnetic and relativistic particle-in-cell (PIC) simulation. The target consists of a thin core part and a thick peripheral part of equivalent plasma densities, while the ratio of the radius of the core part to the laser spot size, and the position of the peripheral part relative to the fixed core part were varied. The positive effects of this core-peripheral target structure could be expected from the knowledge of the typical target normal sheath acceleration (TNSA) mechanism in a laser-plasma interaction, and were apparently evidenced from the comparison with the case of a conventional simple planar target and the case of the transversal size reduction of the simple planar target. Improvements of the beam qualities including the collimation, the forward directionality, and the beam divergence were verified by detailed analysis of relativistic momentum, angular directionality, and the spatial density map of the accelerated protons.

• 한국지반공학회논문집
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• 제19권4호
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• pp.179-190
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• 2003

용액형 주입재의 경우 침투성은 우수하나, 현탁액형 주입재에 비하여 강도와 내구성이 현저하게 떨어지기 때문에 지반강도증대 및 차수효과를 얻기가 어렵다. 그러므로 현탁액형 그라우팅의 침투성 향상과 경제성을 고려하여 현장에서 초미립화된 주입재를 제조하는 분쇄기술의 실용화가 절실히 요구되고 있다. 따라서 본 연구에서는 현장에서 적용될 수 있는 습식분쇄기를 이용하여 피분쇄물의 물시멘트비와 분쇄장비의 분쇄시간과 분쇄속도를 조정하여 최적분쇄능력을 파악하고 피분쇄물의 점도, 침투성 및 일축압축강도 등과 같은 제조인자별 물리적 특성을 평가하였다. 또한, 보통포틀랜드시멘트를 현장에서 초미립화 할 수 있는 마이크로 습식분쇄기와, 뭉쳐진 입자를 강제로 분리할 수 있는 고속전단믹서를 현장에 적용하여 전기비저항탐사와 변수위투수시험으로 주입효과의 변화를 검토하였다. 그 결과 침투효과가 대단히 우수하였고 고속전단믹서를 사용한 경우 주입재의 입자분리가 뛰어남을 알 수 있었다.