• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.95-101
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• 2007

Recently, small-animal imaging technology has been rapidly developed for longitudinal screening of laboratory animals such as mice and rats. One of newly developed imaging modalities for small animals is an x-ray micro-CT (computed tomography). We have developed two types of x-ray micro-CT systems for small animal imaging. Both systems use flat-panel x-ray detectors and micro-focus x-ray sources to obtain high spatial resolution of $10{\mu}m$. In spite of the relatively large field-of-view (FOV) of flat-panel detectors, the spatial resolution in the whole-body imaging of rats should be sacrificed down to the order of $100{\mu}m$ due to the limited number of x-ray detector pixels. Though the spatial resolution of cone-beam CTs can be improved by moving an object toward an x-ray source, the FOV should be reduced and the object size is also limited. To overcome the limitation of the object size and resolution, we introduce zoom-in micro-tomography for high-resolution imaging of a local region-of-interest (ROI) inside a large object. For zoom-in imaging, we use two kinds of projection data in combination, one from a full FOV scan of the whole object and the other from a limited FOV scan of the ROI. Both of our micro-CT systems have zoom-in micro-tomography capability. One of both is a micro-CT system with a fixed gantry mounted with an x-ray source and a detector. An imaged object is laid on a rotating table between a source and a detector. The other micro-CT system has a rotating gantry with a fixed object table, which makes whole scans without rotating an object. In this paper, we report the results of in vivo small animal study using the developed micro-CTs.

• Journal of Biomedical Engineering Research
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• v.25 no.2
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• pp.97-102
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• 2004

We developed an x-ray cone-beam micro computed tomography (micro-CT) system for small-animal imaging. The micro-CT system consists of a 2-D flat-panel x-ray detector with a field-of-view (FOV) of 120${\times}$120 mm2, a micro-focus x-ray source, a scan controller and a parallel image reconstruction system. Imaging performances of the micro-CT system have been evaluated in terms of contrast and spatial resolution. The minimum resolvable contrast has been found to be less than 36 CT numbers at the dose of 95 mGy and the spatial resolution about 14 lp/mm. As small animal imaging results, we present high resolution 3-D images of rat organs including a femur, a heart and vessels. We expected that the developed micro-CT system can be greatly used in biomedical studies using small animals.

• Journal of the Mineralogical Society of Korea
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• v.23 no.3
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• pp.211-217
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• 2010

A micro-focus X-ray computed tomography (CT) was employed to determine quantitative phase analysis of skarn Zn-Pb-Cu ore by nondestructive visualization of the internal mineral distribution of a skarn ore. The micro CT images of the ore were calibrated to remove beam hardening artifacts, and compared with its scanning electron microscope (SEM) images to set the threshold of CT number range covering sulfide ore minerals. The volume ratio of sulfide and gangue minerals was calculated 20.5% and 79.5%, respectively. The quantitative 3D X-ray CT could be applied to analyse the distribution of economic minerals and their recovery.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1301-1302
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• 2008

In this study, the fracture strength for fracture mechanism porous calcium phosphate made from sintered with ${\beta}$-tricalcium phosphate obtained by wet precipitation procedure is analyzed using finite element method and experiment measurement. First, three $3{\times}3{\times}3mm^3$ and $5{\times}5{\times}5mm^3$ specimens are prepared and tomographic images of one $5{\times}5{\times}5mm^3$ specimen are obtained by micro focus X-ray CT. The compression tests using the specimens are carried out to measure the elastic modulus and fracture strength to analyze the fracture mechanism of porous calcium phosphate specimen. The tomographic images are reconstructed by 3D reconstruction program. The finite elements are directly built up in the reconstructed specimen. The numerical simulation for the compression tests is performed using the element. The mechanism of calcium phosphate of simulation are obtained by the compression tests using there cylindric specimen of height 19.5 mm and diameter 10 mm. From the results, the applicability of porous calcium phosphate is evaluated to care fracture and vacant bone of a patient as the reinforcement material.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1663-1666
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• 2007

The finite element method is applied to analyze the deformation mechanisms in the closed-cell Al foam under the compression. The modeling of the real cellular structure proceeds with the concept of the reverse engineering. First of all, the small, $10{\times}\;10{\times}\;10mm^3$ sized specimens of the closed-cell Al foam are prepared. The micro focus X-ray CTsystem of SHIMADZU Corp. is used to scan the full structures of the specimens. The scanned structures are converted to the geometric surfaces and solids through the software for 3-D scan data processing, RapidFormTMof INUS Tech. Inc. Then the solid meshes are directly generated on the converted geometric solids for the finite element analysis. The large elastic-plastic deformation and 3-D contact problems for the Al cellular material are considered. The clear and successful analysis for the deformation mechanisms in the closed-cell Al foam is carried out through the comparison of the numerical results in this research with the referred experimental ones.

• Tunnel and Underground Space
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• v.22 no.5
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• pp.339-345
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• 2012

Information on the deformation behavior and fracture strength of rocks subjected to dynamic loadings is important to stability analyses of underground openings underground vibration due to rock blasts, earthquakes and rock bursts. In this study, Split Hopkinson Pressure Bar (SHPB) system was applied to estimate dynamic compressive and tensile fracture strengths of limestone and also examine deformation behavior of limestones under dynamic loadings. A micro-focus X-ray CT scanner was used to observe non-destructively inside the impacted limestone specimens. From the dynamic tests, it was revealed that the limestone have over 140MPa dynamic compressive strength and the strain-rate dependency of the strength. Dynamic Brazilian tensile strength of the limestone exceeds 21MPa and shows over 3 times static Brazilian tensile strength.