• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.2781-2784
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• 2007

Early detection of a disease is important to tackle treatment issues in a better manner. Several diagnostic techniques are in use, these days; for such purpose and tremendous research is going on to develop newer and newer methods. However, more work is required to be done to develop cheap and reliable early detection techniques. Micro-fluidic chips are also playing key role to deliver new devices for better health care. The present study focuses on a review of recent developments in the interrogation of different techniques and present state-of-the-art of microfluidic sensor for better, quick, easy, rapid, early, inexpensive and portable POCT (Point of Care testing device) device for a particular study, in this case, bone disease called osteoporosis. Some simulations of the microchip are also made to enable feasibility of the development of a blood-chip-based system. The proposed device will assist in early detection of diseases in an effective and successful manner.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 학술대회
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• pp.14-17
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• 2008

Recently, several advanced flow visualization techniques such as Particle Image Velocimetry (PIV) including stereo PIV, holographic PIV, and dynamic PIV have been developed. These advanced techniques have strong potential as the experimental technology which can be used for verifying numerical simulation. In addition, there would be indispensable in solving complicated thermo-fluid flow problems not only in the industrial fields such as automotive, space, electronics, aero- and hydro-dynamics, steel, and information engineering, but also in the basic research fields of medical science, bio-medical engineering, environmental and energy engineering etc. Especially, NT Nano Technology) and BT (Bio Technology) strongly demand these advanced measurement techniques, because it is difficult for conventional methods to observe most complicated nano- and bio-fluidic phenomena. In this paper, the basic principle of these advanced visualization techniques and their practical applications which cannot be resolved by conventional methods, such as flow in automotive HVAC system, ship and propeller wake, three-dimensional flow measurement in micro-conduits, and flow around a circulating cylinder will be introduced.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년 추계학술대회논문집
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• pp.14-17
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• 2008

Recently, several advanced flow visualization techniques such as Particle Image Velocimetry (PIV) including stereo PIV, holographic PIV, and dynamic PIV have been developed. These advanced techniques have strong potential as the experimental technology which can be used for verifying numerical simulation. In addition, there would be indispensable in solving complicated thermo-fluid flow problems not only in the industrial fields such as automotive, space, electronics, aero- and hydro-dynamics, steel, and information engineering, but also in the basic research fields of medical science, bio-medical engineering, environmental and energy engineering etc. Especially, NT (Nano Technology) and BT (Bio Technology) strongly demand these advanced measurement techniques, because it is difficult for conventional methods to observe most complicated nano- and bio-fluidic phenomena. In this paper, the basic principle of these advanced visualization techniques and their practical applications which cannot be resolved by conventional methods, such as flow in automotive HVAC system, ship and propeller wake, three-dimensional flow measurement in micro-conduits, and flow around a circulating cylinder will be introduced.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2005년도 춘계 학술대회논문집
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• pp.65-69
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• 2005

Curretly, the development of MEMS(Micro Electronic Mechanical System) technology awakes many research's interest for the aerodynamics. This work presents the development of a compact synthetic jet actuator for flow separation control at the flat plate. The formation and evolution of fluidic actuators based on synthetic jet technology are investigated using Reynolds-Averaged Navier-Stokes equations. Also, 2-Dimensional, unsteady, incompressible Navier-Stokes equation solver with single partitioning method for Multi-Block grid to analyze and a modeled boundary condition in developed fo. the synthetic jet actuator. Both laminar and turbulent jets are investigated. Results show very good agreement with experimental measurements. A jet flow develops, even though no net mass flow is introduced. Pair of counter-rotating vortices are observed near the jet exit as are observed in the experiments.

• 센서학회지
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• 제13권2호
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• pp.85-89
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• 2004

This paper represents the development of high sensitivity photo-sensor for the fluorescence detection in the integrated biological analysis system. The finger-type PIN photodiodes were fabricated as the photo-sensor, and had a high sensitivity ($I_{light}/I_{dark}$ = 8720). The interference filter consisted of $TiO_{2}$ and $SiO_{2}$ was directly deposited on the photodiodes. Deposited filter with 95.5% reflection under 532 nm and 98% transmission over 580 nm exceedingly decreased the magnitude of background signal in the detection. The PDMS micro-fluidic channels are bonded on the photodiode by $O_{2}$ plasma treatment. The detection current was proportional to two primary parameters (light intensity, concentration), and the on-chip detection system could detect fluorescence signals down to 100 nM concentration (LOD = Limit of detection of rhodamine).

• 센서학회지
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• 제17권5호
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• pp.369-374
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• 2008

A novel fiber optic surface plasmon resonance (SPR) sensor using cyclic olefin copolymer (COC) prism with the spectral modulation is presented. The SPR sensor chip is fabricated using the SU-8 photolithography, Ni-electroplating and COC injection molding process. The sidewall of the COC prism is partially deposited with Au/Cr (45/2.nm thickness) by e-beam evaporator, and the thermal bonding process is conducted for micro fluidic channels and optical fibers alignment. The SPR spectrum for a phosphate buffered saline (0.1.M PBS, pH.7.2) solution shows a distinctive dip at 1300.nm wavelength, which shifts toward longer wavelength with respect to the bovine serum albumin (BSA)concentrations. The sensitivity of the wavelength shift is $1.16\;nm{\cdot}{\mu}g^{-1}{\cdot}{\mu}l^{-1}$. From the wavelength of SPR dips, the refractive indices (RI) of the BSA solutions can be theoretically calculated using Kretchmann configuration, and the change rate of the RI was found to be $2.3{\times}10^{-5}RI{\cdot}{\mu}g^{-1}{\cdot}l^{-1}$. The realized fiber optic SPR sensor with a COC prism has clearly shown the feasibility of a new disposable, low cost and miniaturized SPR biosensor for biochemical molecular analyses.

• Korean Chemical Engineering Research
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• 제57권5호
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• pp.730-734
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• 2019

열영동은 매질의 온도 구배에 의해 입자가 이동하는 현상이다. 본 논문에서는 미세유체 채널에서 입자의 열영동 현상에 대해서 논의한다. 흐름이 없는 비유동 채널에서 열원인 백금 와이어에 가해지는 전압에 비례해서 열영동에 의한 마이크로 입자의 이동이 더 크게 나타남을 확인하였다. 전압에 따른 백금 와이어 주변 온도 변화는 Callendar-van Dusen 식을 이용하여 예측하였다. 동일한 시스템에서 나노 입자의 열영동 현상을 관찰한 결과, 나노 입자도 마이크로 입자와 유사한 열영동 거동을 보임을 확인하였다. 마지막으로 Y 모양 미세유체 채널을 제작하고 백금 와이어 열원을 채널 내에 설치하여, 채널을 흐르는 현탁액 내의 입자의 열영동 현상을 구현하고, 이를 기반으로 현탁액의 흐름을 제어할 수 있음을 보인다.