• Korean Journal of Health Education and Promotion
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• v.33 no.4
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• pp.79-87
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• 2016

Objectives: This study aims to identify participants-focused health education approaches for the management of metabolic syndrome. Methods: Data for metabolic parameters of 855,282 Koreans in 2012 were extracted and analysed from the data base of Korea Association of Health Promotion. Literature and documents including study protocols, program contents, evaluation reports and published articles were reviewed in relation to increasing effectiveness and efficiency of health education for managing metabolic syndrome. Results: Health education program should be based on participants-focused perspectives, in which clients' demographic characteristics, composition patterns of metabolic risk factors, and readiness of change are appreciated. Development of theory-based strategies for healthy behavior change and evidence-based program components are also important factors in designing and conducting health education intervention. Multiple health behavior intervention can offer a new paradigm for more comprehensive and efficient health education. Implementation fidelity needs to be systematically evaluated and strengthened to improve the validity of the health education efforts. Conclusion: Enhancing participants-focused health education is the responsibility of health education specialists in promoting the management of metabolic syndrome.

• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.45-56
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• 2018

Cancer is the leading cause of human deaths worldwide. Understanding the biology underlying the evolution of cancer is important for reducing the economic and social burden of cancer. In addition to genetic aberrations, recent studies demonstrate metabolic rewiring, such as aerobic glycolysis, glutamine dependency, accumulation of intermediates of glycolysis, and upregulation of lipid and amino acid synthesis, in several types of cancer to support their high demands on nutrients for building blocks and energy production. Moreover, oncogenic mutations are known to be associated with metabolic reprogramming in cancer, and these overall changes collectively influence tumor-microenvironment interactions and cancer progression. Accordingly, several agents targeting metabolic alterations in cancer have been extensively evaluated in preclinical and clinical settings. Additionally, metabolic reprogramming is considered a novel target to control cancers harboring un-targetable oncogenic alterations such as KRAS. Focusing on lung cancer, here, we highlight recent findings regarding metabolic rewiring in cancer, its association with oncogenic alterations, and therapeutic strategies to control deregulated metabolism in cancer.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.17 no.4
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• pp.487-497
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• 2010

Purpose: This study examined the validity and reliability to develop a lifestyle evaluation tool for metabolic syndrome patients. Methods: A methodological research design was used. The construct factors and preliminary items were identified by reviewing previous researches and tools related to lifestyle and reviewed by ten experts. It was tested with 195 patients with metabolic syndrome in a university hospital. The data were analyzed with SPSS/WIN 14.0. Results: To test the validity, principal component analyses were used and resulted in the extraction of six components. The convergent validity resulted r= .72 (p<.001) with Health Promotion Lifestyle Profile. The discriminant validity with Center for Epidemiologic Studies Depression Scale resulted r= -.15 (p=.004). The Internal consistency of the tool had an Cronbach's a of .92. The self-report format Lifestyle Evaluation Tool for the patients with metabolic syndrome was developed with 36 items and four-rating scales:'physical activity and weight control' eight items, 'dietary habits' sixteen items, 'drinking and smoking' three items, 'sleep and rest' two items, 'stress' three items, 'drug and health management' four items. Conclusion: This Tool will evaluate health behaviors in patients with metabolic syndrome. Also, it will contribute to the development of nursing intervention to improve the metabolic syndrome patients' lifestyle.

• Journal of Microbiology and Biotechnology
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• v.15 no.1
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• pp.161-174
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• 2005

Abstract Glycolysis has a main function to provide ATP and precursor metabolites for biomass production. Although glycolysis is one of the most important pathways in cellular metabolism, the details of its regulation mechanism and regulating chemicals are not well known yet. The regulation of the glycolytic pathway is very robust to allow for large fluxes at almost constant metabolite levels in spite of changing environmental conditions and many reaction effectors like inhibitors, activating compounds, cofactors, and related metal ions. These changing environmental conditions and metabolic reaction effectors were focused on to understand their roles in the metabolic networks. In this study, we have investigated for construction of the regulatory map of the glycolytic metabolic network and tried to collect all the effectors as much as possible which might affect the glycolysis metabolic pathway. Using the results of this study, it is expected that a complex metabolic situation can be more precisely analyzed and simulated by using available programs and appropriate kinetic data.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.3
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• pp.551-557
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• 2011

The purpose of this study is to investigate the relation between brachial-ankle pulse wave velocity and the features of metabolic syndrome, and differences according to sex in patients diagnosed cerebral infarction. The study group comprised 61 patients over age 30 who were diagnosed cerebral infarction, accompanied with metabolic syndrome. The brachial-ankle pulse wave velocity, blood pressure, lipid profiles, fasting blood glucose, body mass index were measured. Also we checked past history of patients. Then we analyzed the association between brachial-ankle pulse wave velocity and the features of metabolic syndrome. Pearson correlation analysis reflected the variables affecting the brachial-ankle pulse wave velocity as follows : Age, SBP(systolic blood pressure), DBP(diastolic blood pressure), FBS(fasting blood glucose) were positively correlated. As a result of regression analysis, in patients with cerebral infarction accompanied with metabolic syndrome, the brachial-ankle pulse wave velocity is affected by age to men, SBP, FBS, DBP to women. The brachial-ankle pulse wave velocity is not affected by the components of metabolic syndrome, except blood pressure, FBS, in patients with ischemic stroke.

• Journal of muscle and joint health
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• v.21 no.1
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• pp.46-54
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• 2014

Purpose: This study was designed to explore the stage distribution of subjects according to stages of change for exercise and to identify factors that could discriminate subjects in various stages. Methods: The sample consisted of 182 subjects who had metabolic syndrome. The instruments used in this study were the stage placement instrument for exercise, the metabolic syndrome knowledge and metabolic syndrome health belief scale, and the metabolic syndrome exercise self efficacy scale. Data were analyzed using chi-square, ANOVA, and discriminant analysis by using the SPSS 19.0 program. Results: For exercise stages, exercise efficacy, occupation, and exercise benefit showed high standardized canonical discriminant function coefficients. Subjects in precontemplation/contemplation stage for exercise were more likely to have occupations, had less exercise efficacy and exercise benefit than those in other stage. Conclusion: This study implies that the level of exercise efficacy and exercise benefit of subjects in precontemplation/contemplation stage need to be enhanced in developing exercise program incorporating the stage of change for metabolic syndrome patients.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.13 no.1
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• pp.1-19
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• 2013

Inherited metabolic disorders are individually rare but as a whole, they are nor rare. Since Archibald Garrod introduced a concept of "inborn error of metabolism" or "chemical individuality", more than 600 diseases are currently known, affecting approximately one in 500 newborns cumulatively. They frequently manifest with acute, life-threatening crisis that requires immediate specific intervention or they present with insidious diverse symptoms and signs involving multiple visceral organs or tissues as well as central nervous system, hampering a correct diagnosis. In addition, many pediatricians are not familiar with all diagnostic and therapeutic strategies for diverse inherited metabolic disorders. However, the prognosis of affected children are heavily dependent on rapid and effective treatment. In this lecture, practical guidelines for the specific diagnosis based on diverse clinical features of inherited metabolic disorders will be described. Many sophisticated laboratory tests are available for the confirmatory diagnosis of each disease, which is challenging to general pediatricians with respect to knowledge about biochemical metabolite assay test, enzymatic test and DNA diagnostic tests. Sample collections, indications, methods and interpretation of results in varying laboratory tests will be listed as well.

• KSBB Journal
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• v.24 no.3
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• pp.287-290
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• 2009

Metabolic network is composed of more than thousands of metabolic reactions. Therefore, understanding of metabolic behavior of microorganisms is required to engineer metabolism of microorganisms. In this paper, we employed ARACNE (Algorithm for the Reconstruction of Accurate Cellular Networks) to quantify relationships among metabolic subpathways. The results showed that ARACNE analysis can give new insight into the study of bacterial metabolism.

• Korean Journal of Occupational Health Nursing
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• v.22 no.4
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• pp.334-342
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• 2013

Purpose: This study attempted to compare the metabolic syndrome components, liver function and heathy living habits according to abdominal obesity in male and female workers. Methods: The subjects of this study are 1,078 adult workers who visited N hospital in Incheon for health examination. The data were analyzed using t-test or $x^2$-test with the SPSS/WIN 20.0 program. Results: Prevalence of metabolic syndrome are 22.2% in male workers, and 5.2% in female workers. There were significant differences in 4 metabolic syndrome components (high blood pressure, elevated blood sugar, hypertriglyceridemia, low HDL cholesterolemia), abnormal liver function, and living habits (alcohol drinking) according to abdominal obesity in male workers. There were significant differences in 1 metabolic syndrome component (low HDL cholesterolemia), and abnormal liver function in female workers. Conclusion: It is important to manage all metabolic syndrome components and alcohol drinking in the case of male workers with abdominal obesity, and low HDL cholesterolemia in the case of female workers. Also, occupational nurses should include the relevance between abdominal obesity and liver function index when training health for workers in workplace.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.3 no.1
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• pp.4-14
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• 2003

Maple syrup urine disease or branched chain ketoacidurias caused by a deficiency in activity of the branched-chain ${\alpha}$-keto acid dehydrogenase(BCKD) complex. This metabolic block results in the accumulation of the branched-chain amino acids(BCAAs) leucine, isoleucine and valine, and the corresponding branched chain ${\alpha}$-keto acids (BCKAs). Based on the clinical presentation and biochemical responses to thiamine administration, MSUD patients can be divided into five phenotypes : classic, intermediate, intermittent, thiamine responsive and dihydrolipoyl dehydrogenase(E3)-deficient. Classic MSUD has a neonatal onset of encephalopathy, and is the most severe ad most common form. Variant forms of MSUD generally have the initial symptoms by 2 years of age. The majority of untreated classic patients die within the early months of life from recurrent metabolic crisis and neurologic deterioration. Treatment involves both longterm dietary management and aggressive intervention during acute metabolic decompensation. We report here our experience of longterm diet therapy and treatment of acute metabolic decompensation of a case of classic MSUD.