• Clinical Nutrition Research
• /
• v.12 no.4
• /
• pp.320-335
• /
• 2023

Literature showed that soluble fiber has beneficial effects on cardiometabolic risk factors and leptin and adiponectin serum levels. Our aim in this meta-analysis was to determine the effect of soluble fiber supplementation on leptin and adiponectin serum levels. A systematic search was conducted using PubMed, Scopus, and ISI Web of Science for eligible trials up to December 2021. A random-effects model was used to pool calculated effect sizes. Our analysis showed that soluble fiber supplementation did not significantly affect adiponectin (standardized mean difference [SMD], -0.49 Hedges's, 95% confidence interval [CI], -1.20, 0.21, p value = 0.167; I² = 95.4, p value < 0.001) and leptin (SMD, -0.8 Hedges's, 95% CI, -1.70, 0.08, p value = 0.076; I² = 94.6, p value < 0.001) concentrations in comparison with placebo. However, in the subgroup, soluble fiber supplementation had a significant improvement in leptin concentration in overweight and obese patients (SMD, -0.22 Hedges's, 95% CI, -0.43, -0.01, p value = 0.048) and a non-significant beneficial effect in adiponectin level in female (SMD, 0.29 Hedges's, 95% CI, -0.13, 0.71, p value = 0.183) and diabetic patients (SMD, 0.32 Hedges's, 95% CI, -0.67, 1.32, p value = 0.526). A non-linear association between soluble fiber dosage and adiponectin (p_{non-linearity} < 0.001) was observed. Soluble fiber supplementation could not change the circulatory leptin and adiponectin levels. However, beneficial effects were seen in overweight and obese leptin, and increases in adiponectin may also be observed in female and diabetic patients. Further studies are needed to confirm this results.

• Interdisciplinary Bio Central
• /
• v.5 no.1
• /
• pp.1.1-1.8
• /
• 2013

High quality publicly-available transcriptomic data representing relationships in gene expression across a diverse set of biological conditions is used as a context network to explore transcriptomics of the CNS. The context network, 18367Hu-matrix, contains pairwise Pearson correlations for 22,215 human genes across18,637 human tissue samples1. To do this, we compute a network derived from biological samples from CNS cells and tissues, calculate clusters of co-expressed genes from this network, and compare the significance of these to clusters derived from the larger 18367Hu-matrix network. Sorting and visualization uses the publicly available software, MetaOmGraph (http://www.metnetdb.org/MetNet_MetaOm-Graph.htm). This identifies genes that characterize particular disease conditions. Specifically, differences in gene expression within and between two designations of glial cancer, astrocytoma and glioblastoma, are evaluated in the context of the broader network. Such gene groups, which we term outlier-networks, tease out abnormally expressed genes and the samples in which this expression occurs. This approach distinguishes 48 subnetworks of outlier genes associated with astrocytoma and glioblastoma. As a case study, we investigate the relationships among the genes of a small astrocytoma-only subnetwork. This astrocytoma-only subnetwork consists of SVEP1, IGF1, CHRNA3, and SPAG6. All of these genes are highly coexpressed in a single sample of anaplastic astrocytoma tumor (grade III) and a sample of juvenile pilocytic astrocytoma. Three of these genes are also associated with nicotine. This data lead us to formulate a testable hypothesis that this astrocytoma outlier-network provides a link between some gliomas/astrocytomas and nicotine.

• 한국정보교육학회:학술대회논문집
• /
• 2007.08a
• /
• pp.221-226
• /
• 2007

군 복무 중 이러닝을 통해 군 장병의 자기 계발을 돕기 위해 정부는 군 이러닝 포털시스템을 구축하였다. 본 연구에서는 군 이러닝 포털 시스템을 통해 다양한 교육용 콘텐츠를 제공하기 위해 교육용 콘텐츠에 대한 메타데이터를 설계하였다. 군 장병들이 원하는 콘텐츠와 이를 표현하는 방법에 대한 설문 조사를 통해 요구 분석하였으며, 이를 토대로 분류 체계와 분류 항목을 선정하였다. 이러한 분류 체계와 분류 항목을 KEM과 SCORM과 같은 국내 외 콘텐츠 표준화 규격을 참조하여 교육 콘텐츠 메타데이터로 설계하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.17
• /
• pp.7001-7010
• /
• 2014

Isoflavones are phytoestrogens and natural plant compounds which are similar to 17-${\beta}$-estradiol in chemical structure. It is known that they can act as estrogen agonists or antagonists, depending on endocrine estrogenic levels, but actions of isoflavones are rather complex due to large number of variables such as chemical structures and mechanisms. Some hypotheses on biological mechanisms have not satisfactorily been confirmed to date and human epidemiological and experimental studies have been relatively limited. Nevertheless, isoflavones and isoflavone rich foods have become a focus onf interest due to positive health benefits on many diseases, especially prevention of hormone-related cancers, cardiovascular disease, osteoporosis, and adverse postmenopausal symptoms, and improvement of physiological condition such as maintaining cognitive function. This review provides an overview of chemistry, analytical techniques (focused on human biospecimens), functions including biological mechanisms, and effects of isoflavones, on the basis of the available meta-analysis and review articles and some original articles, on health and cancer.

• Annual Conference on Human and Language Technology
• /
• 1994.11a
• /
• pp.223-230
• /
• 1994

본 한글꼴은 음절 및 음소의 가시성을 높이고자 한글 음소의 이중 가로선형 배열을 통한 밀도 분산형 한글꼴과 음소 나열형 한글꼴 등의 새로운 한글꼴의 다양한 표현의 실험 연구이다. 일도 분산형 한글꼴은 새로운 음소형 한글코드(닿소리, 홑소리, 받침 조합형)와 서로 대응하드록 일원화 한글꼴로 한글 및 옛 한글의 음소 조합형의 입.출력이 가능하다. 이러한 시도는 1바이트 이내에서 현대한글 및 옛한글을 구현하며, 이는 한글의 구현원리에 따른 음소형 코드체계의 실현 가능성으로 한글 코드체계의 최적화에 대한 새로운 가설을 제시 한다.

• Lingua Humanitatis
• /
• v.5
• /
• pp.93-106
• /
• 2003

Professor Daihyun Chung has recently presented an intriguing view of Ban-mal(non-honorific expressions) in Korean. He criticizes uses of Ban-mal, on the grounds that they presuppose the existence of hierarchical structures in human beings. Professor Chung also advocates ″a relational theory of Ban-mal″ according to which ascriptions of 'n-mal' should be relativized to the speaker-hearer relationship. He employs this view in showing that uses of Ban-mal indeed presuppose the existence of hierarchical structures in human beings I claim that Professor Chung has not shown the credibility of his relational theory of Ban-mal, and that this very view leads to an unintended and undesirable consequence. Moreover, 1 show that even if we assume that this view is true for the sake of an argument, he is not able to show that uses of Ban-mal indeed presuppose the existence of hierarchical structures. All he can show is rather that uses of 'Ban-mal'(a meta-linguistic expression) presuppose the existence of hierarchical structures. Finally, 1 conclude that what really presupposes the existence of hierarchical structures is the asymmetrical uses of Ban-mal and honorific expressions.

• Annual Conference on Human and Language Technology
• /
• 2011.10a
• /
• pp.110-113
• /
• 2011

스마트 폰의 보급이 대중화됨에 따라 다양한 앱들이 사용되고 있으나 효율적인 사전 탐색에 관한 앱은 그다지 많지 않다. 현재 공개된 한국어 사전 탐색 앱은 완전한 단어이거나 단어의 부분 문자열을 질의로 사용한다. 이 경우 완전한 단어를 기억하지 못하거나 한국어 정보처리를 위한 여러 형태의 음운 정보를 쉽게 탐색할 수 없다. 이러한 문제를 개선하기 위해 본 논문에서는 메타문자를 사용하여 효율적으로 단어를 탐색할 수 있는 앱을 개발한다. 본 논문에서 사용하는 메타문자는 임의의 음절을 표현하는 '*'와 '?'과 종성을 표현하는 ':'를 사용하며 사전구조는 자소 단위의 트라이를 사용한다. 또한 음절은 물론이고 자소(초성, 중성, 종성)로 구성된 질의를 탐색할 수 있다. 더구나 음절과 자소가 혼합된 질의도 사용할 수 있도록 하여 사용자의 편의를 크게 도모하였다.

• Annual Conference on Human and Language Technology
• /
• 2021.10a
• /
• pp.592-596
• /
• 2021

레코드 연결의 대표적인 문제 중 하나는 레코드 간 비교 비용이 크다는 것이다. 이러한 문제를 해결하기 위해서는 레코드 연결에 필수적으로 블로킹 단계가 포함되어야 한다. 블로킹이란 같은 레코드일 가능성이 높은 대상들을 그룹화하여 비교연산을 수행할 대상을 선정하는 단계를 말한다. 블로킹의 목적은 최대한 결과의 recall을 희생시키지 않으면서 비교 연산 횟수 최소화하는 것이다. 메타 블로킹은 가중치 그래프를 블로킹에 적용함으로써 전통적인 블로킹 방식의 한계를 극복하고 더 좋은 성능을 나타내는 모델이다. 본 논문에서는 메타블로킹에서 주목하지 않았던 블록 생성방식을 데이터베이스 속성에 따라 블록을 생성하는 방식으로 개선하고 그에 맞는 가중치 계산식을 제안하였다. 또한 키 기반 블로킹, 메타블로킹, 속성인지 메타블로킹으로 생성된 블로킹 결과에 대한 성능을 측정 및 비교하였다.

• Journal of the Korean Society for Precision Engineering
• /
• v.32 no.4
• /
• pp.353-358
• /
• 2015

Energy consumption reduction has become an important key word in manufacturing that can be achieved through the efficient and optimal use of raw materials and natural resources, and minimization of the harmful effects on nature or human society. The successful implementation of this concept can only be possible by considering a product's entire life cycle and even its disposal from the early design stage. To accomplish this idea with milling, minimum quantity lubrication (MQL) strategies and cutting conditions are analyzed through process modeling and experiments. In this study, a model to predict the cutting energy in the milling process is used to find the cutting conditions, which minimize the cutting energy through a Kriging meta-modeling process. The MQL scheme is developed first to reduce the amount of cutting oil and costs used in the cutting process, which is then employed for the entire modeling and experiments.

• 한국IT서비스학회:학술대회논문집
• /
• 2002.11a
• /
• pp.425-430
• /
• 2002

Over the years, several different approaches have been proposed to enhance the practice of software reuse. These approaches vary in reuse abstraction levels or application domains they focus on. However, it seems that they do not adequately meet the needs of software designers in planning and managing reuse. One reason may be the lack of conceptually well-established framework supporting work domain analysis and modeling. As a new viable solution to this problem, Sutcliffe and his colleagues developed Domain Theory , which is introduced in this paper. Utilizing multidisciplinary perspective, such as cognitive psychology, management science, human-computer interaction, and software engineering. it provides a schematic framework that defines a comprehensive library of generic and reusable models of domain knowledge in terms of generic tasks and meta-domains. It also provides useful methods and guidelines for software reuse, emphasizing the concept of abstraction process in a designer s mind. This paper firstly gives a brief overview of fundamentals of software reuse. Next, it explains the foundation of domain theory and discusses its applicability to software reuse. In particular, the taxonomy of meta-domains and the types of generic tasks are described in more detail. Finally, the future research framework, which primarily addresses the problem of how to apply the domain theory to various work domains, is proposed.