• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5609-5614
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• 2013

Background: Colorectal cancer is the third most common cancer in both men and women in the world and the second leading cause of cancer-related deaths. The incidence of colorectal cancer has increased in Iran in the past three decades and is now considered as a serious problem for our society. This cancer has two types hereditary and non-hereditary, 80% of cases being the latter. Considering that the relationship between SNPs with diseases is a concern, many researchers believed that they offer valuable markers for identifying genes responsible for susceptibility to common diseases. In some cases, they are direct causes of human disease. One SNP can increase risk of cancer, but when considering the rate of overlap and frequency of DNA repair pathways, it might be expected that SNP alone cannot affect the final result of cancer, although several SNPs together can exert a significant influence. Therefore identification of these SNPs is very important. The most important loci which include mutations are: MLH1, MSH2, PMS2, APC, MUTYH, SMAD7, STK11, $XRCC_3$, $DNMT_1$, MTHFR, Exo1, $XRCC_1$ and VDR. Presence of SNPs in these genes decreases or increases risk of colorectal cancer. Materials and Methods: In this article we reviewed the Genes and SNPs associated with non-hereditary and hereditary of colorectal cancer that recently were reported from candidate gene y, meta-analysis and GWAS studies. Results: As with other cancers, colorectal cancer is associated with SNPs in gene loci. Generally, by exploring SNPs, it is feasible to predict the risk of developing colorectal cancer and thus establishing proper preventive measures. Conclusions: SNPs of genes associated with colorectal cancer can be used as a marker SNP panel as a potential tool for improving cancer diagnosis and treatment planning.

• Korean Journal of Adult Nursing
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• v.27 no.5
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• pp.527-536
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• 2015

Purpose: The purpose of this study was to analyze the trend of nursing theories by Korean Journal of Adult Nursing (KJAN) for the last five years and to provide future directions for improvement. Methods: The study analyzed data collected from 323 research papers published in KJAN between 2010~2014. Descriptive analysis was conducted with a focus on frequency and percentage for the quantitative analysis. Qualitative analysis was performed for the analysis of nursing theories. Results: As for research topics, the analysis results based on the meta-paradigm of nursing show that the most frequent factors of analysis were adult patients in the area of human beings, hospitals in the area of environment, depression, anxiety, and suicide in the area of health, and all the influential factors in the area of nursing. The analysis results of uses of nursing theories in the papers reveal that only 4(1.2%) out of total 323 papers used the nursing theories, which indicates that the linkage and utilization of nursing theories in the published papers for the last five years were poor. Conclusion: We needs to make efforts at the society level to activate nursing theory utilization in research which is beloved to connect nursing practice, education, and research.

• The Journal of the Korea Contents Association
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• v.11 no.3
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• pp.505-517
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• 2011

The haptic sense is one of the five human senses that deeply affects cognitive development and everyday lives of children and adults. Recently, researchers and developers have started active discussions and research on haptic technologies. The purpose of this paper is to explain the role of haptics in learning, review studies that have attempted to use haptic technologies to teach students, and discuss how these technologies can be applied in special education context. National and international databases were searched and analyzed using meta-analysis methods. The few studies that have been completed so far are heavily focused on math and science learning. However, haptic technology has great potentials for children with disabilities who can benefit from extra assistance from these devices in wide areas of curriculum including math, science, music, art, history, and so on.

• The Journal of Korean Medicine
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• v.28 no.1 s.69
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• pp.1-10
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• 2007

Background : There has been renewed interest in complementary alternative medicine around the world far a decade. On the other hand, the issue of safety of herbal medicine in Korea has been continuously questioned. Issues raised have included not only chemical residue or heavy metals caused by pollution, but also the toxicity of herbal medicine itself. Objectives : The purpose of this study was to review some herbal medicines subject to controversy of toxicity and figure out what kind of problems they evidence. Methods : In this review, PubMed was used to search medical journals. Keywords such as 'herb, or herbal medicine', 'safety, or adverse events, or adverse effect, or toxicity, or liver injury' were applied. Journals were selected by four inclusion criteria, as objectives should be human, researchers should be medical doctors, literature written in the English language, and types of journals should be meta-analysis or practice guideline or reviews. Finally, 9 cases from 60 journals were included in this review. Results : We reviewed 13 herbal medicines for controversy of toxicity such as ephedra(Mahuang), Arisolochia fangchi, Aristolochia manshuriensis, licorice, skullcap , germander, Syo-saiko-to(Xiao-chai-hu-tang), Chelidonium majus, mistletoe, Dictamnus dasycarpus and madder. Conclusions : It suggested that 'who it is prescribed for' is one of the most important factors to identify the causes of toxicity in herbal medicine and dietary supplements, under specific conditions in Korea.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2004.11a
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• pp.62-67
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• 2004

Many ships in voyage experience weight and buoyancy distribution change by various reasons such as change of sea water density and waves, weather condition, and consumption of fuel, provisions, etc . The weight and buoyancy distribution change can bring the ships out of allowable trim, heeling angle. In these case, the ships should adjust trim and heeling angle by shifting of liquid cargo or ballasting, deballasting of ballast tanks for recovery of initial state or for a stable voyage. But, if the adjustment is performed incorrectly, ship's safety such as longitudinal strength, intact stability, propeller immersion, wide visibility, minimum forward draft cannot be secured correctly. So it is required that the adjustment of trim and heeling angle should be planned not by human operators but by optimization computer algorithm. To make an optimized plan to adjust trim and heeling angle guaranteeing the ship's safety and quickness of process, Uk! combined mechanical analysis and optimization algorithm. The candidate algorithms for the study were heuristic algorithm, meta-heuristic algorithm and uninformed searching algorithm. These are widely used in various kinds of optimization problems. Among them, heuristic algorithm $A^\ast$ was chosen for its optimality. The $A^\ast$ algorithm is then applied for the study. Three core elements of $A^\ast$ Algorithm consists of node, operator, evaluation function were modified and redefined. And we analyzed the $A^\ast$ algorithm by considering cooperation with loading instrument installed in most ships. Finally, the algorithm has been applied to tanker ship's various conditions such as Normal Ballast Condition, Homo Design Condition, Alternate Loading Condition, Also the test results are compared and discussed to confirm the efficiency and the usefulness of the methodology developed the system.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.05a
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• pp.149-152
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• 2017

Big data analysis is an effective analysis techniques of unstructured data such as internet, social network services, web documents generated in mobile environment, e-mail, and social data, as well as formal data well organized in the database. Thus, meta-analysis is a statistical integration method that delivers an opportunity to overview the entire result of integrating and analyzing many quantitative research results. Today, regardless of gender and age is increasing interest in whether you can lead a younger and healthier life. With this change of life which has been developed with a variety of functional health food. Aronia melanocarpa called black chokeberry is a fruit of berry plants belonging to the Rosaceae originally growing in the North America region. In the studies for factors related to quality characteristics and antioxidant activities as the extracts of Aronia in this study, which it is only targeted factors as total sugar, acidity, polyphenol, anthocyanin, antioxidant. Thus, we present the theoretical and practical implications of these results.

• Tuberculosis and Respiratory Diseases
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• v.69 no.2
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• pp.75-80
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• 2010

The year of 2009~2010 brought a number of concepts and new ideas were evaluated with promising results. However, some studies that challenged many beliefs. In acute respiratory distress syndrome (ARDS), recent clinical studies took into consideration of pathophysiologic changes of respiratory system compliance. Meta-analysis of positive end-expiratory pressure trials showed survival benefit of high positive end-expiratory pressure in ARDS. Until now, prone positioning did not show survival benefit in patients with ARDS. Extracorporeal membrane oxygenation (ECMO) based management improved survival in patients with severe ARDS. ECMO can be a management option in severe ARDS. Sedation is a standard practice in critically ill patients needing mechanical ventilation. However, Danish group reported less sedation of critically ill patients receiving mechanical ventilation was associated with an increase in days without ventilation. Although this single center study has some limitations, the overall results are promising. Use of maximal sterile barrier precautions (mask, sterile gown, sterile gloves, and large sterile drapes) with chlorhexidine-impregnated dressing reduced central venous catheter related infection. Selective oropharyngeal decontamination (application of topical antibiotics in the oropharynx) reduced the mortality rate of an intensive care unit (ICU) population. Normoglycemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE-SUGAR) trial reported intensive glucose control increased mortality among adults in the ICU. Some of the results of above papers are promising. However, some ideas may need for more frequent individual assessment and increase the workload of ICU staffs. Before implementation of new practice in ICU, we should take into consideration of individual hospital situation including human and material resources.

• Journal of Biosystems Engineering
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• v.41 no.4
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• pp.373-388
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• 2016

Background: Recent inquiries into high-quality foods have discussed the importance of the functional aspects of foods, in addition to traditional quality indicators such as color, firmness, weight, trimming loss, respiration rate, texture, and soluble solid content. Recently, functional Chinese cabbage, which makes up a large portion of the vegetables consumed in Korea, has been identified as an anticancer treatment. However, the investigation of practical issues, such as the effects of storage conditions on quality indicators (including functional compounds), is still limited. Purpose: We reviewed various studies on variations in the quality indicators and functional compounds of Chinese cabbage in response to different storage environments, focusing on storage temperature and storage period. In particular, we emphasized the effect of storage temperature and storage period on glucosinolate (GSL) levels, in order to provide guidelines for optimizing storage environments to maximize GSLs. Additionally, we used response surface methodology to propose experimental designs for future studies exploring the optimal storage conditions for enhancing GSL contents. Review: Large variations in quality indicators were observed depending on the cultivar, the type of storage, the storage conditions, and the harvest time. In particular, GSL content varied with storage conditions, indicating that either low temperatures or adequate air composition by controlled atmospheric storage may preserve GSL levels, as well as prolonging shelf life. Even though genetic and biochemical approaches are preferred for developing functional Chinese cabbage, it is important to establish a practical method for preserving quality for marketability; a prospective study into optimal storage conditions for preserving functional compounds (which can be applied in farms), is required. This may be achievable with the comprehensive meta-analysis of currently published data introduced in this review, or by conducting newly designed experiments investigating the relationship between storage conditions and the levels of functional compounds.

• Journal of Integrative Natural Science
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• v.14 no.3
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• pp.78-86
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• 2021

Personal space is an invisible space around people and plays an important role in human communication. Individual spaces are known to change according to gender and relationships in communication between people. This study examines whether such personal space exists between characters on a metabus. Gender participants took up short personal space, and female participants found that on the Metabus, they changed their personal space according to their intimacy or gender with other people's characters rather than their own. Male participants are thought to change their personal space according to their personality in case of reason in Metabus. From this, it is thought that the participant continues to have physicality, just as the meta-bus actually has a body. Female participants found that in Metabuses, as in the real world, gender between characters has a similar short personal space, rather than gender, and intimacy between characters. In the case of male participants, it was shown that the closeness between the characters was similar to that of the personal space, but the gender of other characters did not change the personal space. Future validation of personal space for metabus characters requires comparison of shapes of individual spaces and cultures, such as individual characteristics, such as introduction and extroversion of individual space, and experiments of gender. In this experiment, the number of female experiment participants is strongly required in future experiments, as compared with male experiment participants, and the need for various cultural experiments is also required.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.6
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• pp.301-308
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• 2018

This paper presents an optimal design method of a hybrid structural control system considering multi-hazard. Unlike a typical structural control system in which one system is designed for one specific type of hazard, a simultaneous optimal design method for both active and passive control systems is proposed for the mitigation of seismic and wind induced vibration responses of structures. As a numerical example, an optimal design problem is illustrated for a hybrid mass damper(HMD) and 30 viscous dampers which are installed on a 30 story building structure. In order to solve the optimization problem, a self-adaptive Harmony Search(HS) algorithm is adopted. Harmony Search algorithm is one of the meta-heuristic evolutionary methods for the global optimization, which mimics the human player's tuning process of musical instruments. A self-adaptive, dynamic parameter adjustment algorithm is also utilized for the purpose of broad search and fast convergence. The optimization results shows that the performance and effectiveness of the proposed system is superior with respect to a reference hybrid system in which the active and passive systems are independently optimized.