• The Korean Journal of Physiology and Pharmacology
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• 제28권2호
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• pp.107-112
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• 2024

27-Hydroxycholesterol (27OHChol), a prominent cholesterol metabolite present in the bloodstream and peripheral tissues, is a kind of immune oxysterol that elicits immune response. Recent research indicates the involvement of 27OHChol in metabolic inflammation (meta-inflammation) characterized by chronic responses associated with metabolic irregularities. 27OHChol activates monocytic cells such that they secrete pro-inflammatory cytokines and chemokines, and increase the expression of cell surface molecules such as pattern-recognition receptors that play key roles in immune cell-cell communication and sensing metabolism-associated danger signals. Levels of 27OHChol increase when cholesterol metabolism is disrupted, and the resulting inflammatory responses can contribute to the development and complications of metabolic syndrome, including obesity, insulin resistance, and cardiovascular diseases. Since 27OHChol can induce chronic immune response by activating monocyte-macrophage lineage cells that play a crucial role in meta-inflammation, it is essential to understand the 27OHChol-induced inflammatory responses to unravel the roles and mechanisms of action of this cholesterol metabolite in chronic metabolic disorders.

• Animal Bioscience
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• 제37권7호
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• pp.1185-1195
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• 2024

Objective: This meta-analysis aimed to evaluate the impact of wilted and unwilted silage on various parameters, such as nutrient content, fermentation quality, bacterial populations, and digestibility. Methods: Thirty-six studies from Scopus were included in the database and analyzed using a random effects model in OpenMEE software. The studies were grouped into two categories: wilting silage (experiment group) and non-wilting silage (control group). Publication bias was assessed using a fail-safe number. Results: The results showed that wilting before ensiling significantly increased the levels of dry matter, water-soluble carbohydrates, neutral detergent fiber, and acid detergent fiber, compared to non-wilting silage (p<0.05). However, wilting significantly decreased dry matter losses, lactic acid, acetic acid, butyric acid, and ammonia levels (p<0.05). The pH, crude protein, and ash contents remained unaffected by the wilting process. Additionally, the meta-analysis revealed no significant differences in bacterial populations, including lactic acid bacteria, yeast, and aerobic bacteria, or in vitro dry matter digestibility between the two groups (p>0.05). Conclusion: Wilting before ensiling significantly improved silage quality by increasing dry matter and water-soluble carbohydrates, as well as reducing dry matter losses, butyric acid, and ammonia. Importantly, wilting did not have a significant impact on pH, crude protein, or in vitro dry matter digestibility.

• 한국임상약학회지
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• 제34권1호
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• pp.71-78
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• 2024

Background: Oral cancer drugs, particularly tyrosine kinase inhibitors (TKIs), are increasingly popular due to their convenience. However, they pose challenges like drug interactions, especially with medications like azole antifungals. While the FDA provides some guidance, more detailed information is needed to manage these interactions effectively. A meta-analysis was conducted to understand the impact of interactions between TKIs and azole antifungals on adverse events during clinical studies. Methods: A meta-analysis followed PRISMA guidelines. Data from PubMed, EMBASE, and references were searched until November 30, 2021. Inclusion criteria encompassed studies on TKI-antifungal interactions in English. Study selection and quality assessment were conducted by two independent investigators. Results: Out of 158 articles, 11 were selected for analysis. Combination therapy showed a slight increase in adverse events but was not statistically significant (OR 1.02, 95% CI 0.49-2.13, p=0.95). AUC and Cmax fold changes did not significantly impact adverse event development. Both itraconazole and ketoconazole showed no significant difference in adverse event development compared to TKI alone. Conclusions: Study finds TKI-DDI not significantly linked to AE increase; azole antifungal types not related to AE. Future DDI research crucial for drug development.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3607-3612
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• 2013

Introduction: Reported prognostic roles of hypoxic inducible factor (HIF) expression in non-small cell lung cancer (NSCLC) have varied. This meta-analysis aimed to examine the relationship between HIF expression and clinical outcome in NSCLC patients. Methods: PubMed were used to identify relevant literature with the last report up to December $20^{th}$, 2012. After careful review, survival data were collected from eligible studies. We completed the meta-analysis using Stata statistical software (Version 11) and combined hazard ratio (HR) for overall survival (OS). Subgroup specificity, heterogeneity and publication bias were also assessed. All of the results were verified by two persons to ensure accuracy. Results: Eight studies were finally stepped into this meta-analysis in which seven had available data for HIF-$1{\alpha}$ and three for HIF-$2{\alpha}$. Combined HRs suggested that higher expression of $HIF1{\alpha}$ had a negative impact on NSCLC patient survival (HR=1.50; 95%CI=1.07-2.10; p=0.019). The expression of HIF-$2{\alpha}$ was also relative to a poorer survival (HR=2.02; 95%CI=1.47-2.77; p=0.000). No bias existed in either of the two groups. Conclusion: This study suggests that elevations of HIF-$1{\alpha}$ and HIF-$2{\alpha}$ expression are both associated with poor outcome for patients with NSCLC. The data support further and high quality investigation of HIF expression for predicting poor outcome in patients with NSCLC.

• 한국지하수토양환경학회지:지하수토양환경
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• 제22권5호
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• pp.63-70
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• 2017

Radon concentrations were measured in 250 groundwater samples collected from the Goesan area where uraniferous black slate and granites abundantly occur in the formations. The measured radon levels ranged from 0.90 to 7,218.7 Bq/L with the median value of 54.3 Bq/L, similar to the value measured in the nationwide survey in 4,853 wells (52.1 Bq/L). The median value was highest in the Cretaceous granite area (390.0 Bq/L) while it was as low as 20.0~58.8 Bq/L in the Ogcheon meta-sedimentary rock areas. About 23.6% of the total samples exceeded the WHO guideline value of 100 Bq/L established in 2011. The exceeding rate was 69.0, 39.4, and 7.0~13.7% in the Cretaceous granite area, Jurassic granite area, and Ogcheon meta-sedimentary rock areas, respectively.

• 아동학회지
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• 제32권3호
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• pp.143-162
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• 2011

This study presents a meta-anlalytic review of 119 studies, published between 1990 and 2009, of gender differences and variables associated with overt and relational aggression during childhood and adolescence. Gender differences in overt aggression were found to be significantly higher in boys than girls, but significant gender differences in relational aggression were not found. Gender differences of only overt aggression are moderated by age and the reporter type. In general, both overt and relational aggression are more strongly related to maladjustment than adjustment. In addition to this, overt and relational aggression has both common and differential associations with relative levels of maladjustment and adjustment. The moderation of these effect sizes of both overt and relational aggression by age and the reporter type was found.

• 응용통계연구
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• 제22권1호
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• pp.107-114
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• 2009

The present study was carried out to summarize the effect of ginseng in the experimental diabetic rats by meta-analysis related studies. The association measure to test effect of ginseng was the mean difference(MD) between group of rats induced streptozotocin(STZ) and group of rats induced STZ treated with ginseng about the considered effect factors. The level of FI, glucose and TG were significantly reduced(< 0.01), and the level of glycogen was significantly increased by treatment with ginseng (< 0.01) After checking the indication of publication bias for the combined MDs by using the funnel plots, the anti-diabetic effects of ginseng is clearly presented in FI, glucose, TG and glycogen (< 0.05).

• Steel and Composite Structures
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• 제24권1호
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• pp.129-140
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• 2017

Structural optimization is one of the popular and active research areas in the field of structural engineering. In the present study, the newly developed moth-flame optimization (MFO) algorithm and its enhanced version termed as enhanced moth-flame optimization (EMFO) are employed to implement the optimization process of planar and 3D steel frame structures with discrete design variables. The main inspiration of this optimizer is the navigation method of moths in nature called transverse orientation. A number of benchmark steel frame optimization problems are solved by the MFO and EMFO algorithms and the results are compared with those of other meta-heuristics. The obtained numerical results indicate that the proposed EMFO algorithm possesses better computational performance compared with other existing meta-heuristics.

• 약학회지
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• 제53권5호
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• pp.265-273
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• 2009

The aims of this study are to conduct meta-analysis for obtaining pooled estimates of the utility weight for stroke and to explore the study design characteristics that determine the utility weight for stroke. Medline (Pubmed), CEA Registry (Tufts Medical Center), and KERIS (Korea Education & Research Information Service) were searched to find out the literature that reported quality of life with stroke. Patient characteristics, utility weights and standard errors were extracted and stratified by severity, study method, respondent and country. All estimates were measured on a 0 to 1 scale with 0 representing the death and 1 representing the perfect health. The pooled estimates of the utility weight were 0.627 for total stroke, 0.756 for mild stroke, 0.631 for moderate stroke, and 0.389 for severe stroke (p=0.0001). Non-patients showed significantly lower utility weights than patients for severe (p=0.0122) stroke.

• 간호행정학회지
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• 제21권3호
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• pp.263-276
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• 2015

Purpose: The study was done to verify the effect size of the variables related to the emotional labor of nurses. Methods: A total of 47 article on variables related to the emotional labor of nurses and published from 2006 to 2014 were used for the meta-analysis. Results: Variables with the largest effect size related to emotional labor were identified as the variables of work task, organization and individual characteristics in descending order of effect size. The sub-factors with the greatest effect size in the work task variable were exhaustion and work commitment, while for organization variables, intention to change jobs had the largest effect size. For individual characteristics, physical symptoms had the largest effect size. Conclusion: The results of this study are meaningful as the first study to integrate research results on variables related to the emotional labor of Korean nurses, providing practical data for the management of emotional labor.