• Title/Summary/Keyword: Meta study

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Efficacy of oxytocin antagonist infusion in improving in vitro fertilization outcomes on the day of embryo transfer: A meta-analysis

  • Kim, Seul Ki;Han, E-Jung;Kim, Sun Mie;Lee, Jung Ryeol;Jee, Byung Chul;Suh, Chang Suk;Kim, Seok Hyun
    • Clinical and Experimental Reproductive Medicine
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    • v.43 no.4
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    • pp.233-239
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    • 2016
  • Objective: Uterine contraction induced by the embryo transfer (ET) process has an adverse effect on embryo implantation. The aim of this study was to determine the effect of oxytocin antagonist supplementation on the day of ET on in vitro fertilization outcomes via a meta-analysis. Methods: We performed a meta-analysis of randomized controlled trials (RCTs). Four online databases (Embase, Medline, PubMed, and Cochrane Library) were searched through May 2015 for RCTs that investigated oxytocin antagonist supplementation on the day of ET. Studies were selected according to predefined inclusion criteria and meta-analyzed using RevMan 5.3. Only RCTs were included in this study. The main outcome measures were the clinical pregnancy rate, the implantation rate, and the miscarriage rate. Results: A total of 123 studies were reviewed and assessed for eligibility. Three RCTs, which included 1,020 patients, met the selection criteria. The implantation rate was significantly better in patients who underwent oxytocin antagonist infusion (19.8%) than in the control group (11.3%) (n = 681; odds ratio [OR], 1.92; 95% confidence interval [CI], 1.25-2.96). No significant difference was found between the two groups in the clinical pregnancy rate (n = 1,020; OR, 1.57; 95% CI, 0.92-2.67) or the miscarriage rate (n = 456; OR, 0.76; 95% CI, 0.44-1.33). Conclusion: The results of this meta-analysis of the currently available literature suggest that the administration of an oxytocin antagonist on the day of ET improves the implantation rate but not the clinical pregnancy rate or miscarriage rate. Additional, large-scale, prospective, randomized studies are necessary to confirm these findings.

Efficacy of Herbal Medicines for the Treatment of Psoriasis : Systematic Review and Meta-analysis (건선의 한약치료 효과에 대한 체계적 문헌 고찰과 메타 분석)

  • Ryu, Deok-Hyun;Ryu, Deok-Seon;Roh, Seok-Sun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.30 no.3
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    • pp.1-19
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    • 2017
  • Objectives : This study aimed to validate the effect of herbal medicine intervention to relieve the symptoms of psoriasis using systematic review and meta-analysis and provide the newest reason of effectiveness of Korean medicine to psoriasis. Methods : Data were collected through electronic database including Pubmed, Cochrane CENTRAL, NDSL OASIS, Koreantk. Two experts assessed risk of bias of randomized controlled trials by Cochrane group's Risk of Bias tool after searching, reviewing and selecting papers. Data were analyzed using Review Manager(RevMan) 5.3 and Comprehensive Meta Analysis 2.0. Results : Total number of selected trials was 16 randomized controlled trials. This study evaluated the risk of bias and effectiveness of herbal medicine to psoriasis. There were high frequency uncertain in selection bias, performance bias and detection bias. In this meta-analysis, Korean medicine treatment was more effective than western medicine (ES:0.507, 95%CI:0.147-0.867) and placebo (ES:0.955, 95%CI:0.598-1.312). Conclusions : Herbal medicine intervention can be an effective for treatment in psoriasis. But enhancing levels of evidence, we must try to accumulate clinical researches of herbal medicine to psoriasis in Korea.

Aromatherapy Nursing Intervention for Pain Relief A Systematic Review and Meta Analysis (향기요법 간호중재의 통증완화 효과 - 체계적 문헌고찰과 메타분석 -)

  • Kang, Rin;Seomun, GyeongAe
    • Journal of Digital Convergence
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    • v.14 no.6
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    • pp.271-283
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    • 2016
  • This study aimed to validate the effect of aromatherapy nursing intervention to relieve the pain using systematic review and meta-analysis. We performed a meta-analysis of studies published between January 2000 and March 2014 which were identified through KERIS, KISS, DBpia, Cochrane Library, Ovid-Medline and Pubmed. Twenty studies with 1029 participants were included in this study. Key words listed in PICO and used for the search were aroma, perfume, perfume inhalation, perfume massage, aromatherapy, pain, pain management. The results of meta-analysis demonstrated statistically significant differences not only for the overall effect but also specifically for aromatherapy nursing intervention on measures of pain. To present more evidence that support the effectiveness of aromatherapy nursing intervention on measures of pain, further research is warranted.

Effects of Periodontal Treatment on Glycated Hemoglobin A Levels in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials

  • Son, So-Hyun;Lee, Eun-Sun
    • Journal of dental hygiene science
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    • v.18 no.3
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    • pp.137-146
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    • 2018
  • This systematic review aimed to investigate the effects of periodontal treatment on glycated hemoglobin A (HbA1c) levels in patients with type 2 diabetes who develop periodontal disease. The search of the MEDLINE, Embase, CINAHL, and Cochrane Library databases was completed on April 8, 2018. The study design was based on randomized clinical trials. Scaling and root planing was performed for the test group, whereas no periodontal treatment or simple oral training was performed for the control group. The main outcome variable was the change in HbA1c levels. We used the Review Manager statistical analysis software for the quantitative analysis of selected documents. Meta-analysis was performed using the inverse variance estimation method of the fixed-effect model to estimate the effects of periodontal treatment on HbA1c levels in patients with type 2 diabetes. A total of 1,011 documents were searched using search strategies, and 10 documents were included in the meta-analysis. The meta-analysis of the selected literature showed that periodontal treatment significantly reduced the HbA1c levels in patients with type 2 diabetes who develop periodontal disease (mean difference, -0.34; 95% confidence interval, -0.43 to -0.26; p<0.001). This study aimed to investigate the effects of periodontal treatment on HbA1c levels, which can be used as a basis for the increasing management of diabetic complications. To improve the quality of life and reduce the burden of medical expenses for patients with diabetes, periodontal disease management through nonsurgical periodontal treatment, such as scaling and root planing, is necessary.

A Meta-Analysis of Influencing Soybean Food Interventions on the Metabolic Syndrome Risk Factors Utilizing Big Data (빅 데이터 분석을 활용한 콩 식품 중재가 대사증후군 위험요인에 미치는 영향 메타분석)

  • Yu, Ok-Kyeong;Cha, Youn-Soo;Jin, Chan-Yong;Nam, Soo-Tai
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2016.05a
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    • pp.134-137
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    • 2016
  • Big data analysis refers the ability to store, manage and analyze collected data from an existing database management tool. In addition, extract value from large amounts of structured or unstructured data set and means the technology to analyze the results. Meta-analysis is a statistical integration method that delivers an opportunity to overview the entire result of integrating and analyzing many quantitative research results. Meta-analysis is sometimes expressed as an analysis of another analysis. Commonly, factors of metabolic syndrome can be defined as abdominal obesity, high triglycerides, low high density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose. This study will find meaningful mediator variables for criterion variables that affect before and after the metabolic syndrome studies, on the basis of the results of a meta-analysis. We reviewed a total of 5 studies related to metabolic syndrome published in Korea between 2000 and 2016, where a cause and effect relationship is established between variables that are specified in the conceptual model of this study.

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A Meta-regression Analysis on Related Protective Variables of social worker's Turnover Intentions (사회복지사의 이직의도 억제와 관련된 변인에 대한 메타회귀분석)

  • Moon, Dong-Kyu
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.11
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    • pp.7564-7574
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    • 2015
  • This study confirmed by a meta-analysis of the effect of suppressing the size of the turnover variable based on the thesis concerning "turnover intention" of the past 15 years, and the trend over the year, according to published meta-regression analysis was verified. The overall effect size for the study was found to inhibit factors medium effect size. Effect size is a private property factor by lower variable salary levels, age and marital status, working period, turnover experience, educational level, showed a work order forms, job characteristics factor is job satisfaction, working conditions, job importance, firm relationships with colleagues, showed a net job autonomy. In addition, organizational characteristic factor effect sizes organizational commitment, organizational commitment, advancement opportunities, compensation satisfaction, organizational justice, participatory doctor had determined the net. Changes in accordance with the published year is closer to 2015 it showed that the effect of inhibiting factors reduced size.

Work-Related Musculoskeletal Disorders in Iranian Dentists: A Systematic Review and Meta-analysis

  • ZakerJafari, Hamid Reza;YektaKooshali, Mohammad Hossein
    • Safety and Health at Work
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    • v.9 no.1
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    • pp.1-9
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    • 2018
  • Background: Work-related musculoskeletal disorders are the most important problems among professions particularly, dentists. This study was conducted to determine the prevalence of musculoskeletal disorders in various parts of the body in Iranian dentists by using systematic review and meta-analysis. Methods: This systematic review and meta-analysis was based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines and searching in national databases such as SID, Magiran, Irandoc, IranMedex, and Medlib, and international databases such as MedLine, Web of Sciences, Scopus, PubMed, ScienceDirect, Cochrane, Embase, Springer, Wiley Online Library, Ebsco, CEBM, and Google Scholar search engine which were published by January 1, 2017. Researched keywords were in Persian and their standard English equivalents were in accordance with their MeSH. The obtained documents were analyzed using Comprehensive Meta-analysis version 2. Results: According to 23 studies through 2,531 Iranian dentists which took part in this study, prevalence of skeletal disorders in Iranian dentists has been 17.6% [confidence interval (CI) 95%:11.7-25.5] in knees, 33.2% (CI 95%:24.1-43.8) in shoulders, 33.4% (CI 95%: 26.8-40.8) in the thorax, 51.9% (CI 95%:46.7-57.2) in necks, 33.7% (CI 95%:28.2-39.6) in wrists/hands, 12.9% (CI 95%:7.7-20.6) in elbows, 37.3% (CI 95%: 31.5-43.5) in lower back, 11.9% (CI 95%:8.7-16.1) in thighs, 12.9% (CI 95%:3.8-36) in the foot, and 10.5% (CI 95%:7-15.4) in legs. Conclusion: Considering the high prevalence of musculoskeletal disorders in Iranian dentists, ergonomics should be included as a lesson in preclinic and also, reeducation courses for ergonomics basics should be executed for graduate dentists.

A Meta-Analysis of Treatment Effects on Viral Pneumonia Using TCM Injections Specified in the Clinical Guideline for COVID-19 in China

  • Chun, Hea Sun;Choi, Su Hyeon;Song, Ho Sueb
    • Journal of Pharmacopuncture
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    • v.24 no.3
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    • pp.107-121
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    • 2021
  • Objectives: The purpose of this study is to analyze the efficacy of traditional Chinese medicine (TCM) injections specified in the clinical guideline for COVID-19 by conducting a meta-analysis of viral pneumonia data. Methods: TCM injections data on viral pneumonia were collected until July 31, 2021. CNKI, PubMed, EMBASE, and the Cochrane electronic database were used to collect the clinical data. "COVID-19," "Viral pneumonia," "Tanreqing," "Xiyanping," "Reduning," "Xingnaojing," "Xuebijing," "Shenmai," "Shengmai," and "Shenfu" were used as keywords. All data collected were mainly about TCM injections and viral pneumonia. Furthermore, studies that included results such as the total effective rate, cough disappearance time, antipyretic time, lung rhomboid disappearance time, and adverse drug reaction were collected for the meta-analysis to identify the efficacy of TCM injections. However, data unrelated to TCM injections specified in the clinical guidelines for COVID-19 or viral pneumonia were excluded. The quality of included RCTs was assessed by the Cochrane Risk of Bias Tool, and Review Manager 5.3 software was used to conduct the meta-analysis. Results: A total of 18 studies with 1540 patients were included in this study. The results of the meta-analysis showed that the total effective rate OR = 4.61 (95% CI 2.92, 7.25, p = 1.00/ I2 = 0%); the cough disappearance time: SMD -1.23 (-1.37, -1.09, p < 0.00001/ I2 = 94%); the antipyretic time: SMD -1.26 (-1.40, -1.11, p < 0.00001/ I2=94%); lung rhomboid disappearance time: SMD -1.17 (-1.33, -1.02, p < 0.00001/ I2 = 89%); and adverse drug reaction was OR 0.36 (95% CI 0.20, 0.64, p = 0.21/ I2 = 30%). From the results, the treatment group (TCM injection) showed better efficacy than the control group (Western medication). Conclusion: Xiyanping, Reduning, and Tanreqing injections may yield benefits as COVID-19 treatments. However, clinical trials on TCM injections for the treatment of COVID-19 are still lacking. More high-quality clinical trials are still required.

Effect of Laughter Therapy on Healthy Life: A Meta-analysis (웃음요법이 건강한 삶에 미치는 효과: 메타분석)

  • Hwang, Sung-Ho;Jeong, Hyeon-Cheol;Hwang, Ji-Won
    • Journal of the Korea Convergence Society
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    • v.10 no.9
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    • pp.291-299
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    • 2019
  • The purpose of this study is to identify the effects of laughter therapy on healthy life of human through meta-analysis of literature. Based on domestic and foreign academic databases, 495 foreign and 199 domestic literature were reviewed focusing on "quality of life," as the ultimate goal of health. The final seven literature were extracted. Analyses was performed in R version 3.5.1. Significant differences (SMD=0.23, p<0.01) were shown in the pre-post comparisons of experimental groups using the mean difference (effects size) analysis of the extracted samples. Significant results were not shown in meta regression analyses setting explanatory variables as 'treatment sessions and durations' and outcome variables as 'treatment effects of laughter therapy'. This study is meaningful in comparative analyses of pre-post experimental groups to establish 'laughter therapy' has a significant effect on improving 'quality of life' and is a useful intervention method, especially for older people, and older women with depression.

A Study on ROK Military PBL Using Simulation and Meta Model (시뮬레이션과 메타 모델을 이용한 한국군 성과기반군수 연구)

  • Won, Bong Yeon;Lee, Sang Jin
    • Journal of the Korea Society for Simulation
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    • v.28 no.1
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    • pp.81-91
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    • 2019
  • The ROK military uses Performance Based Logistics(PBL) as one of the ways to utilize civilian resources and advanced techniques. However, the Korean PBL is mainly focused on purchasing and repairing parts, which is not contributing to the improvement of the availability of overall system. The objective of this study is to suggest the methodology to evaluate the PBL metrics using the simulation and meta model. A meta model is a regression model to analyze the effect of the PBL through simulating various scenarios with performance metrics. As a result, if the PBL is limited to the part level, the performance has little influence on the availability of overall system. In addition, analysis using the meta model shows that it cannot achieve the performance targets when the same metrics are applied to various items without considering the characteristics of the applied items. Therefore, in order to improve availability, PBL coverage should be extended to a system level that includes key components that have a large impact on availability. If multiple items are included in the PBL coverage, the metrics should be applied differently, taking into account the characteristics of each item.