• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5755-5762
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• 2015

Background: Short-course preoperative radiation (SCRT) with delayed surgery was found to increase pathologic complete response (pCR) rates in several trials. However, there was no clear answer on whether SCRT or long-course chemo-radiotherapy (LCRT) is more effective. Therefore we conducted this meta-analysis to evaluate the safety and efficacy of SCRT versus LCRT, both with delayed surgery, for treatment of rectal cancer. Materials and Methods: The literature was searched from PubMed, EMBASE, Web of Science, Cochrane Library and clinicaltrials.gov up to November, 2014. Quality of the randomized controlled trials (RCTs) was evaluated according to the Cochrane's risk of bias tool of RCT. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used to rate the level of evidence. Review Manager 5.3 was employed for statistical analysis. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated. Results: Three RCTs, with a total of 357 rectal cancer patients, were included in this systematic review. Metaanalysis results demonstrated there were no significantly differences in sphincter preservation rate, local recurrence rate, grade 3~4 acute toxicity, R0 resection rate and downstaging rate. Compared with SCRT, LCRT was associated with significant increase in the pCR rate [RR=0.49, 95%CI (0.31, 0.78), P=0.003]. Conclusions: In terms of sphincter preservation rate, local recurrence rate, grade 3~4 acute toxicity, R0 resection rate and downstaging rate, SCRT with delayed surgery is as effective as LCRT with delayed surgery for management of rectal cancer. LCRT significantly increased pCR rate compared with SCRT. Due to risk of bias and imprecision, further multi-center large sample RCTs were needed to confirm this conclusion.

• 정보관리학회지
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• 제29권1호
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• pp.351-374
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• 2012

최근 디지털 기록관리 패러다임 속에서 중추적 역할을 수행하는 대학기록관 웹사이트는 대학기록을 찾고 활용하는 이용자들에게 더욱 더 중요하게 간주되고 있다. 본 연구는 대학기록관 웹사이트가 질적 향상을 이루기 위해서는 다각적 평가와 분석이 필요하다고 보고 국내 9개의 대학기록관을 선정한 후, 이들에 대하여 웹사이트 구성 내용분석, 웹사이트가 지닌 기능적 유용성, 사용성 및 정보품질에 대한 이용자 만족도, 그리고 웹표준 준수여부 등 다섯 가지의 각도에서 메타 분석을 수행하였다. 분석 결과를 토대로 제시된 대학기록관 웹사이트의 개선방안은 다음과 같다. 첫째, 기록정보의 이용을 보다 활성화하기 위해서는 대학기록관의 소개 및 대학기록 활용성에 대한 홍보와 웹사이트에서의 이용자간의 커뮤니케이션을 높일 수 있는 방안을 모색해야 한다. 둘째, 웹사이트의 콘텐츠 빈약함은 이용자의 이용도를 떨어뜨리므로 체계적인 대학기록의 수집과 함께 디지털화하는 작업에 집중적인 노력이 필요하다. 셋째, 가장 불만족스럽게 나타난 '검색 기능'을 보완하기 위해서는 이용자 중심의 검색인터페이스를 개발이 필요하다. 넷째, 이용자의 만족도에 가장 큰 영향을 미치는 요인이 웹사이트에 대한 '호감도'이므로 이 점을 고려하여 대학기록관 웹사이트를 디자인해야 할 것이다. 마지막으로 웹사이트는 웹표준을 준수하여 보편적 웹접근성을 높여야 할 것이다.

• 한국인터넷방송통신학회논문지
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• 제21권5호
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• pp.127-134
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• 2021

최근 빅데이터 산업의 확대로 고품질의 데이터를 확보하는 것이 중요한 이슈로 떠오르고 있다. 고품질의 데이터를 확보하기 위해서는 데이터에 품질에 대한 정확한 평가가 선행되어야 한다. 데이터의 품질은 데이터에 대한 통계와 같은 메타정보를 통해 평가할 수 있는데 이러한 메타정보를 자동으로 추출하는 기능을 데이터 프로파일링이라고 하다. 지금까지 데이터 프로파일링 소프트웨어는 기존의 데이터 품질 또는 시각화 관련 소프트웨어의 부품이나 추가적인 서비스로 제공되는 것이 일반적이었다. 따라서 프로파일링이 요구되는 다양한 환경에서 직접적으로 사용하기에는 적합하지 않았다. 본 논문에서는 이를 해결하기 위해 마이크로 서비스 아키텍처를 적용하여 다양한 환경에서 서비스가 가능한 데이터 프로파일링 소프트웨어의 개발 결과를 제시한다. 개발된 데이터 프로파일러는 restful API를 통해 데이터의 메타정보에 대한 요청과 응답을 제공하여 사용하기 쉬운 서비스를 제공한다. 또한, 특정 환경에 종속되지 않고 다양한 빅데이터 플랫폼이나 데이터 분석 도구들과 원활한 연계가 가능하다는 장점이 있다.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.361-375
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• 2018

We aimed to compare the efficacy and safety of long-acting injectable (LAI) and oral second-generation antipsychotics (SGAs) in treating schizophrenia by performing a systematic review and meta-analysis. MEDLINE, EMBASE, PsycINFO, CINAHL, and the Cochrane Library, as well as five Korean databases, were systemically searched to identify studies published from 2000 to 16 April 2015, which compared the efficacy and safety of LAI and oral SGAs. Using data from randomized controlled trials (RCTs), meta-analyses were conducted. In addition, the GRADE (the Grading of Recommendations, Assessment, Development and Evaluation) approach was applied to explicitly assess the quality of the evidence. A total of 30 studies including 17 RCTs and 13 observational studies were selected. The group treated with LAI SGAs was characterized by significantly lower relapse rates, longer times to relapse and fewer hospital days, but also by a higher occurrence of extrapyramidal syndrome and prolactin-related symptoms than that in the group treated with oral SGAs. Our findings demonstrate that there is moderate to high level of evidence suggesting that in the treatment of schizophrenia, LAI SGAs have higher efficacy and are associated with higher rates of extrapyramidal syndrome and prolactin-related symptoms. Additionally, the use of LAI SGAs should be combined with appropriate measures to reduce dopamine $D_2$ antagonism-related symptoms.

• 대한약침학회지
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• 제26권3호
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• pp.211-226
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• 2023

Objectives: Crohn's disease is a chronic gastrointestinal disease that belongs to inflammatory bowel disease. This systematic review aims to assess the level of evidence in randomized controlled trials (RCTs) on the effects of acupuncture for Crohn's disease. Methods: We searched 12 databases from the date of the establishment of each database up to May, 2023 for relevant RCTs. The risk of bias of each study was assessed independently by three reviewers. The level of evidence of meta-analysis was assessed using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation). Results: A total of 12 studies were included. The effective rate (odds ratio [OR] 3.23, 95% confidence interval [CI] 1.43, 7.30) for mild to moderate Crohn's disease patients showed a significant difference between the acupuncture with moxibustion group and the sham-acupuncture with sham-moxibustion group. CDAI change (mean difference [MD] -74.15, 95% CI -93.28, -55.01) for mild to moderate Crohn's disease showed a significant difference between the acupuncture with moxibustion group and the sham-acupuncture with sham-moxibustion group. Conclusion: Although acupuncture with moxibustion showed significant effects compared to sham-acupuncture with sham-moxibustion, the effect of acupuncture alone is inconclusive. Moreover, only the effect of acupuncture treatment on mild to moderate Crohn's disease patients was derived as a remarkable result. To confirm the effectiveness of acupuncture treatment for Crohn's disease, studies using only acupuncture for intervention or more RCTs targeting various Crohn's disease patients according to the CDAI are required.

• Imaging Science in Dentistry
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• 제53권3호
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• pp.177-191
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• 2023

Purpose: This systematic review examined the detection of the posterior superior alveolar artery, along with various anatomic characteristics, on cone-beam computed tomography images. Materials and Methods: Studies were identified electronically through the Web of Science, MEDLINE, Scopus, and Embase databases. The quality of the included studies was evaluated using a 5-item binary scale. The detection rate, location, and classified diameter of the posterior superior alveolar artery were estimated as prevalence values. The diameter of this artery, as well as the distances from the artery to the alveolar crest and sinus floor, were estimated as means with associated 95% confidence intervals. Results: Thirty-seven studies were enrolled, with 34 of these included in the meta-analysis. The mean detection rate was 79% (range: 72%-84%), and the mean diameter was 1.06±0.05 mm (range: 0.96-1.16 mm). The posterior superior alveolar artery was located intraosseously in 64% of cases. The mean distance of the artery from the alveolar crest was 16.71±0.49 mm (range: 15.75-17.68 mm), while the mean distance from the artery to the sinus floor was 8.85±0.4 mm (range: 8.05-9.64 mm). Conclusion: According to the findings of this meta-analysis regarding various anatomic characteristics of the posterior superior alveolar artery, severe hemorrhage after damage to this artery during sinus augmentation procedures is not a substantial clinical problem.

• 대한한의학회지
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• 제43권3호
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• pp.164-180
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• 2022

Objectives: The purpose of this study was to evaluate the effects of shenfu injection on myocardial protective effects after mitral valve replacement surgery. Methods: We searched four international databases (PUBMED, Embase, Web of Science and CNKI) and three domestic electronic databases (OASIS, RISS and NDSL) for relevant studies. We used following keywords 'shenfu', 'valve replacement', 'mitral valve' at PUBMED, Embase and Web of Science; '二尖瓣', '参附注射液', '瓣膜' at CNKI and '이첨판', '판막', '삼부' at domestic databases. The search range included randomized controlled trials. When appropriate, meta-analyses were performed. Results: Seven randomized controlled trials were selected. All studies used Shenfu injection after mitral valve replacement surgery. We analyzed myocardial damage, cardiac function, patients' recovery rate, with various evaluation indicators. We also used meta-analysis for CK-MB, cTnI, MDA and voluntary recovery of heartbeat. CK-MB was analyzed in two subgroups: 8 hours and 24 hours after surgery. Std was -2.34(95% CI -4.10, -0.58) for 8 hours and -1.95(95% CI -4.79 to 0.88) for 24 hours. 8 hours showed statistically significant difference. cTnI appeared significant decrease with Std of -2.13(95% CI -2.60, -1.66). MDA showed significant decrease with Std of -0.95(95% CI -1.43 to -0.47). Voluntary recovery of heartbeat significantly increased with the odd ratio of 4.34(95% CI 1.76, 10.70). Conclusions: We suggest that Shenfu injection after Mitral valve replacement surgery may have significant myocardial protective effects in terms of reducing myocardial damages, reactive oxygen species, increasing cardiac function and patients' recovery after surgery. However, the evidence is limited, further research is required.

• Clinical Endoscopy
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• 제56권1호
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• pp.38-49
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• 2023

Background/Aims: Patients with Barrett's esophagus are at increased risk of developing esophageal adenocarcinoma. Endoscopic therapies aim to eradicate dysplastic and metaplastic tissues. Hybrid argon plasma coagulation (hybrid-APC) utilizes submucosal fluid injection to create a protective cushion prior to ablation that shields the submucosa from injury. We performed a pooled meta-analysis to evaluate the safety and efficacy of hybrid-APC. Methods: We conducted a systematic search of major electronic databases in April 2022. Studies that included patients with dysplastic and non-dysplastic Barrett's esophagus undergoing treatment with hybrid-APC were eligible for inclusion. Outcome measures included complete remission of intestinal metaplasia (CR-IM), stricture formation, serious adverse events, and number of sessions necessary to achieve CR-IM. Results: Overall pooled CR-IM rate for patients undergoing hybrid-APC was 90.8% (95% confidence interval [CI], 0.872-0.939; I²=0%). Pooled stricture rate was 2.0% (95% CI, 0.005-0.042; I²=0%). Overall serious adverse event rate was 2.7% (95% CI, 0.007-0.055; I²=0%). Conclusions: Results of the current meta-analysis suggest that hybrid-APC is associated with high rates of CR-IM and a favorable safety profile. Interpretation of these results is limited by the inclusion of retrospective cohort and case series data. Randomized controlled trials that standardize treatment and outcome evaluation protocols are necessary to understand how this treatment option is comparable to the current standards of care.

• Clinics in Shoulder and Elbow
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• 제27권2호
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• pp.196-202
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• 2024

Background: As the population is aging and indications are expanding, shoulder arthroplasty is becoming more frequent, especially bilateral staged replacement. However, surgeons are hesitant to use bilateral reverse prostheses due to potential limitations on activities of daily living. Methods: This meta-analysis was conducted to compare bilateral anatomic to bilateral reverse shoulder implants. PubMed, Cochrane, and Google Scholar (pages 1-20) were searched until April 2023. The clinical outcomes consisted of postoperative functional scores (American Shoulder and Elbow Surgeons [ASES], Single Assessment Numeric Evaluation [SANE], Physical Component Score [PCS], Mental Component Score, and Simple Shoulder Test), pain, and range of motion (external rotation and forward elevation). Three studies were included in this meta-analysis. Results: Bilateral anatomic implants had better postoperative functional outcomes and range of motion, but no significant difference was seen in postoperative pain when compared to the reverse prosthesis. Better ASES score, SANE score, and PCS as well as better external rotation and forward elevation were seen in the bilateral anatomic shoulder replacement group, but no significant difference in pain levels was seen between the two groups Conclusions: The results may be explained by the lower baseline seen in the reverse prosthesis group, which may be due to an older population and different indications. Nevertheless, more randomized controlled studies are needed to confirm these findings. Level of evidence: III.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제7권1호
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• pp.33-42
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• 2018

본 연구는 국내 웹 접근성 평가 연구동향을 분석하여, 부족한 점과 웹 접근성 평가 연구가 나아가야 할 방향성을 제시하기 위한 목적으로 진행되었다. 목적 달성을 위해 2000년 1월부터 2017년 3월까지 약 17년간 한국연구재단 등재학술지 및 등재후보 학술지에 발표된 논문을 대상으로 총 59편을 선정하였다. 선정된 논문들은 웹 접근성에 대한 평가자, 평가 대상, 평가 방법, 평가 결과별로 분석하였다. 분석 결과, 평가자 측면은 '단독 평가(66%)'가, 평가 대상은 '웹 사이트(83%)'가 가장 높은 비율이었다. 평가 방법은 자동평가, 자동과 수동 병행이 유사한 비율이었다. 마지막으로 웹 접근성 문제없음을 나타낸 논문은 단 2편이었다. 본 연구는 평가 동향을 분석한 메타 연구가 부족한 상태에서 한국의 웹 접근성 연구 및 웹 접근성 평가 연구의 바람직한 방향성을 제언했다는 데 의의가 있다.